Dental ImplantNCT07883811
Effect of Vitamin D3 Supplementation on Serum Sphingosine-1-Phosphate Levels and Dental Implant Osseointegration: A Prospective Study
A study testing Vitamin D3 ( Colecalciferol) in people with Dental Implant, run by Air Force Military Medical University, China.
Trial summary
This study aims to evaluate whether vitamin D3 supplementation can promote dental implant osseointegration by increasing serum sphingosine-1-phosphate (S1P) levels. Sixty patients scheduled for dental implant surgery between July 2025 and December 2026 will be enrolled. Read more about this study
- Who is it for?
- Ages 18 years and older
- Conditions the study is for
- Dental Implant
- What is being tested?
- Vitamin D3 ( Colecalciferol)
- Type of treatment
- Pill or oral medicine
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 60 participants
- Where
- No sites listed yet
- Study dates
- 30 Oct 2026to Oct 2027
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 years and older
- All sexes
- No healthy volunteers
- Adult, Older adult
Who may be able to join
- Patients with a single missing tooth requiring implant restoration.
- Intact lingual or palatal bone wall at the edentulous site, with sufficient bone volume for implant placement confirmed by preoperative CBCT evaluation.
- Healthy opposing and adjacent teeth, with sufficient interocclusal space and normal occlusion and overbite relationships.
- Good treatment compliance. -
- Exclusion Criteria:Severe acute or chronic inflammation at the implant site.
- Insufficient mesiodistal width for implant placement.
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- Presence of poor oral habits such as heavy smoking (>10 cigarettes/day), bruxism, or periodontal disease.
- Pregnant or lactating women.
- Poor general health condition, unable to tolerate surgery.
- Patients currently undergoing orthodontic treatment.
- Patients taking medications affecting bone metabolism.
- Allergy to Vitamin D3.
- Any medical condition contraindicated for Vitamin D3 supplementation.
- -
Who cannot join
None listed.
Trial locations and contacts
No sites are listed yet. Contact the study team or a site near you to ask about taking part.
About this study
This study aims to evaluate whether vitamin D3 supplementation can promote dental implant osseointegration by increasing serum sphingosine-1-phosphate (S1P) levels. Sixty patients scheduled for dental implant surgery between July 2025 and December 2026 will be enrolled. Before surgery, baseline clinical data, cone-beam computed tomography (CBCT) imaging data, and blood samples for serum S1P measurement by ELISA will be collected. Based on baseline S1P levels, 40 patients with low S1P levels will be selected and randomized into a control group and an intervention group, with the intervention group receiving daily vitamin D3 supplementation (800 IU) from immediately after surgery until 3 months postoperatively. At the 3-month follow-up, CBCT images will be acquired again and compared with baseline to assess osseointegration, implant stability will be evaluated by measuring implant stability quotient (ISQ) values, and serum S1P levels will be re-measured. Statistical analysis will be performed using R software. The primary endpoint is the effect of vitamin D3 supplementation on dental implant osseointegration, while secondary endpoints include changes in serum S1P levels, implant stability (ISQ), and safety.
- Conditions
- Dental Implant
- Being tested
- Vitamin D3 ( Colecalciferol)
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Vitamin D3 ( Colecalciferol)Dietary supplement
Oral vitamin D3 supplementation at a dose of 800 IU daily for 3 months postoperatively.
| Study group | Role | What they receive |
|---|---|---|
| High S1P group | No intervention | Patients with high baseline S1P levels receiving standard postoperative care without vitamin D3 supplementation. |
| Low S1P control group | No intervention | Patients with low baseline S1P levels receiving standard postoperative care without vitamin D3 supplementation. |
| Low S1P vitamin D3 intervention group | Experimental | Patients with low baseline S1P levels receiving daily oral vitamin D3 supplementation (800 IU) for 3 months postoperatively. Receives: Dietary Supplement: Vitamin D3 ( Colecalciferol) |
What is being measured
The primary outcome is the main question the study is designed to answer.
Effect of Vitamin D3 Supplementation on Dental Implant Osseointegration
Assessment of peri-implant bone changes and osseointegration using cone-beam computed tomography (CBCT) at 3 months postoperatively compared with baseline.
Measured: Baseline and 3 months postoperatively
Secondary outcomes (2)
Baseline and 3 months postoperatively
Change in serum S1P levels measured by ELISA from baseline to 3 months postoperatively.
Measured: Baseline and 3 months postoperatively
Implant Stability Quotient (ISQ)
Measurement of implant stability quotient (ISQ) values to evaluate implant stability at 3 months postoperatively.
Measured: 3 months postoperatively
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted20 Oct 2026
- Study start30 Oct 2026 (estimated)
- Primary completionOct 2027 (estimated)
- Study completionOct 2027 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Dental ImplantStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Enrolment
- 60 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Air Force Military Medical University, China
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Wang Jing, Air Force Military Medical University, China
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07883811
- Sponsor's protocol ID
- KQ-YJ-2025/225
- Status last verified
- Oct 2026
- First submitted
- 13 Oct 2026
- Last updated
- 20 Oct 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No: The individual participant data (IPD) will not be shared due to privacy and ethical restrictions. The data contain sensitive patient information, and sharing them would compromise participant confidentiality. Additionally, national and institutional regulations restrict the sharing of clinical data with external parties or international databases. De-identified data may be available from the corresponding author upon reasonable request and with approval from the institutional ethics committee.
Study at a glance
From the registry record, last updated by the sponsor on 20 Oct 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Effect of Vitamin D3 Supplementation on Serum Sphingosine-1-Phosphate Levels and Dental Implant Osseointegration: A Prospective Study
- ClinicalTrials.gov ID
- NCT07883811
- Acronym / sponsor ID
- KQ-YJ-2025/225
- Conditions
- Dental Implant
- Study type
- Interventional
- Recruitment status
- Not yet recruiting
- Enrolment
- 60 participants (estimated)
- Lead sponsor
- Air Force Military Medical University, ChinaUniversity, hospital or other
- Study start
- 30 Oct 2026 (estimated)
- Primary completion
- Oct 2027 (estimated)
- Study completion
- Oct 2027 (estimated)
- First posted
- 20 Oct 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
This study aims to evaluate whether vitamin D3 supplementation can promote dental implant osseointegration by increasing serum sphingosine-1-phosphate (S1P) levels. Sixty patients scheduled for dental implant surgery between July 2025 and December 2026 will be enrolled. Before surgery, baseline clinical data, cone-beam computed tomography (CBCT) imaging data, and blood samples for serum S1P measurement by ELISA will be collected. Based on baseline S1P levels, 40 patients with low S1P levels will be selected and randomized into a control group and an intervention group, with the intervention group receiving daily vitamin D3 supplementation (800 IU) from immediately after surgery until 3 months postoperatively. At the 3-month follow-up, CBCT images will be acquired again and compared with baseline to assess osseointegration, implant stability will be evaluated by measuring implant stability quotient (ISQ) values, and serum S1P levels will be re-measured. Statistical analysis will be performed using R software. The primary endpoint is the effect of vitamin D3 supplementation on dental implant osseointegration, while secondary endpoints include changes in serum S1P levels, implant stability (ISQ), and safety.
Study design
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Number of arms
- 3
| Arm | Type | Receives |
|---|---|---|
| High S1P group | No intervention | –Patients with high baseline S1P levels receiving standard postoperative care without vitamin D3 supplementation. |
| Low S1P control group | No intervention | –Patients with low baseline S1P levels receiving standard postoperative care without vitamin D3 supplementation. |
| Low S1P vitamin D3 intervention group | Experimental | Dietary Supplement: Vitamin D3 ( Colecalciferol)Patients with low baseline S1P levels receiving daily oral vitamin D3 supplementation (800 IU) for 3 months postoperatively. |
Who may qualify
- Ages
- 18 years and older
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (14 listed)
- Patients with a single missing tooth requiring implant restoration.
- Intact lingual or palatal bone wall at the edentulous site, with sufficient bone volume for implant placement confirmed by preoperative CBCT evaluation.
- Healthy opposing and adjacent teeth, with sufficient interocclusal space and normal occlusion and overbite relationships.
- Good treatment compliance. -
- Exclusion Criteria:Severe acute or chronic inflammation at the implant site.
Key exclusion criteria (0 listed)
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Vitamin D3 ( Colecalciferol)Oral vitamin D3 supplementation at a dose of 800 IU daily for 3 months postoperatively. | Dietary supplement | Low S1P vitamin D3 intervention group |
Primary outcome
Effect of Vitamin D3 Supplementation on Dental Implant Osseointegration
Time frame: Baseline and 3 months postoperatively
Assessment of peri-implant bone changes and osseointegration using cone-beam computed tomography (CBCT) at 3 months postoperatively compared with baseline.
2 secondary outcomes
Baseline and 3 months postoperatively
Time frame: Baseline and 3 months postoperatively
Implant Stability Quotient (ISQ)
Time frame: 3 months postoperatively
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 20 Oct 2026.
- Individual participant dataSharing planned: No. The individual participant data (IPD) will not be shared due to privacy and ethical restrictions. The data contain sensitive patient information, and sharing them would compromise participant confidentiality. Additionally, national and institutional regulations restrict the sharing of clinical data with external parties or international databases. De-identified data may be available from the corresponding author upon reasonable request and with approval from the institutional ethics committee.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
Questions about this trial
What is this clinical trial studying?
A study testing Vitamin D3 ( Colecalciferol) in people with Dental Implant, run by Air Force Military Medical University, China.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 14 inclusion and 0 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: opening soon, as of the sponsor's last update on 20 Oct 2026. Status can change between updates, so confirm with the study contact before making plans.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact Wang Jing Professor Wang (+861576548676, zajy5073@163.com), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Effect of Vitamin D3 Supplementation on Dental Implant Osseointegration (time frame: Baseline and 3 months postoperatively). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 20 Oct 2026.