Traumatic Peripheral Nerve InjuryNCT07879092
Effect of Ultrasound Guided PRP Injection on Post Trumatic Peripheral Nerve Regeneration.
A study testing US guided PRP injection and Rehabilitation in people with Traumatic Peripheral Nerve Injury, run by Seham A. Elazab at 1 site in Egypt.
Trial summary
This study is a prospective non randomized controlled trial evaluating the effect of ultrasound-guided platelet-rich plasma (PRP) injections on peripheral nerve regeneration. Patients receiving PRP were compared with a control cohort managed conservatively without PRP. Read more about this study
- Who is it for?
- Ages 18 to 45 years
- Conditions the study is for
- Traumatic Peripheral Nerve Injury
- What is being tested?
- US guided PRP injection and Rehabilitation
- Type of treatment
- Injection or infusion
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 60 participants
- Where
- 1 siteEgypt
- Study dates
- 15 May 2026to 15 Jan 2027
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 45 years
- All sexes
- No healthy volunteers
- Adult
Who may be able to join
- Age 18 -45 years Clinical evidence of peripheral nerve injury Electrophysiological confirmation by nerve conduction studies (NCS) Ultrasound evidence of complete or partial continuity, neuroma, or entrapment Stable neurological deficit for at least 4 weeks prior to enrollment.
Who cannot join
- Complete nerve transection without surgical repair Active infection Coagulopathy or platelet disorders Prior regenerative injection therapy to the affected nerve.
Trial locations and contacts
1 site in 1 country. Contact the study team or a site near you to ask about taking part.
Egypt1 site, 1 recruiting
- Recruiting
AL zahraa university hospital
Cairo, Abbasia
Fatema Magdi M Magdi, 01556911988, s.abdallah.azab@gmail.com
About this study
This study is a prospective non randomized controlled trial evaluating the effect of ultrasound-guided platelet-rich plasma (PRP) injections on peripheral nerve regeneration.
Patients receiving PRP were compared with a control cohort managed conservatively without PRP.
- Conditions
- Traumatic Peripheral Nerve Injury
- Being tested
- US guided PRP injection, Rehabilitation
- Keywords
- Platelet Rich Plasma.peripheral nerve regeneration.ultrasound guided injection.
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
US guided PRP injectionOther
US guided PRP injection for injured nerve and denervated muscles
RehabilitationOther
usual rehabilitation program
| Study group | Role | What they receive |
|---|---|---|
| PRP Intervention | Experimental | 30 trumatic nerve injury patients Receives: Other: US guided PRP injection; Other: Rehabilitation |
| 30 trumatic nerve injury patients as control group | Active comparator | rehabilitation only Receives: Other: Rehabilitation |
What is being measured
The primary outcome is the main question the study is designed to answer.
Change in Muscle Strength Using the Medical Research Council (MRC) Scale
Change in muscle strength of the predefined target muscle from baseline, assessed using the Medical Research Council (MRC) scale (0-5), where 0 indicates no muscle contraction and 5 indicates normal muscle strength. Higher scores indicate better muscle recovery.
Measured: Baseline and every 3 weeks up to Week 24, including assessments at 3 and 6 months.
Secondary outcomes (3)
Change in Compound Muscle Action Potential (CMAP) Amplitude
Change in CMAP amplitude (mV) of the affected motor nerve from baseline, measured using standardized nerve conduction studies. Higher amplitudes may indicate improved motor axonal function.
Measured: Baseline, 3 months, and 6 months after treatment initiation.
Change in Voluntary Motor Unit Recruitment on Needle EMG
Voluntary motor unit recruitment will be assessed using needle EMG during maximal voluntary contraction and graded on a four-point ordinal scale: 0 = absent, 1 = severely reduced (discrete activity), 2 = reduced (incomplete interference pattern), and 3 = full interference pattern. Assessments will be performed at baseline, 3 months, and 6 months.
Measured: Baseline, 3 months, and 6 months after treatment initiation.
Change in Muscle Echogenicity on Ultrasound
Change in mean grayscale echogenicity of the predefined target muscle, measured from standardized ultrasound images using quantitative image analysis (0-255 grayscale units). Measurements will be obtained from a consistent anatomical location using standardized imaging settings.
Measured: Baseline, 3 months, and 6 months after treatment initiation.
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted16 Oct 2026
- Study start15 May 2026
- Primary completion15 Dec 2026 (estimated)
- Study completion15 Jan 2027 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Traumatic Peripheral Nerve InjuryStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Non-randomised
- Intervention model
- Parallel groups
- Masking
- Single blind
- Who is masked
- Outcomes assessor
- Enrolment
- 60 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Seham A. Elazab
- Sponsor type
- University, hospital or other
- Responsible party
- Sponsor-investigator, Seham A. Elazab, Al-Azhar University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07879092
- Sponsor's protocol ID
- 3208
- Status last verified
- Oct 2026
- First submitted
- 10 Oct 2026
- Last updated
- 16 Oct 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Study at a glance
From the registry record, last updated by the sponsor on 16 Oct 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Effect of Ultrasound Guided PRP Injection on Post Trumatic Peripheral Nerve Regeneration.
- ClinicalTrials.gov ID
- NCT07879092
- Acronym / sponsor ID
- 3208
- Conditions
- Traumatic Peripheral Nerve Injury
- Keywords
- Platelet Rich Plasma.peripheral nerve regeneration.ultrasound guided injection.
- Study type
- Interventional
- Recruitment status
- Recruiting
- Enrolment
- 60 participants (estimated)
- Lead sponsor
- Seham A. ElazabUniversity, hospital or other
- Study start
- 15 May 2026 (actual)
- Primary completion
- 15 Dec 2026 (estimated)
- Study completion
- 15 Jan 2027 (estimated)
- First posted
- 16 Oct 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
This study is a prospective non randomized controlled trial evaluating the effect of ultrasound-guided platelet-rich plasma (PRP) injections on peripheral nerve regeneration.
Patients receiving PRP were compared with a control cohort managed conservatively without PRP.
Study design
- Primary purpose
- Treatment
- Allocation
- Non-randomised
- Intervention model
- Parallel groups
- Masking
- Single blind (outcomes assessor)
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| PRP Intervention | Experimental | Other: US guided PRP injection, Other: Rehabilitation30 trumatic nerve injury patients |
| 30 trumatic nerve injury patients as control group | Active comparator | Other: Rehabilitationrehabilitation only |
Who may qualify
- Ages
- 18 to 45 years
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult
Key inclusion criteria (1 listed)
- Age 18 -45 years Clinical evidence of peripheral nerve injury Electrophysiological confirmation by nerve conduction studies (NCS) Ultrasound evidence of complete or partial continuity, neuroma, or entrapment Stable neurological deficit for at least 4 weeks prior to enrollment.
Key exclusion criteria (1 listed)
- Complete nerve transection without surgical repair Active infection Coagulopathy or platelet disorders Prior regenerative injection therapy to the affected nerve.
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| US guided PRP injectionUS guided PRP injection for injured nerve and denervated muscles | Other | PRP Intervention |
| Rehabilitationusual rehabilitation program | Other | 30 trumatic nerve injury patients as control group, PRP Intervention |
Primary outcome
Change in Muscle Strength Using the Medical Research Council (MRC) Scale
Time frame: Baseline and every 3 weeks up to Week 24, including assessments at 3 and 6 months.
Change in muscle strength of the predefined target muscle from baseline, assessed using the Medical Research Council (MRC) scale (0-5), where 0 indicates no muscle contraction and 5 indicates normal muscle strength. Higher scores indicate better muscle recovery.
3 secondary outcomes
Change in Compound Muscle Action Potential (CMAP) Amplitude
Time frame: Baseline, 3 months, and 6 months after treatment initiation.
Change in Voluntary Motor Unit Recruitment on Needle EMG
Time frame: Baseline, 3 months, and 6 months after treatment initiation.
Change in Muscle Echogenicity on Ultrasound
Time frame: Baseline, 3 months, and 6 months after treatment initiation.
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 16 Oct 2026.
- Individual participant dataSharing planned: No
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing US guided PRP injection and Rehabilitation in people with Traumatic Peripheral Nerve Injury, run by Seham A. Elazab at 1 site in Egypt.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 1 inclusion and 1 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: looking for participants now, as of the sponsor's last update on 16 Oct 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Egypt. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Each site lists its own contact: choose the nearest one under Trial locations. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Change in Muscle Strength Using the Medical Research Council (MRC) Scale (time frame: Baseline and every 3 weeks up to Week 24, including assessments at 3 and 6 months.). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 16 Oct 2026.