Cerebral ThrombosisNCT07888062
TOF-MRV Versus Post-Contrast 3D T1 MRI in Dural Venous Sinus Thrombosis
An observational study of Cerebral Thrombosis and Venous Thrombosis, run by Assiut University.
Trial summary
This cross-sectional study aims to compare the diagnostic performance of time-of-flight MR venography and post-contrast 3D T1-weighted MRI in the detection of dural venous sinus thrombosis. Read more about this study
- Who is it for?
- Ages 18 years and older
- Conditions the study is for
- Cerebral Thrombosis, Venous Thrombosis
- How many people
- 80 participants
- Where
- No sites listed yet
- Study dates
- 20 Oct 2026to 10 Jan 2028
- Phase
- Observational
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 years and older
- All sexes
- No healthy volunteers
- Adult, Older adult
Study population: Adult patients aged 18 years or older with suspected dural venous sinus thrombosis undergoing MRI including both time-of-flight MR venography and post-contrast 3D T1-weighted imaging at Assiut University Hospitals.
Who may be able to join
- - Age 18 years or older
- Patients with suspected dural venous sinus thrombosis
- Written informed consent
Who cannot join
- - Incomplete MRI examination
- Absence of either TOF-MRV or post-contrast 3D T1WI
- Severe motion or susceptibility artifacts
- Previous surgery involving the dural venous sinuses
- Direct tumor invasion of a dural venous sinus
- Poor-quality or technically inadequate MRV
Trial locations and contacts
No sites are listed yet. Contact the study team or a site near you to ask about taking part.
About this study
Official title: Comparative Diagnostic Performance of Time-of-Flight MR Venography and Post-Contrast 3D T1-Weighted MRI in the Detection of Dural Venous Sinus Thrombosis
This cross-sectional study aims to compare the diagnostic performance of time-of-flight MR venography and post-contrast 3D T1-weighted MRI in the detection of dural venous sinus thrombosis.
Read the detailed description
Dural venous sinus thrombosis is an uncommon but potentially serious cerebrovascular disorder with variable clinical presentation. Imaging plays a central role in diagnosis.
This observational study will prospectively evaluate patients with suspected dural venous sinus thrombosis using both time-of-flight MR venography and post-contrast 3D T1-weighted imaging to compare their diagnostic findings for thrombosis in the major dural venous sinuses.
- Conditions
- Cerebral Thrombosis, Venous Thrombosis
- Keywords
- Time-of-flight MR venography, Post-contrast 3D T1, Dural venous sinus thrombosis, MRI, Assiut
- Medical subject headings
- Intracranial Thrombosis, Venous Thrombosis
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
| Study group | Role | What they receive |
|---|---|---|
| Patients with Suspected Dural Venous Sinus Thrombosis | Adult patients with clinical suspicion of dural venous sinus thrombosis undergoing both time-of-flight MR venography and post-contrast 3D T1-weighted MRI. |
What is being measured
The primary outcome is the main question the study is designed to answer.
Number of patients with positive findings on TOF-MRV
Number of patients showing findings suggestive of dural venous sinus thrombosis on time-of-flight MR venography.
Measured: Baseline
Secondary outcomes (4)
Number of patients with positive findings on post-contrast 3D T1WI
Number of patients showing findings suggestive of dural venous sinus thrombosis on post-contrast 3D T1-weighted imaging.
Measured: Baseline
Number of patients with complete thrombosis on TOF-MRV
Number of patients classified as complete thrombosis or occlusion on time-of-flight MR venography.
Measured: Baseline
Number of patients with complete thrombosis on post-contrast 3D T1WI
Number of patients classified as complete thrombosis or occlusion on post-contrast 3D T1-weighted imaging.
Measured: Baseline
Number of discordant findings
Number of patients with discordant results between time-of-flight MR venography and post-contrast 3D T1-weighted imaging.
Measured: Baseline
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted22 Oct 2026
- Study start20 Oct 2026 (estimated)
- Primary completion20 Oct 2027 (estimated)
- Study completion10 Jan 2028 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Cerebral ThrombosisStudies of the same condition, open and under way.
- More trials run by Assiut UniversityThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Observational
- Observational model
- Case only
- Time perspective
- Cross-sectional
- Enrolment
- 80 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Assiut University
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Manar Eid Mohammed, Assiut University
- Investigators
- Samy A Abdel Aziz, prof, Study chair, Diagnostic and interventional radiology Department, Assiut University Hospitals
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07888062
- Sponsor's protocol ID
- TOF-MRV-DVST-Assiut-2026
- Status last verified
- Oct 2026
- First submitted
- 15 Oct 2026
- Last updated
- 22 Oct 2026
- Results posted
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Study at a glance
From the registry record, last updated by the sponsor on 22 Oct 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Comparative Diagnostic Performance of Time-of-Flight MR Venography and Post-Contrast 3D T1-Weighted MRI in the Detection of Dural Venous Sinus Thrombosis
- ClinicalTrials.gov ID
- NCT07888062
- Acronym / sponsor ID
- TOF-MRV-DVST-Assiut-2026
- Conditions
- Cerebral Thrombosis, Venous Thrombosis
- Keywords
- Time-of-flight MR venography, Post-contrast 3D T1, Dural venous sinus thrombosis, MRI, Assiut
- Study type
- Observational
- Recruitment status
- Not yet recruiting
- Enrolment
- 80 participants (estimated)
- Lead sponsor
- Assiut UniversityUniversity, hospital or other
- Study start
- 20 Oct 2026 (estimated)
- Primary completion
- 20 Oct 2027 (estimated)
- Study completion
- 10 Jan 2028 (estimated)
- First posted
- 22 Oct 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
This cross-sectional study aims to compare the diagnostic performance of time-of-flight MR venography and post-contrast 3D T1-weighted MRI in the detection of dural venous sinus thrombosis.
Detailed description
Dural venous sinus thrombosis is an uncommon but potentially serious cerebrovascular disorder with variable clinical presentation. Imaging plays a central role in diagnosis.
This observational study will prospectively evaluate patients with suspected dural venous sinus thrombosis using both time-of-flight MR venography and post-contrast 3D T1-weighted imaging to compare their diagnostic findings for thrombosis in the major dural venous sinuses.
Study design
- Observational model
- Case only
- Time perspective
- Cross-sectional
- Number of arms
- 1
| Arm | Type | Receives |
|---|---|---|
| Patients with Suspected Dural Venous Sinus Thrombosis | – | –Adult patients with clinical suspicion of dural venous sinus thrombosis undergoing both time-of-flight MR venography and post-contrast 3D T1-weighted MRI. |
Who may qualify
- Ages
- 18 years and older
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
- Study population
- Adult patients aged 18 years or older with suspected dural venous sinus thrombosis undergoing MRI including both time-of-flight MR venography and post-contrast 3D T1-weighted imaging at Assiut University Hospitals.
Key inclusion criteria (3 listed)
- - Age 18 years or older
- Patients with suspected dural venous sinus thrombosis
- Written informed consent
Key exclusion criteria (6 listed)
- - Incomplete MRI examination
- Absence of either TOF-MRV or post-contrast 3D T1WI
- Severe motion or susceptibility artifacts
- Previous surgery involving the dural venous sinuses
- Direct tumor invasion of a dural venous sinus
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Primary outcome
Number of patients with positive findings on TOF-MRV
Time frame: Baseline
Number of patients showing findings suggestive of dural venous sinus thrombosis on time-of-flight MR venography.
4 secondary outcomes
Number of patients with positive findings on post-contrast 3D T1WI
Time frame: Baseline
Number of patients with complete thrombosis on TOF-MRV
Time frame: Baseline
Number of patients with complete thrombosis on post-contrast 3D T1WI
Time frame: Baseline
Number of discordant findings
Time frame: Baseline
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 22 Oct 2026.
- Individual participant dataSharing planned: No
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
Samy A Abdel Aziz, prof study chair
Diagnostic and interventional radiology Department, Assiut University Hospitals
Questions about this trial
What is this clinical trial studying?
An observational study of Cerebral Thrombosis and Venous Thrombosis, run by Assiut University.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 3 inclusion and 6 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: opening soon, as of the sponsor's last update on 22 Oct 2026. Status can change between updates, so confirm with the study contact before making plans.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact Manar E Mohamed (+20 10 68879493, saeidmanar54@gmail.com), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Number of patients with positive findings on TOF-MRV (time frame: Baseline). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 22 Oct 2026.