DementiaHLC-CogMarkNCT07890207
Human-LLM Conversations as a Digital Signature of Cognitive Performance in Adults
An observational study of Dementia, run by Technion, Israel Institute of Technology.
Trial summary
Subtle changes in language are among the early signs of cognitive decline in Alzheimer's disease and related conditions. Researchers are therefore studying whether language can help identify cognitive changes earlier and at larger scale. Read more about this study
- Who is it for?
- Ages 60 years and olderHealthy volunteers can take part
- Conditions the study is for
- Dementia
- How many people
- 100 participants
- Where
- No sites listed yet
- Study dates
- 1 Dec 2026to 30 Jun 2027
- Phase
- Observational
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 60 years and older
- All sexes
- Healthy volunteers accepted
- Adult, Older adult
Study population: Adults over the age of 60, proficient in English, regular (daily) use of AI-based chatbots. All levels of cognitive performance.
Who may be able to join
- Adults over the age of 60, proficient in English, regular (daily) use of AI-based chatbots.
Who cannot join
- All else.
About this study
Subtle changes in language are among the early signs of cognitive decline in Alzheimer's disease and related conditions. Researchers are therefore studying whether language can help identify cognitive changes earlier and at larger scale. Conversational AI tools (large language models, or LLMs) such as ChatGPT, Gemini, and Claude are now widely used, including by middle-aged and older adults. A conversation with an AI chatbot is more than a sample of written language: it shows how a person works toward a goal over several exchanges. This includes how they phrase requests, add constraints, keep track of context, notice errors, and revise their instructions. These behaviors may reflect language, attention, working memory, planning, and other aspects of cognitive function.
This exploratory, observational study will examine whether features of people's conversations with AI chatbots are associated with performance on a standard cognitive screening test. The study does not involve any treatment or intervention and is not intended to diagnose Alzheimer's disease, mild cognitive impairment, dementia, or any other condition.
Read more
Participants: 100 adults aged 60 and above who use AI chatbots and are proficient in English. Participants are recruited online through research crowdsourcing platforms (Prolific and DataForce). They do not need to have, or report, any diagnosis. No participants are recruited through clinics or hospitals.
Procedure: Participants complete a single online session of about 20 to 30 minutes. After giving informed consent, they:
Complete a background questionnaire covering demographics, language background, and AI chatbot use. Optional questions cover relevant medical and family history.
Upload three to five of their own previous conversations with an AI chatbot. They are asked to remove names and other identifying details first and to avoid highly sensitive conversations. They then answer a few short questions about each conversation.
Complete two short everyday tasks with a chatbot in the study interface: planning an activity and drafting a short message. The timing of typing and messages within the study interface is recorded.
Complete a remote MoCA test (XpressO), a validated self-administered digital cognitive screening tool, and the PHQ-8, a brief questionnaire on depressive symptoms.
A subset of participants may be invited to an optional additional assessment: the standard Montreal Cognitive Assessment (MoCA), administered by a trained examiner over video call. This is used to check how well the online test agrees with standard administration, and requires separate consent.
Outcomes: The primary outcome is the association between linguistic and interactional features of participants' AI conversations and their cognitive screening score, analyzed mainly as a continuous measure. Features include how specific and well structured requests are, how context is maintained, repetition, clarification, error recognition, revision strategies, progress through multi-step tasks, and typing and timing patterns. Secondary aims are to describe how adults aged 60 and over use AI chatbots, and to assess whether these features could support future computational methods for studying early cognitive change. Demographic, language, health, mood, and technology-use variables are considered as possible confounders.
Risks and safeguards: The study is minimal risk. The main risk is to privacy, because past chatbot conversations may contain personal information. Participants choose which conversations to share and are asked to remove identifying details. The research team removes any remaining direct identifiers, and data are stored on secure, access-restricted university servers. Data are analyzed by the academic research team and its research partner for research purposes only. Participants may feel mild fatigue or frustration; they can skip questions, take breaks, or stop at any time, and receive proportional compensation if they stop early. Individual scores are not reported. Participants whose screening score falls in the range that may indicate impairment receive a non-diagnostic note that explains the limits of screening tests and suggests discussing any memory concerns with a physician.
- Conditions
- Dementia
- Being tested
- No Intervention: Observational Cohort
- Keywords
- Dementia, AI, LLM, NLP, GPT, Large language models
- Medical subject headings
- Dementia
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
No Intervention: Observational CohortOther
No intervention. Collecting cohort and analyzing data.
| Study group | Role | What they receive |
|---|---|---|
| All participants | Adults over the age of 60, proficient in English, who regularly use LLMs like GPT. Receives: Other: No Intervention: Observational Cohort |
What is being measured
The primary outcome is the main question the study is designed to answer.
Association between features of human-AI chatbot conversations and cognitive screening score
The study measures linguistic and interactional features from participants' uploaded AI chatbot conversations and from two standardized chatbot tasks. Examples include request specificity and structure, context maintenance, repetition, clarification, error recognition, revision strategies, task progression, and typing and timing patterns. The association between these features and the MoCA XpressO total score is analyzed, with the score treated as a continuous measure.
Measured: Day 1 (single online session at enrollment, about 20-30 minutes)
Secondary outcomes (2)
Patterns of AI chatbot use
Descriptive summary of self-reported AI chatbot use: platforms used, duration and frequency of use, main purposes, language of use, and whether others help with use. Collected by questionnaire.
Measured: Day 1 (single online session at enrollment)
Performance of conversation features in estimating cognitive screening score
How well computational models based on conversation features estimate the MoCA XpressO score, assessed with cross-validation. Reported as correlation with the observed score and as the area under the ROC curve for classifying scores above versus below the validated cutoff.
Measured: Day 1 (single online session at enrollment)
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted22 Oct 2026
- Study start1 Dec 2026 (estimated)
- Primary completion30 Mar 2027 (estimated)
- Study completion30 Jun 2027 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for DementiaStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Observational
- Observational model
- Case only
- Time perspective
- Cross-sectional
- Enrolment
- 100 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Technion, Israel Institute of Technology
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Lotem Peled-Cohen, Technion, Israel Institute of Technology
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07890207
- Sponsor's protocol ID
- Technion- Israel Institute for
- Acronym
- HLC-CogMark
- Status last verified
- Oct 2026
- First submitted
- 18 Oct 2026
- Last updated
- 22 Oct 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
Study at a glance
From the registry record, last updated by the sponsor on 22 Oct 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Human-LLM Conversations as a Digital Signature of Cognitive Performance in Adults
- ClinicalTrials.gov ID
- NCT07890207
- Acronym / sponsor ID
- HLC-CogMark / Technion- Israel Institute for
- Conditions
- Dementia
- Keywords
- Dementia, AI, LLM, NLP, GPT, Large language models
- Study type
- Observational
- Recruitment status
- Not yet recruiting
- Enrolment
- 100 participants (estimated)
- Lead sponsor
- Technion, Israel Institute of TechnologyUniversity, hospital or other
- Study start
- 1 Dec 2026 (estimated)
- Primary completion
- 30 Mar 2027 (estimated)
- Study completion
- 30 Jun 2027 (estimated)
- First posted
- 22 Oct 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
Subtle changes in language are among the early signs of cognitive decline in Alzheimer's disease and related conditions. Researchers are therefore studying whether language can help identify cognitive changes earlier and at larger scale. Conversational AI tools (large language models, or LLMs) such as ChatGPT, Gemini, and Claude are now widely used, including by middle-aged and older adults. A conversation with an AI chatbot is more than a sample of written language: it shows how a person works toward a goal over several exchanges. This includes how they phrase requests, add constraints, keep track of context, notice errors, and revise their instructions. These behaviors may reflect language, attention, working memory, planning, and other aspects of cognitive function.
This exploratory, observational study will examine whether features of people's conversations with AI chatbots are associated with performance on a standard cognitive screening test. The study does not involve any treatment or intervention and is not intended to diagnose Alzheimer's disease, mild cognitive impairment, dementia, or any other condition.
Participants: 100 adults aged 60 and above who use AI chatbots and are proficient in English. Participants are recruited online through research crowdsourcing platforms (Prolific and DataForce). They do not need to have, or report, any diagnosis. No participants are recruited through clinics or hospitals.
Procedure: Participants complete a single online session of about 20 to 30 minutes. After giving informed consent, they:
Complete a background questionnaire covering demographics, language background, and AI chatbot use. Optional questions cover relevant medical and family history.
Upload three to five of their own previous conversations with an AI chatbot. They are asked to remove names and other identifying details first and to avoid highly sensitive conversations. They then answer a few short questions about each conversation.
Complete two short everyday tasks with a chatbot in the study interface: planning an activity and drafting a short message. The timing of typing and messages within the study interface is recorded.
Complete a remote MoCA test (XpressO), a validated self-administered digital cognitive screening tool, and the PHQ-8, a brief questionnaire on depressive symptoms.
A subset of participants may be invited to an optional additional assessment: the standard Montreal Cognitive Assessment (MoCA), administered by a trained examiner over video call. This is used to check how well the online test agrees with standard administration, and requires separate consent.
Outcomes: The primary outcome is the association between linguistic and interactional features of participants' AI conversations and their cognitive screening score, analyzed mainly as a continuous measure. Features include how specific and well structured requests are, how context is maintained, repetition, clarification, error recognition, revision strategies, progress through multi-step tasks, and typing and timing patterns. Secondary aims are to describe how adults aged 60 and over use AI chatbots, and to assess whether these features could support future computational methods for studying early cognitive change. Demographic, language, health, mood, and technology-use variables are considered as possible confounders.
Risks and safeguards: The study is minimal risk. The main risk is to privacy, because past chatbot conversations may contain personal information. Participants choose which conversations to share and are asked to remove identifying details. The research team removes any remaining direct identifiers, and data are stored on secure, access-restricted university servers. Data are analyzed by the academic research team and its research partner for research purposes only. Participants may feel mild fatigue or frustration; they can skip questions, take breaks, or stop at any time, and receive proportional compensation if they stop early. Individual scores are not reported. Participants whose screening score falls in the range that may indicate impairment receive a non-diagnostic note that explains the limits of screening tests and suggests discussing any memory concerns with a physician.
Study design
- Observational model
- Case only
- Time perspective
- Cross-sectional
- Number of arms
- 1
| Arm | Type | Receives |
|---|---|---|
| All participants | – | Other: No Intervention: Observational CohortAdults over the age of 60, proficient in English, who regularly use LLMs like GPT. |
Who may qualify
- Ages
- 60 years and older
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Adult, Older adult
- Study population
- Adults over the age of 60, proficient in English, regular (daily) use of AI-based chatbots. All levels of cognitive performance.
Key inclusion criteria (1 listed)
- Adults over the age of 60, proficient in English, regular (daily) use of AI-based chatbots.
Key exclusion criteria (1 listed)
- All else.
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| No Intervention: Observational CohortNo intervention. Collecting cohort and analyzing data. | Other | All participants |
Primary outcome
Association between features of human-AI chatbot conversations and cognitive screening score
Time frame: Day 1 (single online session at enrollment, about 20-30 minutes)
The study measures linguistic and interactional features from participants' uploaded AI chatbot conversations and from two standardized chatbot tasks. Examples include request specificity and structure, context maintenance, repetition, clarification, error recognition, revision strategies, task progression, and typing and timing patterns. The association between these features and the MoCA XpressO total score is analyzed, with the score treated as a continuous measure.
2 secondary outcomes
Patterns of AI chatbot use
Time frame: Day 1 (single online session at enrollment)
Performance of conversation features in estimating cognitive screening score
Time frame: Day 1 (single online session at enrollment)
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 22 Oct 2026.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
The record lists no contact. Use the official record to reach the sponsor.
Questions about this trial
What is this clinical trial studying?
An observational study of Dementia, run by Technion, Israel Institute of Technology.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 1 inclusion and 1 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: opening soon, as of the sponsor's last update on 22 Oct 2026. Status can change between updates, so confirm with the study contact before making plans.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Association between features of human-AI chatbot conversations and cognitive screening score (time frame: Day 1 (single online session at enrollment, about 20-30 minutes)). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 22 Oct 2026.