EdentulismNCT07891117
Multi-Evaluation of Dental Abutments With Different Surfaces
A study testing Multi-unit Abutments Xeal™ with Nobel TiUltra™ implant Parallel CC and Conventional titanium multi-unit abutments with Nobel TiUltra™ implant Parallel CC in people with Edentulism and Dental Implant, run by Kutahya Health Sciences University at 1 site in Turkey (Türkiye).
Trial summary
The placement of dental implants has been a routine procedure for the rehabilitation of fully or partially edentulous patients for nearly 40 years. Dental abutments are intermediary components that connect prosthetic teeth to the implants after healing. Read more about this study
- Who is it for?
- Ages 18 years and older
- Conditions the study is for
- Edentulism, Dental Implant, Prosthetic Abutment
- What is being tested?
- Multi-unit Abutments Xeal™ with Nobel TiUltra™ implant Parallel CC and Conventional titanium multi-unit abutments with Nobel TiUltra™ implant Parallel CC
- Type of treatment
- Medical device
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 44 participants
- Where
- 1 siteTurkey (Türkiye)
- Study dates
- 1 Sep 2026to 1 Jun 2029
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 years and older
- All sexes
- No healthy volunteers
- Adult, Older adult
Who may be able to join
- Age>18 years old
- Systemically healthy patients
- Presence of edentulous areas in the mandibular or maxillary posterior region
- Presence of natural teeth in the opposing arch
- Periodontal health
- Absence of oral or mucosal disease
Show all 12Show fewer
- Presence of bone suitable for implant placement with a minimum diameter of 3.75 mm and height of 8 mm
- No need for simultaneous augmentation
- Two-unit splinted implant-supported prosthesis
- Prosthetic superstructure made of metal-supported porcelain-fused material
- A healed maxillary or mandibular molar or premolar site (>3 months) with sufficient bone available for implant placement without the need for bone grafting
- Not having used any antibiotics in the 6 months immediately preceding the surgery.
Who cannot join
- Being outside the specified age range
- Systemic disease
- Patients who have received radiotherapy to the head and neck region
- Severe bruxism or clenching
- Patients who smoke more than 10 cigarettes per day
- Use of drugs that suppress the immune system or impair healing, use of steroids or bisphosphonates
Show all 15Show fewer
- Patients with alcohol or substance dependence
- Patients who do not comply with treatment
- Pregnancy or breastfeeding
- Patients with intellectual retardation
- Untreated periodontal disease
- Use of any drug or device within the 6 months immediately before surgery
- Patients with conditions that could complicate surgical procedures/need advanced bone augmentation procedures
- Allergy to any component of the implant or abutment
- The need for bone or soft tissue reconstruction at the time of implant placement.
Trial locations and contacts
1 site in 1 country. Contact the study team or a site near you to ask about taking part.
Turkey (Türkiye)1 site, 1 recruiting
- Recruiting
Kutahya Health Sciences University Faculty of Dentistry
Kütahya, 43100
Berceste Guler Ayyildiz, Assoc. Prof. Dr., 905059359207, berceste.guler@ksbu.edu.tr
Seyma Eken, Assist. Prof. Dr., 905518489820, seyma.eken@ksbu.edu.tr
About this study
Official title: Multimodal Evaluation-Clinical, Radiological, Microbiological, and 3D Soft Tissue Analysis-of Dental Abutments With Different Surfaces in the Posterior Region
The placement of dental implants has been a routine procedure for the rehabilitation of fully or partially edentulous patients for nearly 40 years. Dental abutments are intermediary components that connect prosthetic teeth to the implants after healing. Depending on the properties of the abutment material, plaque accumulation and bacterial adhesion may lead to inflammation and bone loss in peri-implant tissues. Developed by Nobel Biocare, the Xeal™ abutment surface protects the underlying bone, supports stable soft tissue integration, and has been shown to reduce marginal bone loss and promote healthier mucosa compared to machined abutments. However, previous studies have mostly relied on clinical and radiographic evaluations, without three-dimensional evaluation or microbiological analysis. This study aimed to evaluate peri-implant marginal bone loss (MBL), digital evaluation of peri-implant soft tissue, and differences in the microbial composition of the oral microflora colonizing the soft tissue/abutment interface between Multi-unit Abutments Xeal™ and conventional titanium multi-unit abutments placed in the posterior region.
Read the detailed description
The study will include 44 patients (88 implants) with tooth loss in the maxillary or mandibular posterior region, for whom implant-supported fixed prostheses (supported by two implants each) are planned. These two-unit, splinted, implant-supported bridges will utilize two different types of abutments. Each implant will be randomly assigned to either the control group or the test group using the sealed-envelope method.
All patients will undergo the same surgical procedure and receive the same type of dental implant, in accordance with the established protocol. For the placement of both provisional and definitive fixed prostheses, multi-unit abutments with a "Xeal™" surface will be used for the test group, while titanium multi-unit abutments will be used for the control group.
Prior to surgery, clinical measurements will be recorded, and the peri-implant soft tissues will be digitally scanned using an intraoral scanner (IOS). For both abutment groups, the thickness and width of the keratinized mucosa, as well as the implant placement site, will be measured digitally with the aid of an intraoral scanner (IOS). Before and during the dental implant procedure, the bone thickness around the implant site-in the mesial, distal, buccal, and lingual/palatal directions-and the height of the supracrestal tissue will be recorded.
The dental implants will be placed, and the multi-unit abutments will be tightened to the appropriate torque values. Primary and secondary stability values for the implants will be measured via the multi-unit abutments.
Subsequently, provisional fixed prostheses will be fabricated. After 3 months, the definitive prostheses will be constructed.
For the purpose of radiographic evaluation; Standard periapical radiographs will be taken postoperatively (Tb), immediately after prosthetic loading (T0), and at 1 month (T1), 3 months (T2), 6 months (T3), and 1 year (T4). Marginal bone loss (MBL) will be assessed using measurements taken from these standard periapical radiographs with the aid of software throughout the one-year follow-up period. Following the surgery-at time points T0, T1, T2, T3, and T4-digital soft tissue assessment will be performed using an intraoral scanner (IOS), clinical parameters will be recorded, and subgingival microbial samples will be collected from the deepest pocket area of each implant.
- Conditions
- Edentulism, Dental Implant, Prosthetic Abutment
- Being tested
- Multi-unit Abutments Xeal™ with Nobel TiUltra™ implant Parallel CC, Conventional titanium multi-unit abutments with Nobel TiUltra™ implant Parallel CC
- Keywords
- edentulism, posterior region, screw-retained, digital, prosthetic abutment
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Multi-unit Abutments Xeal™ with Nobel TiUltra™ implant Parallel CCDevice
All implant surgeries will be performed under local anesthesia. A midcrestal incision will be made with a 15C blade, followed by careful elevation of a full-thickness flap. Implant insertion will be carried out according to the manufacturer's instructions, and a Nobel TiUltra™ implant will be placed 0.5-1 mm subcrestally. Following implant placement, primary implant stability will be measured using the Osstell device. Non-engaging temporary abutment will be placed for fabrication of the temporary fixed prosthesis, which will be constructed approximately 1 mm infraocclusally. The flap will be closed primarily. After 12 weeks, the temporary prosthesis will be removed and secondary implant stability will be assessed with an Osstell device. Impressions will be taken at the abutment level, and a permanent metal-supported porcelain fixed prosthesis will be fabricated and screwed onto the Multi-unit Abutments Xeal™ with a torque of 15 Ncm.
Conventional titanium multi-unit abutments with Nobel TiUltra™ implant Parallel CCDevice
All implant surgeries will be performed under local anesthesia. A midcrestal incision will be made with a 15C blade, followed by careful elevation of a full-thickness flap. Implant insertion will be carried out according to the manufacturer's instructions, and a Nobel TiUltra™ implant will be placed 0.5-1 mm subcrestally. Following implant placement, primary implant stability will be measured using the Osstell device. Non-engaging temporary abutment will be placed for fabrication of the temporary fixed prosthesis, which will be constructed approximately 1 mm infraocclusally. The flap will be closed primarily. After 12 weeks, the temporary prosthesis will be removed and secondary implant stability will be assessed with an Osstell device. Impressions will be taken at the abutment level, and a permanent metal-supported porcelain fixed prosthesis will be fabricated and screwed onto the Conventional titanium multi-unit abutments with a torque of 15 Ncm.
| Study group | Role | What they receive |
|---|---|---|
| Control group | Experimental | According to the protocol, each patient will receive two Nobel TiUltra™ implant Parallel CCs, with one implant being fitted with a Conventional titanium multi-unit abutment. Receives: Device: Conventional titanium multi-unit abutments with Nobel TiUltra™ implant Parallel CC |
| Test group | Experimental | According to the protocol, each patient will receive two Nobel TiUltra™ implant Parallel CCs, with one implant being fitted with a Multi-unit Abutments Xeal™. Receives: Device: Multi-unit Abutments Xeal™ with Nobel TiUltra™ implant Parallel CC |
What is being measured
The primary outcome is the main question the study is designed to answer.
qPCR analysis outcomes of microbiological samples
Microbiological composition will be the primary outcome measure, assessed at the T1-T4 time points up to 12 months after prosthesis loading
Measured: 12 month follow-up
Secondary outcomes (3)
Marginal bone level changes (ΔMBL) (mm)
Peri-implant ΔMBL (change in marginal bone loss) values during the period from T0 to T4 (from the time of prosthetic loading up to 12 months) post-loading on periapical radiographs.
Measured: 12 month follow-up
Peri-implant keratinized width changes digitally (mm)
Differences in keratinized gingival width measurements between time points T0 and T4 (from the time of prosthetic loading up to 12 months), as assessed via IOS, between the two groups
Measured: 12 month follow-up
Implant stabilization values (ISQ)
Primary and secondary stabilization values will be measured at intraoperation and follow-up 3rd months (before prosthetic loading)
Measured: At intraoperatively and before prosthetic loading session
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted23 Oct 2026
- Study start1 Sep 2026
- Primary completion1 Jun 2028 (estimated)
- Study completion1 Jun 2029 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (14)Papers the sponsor has linked to this study.
- Other trials for EdentulismStudies of the same condition, open and under way.
- More trials run by Kutahya Health Sciences UniversityThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Crossover
- Model description
- All patients will undergo identical implant surgery procedures as per the proposed protocol. Temporary and permanent fixed prostheses will be placed using Multi-unit Abutments Xeal™ for the test group and titanium multi-unit abutments for the control group. Test group: Multi-unit Abutments Xeal™ with Nobel TiUltra™ implant Parallel CC. Control group: Conventional titanium multi-unit abutments with Nobel TiUltra™ implant Parallel CC
- Masking
- Double blind
- Who is masked
- Participant, Outcomes assessor
- Enrolment
- 44 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Kutahya Health Sciences University
- Sponsor type
- University, hospital or other
- Collaborators
- Nobel Biocare
- Responsible party
- Principal investigator, Berceste Guler Ayyildiz, Kutahya Health Sciences University
- Investigators
- Berceste Guler Ayyildiz, Study director, Kutahya Health Sciences University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07891117
- Sponsor's protocol ID
- KAD001/2026-01
- Other IDs
- 2026-1872
- Status last verified
- Oct 2026
- First submitted
- 12 Oct 2026
- Last updated
- 23 Oct 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- Undecided
Publications
Nobel Biocare. Data on file.
Bozkaya S, Uraz A, Guler B, Kahraman SA, Turhan Bal B. The stability of implants and microbiological effects following photobiomodulation therapy with one-stage placement: A randomized, controlled, single-blinded, and split-mouth clinical study. Clin Implant Dent Relat Res. 2021 Jun;23(3):329-340. doi: 10.1111/cid.12999. Epub 2021 Apr 14.
PubMed 33851765Ainamo J, Bay I. Problems and proposals for recording gingivitis and plaque. Int Dent J. 1975 Dec;25(4):229-35.
PubMed 1058834O'Leary TJ, Drake RB, Naylor JE. The plaque control record. J Periodontol. 1972 Jan;43(1):38. doi: 10.1902/jop.1972.43.1.38. No abstract available.
PubMed 4500182Mombelli A, van Oosten MA, Schurch E Jr, Land NP. The microbiota associated with successful or failing osseointegrated titanium implants. Oral Microbiol Immunol. 1987 Dec;2(4):145-51. doi: 10.1111/j.1399-302x.1987.tb00298.x. No abstract available.
PubMed 3507627Nosswitz M, Teale M, Mathes S, Venturato A, Gasser A. Evaluation of Anodized Surfaces Designed for Improved Soft Tissue Integration, Foundation for Oral Rehabilitation; 2019
Mussano F, Genova T, Laurenti M, Zicola E, Munaron L, Rivolo P, Mandracci P, Carossa S. Early Response of Fibroblasts and Epithelial Cells to Pink-Shaded Anodized Dental Implant Abutments: An In Vitro Study. Int J Oral Maxillofac Implants. 2018 May/Jun;33(3):571-579. doi: 10.11607/jomi.6479.
PubMed 29763495Stević, M., Tatić, Z., Biočanin, V., Đurić, D., & Đukić, I. (2021). History of implantology from the aspect of osseointegration and mucointegration. Timočki medicinski glasnik, 46(1), 29-36.
Te Lin Y, Li C, Korostoff J, Fiorellini JP, Yang J, Chang YC. Three-dimensional digital quantitative analysis of periodontal and peri-implant phenotype-A narrative review. Periodontol 2000. 2025 Jul 11. doi: 10.1111/prd.12639. Online ahead of print.
PubMed 40641458Milleret V, Lienemann PS, Gasser A, Bauer S, Ehrbar M, Wennerberg A. Rational design and in vitro characterization of novel dental implant and abutment surfaces for balancing clinical and biological needs. Clin Implant Dent Relat Res. 2019 Mar;21 Suppl 1:15-24. doi: 10.1111/cid.12736. Epub 2019 Feb 27.
PubMed 30809940Yılmaz HG, Yılmaz SK. Effect of Different Abutment Materials on Health of Peri-İmplant Tissues. EÜ Dişhek Fak Derg 2011; 32: 69-75.
Welander M, Abrahamsson I, Berglundh T. The mucosal barrier at implant abutments of different materials. Clin Oral Implants Res. 2008 Jul;19(7):635-41. doi: 10.1111/j.1600-0501.2008.01543.x. Epub 2008 May 19.
PubMed 18492075Linkevicius T, Vaitelis J. The effect of zirconia or titanium as abutment material on soft peri-implant tissues: a systematic review and meta-analysis. Clin Oral Implants Res. 2015 Sep;26 Suppl 11:139-47. doi: 10.1111/clr.12631. Epub 2015 Jun 13.
PubMed 26073346Singh, S., Saifi, D., Singhal, M. K., & Saxena, I. Rational Design and Characterization of Novel Dental Implant and Surfaces: Mucointegration with Enhanced Osseointegration
Study at a glance
From the registry record, last updated by the sponsor on 23 Oct 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Multimodal Evaluation-Clinical, Radiological, Microbiological, and 3D Soft Tissue Analysis-of Dental Abutments With Different Surfaces in the Posterior Region
- ClinicalTrials.gov ID
- NCT07891117
- Acronym / sponsor ID
- KAD001/2026-01
- Conditions
- Edentulism, Dental Implant, Prosthetic Abutment
- Keywords
- edentulism, posterior region, screw-retained, digital, prosthetic abutment
- Study type
- Interventional
- Recruitment status
- Recruiting
- Enrolment
- 44 participants (estimated)
- Lead sponsor
- Kutahya Health Sciences UniversityUniversity, hospital or other
- Collaborators
- Nobel Biocare
- Study start
- 1 Sep 2026 (actual)
- Primary completion
- 1 Jun 2028 (estimated)
- Study completion
- 1 Jun 2029 (estimated)
- First posted
- 23 Oct 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
The placement of dental implants has been a routine procedure for the rehabilitation of fully or partially edentulous patients for nearly 40 years. Dental abutments are intermediary components that connect prosthetic teeth to the implants after healing. Depending on the properties of the abutment material, plaque accumulation and bacterial adhesion may lead to inflammation and bone loss in peri-implant tissues. Developed by Nobel Biocare, the Xeal™ abutment surface protects the underlying bone, supports stable soft tissue integration, and has been shown to reduce marginal bone loss and promote healthier mucosa compared to machined abutments. However, previous studies have mostly relied on clinical and radiographic evaluations, without three-dimensional evaluation or microbiological analysis. This study aimed to evaluate peri-implant marginal bone loss (MBL), digital evaluation of peri-implant soft tissue, and differences in the microbial composition of the oral microflora colonizing the soft tissue/abutment interface between Multi-unit Abutments Xeal™ and conventional titanium multi-unit abutments placed in the posterior region.
Detailed description
The study will include 44 patients (88 implants) with tooth loss in the maxillary or mandibular posterior region, for whom implant-supported fixed prostheses (supported by two implants each) are planned. These two-unit, splinted, implant-supported bridges will utilize two different types of abutments. Each implant will be randomly assigned to either the control group or the test group using the sealed-envelope method.
All patients will undergo the same surgical procedure and receive the same type of dental implant, in accordance with the established protocol. For the placement of both provisional and definitive fixed prostheses, multi-unit abutments with a "Xeal™" surface will be used for the test group, while titanium multi-unit abutments will be used for the control group.
Prior to surgery, clinical measurements will be recorded, and the peri-implant soft tissues will be digitally scanned using an intraoral scanner (IOS). For both abutment groups, the thickness and width of the keratinized mucosa, as well as the implant placement site, will be measured digitally with the aid of an intraoral scanner (IOS). Before and during the dental implant procedure, the bone thickness around the implant site-in the mesial, distal, buccal, and lingual/palatal directions-and the height of the supracrestal tissue will be recorded.
The dental implants will be placed, and the multi-unit abutments will be tightened to the appropriate torque values. Primary and secondary stability values for the implants will be measured via the multi-unit abutments.
Subsequently, provisional fixed prostheses will be fabricated. After 3 months, the definitive prostheses will be constructed.
For the purpose of radiographic evaluation; Standard periapical radiographs will be taken postoperatively (Tb), immediately after prosthetic loading (T0), and at 1 month (T1), 3 months (T2), 6 months (T3), and 1 year (T4). Marginal bone loss (MBL) will be assessed using measurements taken from these standard periapical radiographs with the aid of software throughout the one-year follow-up period. Following the surgery-at time points T0, T1, T2, T3, and T4-digital soft tissue assessment will be performed using an intraoral scanner (IOS), clinical parameters will be recorded, and subgingival microbial samples will be collected from the deepest pocket area of each implant.
Study design
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Crossover
- Masking
- Double blind (participant, outcomes assessor)
- Number of arms
- 2
- Model description
- All patients will undergo identical implant surgery procedures as per the proposed protocol. Temporary and permanent fixed prostheses will be placed using Multi-unit Abutments Xeal™ for the test group and titanium multi-unit abutments for the control group. Test group: Multi-unit Abutments Xeal™ with Nobel TiUltra™ implant Parallel CC. Control group: Conventional titanium multi-unit abutments with Nobel TiUltra™ implant Parallel CC
| Arm | Type | Receives |
|---|---|---|
| Control group | Experimental | Device: Conventional titanium multi-unit abutments with Nobel TiUltra™ implant Parallel CCAccording to the protocol, each patient will receive two Nobel TiUltra™ implant Parallel CCs, with one implant being fitted with a Conventional titanium multi-unit abutment. |
| Test group | Experimental | Device: Multi-unit Abutments Xeal™ with Nobel TiUltra™ implant Parallel CCAccording to the protocol, each patient will receive two Nobel TiUltra™ implant Parallel CCs, with one implant being fitted with a Multi-unit Abutments Xeal™. |
Who may qualify
- Ages
- 18 years and older
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (12 listed)
- Age>18 years old
- Systemically healthy patients
- Presence of edentulous areas in the mandibular or maxillary posterior region
- Presence of natural teeth in the opposing arch
- Periodontal health
Key exclusion criteria (15 listed)
- Being outside the specified age range
- Systemic disease
- Patients who have received radiotherapy to the head and neck region
- Severe bruxism or clenching
- Patients who smoke more than 10 cigarettes per day
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Multi-unit Abutments Xeal™ with Nobel TiUltra™ implant Parallel CCAll implant surgeries will be performed under local anesthesia. A midcrestal incision will be made with a 15C blade, followed by careful elevation of a full-thickness flap. Implant insertion will be carried out according to the manufacturer's instructions, and a Nobel TiUltra™ implant will be placed 0.5-1 mm subcrestally. Following implant placement, primary implant stability will be measured using the Osstell device. Non-engaging temporary abutment will be placed for fabrication of the temporary fixed prosthesis, which will be constructed approximately 1 mm infraocclusally. The flap will be closed primarily. After 12 weeks, the temporary prosthesis will be removed and secondary implant stability will be assessed with an Osstell device. Impressions will be taken at the abutment level, and a permanent metal-supported porcelain fixed prosthesis will be fabricated and screwed onto the Multi-unit Abutments Xeal™ with a torque of 15 Ncm. | Device | Test group |
| Conventional titanium multi-unit abutments with Nobel TiUltra™ implant Parallel CCAll implant surgeries will be performed under local anesthesia. A midcrestal incision will be made with a 15C blade, followed by careful elevation of a full-thickness flap. Implant insertion will be carried out according to the manufacturer's instructions, and a Nobel TiUltra™ implant will be placed 0.5-1 mm subcrestally. Following implant placement, primary implant stability will be measured using the Osstell device. Non-engaging temporary abutment will be placed for fabrication of the temporary fixed prosthesis, which will be constructed approximately 1 mm infraocclusally. The flap will be closed primarily. After 12 weeks, the temporary prosthesis will be removed and secondary implant stability will be assessed with an Osstell device. Impressions will be taken at the abutment level, and a permanent metal-supported porcelain fixed prosthesis will be fabricated and screwed onto the Conventional titanium multi-unit abutments with a torque of 15 Ncm. | Device | Control group |
Primary outcome
qPCR analysis outcomes of microbiological samples
Time frame: 12 month follow-up
Microbiological composition will be the primary outcome measure, assessed at the T1-T4 time points up to 12 months after prosthesis loading
3 secondary outcomes
Marginal bone level changes (ΔMBL) (mm)
Time frame: 12 month follow-up
Peri-implant keratinized width changes digitally (mm)
Time frame: 12 month follow-up
Implant stabilization values (ISQ)
Time frame: At intraoperatively and before prosthetic loading session
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 23 Oct 2026.
- Results publicationNobel Biocare. Data on file.
- Results publication: PubMed 33851765Bozkaya S, Uraz A, Guler B, Kahraman SA, Turhan Bal B. The stability of implants and microbiological effects following photobiomodulation therapy with one-stage placement: A randomized, controlled, single-blinded, and split-mouth clinical study. Clin Implant Dent Relat Res. 2021 Jun;23(3):329-340. doi: 10.1111/cid.12999. Epub 2021 Apr 14.
- Results publication: PubMed 1058834Ainamo J, Bay I. Problems and proposals for recording gingivitis and plaque. Int Dent J. 1975 Dec;25(4):229-35.
- Results publication: PubMed 4500182O'Leary TJ, Drake RB, Naylor JE. The plaque control record. J Periodontol. 1972 Jan;43(1):38. doi: 10.1902/jop.1972.43.1.38. No abstract available.
- Results publication: PubMed 3507627Mombelli A, van Oosten MA, Schurch E Jr, Land NP. The microbiota associated with successful or failing osseointegrated titanium implants. Oral Microbiol Immunol. 1987 Dec;2(4):145-51. doi: 10.1111/j.1399-302x.1987.tb00298.x. No abstract available.
- Results publicationNosswitz M, Teale M, Mathes S, Venturato A, Gasser A. Evaluation of Anodized Surfaces Designed for Improved Soft Tissue Integration, Foundation for Oral Rehabilitation; 2019
- Results publication: PubMed 29763495Mussano F, Genova T, Laurenti M, Zicola E, Munaron L, Rivolo P, Mandracci P, Carossa S. Early Response of Fibroblasts and Epithelial Cells to Pink-Shaded Anodized Dental Implant Abutments: An In Vitro Study. Int J Oral Maxillofac Implants. 2018 May/Jun;33(3):571-579. doi: 10.11607/jomi.6479.
- Results publicationStević, M., Tatić, Z., Biočanin, V., Đurić, D., & Đukić, I. (2021). History of implantology from the aspect of osseointegration and mucointegration. Timočki medicinski glasnik, 46(1), 29-36.
- Results publication: PubMed 40641458Te Lin Y, Li C, Korostoff J, Fiorellini JP, Yang J, Chang YC. Three-dimensional digital quantitative analysis of periodontal and peri-implant phenotype-A narrative review. Periodontol 2000. 2025 Jul 11. doi: 10.1111/prd.12639. Online ahead of print.
- Results publication: PubMed 30809940Milleret V, Lienemann PS, Gasser A, Bauer S, Ehrbar M, Wennerberg A. Rational design and in vitro characterization of novel dental implant and abutment surfaces for balancing clinical and biological needs. Clin Implant Dent Relat Res. 2019 Mar;21 Suppl 1:15-24. doi: 10.1111/cid.12736. Epub 2019 Feb 27.
- Results publicationYılmaz HG, Yılmaz SK. Effect of Different Abutment Materials on Health of Peri-İmplant Tissues. EÜ Dişhek Fak Derg 2011; 32: 69-75.
- Results publication: PubMed 18492075Welander M, Abrahamsson I, Berglundh T. The mucosal barrier at implant abutments of different materials. Clin Oral Implants Res. 2008 Jul;19(7):635-41. doi: 10.1111/j.1600-0501.2008.01543.x. Epub 2008 May 19.
- Individual participant dataSharing planned: Undecided
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
Berceste Guler Ayyildiz study director
Kutahya Health Sciences University
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Multi-unit Abutments Xeal™ with Nobel TiUltra™ implant Parallel CC and Conventional titanium multi-unit abutments with Nobel TiUltra™ implant Parallel CC in people with Edentulism and Dental Implant, run by Kutahya Health Sciences University at 1 site in Turkey (Türkiye).
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 12 inclusion and 15 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: looking for participants now, as of the sponsor's last update on 23 Oct 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Turkey (Türkiye). Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact Berceste Guler Ayyildiz, Assoc. Prof. Dr. (905059359207, berceste.guler@ksbu.edu.tr), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
qPCR analysis outcomes of microbiological samples (time frame: 12 month follow-up). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT07891117, which also lists 14 linked publications.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 23 Oct 2026.