Cerival PainNCT07887698
Effects of Instrument-Assisted Soft Tissue Mobilization Versus Post Facilitation Stretch Technique in Chronic Neck Pain
A study testing Instrument Assisted Soft Tissue Mobilization and Post Facilitation Stretch in people with Cerival Pain and Chronic Neck Pain, run by Foundation University Islamabad at 1 site in Pakistan.
Trial summary
Chronic neck pain is a prevalent musculoskeletal condition that commonly results in persistent pain, reduced cervical range of motion (ROM), functional disability, and decreased quality of life. Read more about this study
- Who is it for?
- Ages 18 to 50 years
- Conditions the study is for
- Cerival Pain, Chronic Neck Pain
- What is being tested?
- Instrument Assisted Soft Tissue Mobilization and Post Facilitation Stretch
- Type of treatment
- Surgery or procedure
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 38 participants
- Where
- 1 sitePakistan
- Study dates
- 12 Feb 2026to 18 Jan 2027
- Phase
- Interventional
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 50 years
- All sexes
- No healthy volunteers
- Adult
Who may be able to join
- Patients aged 18-50 years
- Chronic neck pain ≥ 12 weeks
- Nonspecific neck pain
- NPRS score ≥ 3
- Restricted or painful cervical ROM
- Neck disability score 15- >35 (moderate to severe disability)
Who cannot join
- History of cervical surgery or recent trauma
- Inflammatory, infectious, or malignant spinal conditions
- Cervical disc pathology with neurological signs
- Pregnancy
- Skin lesions or conditions contraindicating IASTM
Trial locations and contacts
1 site in 1 country. Contact the study team or a site near you to ask about taking part.
Pakistan1 site, 1 recruiting
- Recruiting
Foundation University College of Physical Therapy
Islamabad, Punjab Province, 44000
Ruqia Begum, MS-OMPT, +92-3115532544, ruqia@fui.edu.pk
About this study
Chronic neck pain is a prevalent musculoskeletal condition that commonly results in persistent pain, reduced cervical range of motion (ROM), functional disability, and decreased quality of life. Instrument-Assisted Soft Tissue Mobilization (IASTM) and Post Facilitation Stretch (PFS) are two manual therapy techniques frequently used in physiotherapy practice; however, limited evidence is available comparing their effectiveness in individuals with chronic neck pain. This randomized controlled trial aims to compare the effects of IASTM and PFS on pain intensity, cervical ROM, and neck-related disability. A total of 38 participants aged 18-50 years with non-specific chronic neck pain of at least 12 weeks' duration will be recruited using non-probability purposive sampling and randomly allocated into two equal groups. Group A will receive IASTM, while Group B will receive PFS. Both groups will also receive conventional physiotherapy consisting of hot pack application and transcutaneous electrical nerve stimulation (TENS). Treatment will be provided three times per week for two consecutive weeks, totaling six treatment sessions. Outcome measures will include the Numeric Pain Rating Scale (NPRS) to assess pain intensity, the Cervical Range of Motion (CROM) instrument to measure cervical mobility, and the Neck Disability Index (NDI) to evaluate functional disability. Assessments will be conducted at baseline, after the third treatment session, and at the completion of the intervention period. The study findings are expected to provide evidence regarding the comparative effectiveness of IASTM and PFS in the management of chronic neck pain and assist physiotherapists in selecting the most effective manual therapy approach to improve pain, cervical mobility, and functional outcomes in individuals with chronic neck pain.
Read the detailed description
Chronic neck pain (CNP) is one of the most prevalent musculoskeletal disorders worldwide and is a major contributor to pain, disability, reduced work productivity, and poor quality of life. It is defined as pain or discomfort in the cervical region persisting for more than 12 weeks and is commonly associated with muscle tightness, soft tissue restrictions, reduced cervical range of motion (ROM), impaired neuromuscular control, and functional limitations that interfere with daily activities. The condition has a multifactorial etiology involving mechanical, postural, ergonomic, and psychosocial factors. Prolonged forward head posture, repetitive occupational tasks, and extended use of computers and digital devices increase mechanical stress on cervical structures, leading to muscle fatigue, ligamentous strain, joint dysfunction, and persistent pain. Chronic neck pain frequently affects the upper trapezius, levator scapulae, and suboccipital muscles, resulting in movement impairments and decreased functional capacity. Despite the widespread use of physiotherapy interventions, uncertainty remains regarding the comparative effectiveness of several commonly used manual therapy techniques. Instrument-Assisted Soft Tissue Mobilization (IASTM) and Post Facilitation Stretch (PFS) are two manual therapy techniques frequently used in clinical physiotherapy practice to improve pain, tissue mobility, flexibility, and function. IASTM utilizes specialized instruments to apply controlled mechanical pressure to soft tissues with the aim of reducing myofascial restrictions, improving circulation, promoting tissue remodeling, and restoring mobility. PFS is a muscle energy-based stretching technique that combines a brief submaximal isometric contraction with passive stretching to facilitate neuromuscular inhibition, decrease muscle tightness, and improve muscle flexibility. Although previous studies have demonstrated beneficial effects of both interventions individually, there is limited evidence directly comparing their effectiveness in individuals with chronic neck pain, particularly when multiple clinically important cervical muscles are treated. Therefore, further comparative research is needed to guide evidence-based clinical decision-making. The primary objective of this randomized controlled trial is to compare the effects of Instrument-Assisted Soft Tissue Mobilization and Post Facilitation Stretch on pain intensity, cervical range of motion, and neck-related disability in individuals with chronic neck pain. The study seeks to determine whether one intervention provides superior clinical outcomes and to generate evidence that may improve rehabilitation strategies for this patient population. This randomized controlled trial will be conducted over a period of one year at the Foundation University College of Physical Therapy, Islamabad. Participants will be recruited using a non-probability purposive sampling technique. Individuals aged 18-50 years with non-specific chronic neck pain of at least 12 weeks' duration, a Numeric Pain Rating Scale (NPRS) score of 3 or greater, painful or restricted cervical range of motion, and moderate to severe disability according to the Neck Disability Index (NDI) will be eligible for inclusion. A total of 38 participants will be enrolled and randomly allocated into two equal groups using sealed opaque envelope randomization performed by a research assistant not involved in the intervention. The study will employ a single-blinded design to minimize assessment bias. Participants allocated to Group A will receive Instrument-Assisted Soft Tissue Mobilization targeting the upper trapezius, levator scapulae, and suboccipital muscles. The intervention will involve systematic identification and treatment of soft tissue restrictions using longitudinal, fanning, and cross-fiber strokes, followed by muscle-specific stretching. Participants allocated to Group B will receive Post Facilitation Stretch directed at the same muscle groups. The PFS protocol will consist of controlled submaximal isometric contractions followed by passive stretching to reduce muscle tightness, restore muscle length, and improve flexibility. Both groups will also receive conventional physiotherapy consisting of hot pack application and transcutaneous electrical nerve stimulation (TENS). Treatment will be administered three times per week for two consecutive weeks, resulting in six treatment sessions for each participant. Standardized treatment protocols will be followed to ensure consistency throughout the study. Pain intensity will be assessed using the Numeric Pain Rating Scale (NPRS), cervical mobility will be measured using the Cervical Range of Motion (CROM) instrument, and functional disability will be evaluated using the Neck Disability Index (NDI). Outcome assessments will be performed at baseline, after the third treatment session, and following completion of the two-week intervention period. Appropriate statistical methods will be applied according to the distribution of the collected data, with statistical significance established at a p-value of less than 0.05. The study will compare both within-group and between-group changes in pain, cervical range of motion, and disability to determine the relative effectiveness of the two interventions. Ethical approval will be obtained from the Ethical Review Committee of Foundation University before commencement of the study. Written informed consent will be obtained from all participants after they have received comprehensive information regarding the study objectives, procedures, potential benefits, and their rights. Participation will be entirely voluntary, and participants will have the right to withdraw from the study at any stage without affecting their routine care. Confidentiality and anonymity of participant information will be maintained throughout the research process, and all collected data will be used exclusively for research purposes. The findings of this randomized controlled trial are expected to provide valuable evidence regarding the comparative effectiveness of Instrument-Assisted Soft Tissue Mobilization and Post Facilitation Stretch in the management of chronic neck pain. The results may assist physiotherapists in selecting the most appropriate manual therapy intervention to reduce pain, improve cervical range of motion, decrease disability, and optimize rehabilitation outcomes. Furthermore, because comparable randomized controlled trials on these interventions have not been conducted in Pakistan according to the study rationale, this research may contribute to the national evidence base and support the development of evidence-based clinical practice guidelines for the rehabilitation of individuals with chronic neck pain.
- Conditions
- Cerival Pain, Chronic Neck Pain
- Being tested
- Instrument Assisted Soft Tissue Mobilization, Post Facilitation Stretch
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Instrument Assisted Soft Tissue MobilizationProcedure or surgery
Instrument-Assisted Soft Tissue Mobilization (IASTM) is a manual therapy technique that utilizes specially designed stainless-steel instruments to detect and treat soft tissue restrictions, myofascial adhesions, and scar tissue. The technique involves applying controlled mechanical pressure using longitudinal, fanning, and cross-fiber strokes to improve tissue mobility, enhance local circulation, stimulate tissue remodeling, and reduce pain. In this study, IASTM will be applied to the upper trapezius, levator scapulae, and suboccipital muscles following conventional physiotherapy. The intervention aims to restore normal soft tissue mobility, improve cervical range of motion, decrease pain, and enhance functional outcomes in individuals with chronic neck pain.
Post Facilitation StretchProcedure or surgery
Post Facilitation Stretch (PFS) is a muscle energy-based manual therapy technique designed to reduce muscle tightness, improve flexibility, and restore normal muscle length through neuromuscular inhibition. The technique involves positioning the target muscle at its initial barrier, followed by a controlled submaximal isometric contraction against therapist resistance for 5-10 seconds. After the contraction, the patient relaxes while the therapist gently stretches the muscle to a new barrier. This sequence is repeated for 3-5 cycles to enhance muscle extensibility and reduce stiffness. In this study, PFS will be applied to the upper trapezius, levator scapulae, and suboccipital muscles following conventional physiotherapy to improve cervical mobility, reduce pain, and enhance functional outcomes in individuals with chronic neck pain.
| Study group | Role | What they receive |
|---|---|---|
| Group A Instrument Assisted Soft Tissue Mobilization | Experimental | Not described Receives: Procedure: Instrument Assisted Soft Tissue Mobilization |
| Group B Post Facilitation Stretch | Experimental | Not described Receives: Procedure: Post Facilitation Stretch |
What is being measured
The primary outcome is the main question the study is designed to answer.
Neck Pain
Pain intensity will be the primary outcome of this study and will be assessed using the Numeric Pain Rating Scale (NPRS). The NPRS is an 11-point self-reported scale ranging from 0 to 10, where 0 indicates no pain and 10 represents the worst imaginable pain.
Measured: Baseline and after 2 weeks
Cerical Range of motion
Cervical range of motion (ROM) will be the second primary outcome of this study and will be assessed using the Cervical Range of Motion (CROM) instrument. The CROM device is a valid, reliable, and clinically accepted tool designed to measure active cervical movements, including flexion, extension, right and left lateral flexion, and right and left rotation. It provides objective and precise measurements in degrees, allowing accurate evaluation of cervical mobility.
Measured: Baseline and after 2 weeks
Neck Disability
Neck disability will be the primary outcome of this study and will be assessed using the Neck Disability Index (NDI). The NDI is a valid, reliable, and widely used self-administered questionnaire that evaluates the impact of neck pain on functional activities and daily living. It consists of 10 items assessing pain intensity, personal care, lifting, reading, headaches, concentration, work, driving, sleeping, and recreation, with each item scored from 0 to 5. The total score ranges from 0 to 50, with higher scores indicating greater disability.
Measured: Baseline and after 2 weeks
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted21 Oct 2026
- Study start12 Feb 2026
- Primary completion18 Dec 2026 (estimated)
- Study completion18 Jan 2027 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Cerival PainStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Enrolment
- 38 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Foundation University Islamabad
- Sponsor type
- University, hospital or other
- Responsible party
- Sponsor
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07887698
- Sponsor's protocol ID
- FUIFUCP/CTR/MSMSK/AbdaraMariam
- Status last verified
- Oct 2026
- First submitted
- 14 Oct 2026
- Last updated
- 21 Oct 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No