Parkinson Disease (PD)NCT07887802
Multimodal Rehabilitation and Balance Assessment in Parkinson's Disease
A study testing Multimodal Rehabilitation Program in people with Parkinson Disease (PD), run by Bilinç Doğruöz Karatekin at 1 site in Turkey (Türkiye).
Trial summary
This study aimed to investigate the relationship between instrumented balance measurements and clinical balance assessments in individuals with Parkinson's disease and to evaluate changes in balance and functional mobility following a 12-week multimodal rehabilitation program. Read more about this study
- Who is it for?
- Ages 18 to 80 years
- Conditions the study is for
- Parkinson Disease (PD)
- What is being tested?
- Multimodal Rehabilitation Program
- Type of treatment
- Lifestyle or therapy programme
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 18 participants
- Where
- 1 siteTurkey (Türkiye)
- Study dates
- 5 Feb 2024to 17 Aug 2026
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 80 years
- All sexes
- No healthy volunteers
- Adult, Older adult
Who may be able to join
- Adults aged 18 years or older.
- Diagnosis of Parkinson's disease.
- Hoehn and Yahr stages 1-3.
- Sufficient cognitive function to understand and follow instructions during assessments and rehabilitation.
- Ability to participate in the rehabilitation program.
- Provision of written informed consent.
Who cannot join
- Advanced Parkinson's disease (Hoehn and Yahr stages 4-5).
- Significant cognitive impairment that could interfere with participation or assessment.
- Other neurological disorders affecting balance or mobility.
- History of surgery within the preceding six months.
- Severe or uncontrolled systemic diseases that could interfere with safe participation in the rehabilitation program.
- Refusal or inability to provide informed consent.
Trial locations and contacts
1 site in 1 country.
Turkey (Türkiye)1 site
Goztepe Prof. Dr. Suleyman Yalcin City Hospital
Istanbul, 34722
About this study
Official title: Instrumented Balance Assessment in Parkinson's Disease: Associations With Clinical Balance and Changes Following Multimodal Rehabilitation
This study aimed to investigate the relationship between instrumented balance measurements and clinical balance assessments in individuals with Parkinson's disease and to evaluate changes in balance and functional mobility following a 12-week multimodal rehabilitation program.
Eighteen individuals with Parkinson's disease participated in this prospective, single-group study. All participants received a rehabilitation program that included balance exercises, aerobic exercise, and balance training using the Korebalance system. The program was conducted twice weekly for 12 weeks.
Read more
Balance was assessed using the Korebalance system and the Berg Balance Scale (BBS). Functional mobility was evaluated using the Timed Up and Go (TUG) test. Assessments were performed before and after the rehabilitation program.
The study examined whether instrumented balance measurements were associated with clinical balance performance and whether balance and functional mobility changed following rehabilitation.
Read the detailed description
This prospective, single-center, single-group pre-post interventional study investigated instrumented balance assessment and changes in balance and functional mobility following multimodal rehabilitation in individuals with Parkinson's disease.
A total of 18 participants with Parkinson's disease were included. Eligible participants were adults aged 18 years or older with Hoehn and Yahr stages 1-3 who were able to participate in the rehabilitation program. Exclusion criteria included advanced Parkinson's disease (Hoehn and Yahr stages 4-5), significant cognitive impairment, other neurological disorders affecting balance, recent surgery within the preceding six months, and severe or uncontrolled systemic diseases that could interfere with participation.
All participants underwent a 12-week multimodal rehabilitation program consisting of two supervised sessions per week. The program included progressive static and dynamic balance exercises, functional mobility training, dual-task activities, moderate-intensity aerobic exercise, and balance training using the Korebalance system.
Balance training included tandem stance, single-leg stance when safely achievable, multidirectional weight shifting and stepping, repeated sit-to-stand exercises, obstacle negotiation, turning, and functional walking. More advanced activities included figure-of-eight walking, step negotiation, reactive postural control, and dual-task exercises combining motor and cognitive tasks. Aerobic training was performed using treadmill walking or stationary cycling at moderate intensity, generally corresponding to a Borg Rating of Perceived Exertion of 11-14.
The primary outcome measures were static and dynamic balance scores obtained using the Korebalance Premiere-19 system. Lower Korebalance scores indicated better balance performance.
Secondary outcome measures included the Berg Balance Scale (BBS), which assessed clinical balance, and the Timed Up and Go (TUG) test, which assessed functional mobility.
Outcome assessments were performed at baseline and after completion of the 12-week rehabilitation program.
Baseline instrumented balance measurements were examined in relation to clinical balance and functional mobility measures. Changes in instrumented balance, clinical balance, and functional mobility were evaluated by comparing measurements obtained before and after rehabilitation.
The study did not include randomization or a control group. All participants received the same multimodal rehabilitation intervention.
- Conditions
- Parkinson Disease (PD)
- Being tested
- Multimodal Rehabilitation Program
- Keywords
- Parkinson's Disease, Balance Rehabilitation, Korebalance, Instrumented Balance Assessment, Berg Balance Scale, Timed Up and Go, Multimodal Rehabilitation, Postural Stability
- Medical subject headings
- Parkinson Disease
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Multimodal Rehabilitation ProgramBehavioural
Participants received a supervised multimodal rehabilitation program twice weekly for 12 weeks (24 sessions). The program included approximately 10 minutes of warm-up exercises, 20 minutes of progressive balance training, and 20 minutes of moderate-intensity aerobic exercise using a treadmill or stationary bicycle. Balance exercises included static and dynamic balance tasks, multidirectional stepping, functional mobility activities, turning, and dual-task training. Additional balance training was performed using the Korebalance Premiere-19 system. Exercise intensity was generally maintained at a Borg Rating of Perceived Exertion of 11-14. Exercises were individually progressed according to participant ability and safety.
| Study group | Role | What they receive |
|---|---|---|
| Multimodal Rehabilitation Group | Experimental | Participants with Parkinson's disease received a 12-week supervised multimodal rehabilitation program, conducted twice weekly. The intervention included progressive balance exercises, functional mobility training, dual-task activities, moderate-intensity aerobic exercise, and Korebalance-assisted balance training. All participants received the same intervention, with no control group. Receives: Behavioral: Multimodal Rehabilitation Program |
What is being measured
The primary outcome is the main question the study is designed to answer.
Change in Static Korebalance Score
Static balance was assessed using the Korebalance Premiere-19 system. Measurements were obtained at baseline and after the 12-week multimodal rehabilitation program. Lower scores indicate better balance performance. Change was calculated as the post-intervention score minus the baseline score.
Measured: Baseline and Week 12
Change in Dynamic Korebalance Score
Dynamic balance was assessed using the Korebalance Premiere-19 system. Measurements were obtained at baseline and after the 12-week multimodal rehabilitation program. Lower scores indicate better balance performance. Change was calculated as the post-intervention score minus the baseline score.
Measured: Baseline and Week 12
Secondary outcomes (2)
Change in Berg Balance Scale Score
Clinical balance was assessed using the Berg Balance Scale (BBS), which consists of 14 items evaluating static and dynamic balance during functional activities. Each item is scored from 0 to 4, resulting in a total score ranging from 0 to 56. Higher scores indicate better balance performance. Change was calculated as the post-intervention score minus the baseline score.
Measured: Baseline and Week 12
Change in Timed Up and Go Test Time
Functional mobility was assessed using the Timed Up and Go (TUG) test. Participants were instructed to stand up from a chair, walk 3 meters, turn around, return to the chair, and sit down. The time required to complete the test was recorded in seconds. Lower values indicate better functional mobility. Change was calculated as the post-intervention time minus the baseline time.
Measured: Baseline and Week 12
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted21 Oct 2026
- Study start5 Feb 2024
- Primary completion17 Aug 2026
- Study completion17 Aug 2026
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Parkinson Disease (PD)Studies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Not applicable
- Intervention model
- Single group
- Model description
- A prospective, single-center, single-group pre-post interventional study. All participants received the same 12-week multimodal rehabilitation program. Outcomes were assessed at baseline and following completion of the intervention. No control group was included.
- Masking
- None (open label)
- Enrolment
- 18 participants (actual)
Sponsor and investigators
- Lead sponsor
- Bilinç Doğruöz Karatekin
- Sponsor type
- University, hospital or other
- Responsible party
- Sponsor-investigator, Bilinç Doğruöz Karatekin, Istanbul Medeniyet University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07887802
- Sponsor's protocol ID
- IMU-PD-2023-0725
- Status last verified
- Oct 2026
- First submitted
- 15 Oct 2026
- Last updated
- 21 Oct 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Study at a glance
From the registry record, last updated by the sponsor on 21 Oct 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Instrumented Balance Assessment in Parkinson's Disease: Associations With Clinical Balance and Changes Following Multimodal Rehabilitation
- ClinicalTrials.gov ID
- NCT07887802
- Acronym / sponsor ID
- IMU-PD-2023-0725
- Conditions
- Parkinson Disease (PD)
- Keywords
- Parkinson's Disease, Balance Rehabilitation, Korebalance, Instrumented Balance Assessment, Berg Balance Scale, Timed Up and Go, Multimodal Rehabilitation, Postural Stability
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 18 participants (actual)
- Lead sponsor
- Bilinç Doğruöz KaratekinUniversity, hospital or other
- Study start
- 5 Feb 2024 (actual)
- Primary completion
- 17 Aug 2026 (actual)
- Study completion
- 17 Aug 2026 (actual)
- First posted
- 21 Oct 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
This study aimed to investigate the relationship between instrumented balance measurements and clinical balance assessments in individuals with Parkinson's disease and to evaluate changes in balance and functional mobility following a 12-week multimodal rehabilitation program.
Eighteen individuals with Parkinson's disease participated in this prospective, single-group study. All participants received a rehabilitation program that included balance exercises, aerobic exercise, and balance training using the Korebalance system. The program was conducted twice weekly for 12 weeks.
Balance was assessed using the Korebalance system and the Berg Balance Scale (BBS). Functional mobility was evaluated using the Timed Up and Go (TUG) test. Assessments were performed before and after the rehabilitation program.
The study examined whether instrumented balance measurements were associated with clinical balance performance and whether balance and functional mobility changed following rehabilitation.
Detailed description
This prospective, single-center, single-group pre-post interventional study investigated instrumented balance assessment and changes in balance and functional mobility following multimodal rehabilitation in individuals with Parkinson's disease.
A total of 18 participants with Parkinson's disease were included. Eligible participants were adults aged 18 years or older with Hoehn and Yahr stages 1-3 who were able to participate in the rehabilitation program. Exclusion criteria included advanced Parkinson's disease (Hoehn and Yahr stages 4-5), significant cognitive impairment, other neurological disorders affecting balance, recent surgery within the preceding six months, and severe or uncontrolled systemic diseases that could interfere with participation.
All participants underwent a 12-week multimodal rehabilitation program consisting of two supervised sessions per week. The program included progressive static and dynamic balance exercises, functional mobility training, dual-task activities, moderate-intensity aerobic exercise, and balance training using the Korebalance system.
Balance training included tandem stance, single-leg stance when safely achievable, multidirectional weight shifting and stepping, repeated sit-to-stand exercises, obstacle negotiation, turning, and functional walking. More advanced activities included figure-of-eight walking, step negotiation, reactive postural control, and dual-task exercises combining motor and cognitive tasks. Aerobic training was performed using treadmill walking or stationary cycling at moderate intensity, generally corresponding to a Borg Rating of Perceived Exertion of 11-14.
The primary outcome measures were static and dynamic balance scores obtained using the Korebalance Premiere-19 system. Lower Korebalance scores indicated better balance performance.
Secondary outcome measures included the Berg Balance Scale (BBS), which assessed clinical balance, and the Timed Up and Go (TUG) test, which assessed functional mobility.
Outcome assessments were performed at baseline and after completion of the 12-week rehabilitation program.
Baseline instrumented balance measurements were examined in relation to clinical balance and functional mobility measures. Changes in instrumented balance, clinical balance, and functional mobility were evaluated by comparing measurements obtained before and after rehabilitation.
The study did not include randomization or a control group. All participants received the same multimodal rehabilitation intervention.
Study design
- Primary purpose
- Treatment
- Allocation
- Not applicable
- Intervention model
- Single group
- Masking
- None (open label)
- Number of arms
- 1
- Model description
- A prospective, single-center, single-group pre-post interventional study. All participants received the same 12-week multimodal rehabilitation program. Outcomes were assessed at baseline and following completion of the intervention. No control group was included.
| Arm | Type | Receives |
|---|---|---|
| Multimodal Rehabilitation Group | Experimental | Behavioral: Multimodal Rehabilitation ProgramParticipants with Parkinson's disease received a 12-week supervised multimodal rehabilitation program, conducted twice weekly. The intervention included progressive balance exercises, functional mobility training, dual-task activities, moderate-intensity aerobic exercise, and Korebalance-assisted balance training. All participants received the same intervention, with no control group. |
Who may qualify
- Ages
- 18 to 80 years
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (6 listed)
- Adults aged 18 years or older.
- Diagnosis of Parkinson's disease.
- Hoehn and Yahr stages 1-3.
- Sufficient cognitive function to understand and follow instructions during assessments and rehabilitation.
- Ability to participate in the rehabilitation program.
Key exclusion criteria (6 listed)
- Advanced Parkinson's disease (Hoehn and Yahr stages 4-5).
- Significant cognitive impairment that could interfere with participation or assessment.
- Other neurological disorders affecting balance or mobility.
- History of surgery within the preceding six months.
- Severe or uncontrolled systemic diseases that could interfere with safe participation in the rehabilitation program.
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Multimodal Rehabilitation ProgramParticipants received a supervised multimodal rehabilitation program twice weekly for 12 weeks (24 sessions). The program included approximately 10 minutes of warm-up exercises, 20 minutes of progressive balance training, and 20 minutes of moderate-intensity aerobic exercise using a treadmill or stationary bicycle. Balance exercises included static and dynamic balance tasks, multidirectional stepping, functional mobility activities, turning, and dual-task training. Additional balance training was performed using the Korebalance Premiere-19 system. Exercise intensity was generally maintained at a Borg Rating of Perceived Exertion of 11-14. Exercises were individually progressed according to participant ability and safety. | Behavioural | Multimodal Rehabilitation Group |
Primary outcome
Change in Static Korebalance Score
Time frame: Baseline and Week 12
Static balance was assessed using the Korebalance Premiere-19 system. Measurements were obtained at baseline and after the 12-week multimodal rehabilitation program. Lower scores indicate better balance performance. Change was calculated as the post-intervention score minus the baseline score.
Change in Dynamic Korebalance Score
Time frame: Baseline and Week 12
Dynamic balance was assessed using the Korebalance Premiere-19 system. Measurements were obtained at baseline and after the 12-week multimodal rehabilitation program. Lower scores indicate better balance performance. Change was calculated as the post-intervention score minus the baseline score.
2 secondary outcomes
Change in Berg Balance Scale Score
Time frame: Baseline and Week 12
Change in Timed Up and Go Test Time
Time frame: Baseline and Week 12
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 21 Oct 2026.
- Individual participant dataSharing planned: No
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
The record lists no contact. Use the official record to reach the sponsor.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Multimodal Rehabilitation Program in people with Parkinson Disease (PD), run by Bilinç Doğruöz Karatekin at 1 site in Turkey (Türkiye).
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 6 inclusion and 6 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 21 Oct 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Turkey (Türkiye). Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Change in Static Korebalance Score (time frame: Baseline and Week 12). The study lists 2 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 21 Oct 2026; AzTrials last refreshed its copy on 8 Nov 2026.