Colorectal CancerNCT07896174
Resistance vs Aerobic Prehabilitation Before Colorectal Cancer Surgery
A study testing Resistance Training Prehabilitation, Aerobic Training Prehabilitation and Standard Trimodal Care in people with Colorectal Cancer and Colorectal Neoplasms, run by Semmelweis University at 1 site in Hungary.
Trial summary
The goal of this clinical trial is to learn which type of exercise before surgery best reduces complications after colorectal surgery in adults with colorectal cancer or precancerous lesions. Read more about this study
- Who is it for?
- Ages 18 years and older
- Conditions the study is for
- Colorectal Cancer, Colorectal Neoplasms, Postoperative Complications
- What is being tested?
- Resistance Training Prehabilitation, Aerobic Training Prehabilitation and Standard Trimodal Care
- Type of treatment
- Pill or oral medicine, Lifestyle or therapy programme
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 480 participants
- Where
- 1 siteHungary
- Study dates
- 27 May 2026to Mar 2028
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 years and older
- All sexes
- No healthy volunteers
- Adult, Older adult
Who may be able to join
- Age over 18 years
- Elective, curative-intent colon or rectal resection
- Malignant or premalignant colorectal lesion
- Signed written informed consent after receiving study information
Who cannot join
- Refusal to participate in the study
- Comorbidities precluding physical prehabilitation
- Physical, neurological or mental status precluding physical prehabilitation
- Unplanned acute surgery required during the prehabilitation period
- Transanal minimally invasive surgery (TAMIS)
- Palliative surgery only
- Pregnancy
- Preoperative preparation program deviating from the study protocol, as deemed necessary by the study team
Trial locations and contacts
1 site in 1 country. Contact the study team or a site near you to ask about taking part.
Hungary1 site, 1 recruiting
- Recruiting
Semmelweis University, Department of Surgery, Transplantation and Gastroenterology
Budapest, 1082
Balazs Banky, MD, PhD, +36208258915, banky.balazs@semmelweis.hu
About this study
Official title: Effect of Preoperative Resistance and Aerobic Endurance Training on Surgical Outcomes and Evaluation of Patient Compliance With Prehabilitation in Colorectal Surgery: A Randomized Controlled Trial
The goal of this clinical trial is to learn which type of exercise before surgery best reduces complications after colorectal surgery in adults with colorectal cancer or precancerous lesions. The main questions it aims to answer are:
- Does resistance (strength) training, aerobic (endurance) training, or a combination of both before surgery lower the rate and severity of complications in the first 30 days after surgery, compared with no exercise program?
- Which factors influence how well patients follow a prehabilitation program, and does following the program affect surgical outcomes?
Read more
Researchers will compare three exercise groups with a control group that receives standard care without an exercise program.
Participants will:
- Be randomly assigned to one of four groups: resistance training, aerobic training, combined training, or no exercise program (control)
- Do the assigned home exercise program for 4 to 6 weeks before surgery, with weekly physiotherapy check-ups in person or by phone
- Receive nutritional counseling, breathing exercises, and psychological support if needed, regardless of group
- Keep a daily exercise diary and record their pulse daily
- Undergo physical fitness tests (walking test, sit-to-stand test, handgrip strength) and quality-of-life questionnaires before surgery and 8 weeks after surgery
Read the detailed description
Background: Prehabilitation, i.e. preparing patients physically, nutritionally and mentally in the weeks before surgery, consistently improves preoperative functional capacity, but its effect on postoperative morbidity after colorectal surgery remains uncertain, especially when compared with Enhanced Recovery After Surgery (ERAS) care. Possible reasons include the lack of a standardized exercise protocol, the unknown optimal type of training, the unidentified patient subgroup most likely to benefit, and heterogeneous patient compliance in largely unsupervised, outpatient programs. In our preclinical study in a rat model, resistance training was associated with better colonic anastomosis healing than aerobic training; no human comparative trial has addressed this question.
Objectives: (1) To compare the effect of resistance training, aerobic endurance training and their combination, delivered within a trimodal prehabilitation program, on postoperative morbidity after elective colorectal resection; (2) to identify, by subgroup analysis, patients most likely to benefit from physical prehabilitation; (3) to assess factors influencing patient compliance and the association between compliance and outcomes.
Design: Single-center, prospective, randomized, controlled, parallel-group trial with four arms (1:1:1:1). Allocation is performed automatically by software randomization embedded in REDCap at enrollment and cannot be modified. Personnel recording outcome data are blinded to group allocation. The trial follows CONSORT recommendations.
Standard care in all arms: dietitian-led nutritional prehabilitation with oral nutritional supplements when indicated; screening for anxiety and depression (BDI, PHQ-9, STAI) with clinical psychologist consultation for high-risk patients; breathing exercises and incentive spirometry training; nurse-led ERAS education, stoma education when indicated, and counseling on smoking and alcohol cessation. Perioperative care follows an audited ERAS program with >80% protocol compliance.
Assessments: baseline nutritional (MUST, InBody), physical (6-minute walk test, 1-minute sit-to-stand test, handgrip strength, frailty scores: CFS, mFI-5, FRAIL), psychological and quality-of-life (SF-36, GIQLI) assessment; CT-based body composition (L3 skeletal muscle index, myosteatosis). Compliance is monitored through a patient diary, weekly physiotherapy visits or phone calls, and daily pulse-wave recordings. Assessments are repeated on the day before surgery and 8 weeks after surgery. Complications are recorded according to the Clavien-Dindo classification. Long-term oncological outcomes are followed up within a separate institutional registry study.
Statistics: Sample size of 120 patients per arm (480 total) was calculated for an expected reduction in postoperative morbidity from 30% to 15% (alpha 0.05, power 80%). An interim analysis is planned after 30 patients per arm to assess the ethical continuation of the trial. Each experimental arm will be compared with the control arm, followed by pairwise comparisons between experimental arms with adjustment for multiple comparisons. Classification and Regression Tree (CART) analysis will be used to identify the subgroup most likely to benefit from prehabilitation.
- Being tested
- Resistance Training Prehabilitation, Aerobic Training Prehabilitation, Standard Trimodal Care
- Keywords
- Prehabilitation, Resistance Training, Aerobic Exercise, Preoperative Exercise, Enhanced Recovery After Surgery, Patient Compliance, Frailty, Sarcopenia
- Medical subject headings
- Colorectal Neoplasms, Postoperative Complications, Patient Compliance, Frailty, Sarcopenia
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Resistance Training PrehabilitationBehavioural
Structured home-based resistance exercise program performed for 4-6 weeks before colorectal surgery, supervised weekly by a physiotherapist.
Aerobic Training PrehabilitationBehavioural
Home-based aerobic exercise (brisk walking or cycling, 2×15 min/day at moderate intensity) performed for 4-6 weeks before colorectal surgery, supervised weekly by a physiotherapist.
Standard Trimodal CareOther
Dietitian-led nutritional prehabilitation with oral nutritional supplements when indicated, psychological screening and clinical psychologist support for high-risk patients, breathing exercises with incentive spirometry, and ERAS-based perioperative care.
| Study group | Role | What they receive |
|---|---|---|
| Resistance Training | Experimental | Home-based resistance training for 4-6 weeks before surgery, in addition to standard trimodal care. Mon/Wed/Fri: seated knee extensions (2×20/day), standing knee raises (2×20/day), calf raises (2×/day), chair-supported squats (2×10/day). Tue/Thu/Sat: biceps curls, lateral raises and front raises with 0.5-1 L water bottles (3×10/day each). Sunday: rest. Weekly physiotherapy check-up in person or by phone. Receives: Behavioral: Resistance Training Prehabilitation; Other: Standard Trimodal Care |
| Aerobic Training | Experimental | Home-based aerobic endurance training for 4-6 weeks before surgery, in addition to standard trimodal care: brisk walking or cycling for 15 minutes twice daily at a target heart rate of approximately 100/min (modified Borg scale 5-6). Weekly physiotherapy check-up in person or by phone. Receives: Behavioral: Aerobic Training Prehabilitation; Other: Standard Trimodal Care |
| Combined Resistance and Aerobic Training | Experimental | Combination of the resistance and aerobic training programs for 4-6 weeks before surgery, in addition to standard trimodal care, with chair-supported squats 4×5 repetitions daily. Weekly physiotherapy check-up in person or by phone. Receives: Behavioral: Resistance Training Prehabilitation; Behavioral: Aerobic Training Prehabilitation; Other: Standard Trimodal Care |
| Standard of Care (Control) | Active comparator | Standard trimodal care without physical exercise prehabilitation: nutritional prehabilitation, psychological support if needed, breathing exercises with incentive spirometry, and ERAS perioperative care. Receives: Other: Standard Trimodal Care |
What is being measured
The primary outcome is the main question the study is designed to answer.
Postoperative Morbidity Within 30 Days
Proportion of participants with any postoperative complication within 30 days after surgery. Complications are graded according to the Clavien-Dindo classification (grade I-V), and the severity distribution will also be reported.
Measured: From surgery to postoperative day 30
Early Postoperative Morbidity Within 7 Days
Proportion of participants with any postoperative complication within 7 days after surgery, graded according to the Clavien-Dindo classification (grade I-V).
Measured: From surgery to postoperative day 7
Secondary outcomes (8)
Postoperative Mortality
All-cause mortality within 7 and 30 days after surgery.
Measured: Postoperative day 7 and day 30
Change in 6-Minute Walk Distance
Distance walked in 6 minutes (meters), measured by the 6-minute walk test.
Measured: At enrollment, the day before surgery (after 4-6 weeks of prehabilitation), and 8 weeks after surgery
Change in Handgrip Strength
Maximal handgrip strength (kg) measured with a hand dynamometer.
Measured: At enrollment, the day before surgery (after 4-6 weeks of prehabilitation), and 8 weeks after surgery
Change in 1-Minute Sit-to-Stand Test
Number of sit-to-stand repetitions completed in 1 minute.
Measured: At enrollment, the day before surgery (after 4-6 weeks of prehabilitation), and 8 weeks after surgery
Change in Health-Related Quality of Life (SF-36)
36-Item Short Form Survey; scores range from 0 to 100, higher scores indicate better health status.
Measured: At enrollment, the day before surgery (after 4-6 weeks of prehabilitation), and 8 weeks after surgery
Change in Gastrointestinal Quality of Life (GIQLI)
Gastrointestinal Quality of Life Index; total score ranges from 0 to 144, higher scores indicate better quality of life.
Measured: At enrollment, the day before surgery (after 4-6 weeks of prehabilitation), and 8 weeks after surgery
Length of Hospital Stay
Number of days from surgery to hospital discharge.
Measured: From surgery to discharge, up to 30 days
Length of Intensive Care Unit Stay
Number of days spent in the intensive care unit after surgery, excluding high dependency unit stay.
Measured: From surgery to discharge, up to 30 days
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted26 Oct 2026
- Study start27 May 2026
- Primary completionMar 2028 (estimated)
- Study completionMar 2028 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (2)Papers the sponsor has linked to this study.
- Other trials for Colorectal CancerStudies of the same condition, open and under way.
- More trials run by Semmelweis UniversityThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Prevention
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Model description
- Four-arm parallel-group design with 1:1:1:1 allocation: resistance training, aerobic training, combined resistance and aerobic training, or standard care without physical prehabilitation. All arms receive standardized nutritional, psychological and respiratory prehabilitation and ERAS perioperative care.
- Masking
- Triple blind
- Who is masked
- Care provider, Investigator, Outcomes assessor
- Enrolment
- 480 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Semmelweis University
- Sponsor type
- University, hospital or other
- Responsible party
- Sponsor
- Investigators
- Balazs Banky, MD, PhD, Principal investigator, Semmelweis University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07896174
- Sponsor's protocol ID
- NNGYK/02258-7/2026
- Other IDs
- BM/5143-3/2026, 1128
- Status last verified
- Oct 2026
- First submitted
- 19 Oct 2026
- Last updated
- 26 Oct 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No: Individual participant data will not be shared. Aggregated results will be published in peer-reviewed journals.
Publications
Levay K, Kovacs S, Budai A, Horvath I, Kovacs N, Mathe D, Szigeti K, Dunai Z, Makra N, Juhasz J, Ostorhazi E, Banky B, Szijarto A, Fulop A. Physical prehabilitation improves colonic anastomosis healing in a malnourished rat model only if attached to effective nutritional prehabilitation - Experimental study. Surgery. 2025 Dec;188:109677. doi: 10.1016/j.surg.2025.109677. Epub 2025 Sep 18.
PubMed 40972191Fulop A, Lakatos L, Susztak N, Szijarto A, Banky B. The effect of trimodal prehabilitation on the physical and psychological health of patients undergoing colorectal surgery: a randomised clinical trial. Anaesthesia. 2021 Jan;76(1):82-90. doi: 10.1111/anae.15215. Epub 2020 Aug 6.
PubMed 32761611
Study at a glance
From the registry record, last updated by the sponsor on 26 Oct 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Effect of Preoperative Resistance and Aerobic Endurance Training on Surgical Outcomes and Evaluation of Patient Compliance With Prehabilitation in Colorectal Surgery: A Randomized Controlled Trial
- ClinicalTrials.gov ID
- NCT07896174
- Acronym / sponsor ID
- NNGYK/02258-7/2026
- Keywords
- Prehabilitation, Resistance Training, Aerobic Exercise, Preoperative Exercise, Enhanced Recovery After Surgery, Patient Compliance, Frailty, Sarcopenia
- Study type
- Interventional
- Recruitment status
- Recruiting
- Enrolment
- 480 participants (estimated)
- Lead sponsor
- Semmelweis UniversityUniversity, hospital or other
- Study start
- 27 May 2026 (actual)
- Primary completion
- Mar 2028 (estimated)
- Study completion
- Mar 2028 (estimated)
- First posted
- 26 Oct 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
The goal of this clinical trial is to learn which type of exercise before surgery best reduces complications after colorectal surgery in adults with colorectal cancer or precancerous lesions. The main questions it aims to answer are:
- Does resistance (strength) training, aerobic (endurance) training, or a combination of both before surgery lower the rate and severity of complications in the first 30 days after surgery, compared with no exercise program?
- Which factors influence how well patients follow a prehabilitation program, and does following the program affect surgical outcomes?
Researchers will compare three exercise groups with a control group that receives standard care without an exercise program.
Participants will:
- Be randomly assigned to one of four groups: resistance training, aerobic training, combined training, or no exercise program (control)
- Do the assigned home exercise program for 4 to 6 weeks before surgery, with weekly physiotherapy check-ups in person or by phone
- Receive nutritional counseling, breathing exercises, and psychological support if needed, regardless of group
- Keep a daily exercise diary and record their pulse daily
- Undergo physical fitness tests (walking test, sit-to-stand test, handgrip strength) and quality-of-life questionnaires before surgery and 8 weeks after surgery
Detailed description
Background: Prehabilitation, i.e. preparing patients physically, nutritionally and mentally in the weeks before surgery, consistently improves preoperative functional capacity, but its effect on postoperative morbidity after colorectal surgery remains uncertain, especially when compared with Enhanced Recovery After Surgery (ERAS) care. Possible reasons include the lack of a standardized exercise protocol, the unknown optimal type of training, the unidentified patient subgroup most likely to benefit, and heterogeneous patient compliance in largely unsupervised, outpatient programs. In our preclinical study in a rat model, resistance training was associated with better colonic anastomosis healing than aerobic training; no human comparative trial has addressed this question.
Objectives: (1) To compare the effect of resistance training, aerobic endurance training and their combination, delivered within a trimodal prehabilitation program, on postoperative morbidity after elective colorectal resection; (2) to identify, by subgroup analysis, patients most likely to benefit from physical prehabilitation; (3) to assess factors influencing patient compliance and the association between compliance and outcomes.
Design: Single-center, prospective, randomized, controlled, parallel-group trial with four arms (1:1:1:1). Allocation is performed automatically by software randomization embedded in REDCap at enrollment and cannot be modified. Personnel recording outcome data are blinded to group allocation. The trial follows CONSORT recommendations.
Standard care in all arms: dietitian-led nutritional prehabilitation with oral nutritional supplements when indicated; screening for anxiety and depression (BDI, PHQ-9, STAI) with clinical psychologist consultation for high-risk patients; breathing exercises and incentive spirometry training; nurse-led ERAS education, stoma education when indicated, and counseling on smoking and alcohol cessation. Perioperative care follows an audited ERAS program with >80% protocol compliance.
Assessments: baseline nutritional (MUST, InBody), physical (6-minute walk test, 1-minute sit-to-stand test, handgrip strength, frailty scores: CFS, mFI-5, FRAIL), psychological and quality-of-life (SF-36, GIQLI) assessment; CT-based body composition (L3 skeletal muscle index, myosteatosis). Compliance is monitored through a patient diary, weekly physiotherapy visits or phone calls, and daily pulse-wave recordings. Assessments are repeated on the day before surgery and 8 weeks after surgery. Complications are recorded according to the Clavien-Dindo classification. Long-term oncological outcomes are followed up within a separate institutional registry study.
Statistics: Sample size of 120 patients per arm (480 total) was calculated for an expected reduction in postoperative morbidity from 30% to 15% (alpha 0.05, power 80%). An interim analysis is planned after 30 patients per arm to assess the ethical continuation of the trial. Each experimental arm will be compared with the control arm, followed by pairwise comparisons between experimental arms with adjustment for multiple comparisons. Classification and Regression Tree (CART) analysis will be used to identify the subgroup most likely to benefit from prehabilitation.
Study design
- Primary purpose
- Prevention
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Triple blind (care provider, investigator, outcomes assessor)
- Number of arms
- 4
- Model description
- Four-arm parallel-group design with 1:1:1:1 allocation: resistance training, aerobic training, combined resistance and aerobic training, or standard care without physical prehabilitation. All arms receive standardized nutritional, psychological and respiratory prehabilitation and ERAS perioperative care.
| Arm | Type | Receives |
|---|---|---|
| Resistance Training | Experimental | Behavioral: Resistance Training Prehabilitation, Other: Standard Trimodal CareHome-based resistance training for 4-6 weeks before surgery, in addition to standard trimodal care. Mon/Wed/Fri: seated knee extensions (2×20/day), standing knee raises (2×20/day), calf raises (2×/day), chair-supported squats (2×10/day). Tue/Thu/Sat: biceps curls, lateral raises and front raises with 0.5-1 L water bottles (3×10/day each). Sunday: rest. Weekly physiotherapy check-up in person or by phone. |
| Aerobic Training | Experimental | Behavioral: Aerobic Training Prehabilitation, Other: Standard Trimodal CareHome-based aerobic endurance training for 4-6 weeks before surgery, in addition to standard trimodal care: brisk walking or cycling for 15 minutes twice daily at a target heart rate of approximately 100/min (modified Borg scale 5-6). Weekly physiotherapy check-up in person or by phone. |
| Combined Resistance and Aerobic Training | Experimental | Behavioral: Resistance Training Prehabilitation, Behavioral: Aerobic Training Prehabilitation, Other: Standard Trimodal CareCombination of the resistance and aerobic training programs for 4-6 weeks before surgery, in addition to standard trimodal care, with chair-supported squats 4×5 repetitions daily. Weekly physiotherapy check-up in person or by phone. |
| Standard of Care (Control) | Active comparator | Other: Standard Trimodal CareStandard trimodal care without physical exercise prehabilitation: nutritional prehabilitation, psychological support if needed, breathing exercises with incentive spirometry, and ERAS perioperative care. |
Who may qualify
- Ages
- 18 years and older
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (4 listed)
- Age over 18 years
- Elective, curative-intent colon or rectal resection
- Malignant or premalignant colorectal lesion
- Signed written informed consent after receiving study information
Key exclusion criteria (8 listed)
- Refusal to participate in the study
- Comorbidities precluding physical prehabilitation
- Physical, neurological or mental status precluding physical prehabilitation
- Unplanned acute surgery required during the prehabilitation period
- Transanal minimally invasive surgery (TAMIS)
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Resistance Training PrehabilitationStructured home-based resistance exercise program performed for 4-6 weeks before colorectal surgery, supervised weekly by a physiotherapist. | Behavioural | Combined Resistance and Aerobic Training, Resistance Training |
| Aerobic Training PrehabilitationHome-based aerobic exercise (brisk walking or cycling, 2×15 min/day at moderate intensity) performed for 4-6 weeks before colorectal surgery, supervised weekly by a physiotherapist. | Behavioural | Aerobic Training, Combined Resistance and Aerobic Training |
| Standard Trimodal CareDietitian-led nutritional prehabilitation with oral nutritional supplements when indicated, psychological screening and clinical psychologist support for high-risk patients, breathing exercises with incentive spirometry, and ERAS-based perioperative care. | Other | Aerobic Training, Combined Resistance and Aerobic Training, Resistance Training, Standard of Care (Control) |
Primary outcome
Postoperative Morbidity Within 30 Days
Time frame: From surgery to postoperative day 30
Proportion of participants with any postoperative complication within 30 days after surgery. Complications are graded according to the Clavien-Dindo classification (grade I-V), and the severity distribution will also be reported.
Early Postoperative Morbidity Within 7 Days
Time frame: From surgery to postoperative day 7
Proportion of participants with any postoperative complication within 7 days after surgery, graded according to the Clavien-Dindo classification (grade I-V).
8 secondary outcomes
Postoperative Mortality
Time frame: Postoperative day 7 and day 30
Change in 6-Minute Walk Distance
Time frame: At enrollment, the day before surgery (after 4-6 weeks of prehabilitation), and 8 weeks after surgery
Change in Handgrip Strength
Time frame: At enrollment, the day before surgery (after 4-6 weeks of prehabilitation), and 8 weeks after surgery
Change in 1-Minute Sit-to-Stand Test
Time frame: At enrollment, the day before surgery (after 4-6 weeks of prehabilitation), and 8 weeks after surgery
Change in Health-Related Quality of Life (SF-36)
Time frame: At enrollment, the day before surgery (after 4-6 weeks of prehabilitation), and 8 weeks after surgery
Change in Gastrointestinal Quality of Life (GIQLI)
Time frame: At enrollment, the day before surgery (after 4-6 weeks of prehabilitation), and 8 weeks after surgery
Length of Hospital Stay
Time frame: From surgery to discharge, up to 30 days
Length of Intensive Care Unit Stay
Time frame: From surgery to discharge, up to 30 days
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 26 Oct 2026.
- Background: PubMed 40972191Levay K, Kovacs S, Budai A, Horvath I, Kovacs N, Mathe D, Szigeti K, Dunai Z, Makra N, Juhasz J, Ostorhazi E, Banky B, Szijarto A, Fulop A. Physical prehabilitation improves colonic anastomosis healing in a malnourished rat model only if attached to effective nutritional prehabilitation - Experimental study. Surgery. 2025 Dec;188:109677. doi: 10.1016/j.surg.2025.109677. Epub 2025 Sep 18.
- Background: PubMed 32761611Fulop A, Lakatos L, Susztak N, Szijarto A, Banky B. The effect of trimodal prehabilitation on the physical and psychological health of patients undergoing colorectal surgery: a randomised clinical trial. Anaesthesia. 2021 Jan;76(1):82-90. doi: 10.1111/anae.15215. Epub 2020 Aug 6.
- Individual participant dataSharing planned: No. Individual participant data will not be shared. Aggregated results will be published in peer-reviewed journals.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
Balazs Banky, MD, PhD principal investigator
Semmelweis University
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Resistance Training Prehabilitation, Aerobic Training Prehabilitation and Standard Trimodal Care in people with Colorectal Cancer and Colorectal Neoplasms, run by Semmelweis University at 1 site in Hungary.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 4 inclusion and 8 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: looking for participants now, as of the sponsor's last update on 26 Oct 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Hungary. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact Balazs Banky, MD, PhD (+36208258915, banky.balazs@semmelweis.hu), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Postoperative Morbidity Within 30 Days (time frame: From surgery to postoperative day 30). The study lists 2 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT07896174, which also lists 2 linked publications.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 26 Oct 2026.