Pain, PostoperativeNCT07891013
Posterior Pericapsular Deep-gluteal Block
A study testing PENG (Pericapsular nerve group) block, LFCN (Lateral femoral cutaneous nerve) block and PPD (Posterior pericapsular deep gluteal) block in people with Pain, Postoperative, run by Ankara Etlik City Hospital.
Trial summary
The goal of this clinical trial is to determine whether adding a posterior pericapsular deep-gluteal (PPD) block to pericapsular nerve group (PENG) and lateral femoral cutaneous nerve (LFCN) blocks improves pain control after total hip arthroplasty. Read more about this study
- Who is it for?
- Ages 18 years and older
- Conditions the study is for
- Pain, Postoperative
- What is being tested?
- PENG (Pericapsular nerve group) block, LFCN (Lateral femoral cutaneous nerve) block and PPD (Posterior pericapsular deep gluteal) block
- Type of treatment
- Surgery or procedure
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 60 participants
- Where
- No sites listed yet
- Study dates
- 20 Oct 2026to 30 Dec 2026
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 years and older
- All sexes
- No healthy volunteers
- Adult, Older adult
Who may be able to join
- Patients aged 18 years or older
- Patients scheduled for elective primary unilateral total hip arthroplasty
- American Society of Anesthesiologists (ASA) physical status I-III
- Patients who provide written informed consent to participate in the study
Who cannot join
- Cognitive impairment that may interfere with pain assessment or study participation
- Known allergy to local anesthetics
- Revision total hip arthroplasty
- Contraindication to spinal anesthesia
- Neuromuscular disease
Trial locations and contacts
No sites are listed yet. Contact the study team or a site near you to ask about taking part.
About this study
Official title: Effect of Posterior Pericapsular Deep-Gluteal Block on Early Postoperative Dynamic Pain After Total Hip Arthroplasty: A Randomized Controlled Trial
The goal of this clinical trial is to determine whether adding a posterior pericapsular deep-gluteal (PPD) block to pericapsular nerve group (PENG) and lateral femoral cutaneous nerve (LFCN) blocks improves pain control after total hip arthroplasty.
The main questions it aims to answer are:
Read more
- Does adding a posterior pericapsular deep-gluteal block reduce clinically significant pain during movement in the early postoperative period?
- Does adding this block reduce postoperative pain and opioid requirements?
- Does adding this block improve functional recovery after surgery?
Researchers will compare patients receiving PENG and LFCN blocks with patients receiving PENG and LFCN blocks plus a posterior pericapsular deep-gluteal block to determine whether blocking the posterior region of the hip provides additional pain relief.
Participants will:
- Receive ultrasound-guided nerve blocks before surgery according to their assigned study group.
- Undergo total hip arthroplasty under spinal anesthesia.
- Have their pain assessed at predefined times after surgery, including during movement.
- Be evaluated for opioid requirements and functional recovery after surgery.
Read the detailed description
Total hip arthroplasty is commonly associated with moderate to severe postoperative pain. Providing effective analgesia can be challenging because of the complex innervation of the hip joint, and no single nerve block or combination of blocks has been demonstrated to be superior for all types of hip surgery.
The pericapsular nerve group (PENG) block and lateral femoral cutaneous nerve (LFCN) block are regional anesthesia techniques used to reduce pain after hip surgery. However, these blocks mainly target the anterior and lateral regions of the hip and may not adequately cover pain arising from the posterior region.
The posterior pericapsular (deep-gluteal) block (PPD) is a recently described regional anesthesia technique designed to target the nerves supplying the posterior region of the hip while preserving motor function. Evidence regarding the additional analgesic benefit of this block in patients undergoing total hip arthroplasty remains limited.
This randomized controlled study will compare patients receiving PENG and LFCN blocks with patients receiving PENG and LFCN blocks combined with PPD block. The primary aim is to determine whether adding the posterior pericapsular (deep-gluteal) block reduces clinically significant pain during movement in the early postoperative period. The study will also evaluate postoperative pain, opioid consumption, and quality of functional recovery.
The investigators hypothesize that adding the posterior pericapsular (deep-gluteal) block to PENG and LFCN blocks will provide better early postoperative analgesia than PENG and LFCN blocks alone.
- Conditions
- Pain, Postoperative
- Being tested
- PENG (Pericapsular nerve group) block, LFCN (Lateral femoral cutaneous nerve) block, PPD (Posterior pericapsular deep gluteal) block
- Keywords
- total hip arthroplasty, analgesia, pain, pericapsular nerve group (PENG) block, posterior pericapsular deep gluteal block, lateral femoral cutaneous (LFCN) block, regional anesthesia
- Medical subject headings
- Pain, Postoperative, Agnosia, Pain, Bites and Stings
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
PENG (Pericapsular nerve group) blockProcedure or surgery
An ultrasound-guided pericapsular nerve group (PENG) block will be performed in the preoperative period, approximately 30 minutes before surgery.
LFCN (Lateral femoral cutaneous nerve) blockProcedure or surgery
An ultrasound-guided lateral femoral cutaneous nerve (LFCN) block will be performed in the preoperative period, approximately 30 minutes before surgery.
PPD (Posterior pericapsular deep gluteal) blockProcedure or surgery
An ultrasound-guided posterior pericapsular deep-gluteal block will be performed in the preoperative period, approximately 30 minutes before surgery.
| Study group | Role | What they receive |
|---|---|---|
| PENG+LFCN group | Active comparator | PENG block : 20 ml %0.25 Bupivacaine LFCN block: 5 ml %0.50 Bupivacaine Receives: Procedure: PENG (Pericapsular nerve group) block; Procedure: LFCN (Lateral femoral cutaneous nerve) block |
| PENG+LFCN+PPD group | Experimental | PENG block: 20 ml %0.25 Bupivacaine LFCN block: 5 ml %0.50 Bupivacaine PPD block: 15 ml %0.25 Bupivacaine Receives: Procedure: PENG (Pericapsular nerve group) block; Procedure: LFCN (Lateral femoral cutaneous nerve) block; Procedure: PPD (Posterior pericapsular deep gluteal) block |
What is being measured
The primary outcome is the main question the study is designed to answer.
6-hour dynamic pain intensity
Dynamic pain will be assessed using the Numerical Rating Scale (NRS), ranging from 0 (no pain) to 10 (worst imaginable pain).
Measured: 6 hours postoperatively
Secondary outcomes (5)
Dynamic pain intensity
Dynamic pain will be assessed using the Numerical Rating Scale (NRS), ranging from 0 (no pain) to 10 (worst imaginable pain).
Measured: 4, 8, 12, and 24 hours postoperatively
Pain intensity at rest
Resting pain will be assessed using the Numerical Rating Scale (NRS), ranging from 0 (no pain) to 10 (worst imaginable pain).
Measured: 4, 6, 8, 12, and 24 hours postoperatively
Cumulative morphine consumption
The cumulative amount of morphine consumed during the first 24 hours postoperatively will be recorded in milligrams (mg).
Measured: Up to 24 hours postoperatively
Time to first rescue analgesic
The time from the end of surgery to the first pain score ≥ 4 at rest or during movement, or to the first patient request for analgesia, will be recorded in hours.
Measured: Up to 24 hours postoperatively
Quality of Recovery (QoR)-15 score
Quality of postoperative recovery will be assessed using the 15-item Quality of Recovery (QoR-15) questionnaire. The total score ranges from 0 to 150, with higher scores indicating better quality of recovery.
Measured: Preoperatively and postoperative day 1
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted23 Oct 2026
- Study start20 Oct 2026 (estimated)
- Primary completion20 Dec 2026 (estimated)
- Study completion30 Dec 2026 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (5)Papers the sponsor has linked to this study.
- Other trials for Pain, PostoperativeStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Supportive care
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Model description
- Participants undergoing total hip arthroplasty will be randomly assigned in a 1:1 ratio to one of two parallel groups. The control group will receive PENG and LFCN blocks, while the intervention group will receive PENG and LFCN blocks combined with a posterior pericapsular deep-gluteal block. Participants will remain in their assigned group throughout the study, and postoperative outcomes will be compared between the two groups.
- Masking
- Double blind
- Who is masked
- Participant, Outcomes assessor
- Enrolment
- 60 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Ankara Etlik City Hospital
- Sponsor type
- Other government
- Responsible party
- Principal investigator, Fatma Özkan Sipahioğlu, Ankara Etlik City Hospital
- Investigators
- Fatma Ozkan Sipahioglu, MD, Principal investigator, Ankara Etlik City Hospital
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07891013
- Sponsor's protocol ID
- PPD Block
- Status last verified
- Oct 2026
- First submitted
- 10 Oct 2026
- Last updated
- 23 Oct 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Publications
Hu J, Wang Q, Hu J, Gong C, Yang J. A modified hip pericapsular nerve block on postoperative pain and functional outcome after total hip arthroplasty: a prospective, double-blind, randomized controlled study. Korean J Anesthesiol. 2025 Aug;78(4):351-360. doi: 10.4097/kja.24593. Epub 2025 Mar 13.
PubMed 40075241Wu H, Li J, Li N, Zhang S, Duan L. Injectate spread following posterior hip pericapsular block: a preliminary single-case anatomical observation in a formalin-fixed cadaver. Front Pain Res (Lausanne). 2026 May 29;7:1867189. doi: 10.3389/fpain.2026.1867189. eCollection 2026.
PubMed 42293426Lee KH, Wang JC, Chang CY, Teng WN, Wang HY, Lee CC, Tsai SW, Chen CF, Wu PK, Chen WM. Regional anaesthesia modalities for primary total hip arthroplasty: a systematic review and component network meta-analysis. Br J Anaesth. 2025 Aug;135(2):469-482. doi: 10.1016/j.bja.2025.04.019. Epub 2025 Jun 6.
PubMed 40483183Vermeylen K, Van Aken D, Versyck B, Casaer S, Bleys R, Bracke P, Groen G. Deep posterior gluteal compartment block for regional anaesthesia of the posterior hip: a proof-of-concept pilot study. BJA Open. 2023 Feb 15;5:100127. doi: 10.1016/j.bjao.2023.100127. eCollection 2023 Mar.
PubMed 37587997Cardoso FA, Fortuna-Costa A, Garcia LV. Analgesic effect of lateral femoral cutaneous nerve block added to the pericapsular nerve group (PENG) block in primary total hip arthroplasty: a randomized clinical trial. Minerva Anestesiol. 2025 Jan-Feb;91(1-2):26-35. doi: 10.23736/S0375-9393.24.18141-2. Epub 2024 Dec 4.
PubMed 39630141
Study at a glance
From the registry record, last updated by the sponsor on 23 Oct 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Effect of Posterior Pericapsular Deep-Gluteal Block on Early Postoperative Dynamic Pain After Total Hip Arthroplasty: A Randomized Controlled Trial
- ClinicalTrials.gov ID
- NCT07891013
- Acronym / sponsor ID
- PPD Block
- Conditions
- Pain, Postoperative
- Keywords
- total hip arthroplasty, analgesia, pain, pericapsular nerve group (PENG) block, posterior pericapsular deep gluteal block, lateral femoral cutaneous (LFCN) block, regional anesthesia
- Study type
- Interventional
- Recruitment status
- Not yet recruiting
- Enrolment
- 60 participants (estimated)
- Lead sponsor
- Ankara Etlik City HospitalOther government
- Study start
- 20 Oct 2026 (estimated)
- Primary completion
- 20 Dec 2026 (estimated)
- Study completion
- 30 Dec 2026 (estimated)
- First posted
- 23 Oct 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
The goal of this clinical trial is to determine whether adding a posterior pericapsular deep-gluteal (PPD) block to pericapsular nerve group (PENG) and lateral femoral cutaneous nerve (LFCN) blocks improves pain control after total hip arthroplasty.
The main questions it aims to answer are:
- Does adding a posterior pericapsular deep-gluteal block reduce clinically significant pain during movement in the early postoperative period?
- Does adding this block reduce postoperative pain and opioid requirements?
- Does adding this block improve functional recovery after surgery?
Researchers will compare patients receiving PENG and LFCN blocks with patients receiving PENG and LFCN blocks plus a posterior pericapsular deep-gluteal block to determine whether blocking the posterior region of the hip provides additional pain relief.
Participants will:
- Receive ultrasound-guided nerve blocks before surgery according to their assigned study group.
- Undergo total hip arthroplasty under spinal anesthesia.
- Have their pain assessed at predefined times after surgery, including during movement.
- Be evaluated for opioid requirements and functional recovery after surgery.
Detailed description
Total hip arthroplasty is commonly associated with moderate to severe postoperative pain. Providing effective analgesia can be challenging because of the complex innervation of the hip joint, and no single nerve block or combination of blocks has been demonstrated to be superior for all types of hip surgery.
The pericapsular nerve group (PENG) block and lateral femoral cutaneous nerve (LFCN) block are regional anesthesia techniques used to reduce pain after hip surgery. However, these blocks mainly target the anterior and lateral regions of the hip and may not adequately cover pain arising from the posterior region.
The posterior pericapsular (deep-gluteal) block (PPD) is a recently described regional anesthesia technique designed to target the nerves supplying the posterior region of the hip while preserving motor function. Evidence regarding the additional analgesic benefit of this block in patients undergoing total hip arthroplasty remains limited.
This randomized controlled study will compare patients receiving PENG and LFCN blocks with patients receiving PENG and LFCN blocks combined with PPD block. The primary aim is to determine whether adding the posterior pericapsular (deep-gluteal) block reduces clinically significant pain during movement in the early postoperative period. The study will also evaluate postoperative pain, opioid consumption, and quality of functional recovery.
The investigators hypothesize that adding the posterior pericapsular (deep-gluteal) block to PENG and LFCN blocks will provide better early postoperative analgesia than PENG and LFCN blocks alone.
Study design
- Primary purpose
- Supportive care
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Double blind (participant, outcomes assessor)
- Number of arms
- 2
- Model description
- Participants undergoing total hip arthroplasty will be randomly assigned in a 1:1 ratio to one of two parallel groups. The control group will receive PENG and LFCN blocks, while the intervention group will receive PENG and LFCN blocks combined with a posterior pericapsular deep-gluteal block. Participants will remain in their assigned group throughout the study, and postoperative outcomes will be compared between the two groups.
| Arm | Type | Receives |
|---|---|---|
| PENG+LFCN group | Active comparator | Procedure: PENG (Pericapsular nerve group) block, Procedure: LFCN (Lateral femoral cutaneous nerve) blockPENG block : 20 ml %0.25 Bupivacaine LFCN block: 5 ml %0.50 Bupivacaine |
| PENG+LFCN+PPD group | Experimental | Procedure: PENG (Pericapsular nerve group) block, Procedure: LFCN (Lateral femoral cutaneous nerve) block, Procedure: PPD (Posterior pericapsular deep gluteal) blockPENG block: 20 ml %0.25 Bupivacaine LFCN block: 5 ml %0.50 Bupivacaine PPD block: 15 ml %0.25 Bupivacaine |
Who may qualify
- Ages
- 18 years and older
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (4 listed)
- Patients aged 18 years or older
- Patients scheduled for elective primary unilateral total hip arthroplasty
- American Society of Anesthesiologists (ASA) physical status I-III
- Patients who provide written informed consent to participate in the study
Key exclusion criteria (5 listed)
- Cognitive impairment that may interfere with pain assessment or study participation
- Known allergy to local anesthetics
- Revision total hip arthroplasty
- Contraindication to spinal anesthesia
- Neuromuscular disease
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| PENG (Pericapsular nerve group) blockAn ultrasound-guided pericapsular nerve group (PENG) block will be performed in the preoperative period, approximately 30 minutes before surgery. | Procedure or surgery | PENG+LFCN group, PENG+LFCN+PPD group |
| LFCN (Lateral femoral cutaneous nerve) blockAn ultrasound-guided lateral femoral cutaneous nerve (LFCN) block will be performed in the preoperative period, approximately 30 minutes before surgery. | Procedure or surgery | PENG+LFCN group, PENG+LFCN+PPD group |
| PPD (Posterior pericapsular deep gluteal) blockAn ultrasound-guided posterior pericapsular deep-gluteal block will be performed in the preoperative period, approximately 30 minutes before surgery. | Procedure or surgery | PENG+LFCN+PPD group |
Primary outcome
6-hour dynamic pain intensity
Time frame: 6 hours postoperatively
Dynamic pain will be assessed using the Numerical Rating Scale (NRS), ranging from 0 (no pain) to 10 (worst imaginable pain).
5 secondary outcomes
Dynamic pain intensity
Time frame: 4, 8, 12, and 24 hours postoperatively
Pain intensity at rest
Time frame: 4, 6, 8, 12, and 24 hours postoperatively
Cumulative morphine consumption
Time frame: Up to 24 hours postoperatively
Time to first rescue analgesic
Time frame: Up to 24 hours postoperatively
Quality of Recovery (QoR)-15 score
Time frame: Preoperatively and postoperative day 1
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 23 Oct 2026.
- Background: PubMed 40075241Hu J, Wang Q, Hu J, Gong C, Yang J. A modified hip pericapsular nerve block on postoperative pain and functional outcome after total hip arthroplasty: a prospective, double-blind, randomized controlled study. Korean J Anesthesiol. 2025 Aug;78(4):351-360. doi: 10.4097/kja.24593. Epub 2025 Mar 13.
- Background: PubMed 42293426Wu H, Li J, Li N, Zhang S, Duan L. Injectate spread following posterior hip pericapsular block: a preliminary single-case anatomical observation in a formalin-fixed cadaver. Front Pain Res (Lausanne). 2026 May 29;7:1867189. doi: 10.3389/fpain.2026.1867189. eCollection 2026.
- Background: PubMed 40483183Lee KH, Wang JC, Chang CY, Teng WN, Wang HY, Lee CC, Tsai SW, Chen CF, Wu PK, Chen WM. Regional anaesthesia modalities for primary total hip arthroplasty: a systematic review and component network meta-analysis. Br J Anaesth. 2025 Aug;135(2):469-482. doi: 10.1016/j.bja.2025.04.019. Epub 2025 Jun 6.
- Background: PubMed 37587997Vermeylen K, Van Aken D, Versyck B, Casaer S, Bleys R, Bracke P, Groen G. Deep posterior gluteal compartment block for regional anaesthesia of the posterior hip: a proof-of-concept pilot study. BJA Open. 2023 Feb 15;5:100127. doi: 10.1016/j.bjao.2023.100127. eCollection 2023 Mar.
- Background: PubMed 39630141Cardoso FA, Fortuna-Costa A, Garcia LV. Analgesic effect of lateral femoral cutaneous nerve block added to the pericapsular nerve group (PENG) block in primary total hip arthroplasty: a randomized clinical trial. Minerva Anestesiol. 2025 Jan-Feb;91(1-2):26-35. doi: 10.23736/S0375-9393.24.18141-2. Epub 2024 Dec 4.
- Individual participant dataSharing planned: No
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
Fatma Ozkan Sipahioglu, MD principal investigator
Ankara Etlik City Hospital
Questions about this trial
What is this clinical trial studying?
A study testing PENG (Pericapsular nerve group) block, LFCN (Lateral femoral cutaneous nerve) block and PPD (Posterior pericapsular deep gluteal) block in people with Pain, Postoperative, run by Ankara Etlik City Hospital.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 4 inclusion and 5 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: opening soon, as of the sponsor's last update on 23 Oct 2026. Status can change between updates, so confirm with the study contact before making plans.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact Fatma Ozkan Sipahioglu, MD (+905531362875, ftmozkan_uzmdr@yahoo.com), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
6-hour dynamic pain intensity (time frame: 6 hours postoperatively). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT07891013, which also lists 5 linked publications.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 23 Oct 2026; AzTrials last refreshed its copy on 26 Oct 2026.