Multiple SclerosisNCT07879950
Local Vibration and Ankle Mobilization in Multiple Sclerosis
A study testing Local Vibration and Ankle Joint Mobilization in people with Multiple Sclerosis, run by Gaziantep Islam Science and Technology University.
Trial summary
This study will investigate the effects of local vibration and ankle joint mobilization on muscle tone, proprioception, and balance in individuals with multiple sclerosis (MS). Participants will be randomly assigned to one of two treatment groups. Read more about this study
- Who is it for?
- Ages 18 to 65 years
- Conditions the study is for
- Multiple Sclerosis
- What is being tested?
- Local Vibration and Ankle Joint Mobilization
- Type of treatment
- Lifestyle or therapy programme
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 60 participants
- Where
- No sites listed yet
- Study dates
- 15 Dec 2026to 15 Jun 2027
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 65 years
- All sexes
- No healthy volunteers
- Adult, Older adult
Who may be able to join
- Age between 18 and 65 years.
- Diagnosis of multiple sclerosis confirmed by a neurologist.
- Expanded Disability Status Scale (EDSS) score ≤6.0.
- Ability to walk at least 100 meters, with or without an assistive device.
- No MS relapse within the previous 3 months.
- Willingness to participate in the study and provision of written informed consent.
Who cannot join
- MS relapse within the previous 3 months.
- Severe cognitive impairment or cognitive problems that may interfere with communication or participation.
- History of orthopedic surgery involving the lower extremity or presence of a severe orthopedic condition affecting lower-extremity function.
- Vestibular system disorder or another neurological condition that may affect balance.
- Any medical condition contraindicating local vibration or manual therapy.
- Inability to participate regularly throughout the study period.
About this study
Official title: Effects of Local Vibration and Ankle Joint Mobilization on Muscle Tone, Proprioception, and Balance in Individuals With Multiple Sclerosis: A Randomized Controlled Trial
This study will investigate the effects of local vibration and ankle joint mobilization on muscle tone, proprioception, and balance in individuals with multiple sclerosis (MS). Participants will be randomly assigned to one of two treatment groups. One group will receive local vibration applied to the gastrocnemius muscle, while the other group will receive ankle joint mobilization. Both interventions will be performed three times per week for six weeks. Muscle tone, ankle joint position sense, and balance will be assessed before and after the intervention. The study aims to determine whether these interventions can improve neuromuscular and balance-related functions in individuals with MS.
- Conditions
- Multiple Sclerosis
- Being tested
- Local Vibration, Ankle Joint Mobilization
- Keywords
- Multiple Sclerosis, Proprioception, Muscle Tone
- Medical subject headings
- Multiple Sclerosis
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Local VibrationBehavioural
Local mechanical vibration applied to the medial and lateral heads of the gastrocnemius muscle at 40 Hz, 3 minutes per muscle head, three times per week for six weeks.
Ankle Joint MobilizationBehavioural
Grade III posterior-to-anterior talocrural joint mobilization, 60 seconds per set with 30 seconds rest, 4 sets per session, three times per week for six weeks.
| Study group | Role | What they receive |
|---|---|---|
| Local Vibration Group | Experimental | Participants in this group will receive local mechanical vibration applied to the medial and lateral heads of the gastrocnemius muscle. The intervention will be performed with the participant in the prone position and the ankle in a neutral position. Local vibration will be applied continuously at a frequency of 40 Hz for 3 minutes to each head of the gastrocnemius muscle, for a total duration of 6 minutes per session. The intervention will be administered three times per week for six weeks. Receives: Behavioral: Local Vibration |
| Ankle Joint Mobilization Group | Active comparator | Participants in this group will receive ankle joint mobilization targeting the talocrural joint. Posterior-to-anterior talocrural mobilization will be performed according to the Maitland concept at Grade III. Participants will be positioned supine with the knee slightly flexed and the ankle in a neutral position. Mobilization will be performed for 60 seconds followed by 30 seconds of rest, for 4 sets per session. The intervention will be administered three times per week for six weeks. Receives: Behavioral: Ankle Joint Mobilization |
What is being measured
The primary outcome is the main question the study is designed to answer.
Ankle Joint Position Sense Error
Ankle proprioception will be assessed using a digital goniometer. Participants will reproduce predetermined target ankle joint angles, and the absolute difference in degrees between the target angle and reproduced angle will be recorded as the joint position sense error. Lower error values indicate better proprioceptive accuracy.
Measured: Baseline and immediately after the 6-week intervention
Secondary outcomes (2)
Muscle Mechanical Properties
Muscle mechanical properties of the gastrocnemius and soleus muscles will be assessed using the MyotonPRO device. Muscle tone, stiffness, and elasticity parameters will be recorded.
Measured: Baseline and immediately after the 6-week intervention
Trunk Sway
Static postural control will be assessed using the Gyko inertial measurement unit sensor. Trunk sway parameters obtained from the sensor will be recorded as objective measures of balance and postural control.
Measured: Baseline and immediately after the 6-week intervention
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted19 Oct 2026
- Study start15 Dec 2026 (estimated)
- Primary completion15 May 2027 (estimated)
- Study completion15 Jun 2027 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Multiple SclerosisStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Single blind
- Who is masked
- Outcomes assessor
- Enrolment
- 60 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Gaziantep Islam Science and Technology University
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Zekiye İpek, Gaziantep Islam Science and Technology University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07879950
- Sponsor's protocol ID
- GİBTÜMS
- Status last verified
- Oct 2026
- First submitted
- 8 Sep 2026
- Last updated
- 19 Oct 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Study at a glance
From the registry record, last updated by the sponsor on 19 Oct 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Effects of Local Vibration and Ankle Joint Mobilization on Muscle Tone, Proprioception, and Balance in Individuals With Multiple Sclerosis: A Randomized Controlled Trial
- ClinicalTrials.gov ID
- NCT07879950
- Acronym / sponsor ID
- GİBTÜMS
- Conditions
- Multiple Sclerosis
- Keywords
- Multiple Sclerosis, Proprioception, Muscle Tone
- Study type
- Interventional
- Recruitment status
- Not yet recruiting
- Enrolment
- 60 participants (estimated)
- Lead sponsor
- Gaziantep Islam Science and Technology UniversityUniversity, hospital or other
- Study start
- 15 Dec 2026 (estimated)
- Primary completion
- 15 May 2027 (estimated)
- Study completion
- 15 Jun 2027 (estimated)
- First posted
- 19 Oct 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
This study will investigate the effects of local vibration and ankle joint mobilization on muscle tone, proprioception, and balance in individuals with multiple sclerosis (MS). Participants will be randomly assigned to one of two treatment groups. One group will receive local vibration applied to the gastrocnemius muscle, while the other group will receive ankle joint mobilization. Both interventions will be performed three times per week for six weeks. Muscle tone, ankle joint position sense, and balance will be assessed before and after the intervention. The study aims to determine whether these interventions can improve neuromuscular and balance-related functions in individuals with MS.
Study design
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Single blind (outcomes assessor)
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| Local Vibration Group | Experimental | Behavioral: Local VibrationParticipants in this group will receive local mechanical vibration applied to the medial and lateral heads of the gastrocnemius muscle. The intervention will be performed with the participant in the prone position and the ankle in a neutral position. Local vibration will be applied continuously at a frequency of 40 Hz for 3 minutes to each head of the gastrocnemius muscle, for a total duration of 6 minutes per session. The intervention will be administered three times per week for six weeks. |
| Ankle Joint Mobilization Group | Active comparator | Behavioral: Ankle Joint MobilizationParticipants in this group will receive ankle joint mobilization targeting the talocrural joint. Posterior-to-anterior talocrural mobilization will be performed according to the Maitland concept at Grade III. Participants will be positioned supine with the knee slightly flexed and the ankle in a neutral position. Mobilization will be performed for 60 seconds followed by 30 seconds of rest, for 4 sets per session. The intervention will be administered three times per week for six weeks. |
Who may qualify
- Ages
- 18 to 65 years
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (6 listed)
- Age between 18 and 65 years.
- Diagnosis of multiple sclerosis confirmed by a neurologist.
- Expanded Disability Status Scale (EDSS) score ≤6.0.
- Ability to walk at least 100 meters, with or without an assistive device.
- No MS relapse within the previous 3 months.
Key exclusion criteria (6 listed)
- MS relapse within the previous 3 months.
- Severe cognitive impairment or cognitive problems that may interfere with communication or participation.
- History of orthopedic surgery involving the lower extremity or presence of a severe orthopedic condition affecting lower-extremity function.
- Vestibular system disorder or another neurological condition that may affect balance.
- Any medical condition contraindicating local vibration or manual therapy.
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Local VibrationLocal mechanical vibration applied to the medial and lateral heads of the gastrocnemius muscle at 40 Hz, 3 minutes per muscle head, three times per week for six weeks. | Behavioural | Local Vibration Group |
| Ankle Joint MobilizationGrade III posterior-to-anterior talocrural joint mobilization, 60 seconds per set with 30 seconds rest, 4 sets per session, three times per week for six weeks. | Behavioural | Ankle Joint Mobilization Group |
Primary outcome
Ankle Joint Position Sense Error
Time frame: Baseline and immediately after the 6-week intervention
Ankle proprioception will be assessed using a digital goniometer. Participants will reproduce predetermined target ankle joint angles, and the absolute difference in degrees between the target angle and reproduced angle will be recorded as the joint position sense error. Lower error values indicate better proprioceptive accuracy.
2 secondary outcomes
Muscle Mechanical Properties
Time frame: Baseline and immediately after the 6-week intervention
Trunk Sway
Time frame: Baseline and immediately after the 6-week intervention
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 19 Oct 2026.
- Individual participant dataSharing planned: No
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
The record lists no contact. Use the official record to reach the sponsor.
Questions about this trial
What is this clinical trial studying?
A study testing Local Vibration and Ankle Joint Mobilization in people with Multiple Sclerosis, run by Gaziantep Islam Science and Technology University.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 6 inclusion and 6 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: opening soon, as of the sponsor's last update on 19 Oct 2026. Status can change between updates, so confirm with the study contact before making plans.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Ankle Joint Position Sense Error (time frame: Baseline and immediately after the 6-week intervention). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 19 Oct 2026.