Cognitive EnhancementNCT07895979
The Efficacy of an IADL-based Non-immersive Virtual Reality Training Program to Enhance ADL Performance and Cognitive Function for Persons at Risk of Dementia
A study testing Daily Life VR Training, Non-Conditional Game VR Training and Traditional Cognitive Training in people with Cognitive Enhancement and Subjective Cognitive Decline (SCD), run by National Taiwan University Hospital at 1 site in Taiwan.
Trial summary
The goal of this clinical trial is to learn if a touchscreen-based virtual reality (VR) training program that simulates everyday life tasks works to improve daily living skills and thinking abilities in adults aged 50 and older, including those at risk of dementia (individuals with Subjective Cognitive Decline or Mild… Read more about this study
- Who is it for?
- Ages 50 years and olderHealthy volunteers can take part
- Conditions the study is for
- Cognitive Enhancement, Subjective Cognitive Decline (SCD), Mild Cognitive Impairmen
- What is being tested?
- Daily Life VR Training, Non-Conditional Game VR Training and Traditional Cognitive Training
- Type of treatment
- Lifestyle or therapy programme
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 216 participants
- Where
- 1 siteTaiwan
- Study dates
- 6 Feb 2026to 31 Jul 2027
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 50 years and older
- All sexes
- Healthy volunteers accepted
- Adult, Older adult
Who may be able to join
- General Inclusion Criteria (Applicable to All Participants):
- Aged 50 years or older.
- Completed at least elementary school education (6 or more years of formal education) and able to read and write in Chinese.
- Group-Specific Inclusion Criteria:
- Cognitively Healthy Middle-Aged and Older Adults Group:
- Taiwanese version of the Montreal Cognitive Assessment (MoCA) score > 26.
Show all 17Show fewer
- Does not meet the diagnostic criteria for Subjective Cognitive Decline (SCD), Mild Cognitive Impairment (MCI), or dementia.
- Subjective Cognitive Decline (SCD) Group:
- Taiwanese version of the Montreal Cognitive Assessment (MoCA) score > 23.
- Subjective Cognitive Decline Questionnaire (SCD-Q) score > 7 (out of a total score of 24).
- Answers "Yes" to both of the following questions: "Do you feel that you have memory problems compared to your previous normal state?" and "Have your family members or close friends noticed that you have memory problems compared to your previous state?"
- Normal performance on standardized neuropsychological tests (Color Trails Test and memory-related tests), defined as scoring higher than 1.5 standard deviations below the age- and education-adjusted normative mean.
- Does not meet the diagnostic criteria for Mild Cognitive Impairment (MCI) or dementia.
- Mild Cognitive Impairment (MCI) Group:
- Taiwanese version of the Montreal Cognitive Assessment (MoCA) score > 21.
- Diagnosed with Mild Cognitive Impairment (MCI) by a neurologist or psychiatrist.
- Does not meet the diagnostic criteria for dementia.
Who cannot join
- Meets the clinical diagnostic criteria for dementia.
- Geriatric Depression Scale Short-Form (GDS-S) score >= 8, or cognitive changes caused by other psychiatric disorders, neurological diseases, or substance abuse with unstable medical conditions and interfering symptoms.
- Severe visual or hearing impairments that prevent the completion of cognitive function assessments.
- Physical illnesses or conditions that prevent participation in the cognitive and physical training interventions.
Trial locations and contacts
1 site in 1 country. Contact the study team or a site near you to ask about taking part.
Taiwan1 site, 1 recruiting
- Recruiting
School of Occupational Therapy, College of Medicine, National Taiwan University
Taipei
Hui-Fen Mao, 886-3366-8178, huifen02@gmail.com
Hsiao-Wen Chen
About this study
The goal of this clinical trial is to learn if a touchscreen-based virtual reality (VR) training program that simulates everyday life tasks works to improve daily living skills and thinking abilities in adults aged 50 and older, including those at risk of dementia (individuals with Subjective Cognitive Decline or Mild Cognitive Impairment). It will also explore what personal factors influence the training results. The main questions it aims to answer are:
- Does the daily life VR training program improve participants' ability to perform complex everyday activities and adapt flexibly to daily life challenges?
- Does the training improve overall thinking skills (such as memory, attention, and problem-solving), brain activity, and mood (depression and anxiety)? Researchers will compare the daily-life VR training program (IADL-VR) to a non-situational game VR program (Game-VR) and a traditional in-person tabletop cognitive training program (Cog-Entity) to see if realistic daily-life VR simulation works better to enhance everyday functioning and brain health.
Read more
Participants will:
- Be randomly assigned to one of the three training groups (daily-life VR tasks, digital brain-training mini-games, or traditional tabletop board games).
- Attend a 2-hour group session once a week for 12 weeks, which includes 1 hour of assigned cognitive training and 1 hour of physical fitness exercise.
- Complete assessments of their daily living skills, thinking abilities, mood, and brain activity (using functional magnetic resonance imaging, or fMRI) within 2 weeks before and after the 12-week program.
- Being tested
- Daily Life VR Training, Non-Conditional Game VR Training, Traditional Cognitive Training
- Keywords
- ADL performance, Cognitive function, virtual reality
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Daily Life VR TrainingBehavioural
Delivered on a 16-inch touchscreen computer incorporating touch, handwriting recognition, and voice interaction. The software features three core daily living themes with 3 to 4 sequential sub-tasks each, graded across 5 to 8 difficulty levels:
- Holiday Reunion Dinner Preparation: Checking home inventory to create a shopping list, supermarket shopping while filtering out audio promotional distractions, price comparison and checkout calculation, and following cooking sequences.
- Health Management: Operating a hospital registration kiosk under time and step constraints, remembering physician and pharmacist instructions during a clinic visit, and organizing a medication pillbox.
- Travel Planning: Packing luggage spatially, navigating bus and train schedules/platforms, reacting to unexpected events (e.g., retrieving blown-away luggage), and problem-solving during travel emergencies (e.g., lost items or suspended train services).
Non-Conditional Game VR TrainingBehavioural
Uses commercial digital cognitive games consisting of 22 short mini-games (under 2 minutes each) across five domains: attention, memory, mathematics, general cognition, and language, without real-life situational integration.
Traditional Cognitive TrainingBehavioural
Uses structured commercial board games and tabletop activities facilitated by an occupational therapist, focusing on a specific cognitive domain each week (attention, working memory, visuospatial skills, executive function, cognitive flexibility, and language).
| Study group | Role | What they receive |
|---|---|---|
| Daily Life VR Training (IADL-VR) | Experimental | Participants practice multi-step, realistic daily scenarios on a touchscreen computer, including shopping and cooking for a holiday meal, hospital registration and medication management, and travel planning. Receives: Behavioral: Daily Life VR Training |
| Non-Conditional Game VR Training (Game-VR) | Active comparator | Participants play short, decontextualized digital brain-training mini-games targeting attention, memory, math, and language. Receives: Behavioral: Non-Conditional Game VR Training |
| Traditional Cognitive Training (Cog-Entity) | Active comparator | Participants engage in therapist-guided tabletop board games targeting various cognitive skills. Receives: Behavioral: Traditional Cognitive Training |
What is being measured
The primary outcome is the main question the study is designed to answer.
Subjective Cognitive Decline Questionnaire (SCD-Q)
Assessed via a semi-structured interview based on the 24 items of the Subjective Cognitive Decline Questionnaire (SCD-Q). Participants identify up to 5 of their most concerning daily life cognitive difficulties and rate each item on two dimensions: (1) Frequency of occurrence, rated from 1 to 10 (where 10 indicates very frequent occurrence), and (2) Perceived distress/bother level, rated from 1 to 10 (where higher scores indicate lower distress, with 10 representing no distress at all).
Measured: Baseline (within 2 weeks prior to intervention) and post-intervention (within 2 weeks after the 12-week intervention)
The Brief University of California San Diego Performance-Based Skills Assessment-Traditional Chinese Version (UPSA-B)
An objective, performance-based measure that evaluates instrumental activities of daily living (IADL) in simulated real-world scenarios across two domains: financial skills and communication skills (telephone use). Total scores range from 0 to 100, with higher scores indicating better everyday functional performance.
Measured: Baseline (within 2 weeks prior to intervention) and post-intervention (within 2 weeks after the 12-week intervention)
IADL Context-Based Cognitive Flexibility Assessment (ICFA)
A performance-based assessment evaluating cognitive flexibility within daily life contexts across 5 IADL-related scenarios (e.g., public transportation use, financial management, and daily life problem-solving). Each scenario consists of two parts assessing (1) spontaneous cognitive flexibility and (2) reactive cognitive flexibility (including intra-dimensional and extra-dimensional shifting). Higher scores indicate better real-life cognitive flexibility.
Measured: Baseline (within 2 weeks prior to intervention) and post-intervention (within 2 weeks after the 12-week intervention)
Secondary outcomes (9)
the Taiwanese Version of the Montreal Cognitive Assessment (MoCA-T)
Assesses global cognitive function across 8 cognitive domains: visuospatial/executive function, naming, memory, attention, language, abstraction, delayed recall, and orientation. Total scores range from 0 to 30, with higher scores indicating better global cognitive function.
Measured: Baseline (within 2 weeks prior to intervention) and post-intervention (within 2 weeks after the 12-week intervention)
Color Trails Test (CTT)
Evaluates sustained attention, alternating attention, and executive function. Consists of two parts: CTT-1 requires connecting numbered circles from 1 to 25 in sequence as quickly as possible; CTT-2 requires connecting numbered circles from 1 to 25 while alternating between pink and yellow colors. Measured by completion time (in seconds), where shorter completion times indicate better attention and executive functioning.
Measured: Baseline (within 2 weeks prior to intervention) and post-intervention (within 2 weeks after the 12-week intervention)
the Wechsler Memory Scale-Third Edition (WMS-III) Family Pictures Subtest
Evaluates immediate and delayed visual memory. Participants view 4 pictures of family scenes and are asked to recall the characters, their spatial locations, and their activities immediately and after a 25-to-35-minute delay. Scores for both immediate recall and delayed recall range from 0 to 64, with higher scores indicating better visual memory.
Measured: Baseline (within 2 weeks prior to intervention) and post-intervention (within 2 weeks after the 12-week intervention)
the Wechsler Memory Scale-Third Edition (WMS-III) Spatial Span Subtest
Assesses visuospatial working memory. Participants tap blocks on a board in the same order (Spatial Span Forward) or reverse order (Spatial Span Backward) as demonstrated by the examiner. Scores for the forward and backward subscales each range from 0 to 16 (total score range: 0 to 32), with higher scores indicating better visuospatial working memory.
Measured: Baseline (within 2 weeks prior to intervention) and post-intervention (within 2 weeks after the 12-week intervention)
Word Sequence Learning Test
Assesses short-term and delayed verbal memory across learning and 10-minute delayed recall phases. Scoring includes position score (range: 0 to 60), accuracy score (range: 0 to 60), total learning score (range: 0 to 20), and 10-minute delayed recall score (range: 0 to 30). Higher scores in each component indicate better verbal learning and memory performance.
Measured: Baseline (within 2 weeks prior to intervention) and post-intervention (within 2 weeks after the 12-week intervention)
Tower of Hanoi (TOH)
A performance-based task evaluating executive planning and problem-solving skills. Participants move perforated disks of varying sizes across three pegs from a start state to a goal state while following specific rules. Performance is evaluated by the number of moves, completion time (in seconds), and number of rule violations, where fewer moves, shorter completion times, and fewer rule violations indicate better planning and problem-solving ability.
Measured: Baseline (within 2 weeks prior to intervention) and post-intervention (within 2 weeks after the 12-week intervention)
Functional Magnetic Resonance Imaging (fMRI)
Evaluates changes in resting-state functional connectivity using a 3.0-Tesla MRI scanner (Magnetom Prisma, Siemens). Includes T1-weighted structural MRI (MPRAGE sequence) and blood-oxygen-level-dependent (BOLD) resting-state functional EPI sequences to assess neural network changes before and after the cognitive intervention.
Measured: Baseline (within 2 weeks prior to intervention) and post-intervention (within 2 weeks after the 12-week intervention)
Geriatric Depression Scale Short-Form (GDS-S)
A 15-item self-report questionnaire assessing the severity of depressive symptoms in older adults. Total scores range from 0 to 15, with higher scores indicating more severe depressive symptoms (a score of 8 or higher suggests clinically significant depressive symptoms).
Measured: Baseline (within 2 weeks prior to intervention) and post-intervention (within 2 weeks after the 12-week intervention)
Beck Anxiety Inventory (BAI)
A 21-item self-report inventory measuring the severity of emotional and somatic symptoms of anxiety. Each item is rated from 0 to 3, yielding a total score ranging from 0 to 63. Higher scores indicate more severe anxiety (8-15: mild to moderate anxiety; 16-25: moderate to severe anxiety; 26-63: severe anxiety).
Measured: Baseline (within 2 weeks prior to intervention) and post-intervention (within 2 weeks after the 12-week intervention)
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted26 Oct 2026
- Study start6 Feb 2026
- Primary completion31 Jul 2027 (estimated)
- Study completion31 Jul 2027 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Cognitive EnhancementStudies of the same condition, open and under way.
- More trials run by National Taiwan University HospitalThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Prevention
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Single blind
- Who is masked
- Outcomes assessor
- Enrolment
- 216 participants (estimated)
Sponsor and investigators
- Lead sponsor
- National Taiwan University Hospital
- Sponsor type
- University, hospital or other
- Responsible party
- Sponsor
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07895979
- Sponsor's protocol ID
- 202401189RINA
- Status last verified
- Feb 2026
- First submitted
- 19 Oct 2026
- Last updated
- 26 Oct 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No: Individual participant data (IPD) will not be shared publicly due to participant privacy protections, ethical restrictions approved by the Institutional Review Board (IRB), and Taiwanese personal data protection regulations. Aggregate data and statistical results will be published in peer-reviewed scientific journals.
Study at a glance
From the registry record, last updated by the sponsor on 26 Oct 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- The Efficacy of an IADL-based Non-immersive Virtual Reality Training Program to Enhance ADL Performance and Cognitive Function for Persons at Risk of Dementia
- ClinicalTrials.gov ID
- NCT07895979
- Acronym / sponsor ID
- 202401189RINA
- Keywords
- ADL performance, Cognitive function, virtual reality
- Study type
- Interventional
- Recruitment status
- Recruiting
- Enrolment
- 216 participants (estimated)
- Lead sponsor
- National Taiwan University HospitalUniversity, hospital or other
- Study start
- 6 Feb 2026 (actual)
- Primary completion
- 31 Jul 2027 (estimated)
- Study completion
- 31 Jul 2027 (estimated)
- First posted
- 26 Oct 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
The goal of this clinical trial is to learn if a touchscreen-based virtual reality (VR) training program that simulates everyday life tasks works to improve daily living skills and thinking abilities in adults aged 50 and older, including those at risk of dementia (individuals with Subjective Cognitive Decline or Mild Cognitive Impairment). It will also explore what personal factors influence the training results. The main questions it aims to answer are:
- Does the daily life VR training program improve participants' ability to perform complex everyday activities and adapt flexibly to daily life challenges?
- Does the training improve overall thinking skills (such as memory, attention, and problem-solving), brain activity, and mood (depression and anxiety)? Researchers will compare the daily-life VR training program (IADL-VR) to a non-situational game VR program (Game-VR) and a traditional in-person tabletop cognitive training program (Cog-Entity) to see if realistic daily-life VR simulation works better to enhance everyday functioning and brain health.
Participants will:
- Be randomly assigned to one of the three training groups (daily-life VR tasks, digital brain-training mini-games, or traditional tabletop board games).
- Attend a 2-hour group session once a week for 12 weeks, which includes 1 hour of assigned cognitive training and 1 hour of physical fitness exercise.
- Complete assessments of their daily living skills, thinking abilities, mood, and brain activity (using functional magnetic resonance imaging, or fMRI) within 2 weeks before and after the 12-week program.
Study design
- Primary purpose
- Prevention
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Single blind (outcomes assessor)
- Number of arms
- 3
| Arm | Type | Receives |
|---|---|---|
| Daily Life VR Training (IADL-VR) | Experimental | Behavioral: Daily Life VR TrainingParticipants practice multi-step, realistic daily scenarios on a touchscreen computer, including shopping and cooking for a holiday meal, hospital registration and medication management, and travel planning. |
| Non-Conditional Game VR Training (Game-VR) | Active comparator | Behavioral: Non-Conditional Game VR TrainingParticipants play short, decontextualized digital brain-training mini-games targeting attention, memory, math, and language. |
| Traditional Cognitive Training (Cog-Entity) | Active comparator | Behavioral: Traditional Cognitive TrainingParticipants engage in therapist-guided tabletop board games targeting various cognitive skills. |
Who may qualify
- Ages
- 50 years and older
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (17 listed)
- Aged 50 years or older.
- Completed at least elementary school education (6 or more years of formal education) and able to read and write in Chinese.
- Cognitively Healthy Middle-Aged and Older Adults Group:
- Subjective Cognitive Decline (SCD) Group:
- Mild Cognitive Impairment (MCI) Group:
Key exclusion criteria (4 listed)
- Meets the clinical diagnostic criteria for dementia.
- Geriatric Depression Scale Short-Form (GDS-S) score >= 8, or cognitive changes caused by other psychiatric disorders, neurological diseases, or substance abuse with unstable medical conditions and interfering symptoms.
- Severe visual or hearing impairments that prevent the completion of cognitive function assessments.
- Physical illnesses or conditions that prevent participation in the cognitive and physical training interventions.
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Daily Life VR TrainingDelivered on a 16-inch touchscreen computer incorporating touch, handwriting recognition, and voice interaction. The software features three core daily living themes with 3 to 4 sequential sub-tasks each, graded across 5 to 8 difficulty levels: 1. Holiday Reunion Dinner Preparation: Checking home inventory to create a shopping list, supermarket shopping while filtering out audio promotional distractions, price comparison and checkout calculation, and following cooking sequences. 2. Health Management: Operating a hospital registration kiosk under time and step constraints, remembering physician and pharmacist instructions during a clinic visit, and organizing a medication pillbox. 3. Travel Planning: Packing luggage spatially, navigating bus and train schedules/platforms, reacting to unexpected events (e.g., retrieving blown-away luggage), and problem-solving during travel emergencies (e.g., lost items or suspended train services). | Behavioural | Daily Life VR Training (IADL-VR) |
| Non-Conditional Game VR TrainingUses commercial digital cognitive games consisting of 22 short mini-games (under 2 minutes each) across five domains: attention, memory, mathematics, general cognition, and language, without real-life situational integration. | Behavioural | Non-Conditional Game VR Training (Game-VR) |
| Traditional Cognitive TrainingUses structured commercial board games and tabletop activities facilitated by an occupational therapist, focusing on a specific cognitive domain each week (attention, working memory, visuospatial skills, executive function, cognitive flexibility, and language). | Behavioural | Traditional Cognitive Training (Cog-Entity) |
Primary outcome
Subjective Cognitive Decline Questionnaire (SCD-Q)
Time frame: Baseline (within 2 weeks prior to intervention) and post-intervention (within 2 weeks after the 12-week intervention)
Assessed via a semi-structured interview based on the 24 items of the Subjective Cognitive Decline Questionnaire (SCD-Q). Participants identify up to 5 of their most concerning daily life cognitive difficulties and rate each item on two dimensions: (1) Frequency of occurrence, rated from 1 to 10 (where 10 indicates very frequent occurrence), and (2) Perceived distress/bother level, rated from 1 to 10 (where higher scores indicate lower distress, with 10 representing no distress at all).
The Brief University of California San Diego Performance-Based Skills Assessment-Traditional Chinese Version (UPSA-B)
Time frame: Baseline (within 2 weeks prior to intervention) and post-intervention (within 2 weeks after the 12-week intervention)
An objective, performance-based measure that evaluates instrumental activities of daily living (IADL) in simulated real-world scenarios across two domains: financial skills and communication skills (telephone use). Total scores range from 0 to 100, with higher scores indicating better everyday functional performance.
IADL Context-Based Cognitive Flexibility Assessment (ICFA)
Time frame: Baseline (within 2 weeks prior to intervention) and post-intervention (within 2 weeks after the 12-week intervention)
A performance-based assessment evaluating cognitive flexibility within daily life contexts across 5 IADL-related scenarios (e.g., public transportation use, financial management, and daily life problem-solving). Each scenario consists of two parts assessing (1) spontaneous cognitive flexibility and (2) reactive cognitive flexibility (including intra-dimensional and extra-dimensional shifting). Higher scores indicate better real-life cognitive flexibility.
9 secondary outcomes
the Taiwanese Version of the Montreal Cognitive Assessment (MoCA-T)
Time frame: Baseline (within 2 weeks prior to intervention) and post-intervention (within 2 weeks after the 12-week intervention)
Color Trails Test (CTT)
Time frame: Baseline (within 2 weeks prior to intervention) and post-intervention (within 2 weeks after the 12-week intervention)
the Wechsler Memory Scale-Third Edition (WMS-III) Family Pictures Subtest
Time frame: Baseline (within 2 weeks prior to intervention) and post-intervention (within 2 weeks after the 12-week intervention)
the Wechsler Memory Scale-Third Edition (WMS-III) Spatial Span Subtest
Time frame: Baseline (within 2 weeks prior to intervention) and post-intervention (within 2 weeks after the 12-week intervention)
Word Sequence Learning Test
Time frame: Baseline (within 2 weeks prior to intervention) and post-intervention (within 2 weeks after the 12-week intervention)
Tower of Hanoi (TOH)
Time frame: Baseline (within 2 weeks prior to intervention) and post-intervention (within 2 weeks after the 12-week intervention)
Functional Magnetic Resonance Imaging (fMRI)
Time frame: Baseline (within 2 weeks prior to intervention) and post-intervention (within 2 weeks after the 12-week intervention)
Geriatric Depression Scale Short-Form (GDS-S)
Time frame: Baseline (within 2 weeks prior to intervention) and post-intervention (within 2 weeks after the 12-week intervention)
Beck Anxiety Inventory (BAI)
Time frame: Baseline (within 2 weeks prior to intervention) and post-intervention (within 2 weeks after the 12-week intervention)
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 26 Oct 2026.
- Individual participant dataSharing planned: No. Individual participant data (IPD) will not be shared publicly due to participant privacy protections, ethical restrictions approved by the Institutional Review Board (IRB), and Taiwanese personal data protection regulations. Aggregate data and statistical results will be published in peer-reviewed scientific journals.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Daily Life VR Training, Non-Conditional Game VR Training and Traditional Cognitive Training in people with Cognitive Enhancement and Subjective Cognitive Decline (SCD), run by National Taiwan University Hospital at 1 site in Taiwan.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 17 inclusion and 4 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: looking for participants now, as of the sponsor's last update on 26 Oct 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Taiwan. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact Hui-Fen Mao (886-3366-8178, huifen02@gmail.com), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Subjective Cognitive Decline Questionnaire (SCD-Q) (time frame: Baseline (within 2 weeks prior to intervention) and post-intervention (within 2 weeks after the 12-week intervention)). The study lists 3 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 26 Oct 2026.