Pes Anserine BursitisNCT07881913
Comparison of Bracing and Eccentric Loading Exercises on Pain Modulation and Functional Improvement in Acute Pes Anserine Bursitis Patients
A study testing Medial-Support Knee Brace and Eccentric Loading Exercise in people with Pes Anserine Bursitis, run by Dr Aneeqa Sultan at 2 sites in Pakistan.
Trial summary
This study aims to compare the effects of knee bracing and eccentric loading exercises on pain and functional ability in adults with acute pes anserine bursitis. Pes anserine bursitis is a condition affecting the inner side of the knee that can cause pain and difficulty with activities such as walking, climbing… Read more about this study
- Who is it for?
- Ages 20 to 50 years
- Conditions the study is for
- Pes Anserine Bursitis
- What is being tested?
- Medial-Support Knee Brace and Eccentric Loading Exercise
- Type of treatment
- Medical device, Lifestyle or therapy programme
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 32 participants
- Where
- 2 sitesPakistan
- Study dates
- 20 Oct 2025to 27 Aug 2026
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 20 to 50 years
- All sexes
- No healthy volunteers
- Adult
Who may be able to join
- Adults aged 20-50 years, both male and female.
- Patients diagnosed with early-stage pes anserine bursitis based on clinical symptoms and imaging.
- Body mass index (BMI) between 20 and 35.
- Pain intensity score between 4 and 7.
- Participants with or without previous surgeries.
Who cannot join
- Advanced arthritis or systemic inflammatory conditions, such as systemic lupus erythematosus (SLE).
- Recent lower-limb fracture.
- Pregnancy or other considerations that contraindicate physical therapy or bracing.
- Neurological disorders affecting mobility, such as spinal cord injuries.
Trial locations and contacts
2 sites in 1 country.
Pakistan2 sites
Lahore Poly Clinic
Lahore, Punjab Province
M. Ali clinic
Lahore, Punjab Province
About this study
This study aims to compare the effects of knee bracing and eccentric loading exercises on pain and functional ability in adults with acute pes anserine bursitis. Pes anserine bursitis is a condition affecting the inner side of the knee that can cause pain and difficulty with activities such as walking, climbing stairs, and standing up from a chair.
A total of 32 participants will be included in the study and divided into two groups. One group will receive a knee-bracing intervention, while the other group will participate in a structured exercise program involving eccentric loading and strengthening exercises for the muscles around the knee.
Read more
The bracing group will be instructed to wear a properly fitted medial-support knee brace for approximately 6-8 hours daily during weight-bearing activities. The exercise group will perform prescribed exercises three times per week for eight weeks, with exercise intensity adjusted according to individual tolerance.
Pain intensity and knee-related functional ability will be assessed using the Visual Analogue Scale (VAS) and the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC). Assessments will be conducted before treatment and at the planned follow-up visits to evaluate changes in symptoms and function.
The findings are intended to help determine which intervention provides greater improvement in pain and functional ability in people with acute pes anserine bursitis and may help guide physiotherapy treatment decisions.
Read the detailed description
Pes anserine bursitis is a condition involving irritation or inflammation of the bursa located near the insertion of the sartorius, gracilis, and semitendinosus tendons on the inner side of the knee. It may cause localized pain and tenderness and can limit daily activities, including walking, climbing stairs, standing up from a chair, and performing other movements involving the knee.
Conservative physiotherapy management may include exercise therapy and external support. Exercise therapy aims to improve the strength and functional capacity of the muscles surrounding the knee, while a knee brace may provide support during weight-bearing activities. However, further comparative evidence is needed to determine which approach provides greater improvements in pain and functional ability in patients with acute pes anserine bursitis.
Study objective
The objective of this randomized controlled trial is to compare the effects of knee bracing and eccentric loading exercises on pain intensity and knee-related functional ability in adults with acute pes anserine bursitis. The study is intended to determine whether either intervention provides greater improvement in the measured outcomes.
Study design and treatment groups
The study uses a two-group, parallel randomized controlled trial design. Eligible participants are assigned to one of two intervention groups following screening and informed consent. The planned sample comprises 32 participants, with 16 participants allocated to each group.
Bracing group
Participants assigned to the bracing group receive a properly fitted medial-support knee brace. The prescribed wearing schedule is approximately 6-8 hours daily during weight-bearing activities for eight weeks. Participants are instructed on the correct use and care of the brace.
Eccentric loading exercise group
Participants assigned to the exercise group follow a structured exercise program targeting the muscles surrounding the knee, including the quadriceps and hamstrings. The program includes strengthening and functional exercises, such as leg raises, hamstring curls, and step-ups. Exercises are prescribed three times per week for eight weeks, with three sets of approximately 10-15 repetitions, adjusted according to the participant's tolerance and ability. Exercise intensity progresses gradually as tolerated.
Outcome assessment
Pain intensity is assessed using the Visual Analogue Scale (VAS), and knee-related symptoms and functional limitations are assessed using the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC). These instruments are used to evaluate changes in pain and function over the course of the intervention.
Baseline assessments are performed before treatment. Follow-up assessments are planned to evaluate treatment response and determine whether improvements are maintained. The final assessment schedule should correspond to the actual visits completed and the time points specified in the approved study protocol.
Data analysis
Participant characteristics are summarized using descriptive statistics. Within-group changes and between-group differences in pain and functional outcomes are evaluated using appropriate statistical methods. The choice of statistical tests depends on the distribution of the data, the study design, and the availability of measurements at each assessment time point.
Potential significance
The findings may contribute to the evidence supporting conservative physiotherapy management of acute pes anserine bursitis. Comparing these interventions may help physiotherapists make informed treatment decisions based on improvements in pain and knee-related function.
- Conditions
- Pes Anserine Bursitis
- Being tested
- Medial-Support Knee Brace, Eccentric Loading Exercise
- Keywords
- Pes Anserine Bursitis, Knee Pain, Knee Bracing, Eccentric Loading Exercises, Exercise Therapy, Physiotherapy, Visual Analogue Scale, Western Ontario and McMaster Universities Osteoarthritis Index
- Medical subject headings
- Bursitis
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Medial-Support Knee BraceDevice
Participants will use a medial-support knee brace daily for 6-8 hours during mobility for 8 weeks. The intervention will be used in patients with acute pes anserine bursitis to assess its effects on pain modulation and functional improvement.
Eccentric Loading ExerciseBehavioural
Participants will perform a structured exercise program targeting the quadriceps and hamstring muscles for 8 weeks. Supervised sessions will be conducted three times per week, with 3 sets of 10-15 repetitions. Exercise intensity will progress according to participant tolerance.
| Study group | Role | What they receive |
|---|---|---|
| Bracing Group | Experimental | Participants will use a medial-support knee brace daily for 6-8 hours during mobility for 8 weeks. The intervention aims to reduce pain and improve functional ability in patients with acute pes anserine bursitis. Receives: Device: Medial-Support Knee Brace |
| Eccentric Loading Exercise Group | Experimental | Participants will receive a structured exercise program targeting the quadriceps and hamstring muscles. Supervised sessions will be conducted three times per week for 8 weeks, with 3 sets of 10-15 repetitions. Exercises will progress from low to moderate intensity according to participant tolerance. Receives: Behavioral: Eccentric Loading Exercise |
What is being measured
The primary outcome is the main question the study is designed to answer.
Change in Pain Intensity Measured by the Visual Analogue Scale (VAS)
Pain intensity will be assessed using the Visual Analogue Scale (VAS) before and after the intervention. Changes in VAS scores will be used to evaluate pain reduction following bracing or eccentric loading exercise in patients with acute pes anserine bursitis.
Measured: Baseline and after 8 weeks of intervention
Secondary outcomes (1)
Change in Knee Pain and Functional Ability Measured by the WOMAC Index
Knee-related pain and functional ability will be assessed using the Western Ontario and McMaster Universities Arthritis Index (WOMAC) before and after the intervention. Changes in WOMAC scores will be used to evaluate improvement following bracing or eccentric loading exercise.
Measured: Baseline and after 8 weeks of intervention
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted20 Oct 2026
- Study start20 Oct 2025
- Primary completion27 Apr 2026
- Study completion27 Aug 2026
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Pes Anserine BursitisStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Model description
- This is a two-arm, parallel-group interventional study comparing knee bracing with eccentric loading exercises in adults with acute pes anserine bursitis. Participants are assigned to one of the two treatment groups and receive the allocated intervention over an 8-week treatment period.
- Masking
- None (open label)
- Enrolment
- 32 participants (actual)
Sponsor and investigators
- Lead sponsor
- Dr Aneeqa Sultan
- Sponsor type
- University, hospital or other
- Responsible party
- Sponsor-investigator, Dr Aneeqa Sultan, Superior University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07881913
- Sponsor's protocol ID
- SU-PAB-2026-01
- Status last verified
- Oct 2026
- First submitted
- 13 Oct 2026
- Last updated
- 20 Oct 2026
- Results posted
- No
- Data monitoring committee
- Yes
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Study at a glance
From the registry record, last updated by the sponsor on 20 Oct 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Comparison of Bracing and Eccentric Loading Exercises on Pain Modulation and Functional Improvement in Acute Pes Anserine Bursitis Patients
- ClinicalTrials.gov ID
- NCT07881913
- Acronym / sponsor ID
- SU-PAB-2026-01
- Conditions
- Pes Anserine Bursitis
- Keywords
- Pes Anserine Bursitis, Knee Pain, Knee Bracing, Eccentric Loading Exercises, Exercise Therapy, Physiotherapy, Visual Analogue Scale, Western Ontario and McMaster Universities Osteoarthritis Index
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 32 participants (actual)
- Lead sponsor
- Dr Aneeqa SultanUniversity, hospital or other
- Study start
- 20 Oct 2025 (actual)
- Primary completion
- 27 Apr 2026 (actual)
- Study completion
- 27 Aug 2026 (actual)
- First posted
- 20 Oct 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
This study aims to compare the effects of knee bracing and eccentric loading exercises on pain and functional ability in adults with acute pes anserine bursitis. Pes anserine bursitis is a condition affecting the inner side of the knee that can cause pain and difficulty with activities such as walking, climbing stairs, and standing up from a chair.
A total of 32 participants will be included in the study and divided into two groups. One group will receive a knee-bracing intervention, while the other group will participate in a structured exercise program involving eccentric loading and strengthening exercises for the muscles around the knee.
The bracing group will be instructed to wear a properly fitted medial-support knee brace for approximately 6-8 hours daily during weight-bearing activities. The exercise group will perform prescribed exercises three times per week for eight weeks, with exercise intensity adjusted according to individual tolerance.
Pain intensity and knee-related functional ability will be assessed using the Visual Analogue Scale (VAS) and the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC). Assessments will be conducted before treatment and at the planned follow-up visits to evaluate changes in symptoms and function.
The findings are intended to help determine which intervention provides greater improvement in pain and functional ability in people with acute pes anserine bursitis and may help guide physiotherapy treatment decisions.
Detailed description
Pes anserine bursitis is a condition involving irritation or inflammation of the bursa located near the insertion of the sartorius, gracilis, and semitendinosus tendons on the inner side of the knee. It may cause localized pain and tenderness and can limit daily activities, including walking, climbing stairs, standing up from a chair, and performing other movements involving the knee.
Conservative physiotherapy management may include exercise therapy and external support. Exercise therapy aims to improve the strength and functional capacity of the muscles surrounding the knee, while a knee brace may provide support during weight-bearing activities. However, further comparative evidence is needed to determine which approach provides greater improvements in pain and functional ability in patients with acute pes anserine bursitis.
Study objective
The objective of this randomized controlled trial is to compare the effects of knee bracing and eccentric loading exercises on pain intensity and knee-related functional ability in adults with acute pes anserine bursitis. The study is intended to determine whether either intervention provides greater improvement in the measured outcomes.
Study design and treatment groups
The study uses a two-group, parallel randomized controlled trial design. Eligible participants are assigned to one of two intervention groups following screening and informed consent. The planned sample comprises 32 participants, with 16 participants allocated to each group.
Bracing group
Participants assigned to the bracing group receive a properly fitted medial-support knee brace. The prescribed wearing schedule is approximately 6-8 hours daily during weight-bearing activities for eight weeks. Participants are instructed on the correct use and care of the brace.
Eccentric loading exercise group
Participants assigned to the exercise group follow a structured exercise program targeting the muscles surrounding the knee, including the quadriceps and hamstrings. The program includes strengthening and functional exercises, such as leg raises, hamstring curls, and step-ups. Exercises are prescribed three times per week for eight weeks, with three sets of approximately 10-15 repetitions, adjusted according to the participant's tolerance and ability. Exercise intensity progresses gradually as tolerated.
Outcome assessment
Pain intensity is assessed using the Visual Analogue Scale (VAS), and knee-related symptoms and functional limitations are assessed using the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC). These instruments are used to evaluate changes in pain and function over the course of the intervention.
Baseline assessments are performed before treatment. Follow-up assessments are planned to evaluate treatment response and determine whether improvements are maintained. The final assessment schedule should correspond to the actual visits completed and the time points specified in the approved study protocol.
Data analysis
Participant characteristics are summarized using descriptive statistics. Within-group changes and between-group differences in pain and functional outcomes are evaluated using appropriate statistical methods. The choice of statistical tests depends on the distribution of the data, the study design, and the availability of measurements at each assessment time point.
Potential significance
The findings may contribute to the evidence supporting conservative physiotherapy management of acute pes anserine bursitis. Comparing these interventions may help physiotherapists make informed treatment decisions based on improvements in pain and knee-related function.
Study design
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Number of arms
- 2
- Model description
- This is a two-arm, parallel-group interventional study comparing knee bracing with eccentric loading exercises in adults with acute pes anserine bursitis. Participants are assigned to one of the two treatment groups and receive the allocated intervention over an 8-week treatment period.
| Arm | Type | Receives |
|---|---|---|
| Bracing Group | Experimental | Device: Medial-Support Knee BraceParticipants will use a medial-support knee brace daily for 6-8 hours during mobility for 8 weeks. The intervention aims to reduce pain and improve functional ability in patients with acute pes anserine bursitis. |
| Eccentric Loading Exercise Group | Experimental | Behavioral: Eccentric Loading ExerciseParticipants will receive a structured exercise program targeting the quadriceps and hamstring muscles. Supervised sessions will be conducted three times per week for 8 weeks, with 3 sets of 10-15 repetitions. Exercises will progress from low to moderate intensity according to participant tolerance. |
Who may qualify
- Ages
- 20 to 50 years
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult
Key inclusion criteria (5 listed)
- Adults aged 20-50 years, both male and female.
- Patients diagnosed with early-stage pes anserine bursitis based on clinical symptoms and imaging.
- Body mass index (BMI) between 20 and 35.
- Pain intensity score between 4 and 7.
- Participants with or without previous surgeries.
Key exclusion criteria (4 listed)
- Advanced arthritis or systemic inflammatory conditions, such as systemic lupus erythematosus (SLE).
- Recent lower-limb fracture.
- Pregnancy or other considerations that contraindicate physical therapy or bracing.
- Neurological disorders affecting mobility, such as spinal cord injuries.
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Medial-Support Knee BraceParticipants will use a medial-support knee brace daily for 6-8 hours during mobility for 8 weeks. The intervention will be used in patients with acute pes anserine bursitis to assess its effects on pain modulation and functional improvement. | Device | Bracing Group |
| Eccentric Loading ExerciseParticipants will perform a structured exercise program targeting the quadriceps and hamstring muscles for 8 weeks. Supervised sessions will be conducted three times per week, with 3 sets of 10-15 repetitions. Exercise intensity will progress according to participant tolerance. | Behavioural | Eccentric Loading Exercise Group |
Primary outcome
Change in Pain Intensity Measured by the Visual Analogue Scale (VAS)
Time frame: Baseline and after 8 weeks of intervention
Pain intensity will be assessed using the Visual Analogue Scale (VAS) before and after the intervention. Changes in VAS scores will be used to evaluate pain reduction following bracing or eccentric loading exercise in patients with acute pes anserine bursitis.
1 secondary outcome
Change in Knee Pain and Functional Ability Measured by the WOMAC Index
Time frame: Baseline and after 8 weeks of intervention
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 20 Oct 2026.
- Individual participant dataSharing planned: No
Related trials for Pes Anserine Bursitis
Not yet recruiting
Efficacy of Platelet-rich Plasma Injection Compare With Corticosteroid in Pes Anserinus Pain Syndrome
Pes Anserine Bursitis, Steroid Injection
Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
The record lists no contact. Use the official record to reach the sponsor.
2 sites in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Medial-Support Knee Brace and Eccentric Loading Exercise in people with Pes Anserine Bursitis, run by Dr Aneeqa Sultan at 2 sites in Pakistan.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 5 inclusion and 4 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 20 Oct 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 2 sites in Pakistan. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Change in Pain Intensity Measured by the Visual Analogue Scale (VAS) (time frame: Baseline and after 8 weeks of intervention). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 20 Oct 2026.