AddictionIVOMOCNCT07878624
Vocal Biomarkers of Craving
An observational study of Addiction, run by University of Bordeaux at 1 site in France.
Trial summary
Addiction is a psychiatric disorder associated with craving, an unwanted, intense and persistent desire to use the substance/addictive behavior, leading to frequent relapses. Craving is fluctuating, influenced by internal factors or environmental context, and can be evaluated only by self-report which can be… Read more about this study
- Who is it for?
- Ages 18 years and older
- Conditions the study is for
- Addiction
- What is being tested?
- Cue reactivity paradigm and Ecological momentary assessment
- How many people
- 120 participants
- Where
- 1 siteFrance
- Study dates
- 28 Oct 2025to Apr 2030
- Phase
- Observational
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 years and older
- All sexes
- No healthy volunteers
- Adult, Older adult
Study population: Participants will be recruited from outpatient addiction treatment centers and the general population through social media, university and research websites, posters, and broader communication campaigns in the Bordeaux metropolitan area.
Who may be able to join
- Identify at least one main problematic substance (cannabis, tobacco, alcohol, opiates, stimulant) or one main problematic addictive behavior (e.g : video games, gambling, food, sex…) as the primary addiction
- PresentDiagnostic and Statistical Manual of Mental Disorders Fifth Edition (DSM-5) diagnosis for current Use Disorder for this primary addiction
- Report regular craving and use of this primary addiction (more than 10 days in the last 30 days)
- For participants recruited in treatment centers: receive outpatient treatment for this primary addiction
Who cannot join
None listed.
Trial locations and contacts
1 site in 1 country. Contact the study team or a site near you to ask about taking part.
Fuschia SERRE, Ph-D contact
France1 site, 1 recruiting
- Recruiting
Université de Bordeaux CNRS UMR 6033 SANPSY
Bordeaux
Fuschia SERRE, Ph-D, +33 05 56 56 17 38, fuschia.serre@u-bordeaux.fr
About this study
Official title: Identification of Vocal Biomarkers Associated With Craving in Addiction
Addiction is a psychiatric disorder associated with craving, an unwanted, intense and persistent desire to use the substance/addictive behavior, leading to frequent relapses. Craving is fluctuating, influenced by internal factors or environmental context, and can be evaluated only by self-report which can be burdensome. It has been shown that craving predicts relapse, making it a major treatment target in addiction. Identify biomarkers of craving could enable to detect craving in a passive way (without major effort from individuals to report it) and would be a major improvement. The goal of this observational study is to explore if voice could be a biomarker of craving in adults with substance or behavioral addictions. The main question it aims to answer is:
- Is there voice features associated with craving episodes in addiction ? Participants will undergo a cue-reactivity protocol with different voice tasks, and then answer Ecological Momentary Assessment (EMA) questionnaires on smartphone, with some of the questionnaires recorded out loud with the smartphone's microphone.
- Conditions
- Addiction
- Being tested
- Cue reactivity paradigm, Ecological momentary assessment
- Keywords
- Addiction, Craving, Voice, Vocal features, Biomarker
- Medical subject headings
- Behavior, Addictive
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Cue reactivity paradigmOther
Single laboratory session during which participants undergo a cue-reactivity protocol and are exposed to neutral, addiction-cue, and stress-inducing conditions. Participants realize three different speech tasks (text reading, image description, response to semi-spontaneous question) recorded before and after the visualization of images, either neutral, addiction- related or stress-related. Craving and stress level are collected at different time during each block. No active treatment or intervention is administered.
Ecological momentary assessmentOther
Repeated ambulatory assessments: short smartphone questionnaires 4 times per day for 14-28 days to report craving, substance use/addictive behavior, and daily experiences, and self-initiated event-contingent reports of craving or substance use/addictive behavior. Some of the questionnaires have vocal items that should be directly answered by the participant speaking out loud. No intervention is provided.
| Study group | Role | What they receive |
|---|---|---|
| Participants with DSM-5 diagnosis for a substance use disorder (SUD) or a behavioral addiction | Adults meeting Diagnostic and Statistical Manual of Mental Disorders Fifth Edition (DSM-5) criteria for diagnosis for a substance use disorder (SUD) /behavioral addiction, recruited to complete voice recordings during cue-reactivity protocol and during 14-28 days Ecological Momentary Assessment (EMA) protocol. Receives: Other: Cue reactivity paradigm; Other: Ecological momentary assessment |
What is being measured
The primary outcome is the main question the study is designed to answer.
Vocal acoustic features during the laboratory cue-reactivity protocol
Comparison of acoustic parameters across conditions (neutral, addiction, versus stress conditions): fundamental frequency, pitch, formants, speech rate, articulation rate will be extracted from voice recordings collected during standardized text reading, image description, and semi-spontaneous speech tasks, using custom Python scripts.
Measured: Day 1 of individual participant timeline
Vocal acoustic features during daily life
Comparison of acoustic parameters in craving versus no-craving assessments: fundamental frequency, pitch, formants, speech rate, articulation rate will be extracted from voice recordings collected during semi-spontaneous speech elicited during EMA questionnaires, using custom Python scripts.
Measured: From day 2 through day 15 (up to day 29) of individual participant timeline
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted16 Oct 2026
- Study start28 Oct 2025
- Primary completionDec 2029 (estimated)
- Study completionApr 2030 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for AddictionStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Observational
- Observational model
- Cohort
- Time perspective
- Cross-sectional
- Enrolment
- 120 participants (estimated)
Sponsor and investigators
- Lead sponsor
- University of Bordeaux
- Sponsor type
- University, hospital or other
- Responsible party
- Sponsor
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07878624
- Sponsor's protocol ID
- 25.01781.000582
- Other IDs
- 2025-A01101-48
- Acronym
- IVOMOC
- Status last verified
- Sep 2026
- First submitted
- 21 Sep 2026
- Last updated
- 16 Oct 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- Yes: Deidentified individual participant data will be available upon reasonable request to the principal investigator. Access will be granted to researchers who provide a methodologically sound proposal for achieving the aims of the approved proposal. A data access agreement may be required before the data are released.
Study at a glance
From the registry record, last updated by the sponsor on 16 Oct 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Identification of Vocal Biomarkers Associated With Craving in Addiction
- ClinicalTrials.gov ID
- NCT07878624
- Acronym / sponsor ID
- IVOMOC / 25.01781.000582
- Conditions
- Addiction
- Keywords
- Addiction, Craving, Voice, Vocal features, Biomarker
- Study type
- Observational
- Recruitment status
- Recruiting
- Enrolment
- 120 participants (estimated)
- Lead sponsor
- University of BordeauxUniversity, hospital or other
- Study start
- 28 Oct 2025 (actual)
- Primary completion
- Dec 2029 (estimated)
- Study completion
- Apr 2030 (estimated)
- First posted
- 16 Oct 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
Addiction is a psychiatric disorder associated with craving, an unwanted, intense and persistent desire to use the substance/addictive behavior, leading to frequent relapses. Craving is fluctuating, influenced by internal factors or environmental context, and can be evaluated only by self-report which can be burdensome. It has been shown that craving predicts relapse, making it a major treatment target in addiction. Identify biomarkers of craving could enable to detect craving in a passive way (without major effort from individuals to report it) and would be a major improvement. The goal of this observational study is to explore if voice could be a biomarker of craving in adults with substance or behavioral addictions. The main question it aims to answer is:
- Is there voice features associated with craving episodes in addiction ? Participants will undergo a cue-reactivity protocol with different voice tasks, and then answer Ecological Momentary Assessment (EMA) questionnaires on smartphone, with some of the questionnaires recorded out loud with the smartphone's microphone.
Study design
- Observational model
- Cohort
- Time perspective
- Cross-sectional
- Number of arms
- 1
| Arm | Type | Receives |
|---|---|---|
| Participants with DSM-5 diagnosis for a substance use disorder (SUD) or a behavioral addiction | – | Other: Cue reactivity paradigm, Other: Ecological momentary assessmentAdults meeting Diagnostic and Statistical Manual of Mental Disorders Fifth Edition (DSM-5) criteria for diagnosis for a substance use disorder (SUD) /behavioral addiction, recruited to complete voice recordings during cue-reactivity protocol and during 14-28 days Ecological Momentary Assessment (EMA) protocol. |
Who may qualify
- Ages
- 18 years and older
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
- Study population
- Participants will be recruited from outpatient addiction treatment centers and the general population through social media, university and research websites, posters, and broader communication campaigns in the Bordeaux metropolitan area.
Key inclusion criteria (4 listed)
- Identify at least one main problematic substance (cannabis, tobacco, alcohol, opiates, stimulant) or one main problematic addictive behavior (e.g : video games, gambling, food, sex…) as the primary addiction
- PresentDiagnostic and Statistical Manual of Mental Disorders Fifth Edition (DSM-5) diagnosis for current Use Disorder for this primary addiction
- Report regular craving and use of this primary addiction (more than 10 days in the last 30 days)
- For participants recruited in treatment centers: receive outpatient treatment for this primary addiction
Key exclusion criteria (0 listed)
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Cue reactivity paradigmSingle laboratory session during which participants undergo a cue-reactivity protocol and are exposed to neutral, addiction-cue, and stress-inducing conditions. Participants realize three different speech tasks (text reading, image description, response to semi-spontaneous question) recorded before and after the visualization of images, either neutral, addiction- related or stress-related. Craving and stress level are collected at different time during each block. No active treatment or intervention is administered. | Other | Participants with DSM-5 diagnosis for a substance use disorder (SUD) or a behavioral addiction |
| Ecological momentary assessmentRepeated ambulatory assessments: short smartphone questionnaires 4 times per day for 14-28 days to report craving, substance use/addictive behavior, and daily experiences, and self-initiated event-contingent reports of craving or substance use/addictive behavior. Some of the questionnaires have vocal items that should be directly answered by the participant speaking out loud. No intervention is provided. | Other | Participants with DSM-5 diagnosis for a substance use disorder (SUD) or a behavioral addiction |
Primary outcome
Vocal acoustic features during the laboratory cue-reactivity protocol
Time frame: Day 1 of individual participant timeline
Comparison of acoustic parameters across conditions (neutral, addiction, versus stress conditions): fundamental frequency, pitch, formants, speech rate, articulation rate will be extracted from voice recordings collected during standardized text reading, image description, and semi-spontaneous speech tasks, using custom Python scripts.
Vocal acoustic features during daily life
Time frame: From day 2 through day 15 (up to day 29) of individual participant timeline
Comparison of acoustic parameters in craving versus no-craving assessments: fundamental frequency, pitch, formants, speech rate, articulation rate will be extracted from voice recordings collected during semi-spontaneous speech elicited during EMA questionnaires, using custom Python scripts.
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 16 Oct 2026.
- Individual participant dataSharing planned: Yes. Deidentified individual participant data will be available upon reasonable request to the principal investigator. Access will be granted to researchers who provide a methodologically sound proposal for achieving the aims of the approved proposal. A data access agreement may be required before the data are released.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
Fuschia SERRE, Ph-D contact
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
An observational study of Addiction, run by University of Bordeaux at 1 site in France.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 4 inclusion and 0 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: looking for participants now, as of the sponsor's last update on 16 Oct 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in France. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact Fuschia SERRE, Ph-D (+33 05 56 56 17 38, fuschia.serre@u-bordeaux.fr), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Vocal acoustic features during the laboratory cue-reactivity protocol (time frame: Day 1 of individual participant timeline). The study lists 2 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 16 Oct 2026.