Dental ImplantNCT07896759
Serum S1P Levels and Dental Implant Osseointegration in Patients
An observational study of Dental Implant, run by Wang Jing at 1 site in China.
Trial summary
This retrospective study aims to investigate whether a specific substance in the blood, called Sphingosine-1-Phosphate (S1P), is related to the degree of osseointegration around dental implants. Read more about this study
- Who is it for?
- Ages 18 years and older
- Conditions the study is for
- Dental Implant
- What is being tested?
- Serum S1P Measurement
- How many people
- 20 participants
- Where
- 1 siteChina
- Study dates
- 8 Aug 2025to 10 Jun 2026
- Phase
- Observational
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 years and older
- All sexes
- No healthy volunteers
- Adult, Older adult
Study population: The study population consists of 20 healthy adult patients (aged 18 years or older) with single tooth loss who underwent dental implant surgery at the Department of Implantology, Third Affiliated Hospital of Air Force Medical University, between August 2025 and August 2026. All patients had sufficient bone volume for implant placement and met the specific inclusion/exclusion criteria (e.g., no severe local inflammation, no heavy smoking, and no medications affecting bone metabolism). Data will be retrospectively extracted from their electronic medical records.
Who may be able to join
- Healthy adults aged 18 years or older.
- Single tooth loss indicated for dental implant restoration.
- Intact lingual and palatal bone walls in the edentulous area, with sufficient bone volume confirmed by preoperative CBCT for implant placement.
- Healthy adjacent and opposing teeth, with sufficient interocclusal space and normal occlusion/overbite relationships.
- Good patient compliance with treatment and follow-up.
Who cannot join
- Severe acute or chronic inflammation at the implant site.
- Insufficient mesiodistal width for implant placement.
- Presence of adverse oral habits or conditions, such as heavy smoking (>10 cigarettes/day), bruxism, or periodontal disease.
- Pregnant or lactating women.
- Poor general health status making the patient unable to tolerate surgery.
- Patients currently undergoing orthodontic treatment.
- Current use of medications affecting bone metabolism.
Trial locations and contacts
1 site in 1 country.
About this study
Official title: Correlation Between Serum S1P Levels and Dental Implant Osseointegration: A Retrospective Study
This retrospective study aims to investigate whether a specific substance in the blood, called Sphingosine-1-Phosphate (S1P), is related to the degree of osseointegration around dental implants. We will review the medical records of 20 patients who have already completed their dental implant surgery and standard follow-up. The S1P levels will be measured using leftover blood samples from their routine preoperative examinations. By analyzing their existing dental x-ray images (CBCT) taken before surgery and during their routine 3-month follow-up, we will evaluate the osseointegration and implant stability. Ultimately, we hope to find out if measuring S1P levels from routine blood tests can help predict the quality of osseointegration after getting dental implants.
Read the detailed description
This is a retrospective observational study. We will review the medical records of 20 patients who underwent dental implant surgery at the Department of Implantology between August 2025 and August 2026, and who have completed the standard 3-month follow-up (second-stage surgery).
Data will be collected retrospectively from the hospital information system. Preoperative baseline characteristics and Cone Beam Computed Tomography (CBCT) scans will be extracted from medical records. Serum S1P levels will be quantified using archived peripheral blood samples obtained during routine preoperative examinations via an Enzyme-Linked Immunosorbent Assay (ELISA) kit. The raw Optical Density (OD) values and calculated concentrations will be independently recorded by two researchers.
At the 3-month follow-up, CBCT scans were taken as a routine clinical procedure before the second-stage surgery. These retrospective follow-up images will be compared with baseline images to evaluate the degree of osseointegration. Implant stability was measured using the Implant Stability Quotient (ISQ) as part of routine care. For radiographic assessment, mean grayscale values (Hounsfield Units, HU) within a 2 mm³ Region of Interest (ROI) at the bone-implant interface will be measured using Mimics software by two blinded radiologists. Finally, the correlation between implant osseointegration outcomes and serum S1P levels will be statistically analyzed using R software.
- Conditions
- Dental Implant
- Being tested
- Serum S1P Measurement
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Serum S1P MeasurementDiagnostic test
Retrospective quantification of serum Sphingosine-1-Phosphate (S1P) levels using ELISA on archived blood samples.
| Study group | Role | What they receive |
|---|---|---|
| Retrospective Cohort | 20 patients who underwent dental implant surgery and completed a standard 3-month follow-up. Preoperative serum S1P levels and radiographic outcomes (CBCT) were retrospectively reviewed and analyzed. Receives: Diagnostic Test: Serum S1P Measurement |
What is being measured
The primary outcome is the main question the study is designed to answer.
Correlation between serum S1P levels and dental implant osseointegration
Osseointegration was evaluated radiographically by measuring Hounsfield Units (HU) at the bone-implant interface using CBCT, and clinically by measuring the Implant Stability Quotient (ISQ). Serum S1P concentrations were quantified using ELISA. The statistical correlation between these parameters was analyzed using R software.
Measured: Preoperative (S1P measurement) and 3 months postoperatively (osseointegration assessment)
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted27 Oct 2026
- Study start8 Aug 2025
- Primary completion10 Jun 2026
- Study completion10 Jun 2026
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Dental ImplantStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Observational
- Observational model
- Cohort
- Time perspective
- Retrospective
- Enrolment
- 20 participants (actual)
Sponsor and investigators
- Lead sponsor
- Wang Jing
- Sponsor type
- University, hospital or other
- Responsible party
- Sponsor-investigator, Wang Jing, Air Force Military Medical University, China
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07896759
- Sponsor's protocol ID
- KQ-YJ-WJ01
- Status last verified
- Oct 2026
- First submitted
- 20 Oct 2026
- Last updated
- 27 Oct 2026
- Results posted
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No: Data contain sensitive patient information and sharing is not permitted by the local ethics committee.
Study at a glance
From the registry record, last updated by the sponsor on 27 Oct 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Correlation Between Serum S1P Levels and Dental Implant Osseointegration: A Retrospective Study
- ClinicalTrials.gov ID
- NCT07896759
- Acronym / sponsor ID
- KQ-YJ-WJ01
- Conditions
- Dental Implant
- Study type
- Observational
- Recruitment status
- Completed
- Enrolment
- 20 participants (actual)
- Lead sponsor
- Wang JingUniversity, hospital or other
- Study start
- 8 Aug 2025 (actual)
- Primary completion
- 10 Jun 2026 (actual)
- Study completion
- 10 Jun 2026 (actual)
- First posted
- 27 Oct 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
This retrospective study aims to investigate whether a specific substance in the blood, called Sphingosine-1-Phosphate (S1P), is related to the degree of osseointegration around dental implants. We will review the medical records of 20 patients who have already completed their dental implant surgery and standard follow-up. The S1P levels will be measured using leftover blood samples from their routine preoperative examinations. By analyzing their existing dental x-ray images (CBCT) taken before surgery and during their routine 3-month follow-up, we will evaluate the osseointegration and implant stability. Ultimately, we hope to find out if measuring S1P levels from routine blood tests can help predict the quality of osseointegration after getting dental implants.
Detailed description
This is a retrospective observational study. We will review the medical records of 20 patients who underwent dental implant surgery at the Department of Implantology between August 2025 and August 2026, and who have completed the standard 3-month follow-up (second-stage surgery).
Data will be collected retrospectively from the hospital information system. Preoperative baseline characteristics and Cone Beam Computed Tomography (CBCT) scans will be extracted from medical records. Serum S1P levels will be quantified using archived peripheral blood samples obtained during routine preoperative examinations via an Enzyme-Linked Immunosorbent Assay (ELISA) kit. The raw Optical Density (OD) values and calculated concentrations will be independently recorded by two researchers.
At the 3-month follow-up, CBCT scans were taken as a routine clinical procedure before the second-stage surgery. These retrospective follow-up images will be compared with baseline images to evaluate the degree of osseointegration. Implant stability was measured using the Implant Stability Quotient (ISQ) as part of routine care. For radiographic assessment, mean grayscale values (Hounsfield Units, HU) within a 2 mm³ Region of Interest (ROI) at the bone-implant interface will be measured using Mimics software by two blinded radiologists. Finally, the correlation between implant osseointegration outcomes and serum S1P levels will be statistically analyzed using R software.
Study design
- Observational model
- Cohort
- Time perspective
- Retrospective
- Number of arms
- 1
| Arm | Type | Receives |
|---|---|---|
| Retrospective Cohort | – | Diagnostic Test: Serum S1P Measurement20 patients who underwent dental implant surgery and completed a standard 3-month follow-up. Preoperative serum S1P levels and radiographic outcomes (CBCT) were retrospectively reviewed and analyzed. |
Who may qualify
- Ages
- 18 years and older
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
- Study population
- The study population consists of 20 healthy adult patients (aged 18 years or older) with single tooth loss who underwent dental implant surgery at the Department of Implantology, Third Affiliated Hospital of Air Force Medical University, between August 2025 and August 2026. All patients had sufficient bone volume for implant placement and met the specific inclusion/exclusion criteria (e.g., no severe local inflammation, no heavy smoking, and no medications affecting bone metabolism). Data will be retrospectively extracted from their electronic medical records.
Key inclusion criteria (5 listed)
- Healthy adults aged 18 years or older.
- Single tooth loss indicated for dental implant restoration.
- Intact lingual and palatal bone walls in the edentulous area, with sufficient bone volume confirmed by preoperative CBCT for implant placement.
- Healthy adjacent and opposing teeth, with sufficient interocclusal space and normal occlusion/overbite relationships.
- Good patient compliance with treatment and follow-up.
Key exclusion criteria (7 listed)
- Severe acute or chronic inflammation at the implant site.
- Insufficient mesiodistal width for implant placement.
- Presence of adverse oral habits or conditions, such as heavy smoking (>10 cigarettes/day), bruxism, or periodontal disease.
- Pregnant or lactating women.
- Poor general health status making the patient unable to tolerate surgery.
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Serum S1P MeasurementRetrospective quantification of serum Sphingosine-1-Phosphate (S1P) levels using ELISA on archived blood samples. | Diagnostic test | Retrospective Cohort |
Primary outcome
Correlation between serum S1P levels and dental implant osseointegration
Time frame: Preoperative (S1P measurement) and 3 months postoperatively (osseointegration assessment)
Osseointegration was evaluated radiographically by measuring Hounsfield Units (HU) at the bone-implant interface using CBCT, and clinically by measuring the Implant Stability Quotient (ISQ). Serum S1P concentrations were quantified using ELISA. The statistical correlation between these parameters was analyzed using R software.
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 27 Oct 2026.
- Individual participant dataSharing planned: No. Data contain sensitive patient information and sharing is not permitted by the local ethics committee.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
The record lists no contact. Use the official record to reach the sponsor.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
An observational study of Dental Implant, run by Wang Jing at 1 site in China.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 5 inclusion and 7 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 27 Oct 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in China. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Correlation between serum S1P levels and dental implant osseointegration (time frame: Preoperative (S1P measurement) and 3 months postoperatively (osseointegration assessment)). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 27 Oct 2026.