Cognitive Recovery After StrokeTuCAN-MediaNCT07885189
Long-Term Cognitive Recovery After Arteria Cerebri Media Ischemia: A Digital Assessment Using the TuCAN-App
An observational study of Cognitive Recovery After Stroke and Cognitive Outcome After Stroke, run by University Hospital Tuebingen at 1 site in Germany.
Trial summary
TuCAN-Media is a longitudinal study investigating cognitive recovery after stroke in severely affected patients (modified Rankin Scale [mRS] score ≥ 3) with large vessel occlusion of the arteria cerebri media/middle cerebral artery (MCA). Read more about this study
- Who is it for?
- Ages 18 years and older
- Conditions the study is for
- Cognitive Recovery After Stroke, Cognitive Outcome After Stroke
- How many people
- 50 participants
- Where
- 1 siteGermany
- Study dates
- 1 Jul 2025to Feb 2027
- Phase
- Observational
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 years and older
- All sexes
- No healthy volunteers
- Adult, Older adult
Study population: primary care clinic
Who may be able to join
- ≥ 18 years of age
- Right- or left-hemispheric MCA occlusion (MCA segments M1-M3 or corresponding perfusion deficit)
- modified Rankin Scale (mRS) score ≥ 3 at the time of the index event
- Informed consent from the patient or their legal representative
Who cannot join
- ≤ 18 years of age
- Pregnancy
- Pre-existing severe dementia
Trial locations and contacts
1 site in 1 country. Contact the study team or a site near you to ask about taking part.
Germany1 site, 1 recruiting
- Recruiting
Department of Neurology; University Hospital
Tübingen
A. Mengel, MD, +49 7071 29 82049, anne.mengel@med.uni-tuebingen.de
About this study
Official title: Digital Cognitive Assessment in Stroke Patients for Evaluating Long-Term Cognitive Recovery: The TuCAN App for Patients With Middle Cerebral Artery Ischemia (TuCAN-Media)"
TuCAN-Media is a longitudinal study investigating cognitive recovery after stroke in severely affected patients (modified Rankin Scale [mRS] score ≥ 3) with large vessel occlusion of the arteria cerebri media/middle cerebral artery (MCA). Cognitive functioning and recovery will be assessed in a comprehensive multi-domain digital-based cognitive testing using the TuCAN-App to facilitate a standardized and rapid testing during the acute phase of a stroke (V2), as well as at 3month(V3)- and 6-month (V4) follow-ups.
- Keywords
- cognitive outcome after stroke, cognitive recovery after stroke, cognitive assessment in stroke patients, digital-based cognitive assessment
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
| Study group | Role | What they receive |
|---|---|---|
| Rec+ | after successfull recanalization (thrombectomy) | |
| Rec- | after unsucessfull recanalization (thrombectomy) |
What is being measured
The primary outcome is the main question the study is designed to answer.
Group comparision (Rec+ vs. Rec-) of cognitive function between acute stroke and at 3 month follow-up
Group comparison of cognitive function between visit 2 (V2) and visit 3 (V3) in patients with and without successful recanalization as assessed by the St. Louis University Mental Status (SLUMS) examination total score
Measured: 3 months
Secondary outcomes (1)
Group comparision (Rec+ vs. Rec-) of cognitive function between 3 months and 6 months follow-up
Group comparison of cognitive function between 3 months and 6 months follow up in patients with successful versus unsuccessful recanalization as assessed by the St. Louis University Mental Status (SLUMS) examination total score
Measured: 6 months
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted21 Oct 2026
- Study start1 Jul 2025
- Primary completionNov 2026 (estimated)
- Study completionFeb 2027 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Cognitive Recovery After StrokeStudies of the same condition, open and under way.
- More trials run by University Hospital TuebingenThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Observational
- Observational model
- Other
- Time perspective
- Prospective
- Enrolment
- 50 participants (estimated)
Sponsor and investigators
- Lead sponsor
- University Hospital Tuebingen
- Sponsor type
- University, hospital or other
- Collaborators
- Sigrid Oergel Foundation
- Responsible party
- Sponsor
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07885189
- Sponsor's protocol ID
- 084/2025BO1
- Acronym
- TuCAN-Media
- Status last verified
- Oct 2026
- First submitted
- 30 Jul 2025
- Last updated
- 21 Oct 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Study at a glance
From the registry record, last updated by the sponsor on 21 Oct 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Digital Cognitive Assessment in Stroke Patients for Evaluating Long-Term Cognitive Recovery: The TuCAN App for Patients With Middle Cerebral Artery Ischemia (TuCAN-Media)"
- ClinicalTrials.gov ID
- NCT07885189
- Acronym / sponsor ID
- TuCAN-Media / 084/2025BO1
- Keywords
- cognitive outcome after stroke, cognitive recovery after stroke, cognitive assessment in stroke patients, digital-based cognitive assessment
- Study type
- Observational
- Recruitment status
- Recruiting
- Enrolment
- 50 participants (estimated)
- Lead sponsor
- University Hospital TuebingenUniversity, hospital or other
- Collaborators
- Sigrid Oergel Foundation
- Study start
- 1 Jul 2025 (actual)
- Primary completion
- Nov 2026 (estimated)
- Study completion
- Feb 2027 (estimated)
- First posted
- 21 Oct 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
TuCAN-Media is a longitudinal study investigating cognitive recovery after stroke in severely affected patients (modified Rankin Scale [mRS] score ≥ 3) with large vessel occlusion of the arteria cerebri media/middle cerebral artery (MCA). Cognitive functioning and recovery will be assessed in a comprehensive multi-domain digital-based cognitive testing using the TuCAN-App to facilitate a standardized and rapid testing during the acute phase of a stroke (V2), as well as at 3month(V3)- and 6-month (V4) follow-ups.
Study design
- Observational model
- Other
- Time perspective
- Prospective
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| Rec+ | – | –after successfull recanalization (thrombectomy) |
| Rec- | – | –after unsucessfull recanalization (thrombectomy) |
Who may qualify
- Ages
- 18 years and older
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
- Study population
- primary care clinic
Key inclusion criteria (4 listed)
- ≥ 18 years of age
- Right- or left-hemispheric MCA occlusion (MCA segments M1-M3 or corresponding perfusion deficit)
- modified Rankin Scale (mRS) score ≥ 3 at the time of the index event
- Informed consent from the patient or their legal representative
Key exclusion criteria (3 listed)
- ≤ 18 years of age
- Pregnancy
- Pre-existing severe dementia
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Primary outcome
Group comparision (Rec+ vs. Rec-) of cognitive function between acute stroke and at 3 month follow-up
Time frame: 3 months
Group comparison of cognitive function between visit 2 (V2) and visit 3 (V3) in patients with and without successful recanalization as assessed by the St. Louis University Mental Status (SLUMS) examination total score
1 secondary outcome
Group comparision (Rec+ vs. Rec-) of cognitive function between 3 months and 6 months follow-up
Time frame: 6 months
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 21 Oct 2026.
- Individual participant dataSharing planned: No
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
Department of Neurology; University Hospital
Tübingen, Germany
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
An observational study of Cognitive Recovery After Stroke and Cognitive Outcome After Stroke, run by University Hospital Tuebingen at 1 site in Germany.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 4 inclusion and 3 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: looking for participants now, as of the sponsor's last update on 21 Oct 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Germany. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Each site lists its own contact: choose the nearest one under Trial locations. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Group comparision (Rec+ vs. Rec-) of cognitive function between acute stroke and at 3 month follow-up (time frame: 3 months). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 21 Oct 2026.