Multiple SclerosisNCT07893925
The Effects of Synchronous and Asynchronous Pilates Training Based on Telerehabilitation on Core Stabilization, Balance, Cognitive Functions, and Quality of Life in Individuals With Multiple Sclerosis: A Single-Blind Randomized Controlled Trial
A study testing Synchronous Telerehabilitation-Based Pilates and Asynchronous Telerehabilitation-Based Pilates in people with Multiple Sclerosis, run by Yuzuncu Yil University at 1 site in Turkey (Türkiye).
Trial summary
This study will compare live video-based and prerecorded video-based Pilates programs in 38 adults aged 18-65 years with multiple sclerosis. Participants will be randomly assigned to one of two groups. Read more about this study
- Who is it for?
- Ages 18 to 65 years
- Conditions the study is for
- Multiple Sclerosis
- What is being tested?
- Synchronous Telerehabilitation-Based Pilates and Asynchronous Telerehabilitation-Based Pilates
- Type of treatment
- Lifestyle or therapy programme
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 38 participants
- Where
- 1 siteTurkey (Türkiye)
- Study dates
- 12 Oct 2026to 12 Nov 2027
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 65 years
- All sexes
- No healthy volunteers
- Adult, Older adult
Who may be able to join
- confirmed diagnosis of multiple sclerosis according to the 2017 McDonald criteria.
- An Expanded Disability Status Scale (EDSS) score between 3.0 and 5.5. Age between 18 and 65 years. Availability of a family member or caregiver to assist with accessing the technological system, if needed.
- An active home internet connection for participants assigned to the synchronous telerehabilitation group.
- Willingness to participate in the study.
Who cannot join
- A neurological disease other than multiple sclerosis. A multiple sclerosis relapse within 30 days before the study or during the study.
- Cognitive impairment severe enough to interfere with following instructions. Other diagnosed conditions that would prevent participation, including cardiovascular, visual, or cognitive conditions.
- Pregnancy.
Trial locations and contacts
1 site in 1 country. Contact the study team or a site near you to ask about taking part.
Turkey (Türkiye)1 site, 1 recruiting
- Recruiting
Van Yüzüncü Yıl University
Van
Asiye Tuba Assistant Prof., +905059556171, tuba.ozdogar@yahoo.com
About this study
This study will compare live video-based and prerecorded video-based Pilates programs in 38 adults aged 18-65 years with multiple sclerosis. Participants will be randomly assigned to one of two groups. The live-session group will exercise with a physiotherapist twice a week for eight weeks, with sessions lasting 45-60 minutes. The prerecorded-video group will follow an exercise program matched in intensity and progressed every two weeks, using an exercise tracking form. Trunk muscle performance, balance, thinking and memory, and quality of life will be assessed before and after the program. The study aims to determine whether live supervision provides additional benefits compared with prerecorded exercise videos.
Read the detailed description
This single-center, assessor-blinded randomized controlled trial will recruit participants receiving routine follow-up at the Multiple Sclerosis Unit of the Department of Neurology, Van Yuzuncu Yil University Faculty of Medicine Hospital.
An independent researcher who is not involved in treatment or outcome assessment will generate the allocation sequence using computer-generated block randomization with a block size of eight. Participants will be assigned to synchronous or asynchronous telerehabilitation. The independent researcher will communicate each participant's allocation to the treating physiotherapist.
The synchronous program will be delivered through live videoconferencing by a physiotherapist certified in Pilates. The asynchronous program will use prerecorded exercise videos matched to the synchronous program in exercise intensity, with progression every two weeks. Participants in the asynchronous group will receive an exercise tracking form to record their participation.
Demographic and clinical information will be collected from participants and medical records. Physical performance assessments will be conducted by a physiotherapist blinded to treatment allocation, and neurological disability will be assessed by a neurologist. Outcome assessments will be performed at baseline and after the eight-week intervention to compare changes within and between groups.
- Conditions
- Multiple Sclerosis
- Being tested
- Synchronous Telerehabilitation-Based Pilates, Asynchronous Telerehabilitation-Based Pilates
- Keywords
- Telerehabilitation, Pilates, Synchronous Telerehabilitation, Asynchronous Telerehabilitation, Core Stability, Balance, Cognitive Function, Quality of Life
- Medical subject headings
- Multiple Sclerosis
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Synchronous Telerehabilitation-Based PilatesBehavioural
An eight-week Pilates exercise program delivered by a Pilates-certified physiotherapist through live videoconferencing, twice weekly for 45-60 minutes per session.
Asynchronous Telerehabilitation-Based PilatesBehavioural
An eight-week Pilates exercise program delivered through prerecorded videos, with exercise intensity matched to the synchronous program and progression every two weeks. Participants record their participation on an exercise tracking form.
| Study group | Role | What they receive |
|---|---|---|
| Synchronous Telerehabilitation-Based Pilates | Experimental | Participants will receive an eight-week Pilates exercise program delivered through live videoconferencing by a Pilates-certified physiotherapist. Sessions will be conducted twice weekly, with each session lasting 45-60 minutes. Receives: Behavioral: Synchronous Telerehabilitation-Based Pilates |
| Asynchronous Telerehabilitation-Based Pilates | Active comparator | Participants will receive an eight-week Pilates exercise program using prerecorded exercise videos. Exercise intensity will be matched to the synchronous program, with progression every two weeks. Participants will receive an exercise tracking form to record their participation. Receives: Behavioral: Asynchronous Telerehabilitation-Based Pilates |
What is being measured
The primary outcome is the main question the study is designed to answer.
Change in Trunk Flexor Endurance
Trunk flexor endurance will be assessed by measuring how long participants can maintain a seated position with the trunk at 60 degrees of flexion, hips and knees at 90 degrees, arms crossed over the chest, and feet stabilized. The test ends when the position can no longer be maintained. Duration is recorded in seconds; longer durations indicate better endurance.
Measured: Baseline and immediately after the 8-week intervention.
Change in Sit-Up Performance
Participants will perform sit-ups from a supine position with knees flexed and feet stabilized by the physiotherapist. The number of successfully completed repetitions will be recorded. Higher repetition counts indicate better performance.
Measured: Baseline and immediately after the 8-week intervention.
Change in Modified Push-Up Performance
Participants will begin in a prone position with hands at shoulder level and elbows flexed alongside the trunk. They will extend their elbows to lift the head, shoulders, and trunk from the floor. The number of successfully completed repetitions will be recorded. Higher repetition counts indicate better performance.
Measured: Baseline and immediately after the 8-week intervention.
Secondary outcomes (6)
Change in Activities-Specific Balance Confidence Scale Score
This 16-item self-report scale assesses confidence in maintaining balance during daily activities. Each item is rated from 0 to 100, and the total score is the mean of the item scores. Higher scores indicate greater balance confidence.
Measured: Baseline and immediately after the 8-week intervention.
Change in Mini-BESTest Score
The Mini Balance Evaluation Systems Test assesses anticipatory postural adjustments, reactive postural control, sensory orientation, and dynamic gait. It includes 14 items scored from 0 to 2, giving a total score of 0-28. Higher scores indicate better balance.
Measured: Baseline and immediately after the 8-week intervention.
Change in Symbol Digit Modalities Test Score
The Symbol Digit Modalities Test, administered as part of the BICAMS battery, assesses cognitive processing speed. The number of correct symbol-digit substitutions completed within 90 seconds is recorded. Higher scores indicate better performance.
Measured: Baseline and immediately after the 8-week intervention.
Change in California Verbal Learning Test Score
The California Verbal Learning Test, administered as part of the BICAMS battery, assesses verbal learning and memory. Performance is measured by the total number of words correctly recalled across the initial five learning trials. Higher scores indicate better verbal learning.
Measured: Baseline and immediately after the 8-week intervention.
Change in Brief Visuospatial Memory Test-Revised Score
The Brief Visuospatial Memory Test-Revised, administered as part of the BICAMS battery, assesses visuospatial learning and memory. Performance is measured by the total recall score across three learning trials. Higher scores indicate better visuospatial learning.
Measured: Baseline and immediately after the 8-week intervention.
Change in Preference-Based Multiple Sclerosis Index Score
This patient-reported measure assesses health-related quality of life across walking, fatigue, mood, concentration, and roles and responsibilities. Responses are combined into a preference-based index score. Higher scores indicate better health-related quality of life.
Measured: Baseline and immediately after the 8-week intervention.
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted26 Oct 2026
- Study start12 Oct 2026
- Primary completion22 Sep 2027 (estimated)
- Study completion12 Nov 2027 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Multiple SclerosisStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Single blind
- Who is masked
- Outcomes assessor
- Enrolment
- 38 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Yuzuncu Yil University
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Asiye Tuba Ozdogar, Yuzuncu Yil University
- Investigators
- Asiye Tuba Özdoğar, PhD, Principal investigator, Yuzuncu Yil University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07893925
- Sponsor's protocol ID
- 2026/03-39
- Status last verified
- Oct 2026
- First submitted
- 12 Oct 2026
- Last updated
- 26 Oct 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Study at a glance
From the registry record, last updated by the sponsor on 26 Oct 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- The Effects of Synchronous and Asynchronous Pilates Training Based on Telerehabilitation on Core Stabilization, Balance, Cognitive Functions, and Quality of Life in Individuals With Multiple Sclerosis: A Single-Blind Randomized Controlled Trial
- ClinicalTrials.gov ID
- NCT07893925
- Acronym / sponsor ID
- 2026/03-39
- Conditions
- Multiple Sclerosis
- Keywords
- Telerehabilitation, Pilates, Synchronous Telerehabilitation, Asynchronous Telerehabilitation, Core Stability, Balance, Cognitive Function, Quality of Life
- Study type
- Interventional
- Recruitment status
- Recruiting
- Enrolment
- 38 participants (estimated)
- Lead sponsor
- Yuzuncu Yil UniversityUniversity, hospital or other
- Study start
- 12 Oct 2026 (actual)
- Primary completion
- 22 Sep 2027 (estimated)
- Study completion
- 12 Nov 2027 (estimated)
- First posted
- 26 Oct 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
This study will compare live video-based and prerecorded video-based Pilates programs in 38 adults aged 18-65 years with multiple sclerosis. Participants will be randomly assigned to one of two groups. The live-session group will exercise with a physiotherapist twice a week for eight weeks, with sessions lasting 45-60 minutes. The prerecorded-video group will follow an exercise program matched in intensity and progressed every two weeks, using an exercise tracking form. Trunk muscle performance, balance, thinking and memory, and quality of life will be assessed before and after the program. The study aims to determine whether live supervision provides additional benefits compared with prerecorded exercise videos.
Detailed description
This single-center, assessor-blinded randomized controlled trial will recruit participants receiving routine follow-up at the Multiple Sclerosis Unit of the Department of Neurology, Van Yuzuncu Yil University Faculty of Medicine Hospital.
An independent researcher who is not involved in treatment or outcome assessment will generate the allocation sequence using computer-generated block randomization with a block size of eight. Participants will be assigned to synchronous or asynchronous telerehabilitation. The independent researcher will communicate each participant's allocation to the treating physiotherapist.
The synchronous program will be delivered through live videoconferencing by a physiotherapist certified in Pilates. The asynchronous program will use prerecorded exercise videos matched to the synchronous program in exercise intensity, with progression every two weeks. Participants in the asynchronous group will receive an exercise tracking form to record their participation.
Demographic and clinical information will be collected from participants and medical records. Physical performance assessments will be conducted by a physiotherapist blinded to treatment allocation, and neurological disability will be assessed by a neurologist. Outcome assessments will be performed at baseline and after the eight-week intervention to compare changes within and between groups.
Study design
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Single blind (outcomes assessor)
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| Synchronous Telerehabilitation-Based Pilates | Experimental | Behavioral: Synchronous Telerehabilitation-Based PilatesParticipants will receive an eight-week Pilates exercise program delivered through live videoconferencing by a Pilates-certified physiotherapist. Sessions will be conducted twice weekly, with each session lasting 45-60 minutes. |
| Asynchronous Telerehabilitation-Based Pilates | Active comparator | Behavioral: Asynchronous Telerehabilitation-Based PilatesParticipants will receive an eight-week Pilates exercise program using prerecorded exercise videos. Exercise intensity will be matched to the synchronous program, with progression every two weeks. Participants will receive an exercise tracking form to record their participation. |
Who may qualify
- Ages
- 18 to 65 years
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (4 listed)
- confirmed diagnosis of multiple sclerosis according to the 2017 McDonald criteria.
- An Expanded Disability Status Scale (EDSS) score between 3.0 and 5.5. Age between 18 and 65 years. Availability of a family member or caregiver to assist with accessing the technological system, if needed.
- An active home internet connection for participants assigned to the synchronous telerehabilitation group.
- Willingness to participate in the study.
Key exclusion criteria (3 listed)
- A neurological disease other than multiple sclerosis. A multiple sclerosis relapse within 30 days before the study or during the study.
- Cognitive impairment severe enough to interfere with following instructions. Other diagnosed conditions that would prevent participation, including cardiovascular, visual, or cognitive conditions.
- Pregnancy.
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Synchronous Telerehabilitation-Based PilatesAn eight-week Pilates exercise program delivered by a Pilates-certified physiotherapist through live videoconferencing, twice weekly for 45-60 minutes per session. | Behavioural | Synchronous Telerehabilitation-Based Pilates |
| Asynchronous Telerehabilitation-Based PilatesAn eight-week Pilates exercise program delivered through prerecorded videos, with exercise intensity matched to the synchronous program and progression every two weeks. Participants record their participation on an exercise tracking form. | Behavioural | Asynchronous Telerehabilitation-Based Pilates |
Primary outcome
Change in Trunk Flexor Endurance
Time frame: Baseline and immediately after the 8-week intervention.
Trunk flexor endurance will be assessed by measuring how long participants can maintain a seated position with the trunk at 60 degrees of flexion, hips and knees at 90 degrees, arms crossed over the chest, and feet stabilized. The test ends when the position can no longer be maintained. Duration is recorded in seconds; longer durations indicate better endurance.
Change in Sit-Up Performance
Time frame: Baseline and immediately after the 8-week intervention.
Participants will perform sit-ups from a supine position with knees flexed and feet stabilized by the physiotherapist. The number of successfully completed repetitions will be recorded. Higher repetition counts indicate better performance.
Change in Modified Push-Up Performance
Time frame: Baseline and immediately after the 8-week intervention.
Participants will begin in a prone position with hands at shoulder level and elbows flexed alongside the trunk. They will extend their elbows to lift the head, shoulders, and trunk from the floor. The number of successfully completed repetitions will be recorded. Higher repetition counts indicate better performance.
6 secondary outcomes
Change in Activities-Specific Balance Confidence Scale Score
Time frame: Baseline and immediately after the 8-week intervention.
Change in Mini-BESTest Score
Time frame: Baseline and immediately after the 8-week intervention.
Change in Symbol Digit Modalities Test Score
Time frame: Baseline and immediately after the 8-week intervention.
Change in California Verbal Learning Test Score
Time frame: Baseline and immediately after the 8-week intervention.
Change in Brief Visuospatial Memory Test-Revised Score
Time frame: Baseline and immediately after the 8-week intervention.
Change in Preference-Based Multiple Sclerosis Index Score
Time frame: Baseline and immediately after the 8-week intervention.
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 26 Oct 2026.
- Individual participant dataSharing planned: No
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
Asiye Tuba Özdoğar, PhD principal investigator
Yuzuncu Yil University
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Synchronous Telerehabilitation-Based Pilates and Asynchronous Telerehabilitation-Based Pilates in people with Multiple Sclerosis, run by Yuzuncu Yil University at 1 site in Turkey (Türkiye).
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 4 inclusion and 3 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: looking for participants now, as of the sponsor's last update on 26 Oct 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Turkey (Türkiye). Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact Zozan TEKİN (5437870353, zozantaha.211@gmail.com), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Change in Trunk Flexor Endurance (time frame: Baseline and immediately after the 8-week intervention.). The study lists 3 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 26 Oct 2026; AzTrials last refreshed its copy on 26 Oct 2026.