Ceritinib Treatment for Recurrent Meningiomas

Grade of Adverse Events classified as per CTCAE v6.0. The higher the grade, the worse and more severe the event.

Grade of Adverse Events classified as per CTCAE v6.0. The higher the grade, the worse and more severe the event.

Liver toxicity indicators in blood: Aspertate aminotransferase (AST) (U/L, Reference range: 6-35), Alanine aminotransferase (ALT) (U/L, Reference range: 6-45), total bilirubin (umol/L, 1.7-18.9), alkaline phosphatase (ALP)

Reference range for calcium concentration in serum: 2.12-2.62 mml/L

White Blood Cell Count (Reference Range: 4.5-11 10^9/L). Can be further subdevided into different types of white blood cells including: Neutrophils (1.88-7.7 10^9/L), Lymphocytes (1-4.8 10^9/L), Monocytes (0-0.8 10^9/L), Eosinophils (0-0.45 10^9/L), Basophils (0-0.022 10^9/L).

Determined in serum. Reference range: 14-45 umol/L

Dipstick measures several values at once: pH (measured in logarithmic units from 0-14, 7 is normal), amount of protein (Normal reference range: under 10-14 mg/dL), glucose (Normal reference range: 0 to 15 mg/dL or 0 to 0.8 mmol/L), ketones (measured in mmol/L), blood (normal: 3 to 4 red blood cells per high power field), nitrites (measured as positive or negative, no scale), leukocyte esterase (measured in leukocytes per microliter)

Determine urine color(normal urine is pale yellow, clarity (normal urine is clear), odor (small, neutral)

Scoring degree of overall abilities and independence as per Shag et al, 1984. Range from "Normal no complaints; no evidence of disease"(100%) to "Dead" (0%)

Measurement to determine pregnancy status in urine, Reference range: 0-4.9 IU/L. Positive test will lead to trial discontinuation.

Measures electrical activity of the heart looking at electrical timing and wave patterns (changes of voltage over time)

The 30- question quality-of-life assessment focussing on the well-being and health of the patient. Items 1-28 use a 4-point scale ("Not at All" to "Very Much"); items 29-30 use a 7-point scale ("Very poor" to "Excellent").

Assessing the neurologic function of the patient. Scale ranges from "normal" to "None to very little function" following Nayak et. al, 2017.

Reference range: 4-5.1 10^12/L

Refererence range: 140-450 10^9/L

Reference range: Female:120-160 g/L, Male: 135-175 g/L

Unit: degrees Celsius, °C

unit: beats/minute

Unit: mmHg

Unit: blood oxygen saturation (SpO₂)

unit: breaths/min

The Barthel Index (after Sinoff et al, 1997) ranks the degree of dependence of patient to perform day-to-day activities. 10 domains assessed include questions on bowel function, bladder function, dressing themselves, mobility.

Reference range: 0.75 - 1.05 mml/L

reference range: 100-109 mmol/L

Reference range: 3.5-5 mmol/L

reference range: 133 - 143 mmol/L

Reference range: 23 - 29 mmol/L

Female: 24 - 160 U/L, Male: 24 - 195 U/L

Reference range: 3.9 - 11 mmol/L

Reference range: 60 - 80 g/L

Reference range: 1.7 - 8.6 umol/L

Reference range: 1.7 - 18.9 umol/L