Preoperative Prehabilitation in Older Adults Undergoing HepatectomyNCT07877311

Prehabilitation Before Liver Surgery in Older Adults

A study testing Preoperative Prehabilitation Program in people with Preoperative Prehabilitation in Older Adults Undergoing Hepatectomy, run by Lining Xu at 6 sites in China.

Active, not recruiting

Under way, not looking for participants. Everyone needed has enrolled. The study is still running.

Official record

Search all trials

Trial summary

Who is it for?: Ages 60 years and older
Conditions the study is for: Preoperative Prehabilitation in Older Adults Undergoing Hepatectomy
What is being tested?: Preoperative Prehabilitation Program
Type of treatment: Lifestyle or therapy programme
Could I receive a placebo?: No, everyone receives an active treatment
How many people: 500 participants
Where: 6 sitesChina
Study dates: 1 Jan 2021to Dec 2027
Phase: Interventional
Are there results?: Not yet: the study is under way

Key requirements

Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.

Ages 60 years and older
All sexes
No healthy volunteers
Adult, Older adult

Who may be able to join

elective liver resection, Child-Pugh class A or B, Eastern Cooperative Oncology Group (ECOG) performance status of 0-2, and ability to understand and comply with the prehabilitation programme

Who cannot join

preoperative Barthel Index <70 (indicating pre-existing severe functional dependence), inability to participate due to severe cognitive impairment (Mini-Mental State Examination <20), uncontrolled psychiatric disease, severe musculoskeletal disorders limiting exercise, active coronary artery disease or heart failure (New York Heart Association class III or IV), end-stage renal disease requiring dialysis, concurrent major surgery, pregnancy or lactation, and enrolment in another interventional trial within 30 days

Trial locations and contacts

6 sites in 1 country.

City, postcode or hospital

6 sites in 1 country

China6 sites

Chinese PLA general hospital
Beijing, Beijing Municipality, 100853
Shenzhen Bao'an District Songgang People's Hospital
Shenzhen, Guangdong, 518105
Hubei Province Integrated Hospital of Chinese and Western Medicine
Wuhan, Hubei, 430015
Affiliated Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Wuhan, Hubei, 430022
Zhongnan Hospital of Wuhan University
Wuhan, Hubei, 430071
Henan Cancer Hospital
Zhengzhou, Henan, 450008

Other trials in China

About this study

Official title: Preoperative Prehabilitation for Older Adults Undergoing Hepatectomy

Many older adults who need liver surgery (hepatectomy) are physically weak before their operation. This can make recovery harder and may lead to more complications after surgery. "Prehabilitation" is a program of exercise and nutrition support that takes place before surgery, with the goal of helping patients get stronger and better prepared.

This study is testing whether a preoperative prehabilitation program helps older adults recover better after liver surgery. We want to find out if it reduces complications and helps patients return to their normal activities sooner.

We are looking for adults aged 65 and older who are scheduled to have liver surgery. Participants will be assigned by chance to either the prehabilitation program or standard care before surgery. The prehabilitation program includes guided exercise and nutrition advice over several weeks before the operation.

If this program works, it could become a routine part of care for older adults preparing for liver surgery, helping them have safer operations and smoother recoveries.

Conditions: Preoperative Prehabilitation in Older Adults Undergoing Hepatectomy
Being tested: Preoperative Prehabilitation Program

What participants receive

What participants receive. In a randomised study each person is assigned to one group by chance.

Preoperative Prehabilitation ProgramBehavioural
Participants in the prehabilitation group receive a multimodal preoperative program initiated 2-4 weeks before scheduled hepatectomy. The program includes: (1) individualized supervised or home-based exercise training (aerobic and resistance exercises, 3-5 sessions per week); (2) nutritional assessment and counseling with protein supplementation as needed; and (3) psychological support including relaxation techniques and preoperative education. The program is delivered by a multidisciplinary team (physiotherapist, dietitian, and nurse) through weekly in-person or telehealth sessions. Participants also receive an individualized home program. The intervention continues until the day before surgery. This program is in addition to standard preoperative care. The control group receives standard preoperative care alone, without structured exercise, nutritional, or psychological prehabilitation.

Study groups in NCT07877311
Study group	Role	What they receive
Prehabilitation Group	Experimental	Not described Receives: Behavioral: Preoperative Prehabilitation Program
Control Group	Active comparator	Not described Receives: Behavioral: Preoperative Prehabilitation Program

What is being measured

The primary outcome is the main question the study is designed to answer.

the rate of recovery of activities of daily living (ADL)
Measured: up to 90 days after surgery

Timeline

From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.

1 Jan 2021Dec 2027

First posted16 Oct 2026
Study start1 Jan 2021
Primary completionDec 2027 (estimated)
Study completionDec 2027 (estimated)

Resources

Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
Publications (22)Papers the sponsor has linked to this study.
Other trials for Preoperative Prehabilitation in Older Adults Undergoing HepatectomyStudies of the same condition, open and under way.
What the trial phases meanHow a treatment moves from first tests in people to approval.

More details

For doctors and researchers: how the study is designed, who runs it, and its registry IDs.

Study design

Study type: Interventional
Phase: Phase N/A
Primary purpose: Prevention
Allocation: Randomised
Intervention model: Parallel groups
Masking: None (open label)
Enrolment: 500 participants (estimated)

IDs, dates and publications

ClinicalTrials.gov ID: NCT07877311
Sponsor's protocol ID: ChinaPLAGH-S2022-664-01
Status last verified: Oct 2026
First submitted: 9 Oct 2026
Last updated: 16 Oct 2026
Results posted: No
FDA-regulated drug: No
FDA-regulated device: No
Individual data sharing: Yes: De-identified individual participant data that underlie the results reported in the primary publication (including text, tables, figures, and appendices) will be shared. Additional documents available will include the Study Protocol and Statistical Analysis Plan. Data will become available beginning 6 months and ending 5 years following article publication. Data will be shared with researchers who provide a methodologically sound proposal. Proposals should be directed to \[xu\_lining@aliyun.com\]. To gain access, data requestors will need to sign a data access agreement.

Publications

Chan AW, Altman DG. Identifying outcome reporting bias in randomised trials on PubMed: review of publications and survey of authors. BMJ. 2005 Apr 2;330(7494):753. doi: 10.1136/bmj.38356.424606.8F. Epub 2005 Jan 28.
PubMed 15681569
Hughes MJ, Hackney RJ, Lamb PJ, Wigmore SJ, Christopher Deans DA, Skipworth RJE. Prehabilitation Before Major Abdominal Surgery: A Systematic Review and Meta-analysis. World J Surg. 2019 Jul;43(7):1661-1668. doi: 10.1007/s00268-019-04950-y.
PubMed 30788536
Pedersen BK, Saltin B. Exercise as medicine - evidence for prescribing exercise as therapy in 26 different chronic diseases. Scand J Med Sci Sports. 2015 Dec;25 Suppl 3:1-72. doi: 10.1111/sms.12581.
PubMed 26606383
Lobo DN, Gianotti L, Adiamah A, Barazzoni R, Deutz NEP, Dhatariya K, Greenhaff PL, Hiesmayr M, Hjort Jakobsen D, Klek S, Krznaric Z, Ljungqvist O, McMillan DC, Rollins KE, Panisic Sekeljic M, Skipworth RJE, Stanga Z, Stockley A, Stockley R, Weimann A. Perioperative nutrition: Recommendations from the ESPEN expert group. Clin Nutr. 2020 Nov;39(11):3211-3227. doi: 10.1016/j.clnu.2020.03.038. Epub 2020 Apr 18.
PubMed 32362485
Gillis C, Carli F. Promoting Perioperative Metabolic and Nutritional Care. Anesthesiology. 2015 Dec;123(6):1455-72. doi: 10.1097/ALN.0000000000000795.
PubMed 26248016
VanderWeele TJ, Ding P. Sensitivity Analysis in Observational Research: Introducing the E-Value. Ann Intern Med. 2017 Aug 15;167(4):268-274. doi: 10.7326/M16-2607. Epub 2017 Jul 11.
PubMed 28693043
Rahbari NN, Garden OJ, Padbury R, Brooke-Smith M, Crawford M, Adam R, Koch M, Makuuchi M, Dematteo RP, Christophi C, Banting S, Usatoff V, Nagino M, Maddern G, Hugh TJ, Vauthey JN, Greig P, Rees M, Yokoyama Y, Fan ST, Nimura Y, Figueras J, Capussotti L, Buchler MW, Weitz J. Posthepatectomy liver failure: a definition and grading by the International Study Group of Liver Surgery (ISGLS). Surgery. 2011 May;149(5):713-24. doi: 10.1016/j.surg.2010.10.001. Epub 2011 Jan 14.
PubMed 21236455
Weimann A, Braga M, Carli F, Higashiguchi T, Hubner M, Klek S, Laviano A, Ljungqvist O, Lobo DN, Martindale R, Waitzberg DL, Bischoff SC, Singer P. ESPEN guideline: Clinical nutrition in surgery. Clin Nutr. 2017 Jun;36(3):623-650. doi: 10.1016/j.clnu.2017.02.013. Epub 2017 Mar 7.
PubMed 28385477
Gustafsson UO, Scott MJ, Hubner M, Nygren J, Demartines N, Francis N, Rockall TA, Young-Fadok TM, Hill AG, Soop M, de Boer HD, Urman RD, Chang GJ, Fichera A, Kessler H, Grass F, Whang EE, Fawcett WJ, Carli F, Lobo DN, Rollins KE, Balfour A, Baldini G, Riedel B, Ljungqvist O. Guidelines for Perioperative Care in Elective Colorectal Surgery: Enhanced Recovery After Surgery (ERAS(R)) Society Recommendations: 2018. World J Surg. 2019 Mar;43(3):659-695. doi: 10.1007/s00268-018-4844-y.
PubMed 30426190
Dunne DF, Jack S, Jones RP, Jones L, Lythgoe DT, Malik HZ, Poston GJ, Palmer DH, Fenwick SW. Randomized clinical trial of prehabilitation before planned liver resection. Br J Surg. 2016 Apr;103(5):504-12. doi: 10.1002/bjs.10096. Epub 2016 Feb 11.
PubMed 26864728
Sebio Garcia R, Yanez-Brage MI, Gimenez Moolhuyzen E, Salorio Riobo M, Lista Paz A, Borro Mate JM. Preoperative exercise training prevents functional decline after lung resection surgery: a randomized, single-blind controlled trial. Clin Rehabil. 2017 Aug;31(8):1057-1067. doi: 10.1177/0269215516684179. Epub 2016 Dec 20.
PubMed 28730888
van Rooijen SJ, Molenaar CJL, Schep G, van Lieshout RHMA, Beijer S, Dubbers R, Rademakers N, Papen-Botterhuis NE, van Kempen S, Carli F, Roumen RMH, Slooter GD. Making Patients Fit for Surgery: Introducing a Four Pillar Multimodal Prehabilitation Program in Colorectal Cancer. Am J Phys Med Rehabil. 2019 Oct;98(10):888-896. doi: 10.1097/PHM.0000000000001221.
PubMed 31090551
Carli F, Bousquet-Dion G, Awasthi R, Elsherbini N, Liberman S, Boutros M, Stein B, Charlebois P, Ghitulescu G, Morin N, Jagoe T, Scheede-Bergdahl C, Minnella EM, Fiore JF Jr. Effect of Multimodal Prehabilitation vs Postoperative Rehabilitation on 30-Day Postoperative Complications for Frail Patients Undergoing Resection of Colorectal Cancer: A Randomized Clinical Trial. JAMA Surg. 2020 Mar 1;155(3):233-242. doi: 10.1001/jamasurg.2019.5474.
PubMed 31968063
Barberan-Garcia A, Ubre M, Roca J, Lacy AM, Burgos F, Risco R, Momblan D, Balust J, Blanco I, Martinez-Palli G. Personalised Prehabilitation in High-risk Patients Undergoing Elective Major Abdominal Surgery: A Randomized Blinded Controlled Trial. Ann Surg. 2018 Jan;267(1):50-56. doi: 10.1097/SLA.0000000000002293.
PubMed 28489682
Silver JK, Baima J. Cancer prehabilitation: an opportunity to decrease treatment-related morbidity, increase cancer treatment options, and improve physical and psychological health outcomes. Am J Phys Med Rehabil. 2013 Aug;92(8):715-27. doi: 10.1097/PHM.0b013e31829b4afe.
PubMed 23756434

Study at a glance

From the registry record, last updated by the sponsor on 16 Oct 2026. Recruitment status is as the sponsor reported it: confirm with the study team.

Official title: Preoperative Prehabilitation for Older Adults Undergoing Hepatectomy
ClinicalTrials.gov ID: NCT07877311
Acronym / sponsor ID: ChinaPLAGH-S2022-664-01
Conditions: Preoperative Prehabilitation in Older Adults Undergoing Hepatectomy
Study type: Interventional
Recruitment status: Active, not recruiting
Enrolment: 500 participants (estimated)
Lead sponsor: Lining XuUniversity, hospital or other
Study start: 1 Jan 2021 (actual)
Primary completion: Dec 2027 (estimated)
Study completion: Dec 2027 (estimated)
First posted: 16 Oct 2026 (actual)
Results: Not posted in the source record

Clinical summary

The research question as the sponsor registered it. This describes what the study plans to test, not what it found.

If this program works, it could become a routine part of care for older adults preparing for liver surgery, helping them have safer operations and smoother recoveries.

Study design

Primary purpose: Prevention
Allocation: Randomised
Intervention model: Parallel groups
Masking: None (open label)
Number of arms: 2

Arm	Type	Receives
Prehabilitation Group	Experimental	Behavioral: Preoperative Prehabilitation Program
Control Group	Active comparator	Behavioral: Preoperative Prehabilitation Program

Who may qualify

Ages: 60 years and older
Sex: All
Healthy volunteers: Not accepted
Age groups: Adult, Older adult

Key inclusion criteria (1 listed)

elective liver resection, Child-Pugh class A or B, Eastern Cooperative Oncology Group (ECOG) performance status of 0-2, and ability to understand and comply with the prehabilitation programme

Key exclusion criteria (1 listed)

preoperative Barthel Index <70 (indicating pre-existing severe functional dependence), inability to participate due to severe cognitive impairment (Mini-Mental State Examination <20), uncontrolled psychiatric disease, severe musculoskeletal disorders limiting exercise, active coronary artery disease or heart failure (New York Heart Association class III or IV), end-stage renal disease requiring dialysis, concurrent major surgery, pregnancy or lactation, and enrolment in another interventional trial within 30 days

Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.

Interventions

Intervention	Type	Arms
Preoperative Prehabilitation ProgramParticipants in the prehabilitation group receive a multimodal preoperative program initiated 2-4 weeks before scheduled hepatectomy. The program includes: (1) individualized supervised or home-based exercise training (aerobic and resistance exercises, 3-5 sessions per week); (2) nutritional assessment and counseling with protein supplementation as needed; and (3) psychological support including relaxation techniques and preoperative education. The program is delivered by a multidisciplinary team (physiotherapist, dietitian, and nurse) through weekly in-person or telehealth sessions. Participants also receive an individualized home program. The intervention continues until the day before surgery. This program is in addition to standard preoperative care. The control group receives standard preoperative care alone, without structured exercise, nutritional, or psychological prehabilitation.	Behavioural	Control Group, Prehabilitation Group

Primary outcome

the rate of recovery of activities of daily living (ADL)
Time frame: up to 90 days after surgery

Results and safety

This study is still under way. Results are not available in the source record yet.

Research links

Official record on ClinicalTrials.govLast updated by the sponsor 16 Oct 2026.
Background: PubMed 15681569Chan AW, Altman DG. Identifying outcome reporting bias in randomised trials on PubMed: review of publications and survey of authors. BMJ. 2005 Apr 2;330(7494):753. doi: 10.1136/bmj.38356.424606.8F. Epub 2005 Jan 28.
Background: PubMed 30788536Hughes MJ, Hackney RJ, Lamb PJ, Wigmore SJ, Christopher Deans DA, Skipworth RJE. Prehabilitation Before Major Abdominal Surgery: A Systematic Review and Meta-analysis. World J Surg. 2019 Jul;43(7):1661-1668. doi: 10.1007/s00268-019-04950-y.
Background: PubMed 26606383Pedersen BK, Saltin B. Exercise as medicine - evidence for prescribing exercise as therapy in 26 different chronic diseases. Scand J Med Sci Sports. 2015 Dec;25 Suppl 3:1-72. doi: 10.1111/sms.12581.
Background: PubMed 32362485Lobo DN, Gianotti L, Adiamah A, Barazzoni R, Deutz NEP, Dhatariya K, Greenhaff PL, Hiesmayr M, Hjort Jakobsen D, Klek S, Krznaric Z, Ljungqvist O, McMillan DC, Rollins KE, Panisic Sekeljic M, Skipworth RJE, Stanga Z, Stockley A, Stockley R, Weimann A. Perioperative nutrition: Recommendations from the ESPEN expert group. Clin Nutr. 2020 Nov;39(11):3211-3227. doi: 10.1016/j.clnu.2020.03.038. Epub 2020 Apr 18.
Background: PubMed 26248016Gillis C, Carli F. Promoting Perioperative Metabolic and Nutritional Care. Anesthesiology. 2015 Dec;123(6):1455-72. doi: 10.1097/ALN.0000000000000795.
Background: PubMed 28693043VanderWeele TJ, Ding P. Sensitivity Analysis in Observational Research: Introducing the E-Value. Ann Intern Med. 2017 Aug 15;167(4):268-274. doi: 10.7326/M16-2607. Epub 2017 Jul 11.
Background: PubMed 21236455Rahbari NN, Garden OJ, Padbury R, Brooke-Smith M, Crawford M, Adam R, Koch M, Makuuchi M, Dematteo RP, Christophi C, Banting S, Usatoff V, Nagino M, Maddern G, Hugh TJ, Vauthey JN, Greig P, Rees M, Yokoyama Y, Fan ST, Nimura Y, Figueras J, Capussotti L, Buchler MW, Weitz J. Posthepatectomy liver failure: a definition and grading by the International Study Group of Liver Surgery (ISGLS). Surgery. 2011 May;149(5):713-24. doi: 10.1016/j.surg.2010.10.001. Epub 2011 Jan 14.
Background: PubMed 28385477Weimann A, Braga M, Carli F, Higashiguchi T, Hubner M, Klek S, Laviano A, Ljungqvist O, Lobo DN, Martindale R, Waitzberg DL, Bischoff SC, Singer P. ESPEN guideline: Clinical nutrition in surgery. Clin Nutr. 2017 Jun;36(3):623-650. doi: 10.1016/j.clnu.2017.02.013. Epub 2017 Mar 7.
Background: PubMed 30426190Gustafsson UO, Scott MJ, Hubner M, Nygren J, Demartines N, Francis N, Rockall TA, Young-Fadok TM, Hill AG, Soop M, de Boer HD, Urman RD, Chang GJ, Fichera A, Kessler H, Grass F, Whang EE, Fawcett WJ, Carli F, Lobo DN, Rollins KE, Balfour A, Baldini G, Riedel B, Ljungqvist O. Guidelines for Perioperative Care in Elective Colorectal Surgery: Enhanced Recovery After Surgery (ERAS(R)) Society Recommendations: 2018. World J Surg. 2019 Mar;43(3):659-695. doi: 10.1007/s00268-018-4844-y.
Background: PubMed 26864728Dunne DF, Jack S, Jones RP, Jones L, Lythgoe DT, Malik HZ, Poston GJ, Palmer DH, Fenwick SW. Randomized clinical trial of prehabilitation before planned liver resection. Br J Surg. 2016 Apr;103(5):504-12. doi: 10.1002/bjs.10096. Epub 2016 Feb 11.
Background: PubMed 28730888Sebio Garcia R, Yanez-Brage MI, Gimenez Moolhuyzen E, Salorio Riobo M, Lista Paz A, Borro Mate JM. Preoperative exercise training prevents functional decline after lung resection surgery: a randomized, single-blind controlled trial. Clin Rehabil. 2017 Aug;31(8):1057-1067. doi: 10.1177/0269215516684179. Epub 2016 Dec 20.
Background: PubMed 31090551van Rooijen SJ, Molenaar CJL, Schep G, van Lieshout RHMA, Beijer S, Dubbers R, Rademakers N, Papen-Botterhuis NE, van Kempen S, Carli F, Roumen RMH, Slooter GD. Making Patients Fit for Surgery: Introducing a Four Pillar Multimodal Prehabilitation Program in Colorectal Cancer. Am J Phys Med Rehabil. 2019 Oct;98(10):888-896. doi: 10.1097/PHM.0000000000001221.
Individual participant dataSharing planned: Yes. De-identified individual participant data that underlie the results reported in the primary publication (including text, tables, figures, and appendices) will be shared. Additional documents available will include the Study Protocol and Statistical Analysis Plan. Data will become available beginning 6 months and ending 5 years following article publication. Data will be shared with researchers who provide a methodologically sound proposal. Proposals should be directed to [xu_lining@aliyun.com]. To gain access, data requestors will need to sign a data access agreement.

Referral and contact

AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.

The record lists no contact. Use the official record to reach the sponsor.

6 sites in 1 country: see every site and its status.

Questions about this trial

What is this clinical trial studying?

A study testing Preoperative Prehabilitation Program in people with Preoperative Prehabilitation in Older Adults Undergoing Hepatectomy, run by Lining Xu at 6 sites in China.

The full registered description is in the About this study section and the official record.

Who may be eligible to take part?

The sponsor lists 1 inclusion and 1 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.

Is this clinical trial currently recruiting?

The record says: under way, not looking for participants, as of the sponsor's last update on 16 Oct 2026. Status can change between updates, so confirm with the study contact before making plans.

Where is the study taking place?

The record lists 6 sites in China. Whether a site is taking part right now should be confirmed with that site. See every site.

What are the possible benefits and risks?

They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.

Are results available for this study?

This study is still under way. Results are not available in the source record yet.

How can a doctor refer a patient or contact the research team?

The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.

What does the primary outcome measure?

the rate of recovery of activities of daily living (ADL) (time frame: up to 90 days after surgery). It is what the study was designed to measure, not a finding.

Where can I read the original study information?

On the ClinicalTrials.gov record for NCT07877311, which also lists 22 linked publications.

Does a listing mean the treatment is approved or proven to work?

No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.

How often is this information updated?

AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 16 Oct 2026.