Hypertension (HTN)NCT07890129
Stopping Blood Pressure Medications Without Tapering in Long-Term Care
A study testing Deprescribing antihypertensives without a taper in people with Hypertension (HTN), run by University of Alberta at 2 sites in Canada.
Trial summary
Blood pressure medications may provide limited benefit and cause side effects in frail older adults. It is unclear how best to stop these medications. Guidelines often recommend gradually reducing the dose, but this process can be time-consuming. Read more about this study
- Who is it for?
- Ages 80 years and older
- Conditions the study is for
- Hypertension (HTN)
- What is being tested?
- Deprescribing antihypertensives without a taper
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 11 participants
- Where
- 2 sitesCanada
- Study dates
- 1 Jun 2025to 30 Nov 2025
- Phase
- Interventional
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 80 years and older
- All sexes
- No healthy volunteers
- Older adult
Who may be able to join
- Taking at least 1 daily antihypertensive medication
- Average systolic blood pressure < 130 mmHg
Who cannot join
- Diagnosis of congestive heart failure
- Use of antihypertensives for indications other than hypertension
- Hospitalization at the time of selection of participants
- Physician or participant/substitute decision maker opt out
Trial locations and contacts
2 sites in 1 country.
Canada2 sites
Carewest Colonel Belcher
Calgary, Alberta, T3B 5Y8
Benevolence Care Centre
Edmonton, Alberta, T5P 3S7
About this study
Official title: Deprescribing Antihypertensives Without a Taper in Long-term Care Facilities: A Quasi-experimental Pre-post Study
Blood pressure medications may provide limited benefit and cause side effects in frail older adults. It is unclear how best to stop these medications. Guidelines often recommend gradually reducing the dose, but this process can be time-consuming. This study examined the feasibility of stopping blood pressure medications without gradually reducing the dose in long-term care residents with low blood pressure. Eligible residents had their medication stopped and were monitored for four weeks.
- Conditions
- Hypertension (HTN)
- Being tested
- Deprescribing antihypertensives without a taper
- Keywords
- Taper, Deprescribing, Antihypertensives, Long-term Care, Frail
- Medical subject headings
- Hypertension
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Deprescribing antihypertensives without a taperOther
Discontinuation of one antihypertensive medication without gradually reducing the dose.
| Study group | Role | What they receive |
|---|---|---|
| Antihypertensive Discontinuation Without Tapering | Experimental | Eligible long-term care residents had one blood pressure medication discontinued without gradually reducing the dose. Receives: Other: Deprescribing antihypertensives without a taper |
What is being measured
The primary outcome is the main question the study is designed to answer.
Successful Antihypertensive Deprescribing
Proportion of participants who discontinued one antihypertensive medication without tapering and remained off that medication for four weeks.
Measured: In the four weeks after medication discontinuation
Secondary outcomes (4)
Change in Systolic and Diastolic Blood Pressure
Change in systolic and diastolic blood pressure from baseline to the end of the four-week follow-up period.
Measured: Baseline and four weeks after medication discontinuation
Change in As-Needed Medication Use
Change in the monthly number of as-needed medication administrations before and after stopping antihypertensive medication
Measured: Three months before and four weeks after medication discontinuation
Change in Number of Falls
Change in the number of falls before and after stopping antihypertensive medication
Measured: Six months before and four weeks after medication discontinuation
Change in Meal Intake
Change in the percentage of meals consumed before and after stopping antihypertensive medication, assessed using categories of 0-25%, 26-50%, 51-75%, and over 75%
Measured: Four weeks before and four weeks after medication discontinuation
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted22 Oct 2026
- Study start1 Jun 2025
- Primary completion30 Nov 2025
- Study completion30 Nov 2025
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Hypertension (HTN)Studies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Not applicable
- Intervention model
- Single group
- Masking
- None (open label)
- Enrolment
- 11 participants (actual)
Sponsor and investigators
- Lead sponsor
- University of Alberta
- Sponsor type
- University, hospital or other
- Responsible party
- Sponsor
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07890129
- Sponsor's protocol ID
- Pro00147733
- Status last verified
- Oct 2026
- First submitted
- 18 Oct 2026
- Last updated
- 22 Oct 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No