Lumbar Disc HerniationSELDISCNCT07895589
Selective Nerve Root Block Versus Sham to Reduce Surgery for Lumbar Disc Herniation
A study testing Selective Nerve Root Block in people with Lumbar Disc Herniation and Lumbar Radiculopathy, run by Karolinska Institutet at 2 sites in Sweden.
Trial summary
The SELDISC trial will investigate whether a selective nerve root block can reduce the need for surgery in adults with a herniated disc in the lower back. A herniated disc can irritate a nerve and cause pain that travels down the leg. Read more about this study
- Who is it for?
- Ages 18 to 66 years
- Conditions the study is for
- Lumbar Disc Herniation, Lumbar Radiculopathy, Lumbar Disc Herniation With Radiculopathy
- What is being tested?
- Selective Nerve Root Block
- Type of treatment
- Injection or infusion, Surgery or procedure
- Could I receive a placebo?
- Yes, some participants may receive a placebo
- How many people
- 262 participants
- Where
- 2 sitesSweden
- Study dates
- Jan 2027to 31 Dec 2036
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 66 years
- All sexes
- No healthy volunteers
- Adult, Older adult
Who may be able to join
- Participants must meet all of the following criteria:
- Age ≥18 years and <67 years at the time of consent.
- MRI-verified single-level lumbar disc herniation corresponding to clinical symptoms.
- Radiculopathy with leg-dominant pain consistent with the affected nerve root.
- Failure of conservative treatment (e.g., physiotherapy, analgesics, activity modification) for at least 6 weeks, with surgery considered appropriate.
- Duration of symptoms less than 12 months.
- Deemed a candidate for lumbar disc surgery by the treating surgeon.
- Ability to provide written informed consent and comply with study procedures.
Who cannot join
- Participants will be excluded if any of the following are present:
- Previous lumbar spine surgery or other lumbar intervention.
- Multi-level disc herniations with an unclear symptomatic level.
- Progressive or severe neurological deficit requiring urgent surgery (e.g., cauda equina syndrome, significant motor deficit).
- Serious spinal pathology other than disc herniation (e.g., infection, tumour, fracture, inflammatory disease, lumbar idiopathic scoliosis, degenerative deformity).
- Relevant systemic comorbidities that increase procedural risk or confound outcomes, including:
Show all 17Show fewer
- Uncontrolled cardiovascular, pulmonary or metabolic disease.
- Immunosuppressive therapy or systemic inflammatory disorders.
- Psychiatric illness or cognitive impairment interfering with study participation.
- Neurological disorders such as Parkinson's disease, multiple sclerosis or polyneuropathy.
- Contraindications to injection therapy, including:
- Uncontrolled coagulopathy or ongoing anticoagulation that cannot be safely reversed.
- Local skin infection or systemic infection.
- Known allergy to study medications (local anaesthetic, corticosteroid or contrast agent).
- Pregnancy or breastfeeding.
- Inability to understand the Swedish language.
- Lack of a Swedish personal identification number.
Trial locations and contacts
2 sites in 1 country. Contact the study team or a site near you to ask about taking part.
Sweden2 sites
Karolinska University Hospital
Stockholm
Anastasios Charalampidis, MD, PhD, +46707267961, anastasios.charalampidis@ki.se
Anastasios Charalampidis, MD, PhD
Stockholm Center for Spine Surgery (RKC)
Stockholm
Martin Skeppholm, MD, PhD, +46703669897, martin.skeppholm@rkc.se
Martin Skeppholm, MD, PhD
About this study
Official title: SELDISC - A Trial on SELective Nerve Root Block for Lumbar DISC Herniation
The SELDISC trial will investigate whether a selective nerve root block can reduce the need for surgery in adults with a herniated disc in the lower back. A herniated disc can irritate a nerve and cause pain that travels down the leg. A nerve root block delivers a local anaesthetic and a corticosteroid near the affected nerve to relieve pain and inflammation.
The study will include 262 adults aged 18-66 years who have persistent leg symptoms despite non-surgical treatment and have been assessed by a spine surgeon as eligible for surgery.
Read more
Participants will be randomly assigned to receive either a selective nerve root block or a sham procedure that mimics the treatment without delivering the active medication near the nerve. Each participant will have an equal chance of receiving either procedure. Participants and the study staff assessing their outcomes will not know which procedure was given. The radiologist performing the procedure will know the allocation.
The main question is whether fewer participants in the nerve root block group undergo surgery within 12 months after randomisation. The study will also compare pain, disability, quality of life, time to surgery, medication use, sick leave, healthcare use and adverse events between the groups.
Read the detailed description
Selective nerve root blocks are used to treat radicular pain associated with lumbar disc herniation. However, their ability to reduce subsequent surgery in patients already considered eligible for surgical treatment remains uncertain. SELDISC will evaluate whether the therapeutic effect of a selective nerve root block exceeds the contextual and procedural effects of a sham intervention.
The trial uses multicentre recruitment with study procedures performed at the Department of Neuroradiology, Karolinska University Hospital, Sweden. Eligible patients will be identified through clinical assessment, review of magnetic resonance imaging and confirmation of surgical candidacy. Following informed consent and baseline assessments, participants will undergo randomisation using a secure web-based system. Allocation concealment will be maintained through a computer-generated sequence with variable block sizes, stratified by recruitment centre and age. Participants will be offered an appointment for the allocated procedure within 72 hours of enrolment.
The sham procedure is designed to reproduce the experience of the active procedure, including preparation, superficial local anaesthesia and image-guided needle placement, without administering a therapeutic injection near the nerve root. The neuroradiologist performing the procedure will know the treatment allocation but will not participate in subsequent clinical care or outcome assessment. Participants, treating surgeons and outcome assessors will remain blinded.
Clinical information and patient-reported outcomes will be collected prospectively and recorded in an electronic study database. Data from medical records and the Swedish Spine Register (Swespine) will supplement study assessments. The economic evaluation will compare costs and quality-adjusted life years between the treatment groups.
Eligible patients who decline randomisation may be followed through Swespine as a separate observational cohort to assess the representativeness of the randomised population. This cohort will not form part of the randomised treatment comparison.
- Being tested
- Selective Nerve Root Block, Sham Procedure
- Keywords
- selective nerve root block, SNRB, Sciatica, Corticosteroid injection, Sham-controlled trial, Lumbar disc surgery, SELDISC
- Medical subject headings
- Intervertebral Disc Displacement, Radiculopathy, Sciatica
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Selective Nerve Root BlockProcedure or surgery
Fluoroscopy-guided needle placement at the affected lumbar nerve root, followed by contrast administration to confirm needle position and injection of a local anaesthetic and a depot corticosteroid.
Sham ProcedureProcedure or surgery
Superficial local anaesthesia and fluoroscopy-guided needle placement to mimic a selective nerve root block, without contrast or therapeutic injectate administration near the nerve root.
| Study group | Role | What they receive |
|---|---|---|
| Selective nerve root block | Experimental | Participants will receive a fluoroscopy-guided selective nerve root block at the affected lumbar nerve root, with injection of a local anaesthetic and a corticosteroid. Receives: Procedure: Selective Nerve Root Block |
| Sham procedure | Sham comparator | Participants will undergo a sham procedure that reproduces the preparation, superficial local anaesthesia and image-guided needle placement of the active intervention, without administering any injectate near the nerve root. Receives: Procedure: Sham Procedure |
What is being measured
The primary outcome is the main question the study is designed to answer.
Proportion of participants undergoing lumbar disc surgery
Proportion of participants who undergo surgery for the index lumbar disc herniation within 12 months after randomisation. The outcome is recorded for each participant as yes or no.
Measured: Within 12 months after randomisation
Secondary outcomes (24)
Time to lumbar disc surgery
Number of days from randomisation to the first surgery for the index lumbar disc herniation. Participants without surgery will be censored at their last follow-up or at 365 days, whichever occurs first.
Measured: From randomisation to 12 months
Leg pain intensity measured using the Visual Analogue Scale
Leg pain intensity measured using a Visual Analogue Scale (VAS) ranging from 0 to 100 mm, with higher scores indicating greater pain. The prespecified secondary comparison is at 12 months after randomisation. Earlier measurements will be used for descriptive and exploratory analyses.
Measured: Baseline; 2 days, 2 weeks, 6 weeks, 3 months and 12 months after randomisation
Back pain intensity measured using the Visual Analogue Scale
Back pain intensity measured using a Visual Analogue Scale (VAS) ranging from 0 to 100 mm, with higher scores indicating greater pain. The prespecified secondary comparison is at 12 months after randomisation. Earlier measurements will be used for descriptive and exploratory analyses.
Measured: Baseline; 2 days, 2 weeks, 6 weeks, 3 months and 12 months after randomisation
Leg pain intensity measured using the Numeric Rating Scale
Leg pain intensity measured using a Numeric Rating Scale (NRS) ranging from 0 (no pain) to 10 (worst imaginable pain). The prespecified secondary comparison is at 12 months after randomisation. Earlier measurements will be used for descriptive and exploratory analyses.
Measured: Baseline; 2 days, 2 weeks, 6 weeks, 3 months and 12 months after randomisation
Back pain intensity measured using the Numeric Rating Scale
Back pain intensity measured using a Numeric Rating Scale (NRS) ranging from 0 (no pain) to 10 (worst imaginable pain). The prespecified secondary comparison is at 12 months after randomisation. Earlier measurements will be used for descriptive and exploratory analyses.
Measured: Baseline; 2 days, 2 weeks, 6 weeks, 3 months and 12 months after randomisation
Oswestry Disability Index
Disability measured using the Oswestry Disability Index (ODI), version 2.0. Scores range from 0 to 100, with higher scores indicating greater disability. The prespecified secondary comparison is at 12 months after randomisation. Earlier measurements will be used for descriptive and exploratory analyses.
Measured: Baseline; 2 days, 2 weeks, 6 weeks, 3 months and 12 months after randomisation
Health-related quality of life measured using the EQ-5D-3L index
Health-related quality of life measured using the EQ-5D-3L descriptive system and converted to an index using the selected value set. Higher index values indicate better health; 1 represents full health, and negative values represent health states valued below death. The prespecified secondary comparison is at 12 months after randomisation. Earlier measurements will be used for descriptive and exploratory analyses.
Measured: Baseline; 2 days, 2 weeks, 6 weeks, 3 months and 12 months after randomisation
Self-rated health measured using the EQ-VAS
EQ-VAS, ranging from 0 (worst imaginable health) to 100 (best imaginable health). The prespecified secondary comparison is at 12 months after randomisation. Earlier measurements will be used for descriptive and exploratory analyses.
Measured: Baseline; 2 days, 2 weeks, 6 weeks, 3 months and 12 months after randomisation
Duration of sick leave
Duration of sick leave during the follow-up period, recorded in days.
Measured: From randomisation to 12 months
Extent of sick leave
Extent of sick leave during the follow-up period. Data will be collected from medical records, the Swedish Spine Registry (Swespine) and the Swedish Social Insurance Agency (Försäkringskassan).
Measured: From randomisation to 12 months
Healthcare visits related to lumbar disc herniation
Number of healthcare visits related to lumbar disc herniation or its treatment during the follow-up period.
Measured: From randomisation to 12 months
Hospitalisations related to lumbar disc herniation
Number of hospitalisations related to lumbar disc herniation or its treatment during the follow-up period.
Measured: From randomisation to 12 months
Re-interventions
Number and type of additional interventions for lumbar disc herniation during the follow-up period, including additional nerve root injections outside the study protocol.
Measured: From randomisation to 12 months
Hospital readmissions
Number of hospital readmissions related to lumbar disc herniation or its treatment during the follow-up period.
Measured: From randomisation to 12 months
Revision lumbar disc surgery
Number of revision operations following the index lumbar disc surgery during the follow-up period.
Measured: From randomisation to 12 months
Adverse events
Number and type of adverse events, including bleeding, infection, neurological deterioration, allergic reactions, steroid-related complications and vasovagal reactions. Severity will be graded using the National Cancer Institute Common Terminology Criteria for Adverse Events
Measured: From randomisation to 12 months
Serious adverse event
Number and type of serious adverse events, defined according to Good Clinical Practice criteria, including death, life-threatening events and events requiring or prolonging hospitalisation.
Measured: From randomisation to 12 months
Surgical complications
Number and severity of surgical complications among participants undergoing surgery, classified using the Clavien-Dindo classification and categorised as minor or major according to the protocol.
Measured: From randomisation to 12 months
Analgesic use
Administered and prescribed doses of analgesics during follow-up. Opioid doses will be converted to oral morphine equivalents where applicable.
Measured: From randomisation to 12 months
Direct medical costs
Direct medical costs associated with treatment and follow-up, including procedures, medications, imaging, outpatient visits, hospitalisations and additional interventions.
Measured: From randomisation to 12 months
Indirect costs
Costs of productivity loss associated with sick leave during the follow-up period.
Measured: From randomisation to 12 months
Quality-adjusted life years
Quality-adjusted life years calculated from EQ-5D-3L index values over the follow-up period. Higher values indicate greater health benefit.
Measured: From randomisation to 12 months
Incremental cost per surgery avoided
Difference in costs between the selective nerve root block and sham groups divided by the difference in the proportion of participants avoiding lumbar disc surgery.
Measured: From randomisation to 12 months
Incremental cost per quality-adjusted life year gained
Difference in costs between the selective nerve root block and sham groups divided by the difference in quality-adjusted life years.
Measured: From randomisation to 12 months
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted26 Oct 2026
- Study startJan 2027 (estimated)
- Primary completionJan 2030 (estimated)
- Study completion31 Dec 2036 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Lumbar Disc HerniationStudies of the same condition, open and under way.
- More trials run by Karolinska InstitutetThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Model description
- Participants will be randomised in a 1:1 ratio to selective nerve root block or a sham procedure in two parallel groups. Randomisation will use a computer-generated sequence with variable block sizes, stratified by recruitment centre and age.
- Masking
- Quadruple blind
- Who is masked
- Participant, Care provider, Investigator, Outcomes assessor
- Enrolment
- 262 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Karolinska Institutet
- Sponsor type
- University, hospital or other
- Collaborators
- Region Stockholm, Ryggkirurgiskt Centrum Stockholm AB, Center for Innovative Medicine (CIMED), Karolinska Institutet
- Responsible party
- Principal investigator, Anastasios Charalampidis MD, PhD, Karolinska Institutet
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07895589
- Sponsor's protocol ID
- 2026-05512-01
- Other IDs
- FoUI-1042366, FoUI-1042522
- Acronym
- SELDISC
- Status last verified
- Oct 2026
- First submitted
- 17 Oct 2026
- Last updated
- 26 Oct 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- Yes: IPD underlying published manuscripts will be accessible for other researchers. The investigators in charge will be responsible for reviewing access requests. Crude data, randomization procedures and intervention details can be shared with other researchers upon reasonable request.
Study at a glance
From the registry record, last updated by the sponsor on 26 Oct 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- SELDISC - A Trial on SELective Nerve Root Block for Lumbar DISC Herniation
- ClinicalTrials.gov ID
- NCT07895589
- Acronym / sponsor ID
- SELDISC / 2026-05512-01
- Keywords
- selective nerve root block, SNRB, Sciatica, Corticosteroid injection, Sham-controlled trial, Lumbar disc surgery, SELDISC
- Study type
- Interventional
- Recruitment status
- Not yet recruiting
- Enrolment
- 262 participants (estimated)
- Lead sponsor
- Karolinska InstitutetUniversity, hospital or other
- Collaborators
- Region Stockholm, Ryggkirurgiskt Centrum Stockholm AB, Center for Innovative Medicine (CIMED), Karolinska Institutet
- Study start
- Jan 2027 (estimated)
- Primary completion
- Jan 2030 (estimated)
- Study completion
- 31 Dec 2036 (estimated)
- First posted
- 26 Oct 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
The SELDISC trial will investigate whether a selective nerve root block can reduce the need for surgery in adults with a herniated disc in the lower back. A herniated disc can irritate a nerve and cause pain that travels down the leg. A nerve root block delivers a local anaesthetic and a corticosteroid near the affected nerve to relieve pain and inflammation.
The study will include 262 adults aged 18-66 years who have persistent leg symptoms despite non-surgical treatment and have been assessed by a spine surgeon as eligible for surgery.
Participants will be randomly assigned to receive either a selective nerve root block or a sham procedure that mimics the treatment without delivering the active medication near the nerve. Each participant will have an equal chance of receiving either procedure. Participants and the study staff assessing their outcomes will not know which procedure was given. The radiologist performing the procedure will know the allocation.
The main question is whether fewer participants in the nerve root block group undergo surgery within 12 months after randomisation. The study will also compare pain, disability, quality of life, time to surgery, medication use, sick leave, healthcare use and adverse events between the groups.
Detailed description
Selective nerve root blocks are used to treat radicular pain associated with lumbar disc herniation. However, their ability to reduce subsequent surgery in patients already considered eligible for surgical treatment remains uncertain. SELDISC will evaluate whether the therapeutic effect of a selective nerve root block exceeds the contextual and procedural effects of a sham intervention.
The trial uses multicentre recruitment with study procedures performed at the Department of Neuroradiology, Karolinska University Hospital, Sweden. Eligible patients will be identified through clinical assessment, review of magnetic resonance imaging and confirmation of surgical candidacy. Following informed consent and baseline assessments, participants will undergo randomisation using a secure web-based system. Allocation concealment will be maintained through a computer-generated sequence with variable block sizes, stratified by recruitment centre and age. Participants will be offered an appointment for the allocated procedure within 72 hours of enrolment.
The sham procedure is designed to reproduce the experience of the active procedure, including preparation, superficial local anaesthesia and image-guided needle placement, without administering a therapeutic injection near the nerve root. The neuroradiologist performing the procedure will know the treatment allocation but will not participate in subsequent clinical care or outcome assessment. Participants, treating surgeons and outcome assessors will remain blinded.
Clinical information and patient-reported outcomes will be collected prospectively and recorded in an electronic study database. Data from medical records and the Swedish Spine Register (Swespine) will supplement study assessments. The economic evaluation will compare costs and quality-adjusted life years between the treatment groups.
Eligible patients who decline randomisation may be followed through Swespine as a separate observational cohort to assess the representativeness of the randomised population. This cohort will not form part of the randomised treatment comparison.
Study design
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Quadruple blind (participant, care provider, investigator, outcomes assessor)
- Number of arms
- 2
- Model description
- Participants will be randomised in a 1:1 ratio to selective nerve root block or a sham procedure in two parallel groups. Randomisation will use a computer-generated sequence with variable block sizes, stratified by recruitment centre and age.
| Arm | Type | Receives |
|---|---|---|
| Selective nerve root block | Experimental | Procedure: Selective Nerve Root BlockParticipants will receive a fluoroscopy-guided selective nerve root block at the affected lumbar nerve root, with injection of a local anaesthetic and a corticosteroid. |
| Sham procedure | Sham comparator | Procedure: Sham ProcedureParticipants will undergo a sham procedure that reproduces the preparation, superficial local anaesthesia and image-guided needle placement of the active intervention, without administering any injectate near the nerve root. |
Who may qualify
- Ages
- 18 to 66 years
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (8 listed)
- Participants must meet all of the following criteria:
- Age ≥18 years and <67 years at the time of consent.
- MRI-verified single-level lumbar disc herniation corresponding to clinical symptoms.
- Radiculopathy with leg-dominant pain consistent with the affected nerve root.
- Failure of conservative treatment (e.g., physiotherapy, analgesics, activity modification) for at least 6 weeks, with surgery considered appropriate.
Key exclusion criteria (17 listed)
- Participants will be excluded if any of the following are present:
- Previous lumbar spine surgery or other lumbar intervention.
- Multi-level disc herniations with an unclear symptomatic level.
- Progressive or severe neurological deficit requiring urgent surgery (e.g., cauda equina syndrome, significant motor deficit).
- Serious spinal pathology other than disc herniation (e.g., infection, tumour, fracture, inflammatory disease, lumbar idiopathic scoliosis, degenerative deformity).
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Selective Nerve Root BlockFluoroscopy-guided needle placement at the affected lumbar nerve root, followed by contrast administration to confirm needle position and injection of a local anaesthetic and a depot corticosteroid. | Procedure or surgery | Selective nerve root block |
| Sham ProcedureSuperficial local anaesthesia and fluoroscopy-guided needle placement to mimic a selective nerve root block, without contrast or therapeutic injectate administration near the nerve root. | Procedure or surgery | Sham procedure |
Primary outcome
Proportion of participants undergoing lumbar disc surgery
Time frame: Within 12 months after randomisation
Proportion of participants who undergo surgery for the index lumbar disc herniation within 12 months after randomisation. The outcome is recorded for each participant as yes or no.
24 secondary outcomes
Time to lumbar disc surgery
Time frame: From randomisation to 12 months
Leg pain intensity measured using the Visual Analogue Scale
Time frame: Baseline; 2 days, 2 weeks, 6 weeks, 3 months and 12 months after randomisation
Back pain intensity measured using the Visual Analogue Scale
Time frame: Baseline; 2 days, 2 weeks, 6 weeks, 3 months and 12 months after randomisation
Leg pain intensity measured using the Numeric Rating Scale
Time frame: Baseline; 2 days, 2 weeks, 6 weeks, 3 months and 12 months after randomisation
Back pain intensity measured using the Numeric Rating Scale
Time frame: Baseline; 2 days, 2 weeks, 6 weeks, 3 months and 12 months after randomisation
Oswestry Disability Index
Time frame: Baseline; 2 days, 2 weeks, 6 weeks, 3 months and 12 months after randomisation
Health-related quality of life measured using the EQ-5D-3L index
Time frame: Baseline; 2 days, 2 weeks, 6 weeks, 3 months and 12 months after randomisation
Self-rated health measured using the EQ-VAS
Time frame: Baseline; 2 days, 2 weeks, 6 weeks, 3 months and 12 months after randomisation
Duration of sick leave
Time frame: From randomisation to 12 months
Extent of sick leave
Time frame: From randomisation to 12 months
Healthcare visits related to lumbar disc herniation
Time frame: From randomisation to 12 months
Hospitalisations related to lumbar disc herniation
Time frame: From randomisation to 12 months
Re-interventions
Time frame: From randomisation to 12 months
Hospital readmissions
Time frame: From randomisation to 12 months
Revision lumbar disc surgery
Time frame: From randomisation to 12 months
Adverse events
Time frame: From randomisation to 12 months
Serious adverse event
Time frame: From randomisation to 12 months
Surgical complications
Time frame: From randomisation to 12 months
Analgesic use
Time frame: From randomisation to 12 months
Direct medical costs
Time frame: From randomisation to 12 months
Indirect costs
Time frame: From randomisation to 12 months
Quality-adjusted life years
Time frame: From randomisation to 12 months
Incremental cost per surgery avoided
Time frame: From randomisation to 12 months
Incremental cost per quality-adjusted life year gained
Time frame: From randomisation to 12 months
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 26 Oct 2026.
- Individual participant dataSharing planned: Yes. IPD underlying published manuscripts will be accessible for other researchers. The investigators in charge will be responsible for reviewing access requests. Crude data, randomization procedures and intervention details can be shared with other researchers upon reasonable request.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
2 sites in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Selective Nerve Root Block in people with Lumbar Disc Herniation and Lumbar Radiculopathy, run by Karolinska Institutet at 2 sites in Sweden.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 8 inclusion and 17 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: opening soon, as of the sponsor's last update on 26 Oct 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 2 sites in Sweden. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. Some participants in this study may receive a placebo. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact Anastasios Charalampidis, MD, PhD (+46707267961, anastasios.charalampidis@ki.se), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Proportion of participants undergoing lumbar disc surgery (time frame: Within 12 months after randomisation). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 26 Oct 2026.