Age-Related Macular Degeneration (AMD)NCT07886177
Prevalence of Age-Related Macular Degeneration in Assiut University Hospitals
An observational study of Age-Related Macular Degeneration (AMD), run by Assiut University.
Trial summary
AMD represents an important cause of irreversible visual impairment in the elderly. Despite its clinical importance, there is limited contemporary epidemiological information regarding AMD among elderly patients in Upper Egypt. Read more about this study
- Who is it for?
- Ages 60 to 100 years
- Conditions the study is for
- Age-Related Macular Degeneration (AMD)
- What is being tested?
- OCT - clear
- Type of treatment
- Medical device
- How many people
- 90 participants
- Where
- No sites listed yet
- Study dates
- Jan 2027to Sep 2028
- How long will I take part?
- 1 Day
- Phase
- Observational
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 60 to 100 years
- All sexes
- No healthy volunteers
- Adult, Older adult
Study population: Elderly patients attending the ophthalmology outpatient clinics of Assiut University Hospitals who fulfill the eligibility criteria.
Who may be able to join
- • Age ≥60 years.
- Attendance at the ophthalmology outpatient clinics during the recruitment period.
- Willingness to participate and ability to provide written informed consent.
- Ability to undergo the planned ophthalmic examination.
Who cannot join
- Macular diseases unrelated to AMD that substantially interfere with AMD assessment, such as diabetic macular edema, macular dystrophy or retinal vein occlusion involving the macula.
- Pathologic myopia with macular complications that mimic or obscure AMD.
- Major ocular trauma or previous vitreoretinal surgery preventing reliable macular assessment.
- Media opacity preventing adequate fundus examination/imaging when retinal assessment cannot subsequently be achieved.
- Active ocular infection preventing safe examination.
- Other retinal disorders judged by the investigator to make AMD classification unreliable.
Trial locations and contacts
No sites are listed yet. Contact the study team or a site near you to ask about taking part.
About this study
Official title: Prevalence and Clinical Characteristics of Age-Related Macular Degeneration Among Elderly Patients Attending Assiut University Hospitals: A Hospital Based Cross Sectional Study.
AMD represents an important cause of irreversible visual impairment in the elderly.
Despite its clinical importance, there is limited contemporary epidemiological information regarding AMD among elderly patients in Upper Egypt.
The availability of slit-lamp biomicroscope, dilated fundus examination, fundus photography and optical coherence tomography at Assiut University Hospitals makes it possible to conduct systematic clinical assessment of elderly patients.
Read the detailed description
Age-related macular degeneration (AMD) is a chronic degenerative macular disorder and an important cause of irreversible visual impairment in older adults. It affects the retinal pigment epithelium, Bruch's membrane and photoreceptor complex, and its clinical spectrum ranges from drusen and pigmentary abnormalities to geographic atrophy and macular neovascularization. AMD is strongly age-related and is influenced by modifiable and non-modifiable factors, particularly smoking, cardiovascular risk factors and genetic susceptibility. The Beckman clinical classification provides a practical framework dividing disease into early, intermediate and late AMD, with late disease comprising geographic atrophy and neovascular AMD. Appropriate assessment of elderly patients includes history, best-corrected visual acuity, dilated fundus examination and retinal imaging when clinically indicated. Contemporary Egyptian epidemiological data remain limited, particularly in Upper Egypt. A 2025 cross-sectional study of 283 elderly residents of geriatric homes in East Cairo reported AMD in 12.7% of participants and described associations with increasing age and several systemic and behavioral factors. However, a geriatric-home population differs from patients attending ophthalmology services, and there are limited data describing AMD among elderly ophthalmic patients in Assiut and Upper Egypt. Assiut University Hospitals serve a large population from Assiut and surrounding governorates and have facilities for standardized ophthalmic examination and macular OCT when indicated. Estimating hospital-based prevalence and documenting the clinical phenotype may provide useful local data for clinical recognition, referral and future epidemiological research. Therefore, this study will assess the prevalence and clinical characteristics of AMD among elderly patients attending Assiut University Hospitals and explore demographic, systemic and ocular factors associated with its presence.
- Conditions
- Age-Related Macular Degeneration (AMD)
- Being tested
- OCT - clear
- Medical subject headings
- Macular Degeneration
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
OCT - clearDevice
Spectral-domain macular OCT for suspected/confirmed AMD, unexplained central visual loss, suspected geographic atrophy or suspected neovascular AMD
OCT - clearDevice
OCT and OCT angio for diagnosis of AMD.
What is being measured
The primary outcome is the main question the study is designed to answer.
Prevalence of AMD among eligible elderly participants.
elderly patients older than 60 years.
Measured: 2 years.
Secondary outcomes (1)
• Distribution of early, intermediate, late non-neovascular and late neovascular AMD. • Frequency of unilateral and bilateral AMD.
Measured: 2 years
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted21 Oct 2026
- Study startJan 2027 (estimated)
- Primary completionSep 2028 (estimated)
- Study completionSep 2028 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (12)Papers the sponsor has linked to this study.
- Other trials for Age-Related Macular Degeneration (AMD)Studies of the same condition, open and under way.
- More trials run by Assiut UniversityThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Observational
- Observational model
- Other
- Time perspective
- Cross-sectional
- Enrolment
- 90 participants (estimated)
- Target duration
- 1 Day
Sponsor and investigators
- Lead sponsor
- Assiut University
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Omar Almoutaz Ahmed Eltayeb, Assiut University
- Investigators
- Ali Natag Ryad, professor, Study director, Assiut UniversityMohamed Anwar Sayed, Associate professor, Study director, Assiut University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07886177
- Sponsor's protocol ID
- AMD prevalence
- Status last verified
- Oct 2026
- First submitted
- 30 Sep 2026
- Last updated
- 21 Oct 2026
- Results posted
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- Undecided
Publications
Chew EY, Clemons TE, Agron E, Sperduto RD, Sangiovanni JP, Davis MD, Ferris FL 3rd; Age-Related Eye Disease Study Research Group. Ten-year follow-up of age-related macular degeneration in the age-related eye disease study: AREDS report no. 36. JAMA Ophthalmol. 2014 Mar;132(3):272-7. doi: 10.1001/jamaophthalmol.2013.6636.
PubMed 24385141Flaxel CJ, Adelman RA, Bailey ST, Fawzi A, Lim JI, Vemulakonda GA, Ying GS. Age-Related Macular Degeneration Preferred Practice Pattern(R). Ophthalmology. 2020 Jan;127(1):P1-P65. doi: 10.1016/j.ophtha.2019.09.024. Epub 2019 Sep 25. No abstract available.
PubMed 31757502Edarous DH, Fahim HI, Momen M, Shaat AAE, Manzour AF. Epidemiology of age-related macular degeneration among elderly in geriatric homes, East Cairo, Egypt. BMC Public Health. 2025 Jul 18;25(1):2495. doi: 10.1186/s12889-025-23680-6.
PubMed 40682000Chakravarthy U, Wong TY, Fletcher A, Piault E, Evans C, Zlateva G, Buggage R, Pleil A, Mitchell P. Clinical risk factors for age-related macular degeneration: a systematic review and meta-analysis. BMC Ophthalmol. 2010 Dec 13;10:31. doi: 10.1186/1471-2415-10-31.
PubMed 21144031Klein R, Cruickshanks KJ, Nash SD, Krantz EM, Nieto FJ, Huang GH, Pankow JS, Klein BE. The prevalence of age-related macular degeneration and associated risk factors. Arch Ophthalmol. 2010 Jun;128(6):750-8. doi: 10.1001/archophthalmol.2010.92.
PubMed 20547953Jonas JB, Cheung CMG, Panda-Jonas S. Updates on the Epidemiology of Age-Related Macular Degeneration. Asia Pac J Ophthalmol (Phila). 2017 Nov-Dec;6(6):493-497. doi: 10.22608/APO.2017251. Epub 2017 Sep 14.
PubMed 28906084Lim LS, Mitchell P, Seddon JM, Holz FG, Wong TY. Age-related macular degeneration. Lancet. 2012 May 5;379(9827):1728-38. doi: 10.1016/S0140-6736(12)60282-7.
PubMed 22559899Wong WL, Su X, Li X, Cheung CM, Klein R, Cheng CY, Wong TY. Global prevalence of age-related macular degeneration and disease burden projection for 2020 and 2040: a systematic review and meta-analysis. Lancet Glob Health. 2014 Feb;2(2):e106-16. doi: 10.1016/S2214-109X(13)70145-1. Epub 2014 Jan 3.
PubMed 25104651Mitchell P, Liew G, Gopinath B, Wong TY. Age-related macular degeneration. Lancet. 2018 Sep 29;392(10153):1147-1159. doi: 10.1016/S0140-6736(18)31550-2.
PubMed 30303083Fleckenstein M, Keenan TDL, Guymer RH, Chakravarthy U, Schmitz-Valckenberg S, Klaver CC, Wong WT, Chew EY. Age-related macular degeneration. Nat Rev Dis Primers. 2021 May 6;7(1):31. doi: 10.1038/s41572-021-00265-2.
PubMed 33958600Vemulakonda GA, Bailey ST, Kim SJ, Kovach JL, Lim JI, Ying GS, Flaxel CJ; American Academy of Ophthalmology Preferred Practice Pattern Retina/Vitreous Committee. Age-Related Macular Degeneration Preferred Practice Pattern(R). Ophthalmology. 2025 Apr;132(4):P1-P74. doi: 10.1016/j.ophtha.2024.12.018. Epub 2025 Feb 7. No abstract available.
PubMed 39918524Ferris FL 3rd, Wilkinson CP, Bird A, Chakravarthy U, Chew E, Csaky K, Sadda SR; Beckman Initiative for Macular Research Classification Committee. Clinical classification of age-related macular degeneration. Ophthalmology. 2013 Apr;120(4):844-51. doi: 10.1016/j.ophtha.2012.10.036. Epub 2013 Jan 16.
PubMed 23332590