Myocardial Injury After Noncardiac Surgery (MINS)TUR-MINSNCT07900035
Myocardial Injury After Transurethral Resection
An observational study of Myocardial Injury After Noncardiac Surgery (MINS), run by Haseki Training and Research Hospital at 1 site in Turkey (Türkiye).
Trial summary
This prospective observational study aims to determine the incidence of myocardial injury after noncardiac surgery (MINS) in adult patients undergoing elective transurethral resection of the prostate (TURP) or transurethral resection of bladder tumor (TURBT). Read more about this study
- Who is it for?
- Ages 18 years and older
- Conditions the study is for
- Myocardial Injury After Noncardiac Surgery (MINS)
- How many people
- 89 participants
- Where
- 1 siteTurkey (Türkiye)
- Study dates
- 1 May 2025to 20 Dec 2025
- Phase
- Observational
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 years and older
- All sexes
- No healthy volunteers
- Adult, Older adult
Study population: Adult patients undergoing elective TURP or TURBT at the participating tertiary hospital.
Who may be able to join
- Age ≥18 years
- ASA physical status I-III
- Scheduled for elective transurethral resection of the prostate (TURP) or transurethral resection of bladder tumor (TURBT)
- Written informed consent provided
Who cannot join
- Refusal to participate
- Myocardial infarction within the previous 6 months
- Recent pulmonary embolism
- Cardioversion within the previous 6 months
- Surgery within the previous month
- Decompensated heart failure
Show all 9Show fewer
- End-stage renal disease requiring dialysis
- Body mass index >40 kg/m²
- Contraindication to spinal anesthesia, including increased intracranial pressure, infection at the puncture site, coagulopathy, severe hypovolemia, or severe aortic and/or mitral stenosis
Trial locations and contacts
1 site in 1 country.
Turkey (Türkiye)1 site
Haseki Training and Research Hospital
Istanbul, Istanbul, 34265
About this study
Official title: Incidence and Perioperative Risk Factors of Myocardial Injury After Noncardiac Surgery Following Transurethral Resection of Bladder Tumor: A Prospective Observational Study
This prospective observational study aims to determine the incidence of myocardial injury after noncardiac surgery (MINS) in adult patients undergoing elective transurethral resection of the prostate (TURP) or transurethral resection of bladder tumor (TURBT). High-sensitivity cardiac troponin T (hs-cTnT) levels are measured preoperatively, 1 hour after surgery, and 48 hours postoperatively. Demographic, clinical, anesthetic, and intraoperative variables are prospectively recorded to explore perioperative factors associated with the development of MINS. The primary outcome is the incidence of MINS within 48 hours after surgery.
Read the detailed description
This prospective, observational, single-center cohort study is designed to evaluate the incidence of myocardial injury after noncardiac surgery (MINS) in adult patients undergoing elective transurethral resection procedures, including transurethral resection of the prostate (TURP) and transurethral resection of bladder tumor (TURBT).
Eligible patients are enrolled consecutively during the study period. The anesthetic technique is not assigned by the investigators and is selected according to routine clinical practice based on the patient's clinical condition, suitability for the technique, patient preference, and the attending anesthesiologist's judgment. Patients may receive either general anesthesia or spinal anesthesia according to standard perioperative care.
Perioperative monitoring includes electrocardiography, pulse oximetry, noninvasive blood pressure measurement, and routine hemodynamic assessment. Intraoperative variables, including blood pressure, heart rate, oxygen saturation, anesthetic technique, type of transurethral procedure, surgery duration, intravenous fluid administration, vasopressor requirement, and clinically relevant hemodynamic or rhythm disturbances, are prospectively recorded.
High-sensitivity cardiac troponin T (hs-cTnT) concentrations are measured at three predefined time points: preoperatively before anesthesia, 1 hour after surgery, and 48 hours postoperatively. MINS is defined according to postoperative hs-cTnT criteria after exclusion of overt non-ischemic causes of troponin elevation. A postoperative hs-cTnT concentration of 20 to <65 ng/L is considered diagnostic when accompanied by an absolute increase of at least 5 ng/L from the preoperative value, whereas a postoperative hs-cTnT concentration of ≥65 ng/L fulfills the biomarker criterion for MINS. Ischemic symptoms or electrocardiographic changes are not required for the diagnosis.
The primary outcome is the incidence of MINS within the first 48 hours after transurethral resection. Secondary objectives include evaluation of perioperative changes in hs-cTnT concentrations and exploratory assessment of demographic, clinical, anesthetic, procedural, and intraoperative factors associated with the development of MINS.
Potential associated factors include age, sex, American Society of Anesthesiologists physical status, cardiovascular and other relevant comorbidities, type of transurethral procedure, anesthetic technique, duration of surgery, intraoperative hypotension, hypertension, bradycardia, tachycardia, hypoxemia, arrhythmia, ST-segment changes, vasopressor requirement, atropine administration, and perioperative intravenous fluid administration.
As this is an observational study, no study-specific therapeutic intervention is performed and perioperative management is conducted according to routine clinical practice.
- Keywords
- mycardial injury after noncardiac surgery, High-Sensitivity Cardiac Troponin T, Transurethral Resection, Perioperative Myocardial Injury.
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
| Study group | Role | What they receive |
|---|---|---|
| Patients Undergoing Transurethral Resection | Adult patients undergoing elective transurethral resection of the prostate (TURP) or transurethral resection of bladder tumor (TURBT) are prospectively observed. The anesthetic technique (general or spinal anesthesia) is selected according to routine clinical practice and is not assigned by the investigators. |
What is being measured
The primary outcome is the main question the study is designed to answer.
Incidence of Myocardial Injury After Noncardiac Surgery (MINS)
Percentage of participants who meet the predefined high-sensitivity cardiac troponin T (hs-cTnT) criteria for MINS within 48 hours after surgery. MINS is defined as a postoperative hs-cTnT concentration of 20 to <65 ng/L with an absolute increase of at least 5 ng/L from the preoperative value, or a postoperative hs-cTnT concentration ≥65 ng/L, after exclusion of overt non-ischemic causes of troponin elevation.
Unit of Measure: Percentage of participants with MINS Measurement Tool/Parameter: High-sensitivity cardiac troponin T (hs-cTnT)
Measured: Within 48 hours after surgery
Secondary outcomes (7)
Change in High-Sensitivity Cardiac Troponin T Concentration
hs-cTnT concentrations measured preoperatively before anesthesia, 1 hour after surgery, and 48 hours after surgery will be compared to evaluate perioperative changes.
Unit of Measure: ng/L Measurement Tool/Parameter: High-sensitivity cardiac troponin T assay
Measured: Preoperative baseline, 1 hour after surgery, and 48 hours after surgery
Peak Postoperative hs-cTnT Concentration
Highest hs-cTnT concentration measured at the predefined postoperative measurement points.
Unit of Measure: ng/L Measurement Tool/Parameter: High-sensitivity cardiac troponin T assay
Measured: Within 48 hours after surgery
Association Between Age and MINS
Description: Association between participant age and occurrence of MINS. Unit of Measure: Years Measurement Tool/Parameter: Chronological age obtained from medical records
Measured: Preoperative assessment through 48 hours after surgery
Association Between Body Mass Index and MINS
Association between body mass index and occurrence of MINS. Body mass index is calculated as body weight in kilograms divided by height in meters squared.
Unit of Measure: kg/m² Measurement Tool/Parameter: Body mass index calculated from measured body weight and height
Measured: Preoperative assessment through 48 hours after surgery
Association Between ASA Physical Status and MINS
Association between American Society of Anesthesiologists physical status classification and occurrence of MINS.
Unit of Measure: Percentage of participants in each ASA physical status category Measurement Tool/Parameter: ASA Physical Status Classification System
Measured: Preoperative assessment through 48 hours after surgery
Association Between Congestive Heart Failure and MINS
Association between pre-existing congestive heart failure and occurrence of MINS.
Unit of Measure: Percentage of participants with congestive heart failure Measurement Tool/Parameter: Medical history and medical record review
Measured: Preoperative assessment through 48 hours after surgery
Association Between Hypertension and MINS
Association between pre-existing hypertension and occurrence of MINS. Unit of Measure: Percentage of participants with hypertension Measurement Tool/Parameter: Medical history and medical record review
Measured: Preoperative assessment through 48 hours after surgery
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted28 Oct 2026
- Study start1 May 2025
- Primary completion20 Dec 2025
- Study completion20 Dec 2025
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (1)Papers the sponsor has linked to this study.
- Other trials for Myocardial Injury After Noncardiac Surgery (MINS)Studies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Observational
- Observational model
- Cohort
- Time perspective
- Prospective
- Enrolment
- 89 participants (actual)
Sponsor and investigators
- Lead sponsor
- Haseki Training and Research Hospital
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Sinan Uzman, Haseki Training and Research Hospital
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07900035
- Sponsor's protocol ID
- MINS-TUR-2025-01
- Acronym
- TUR-MINS
- Status last verified
- Oct 2026
- First submitted
- 14 Oct 2026
- Last updated
- 28 Oct 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No: Individual participant data will not be publicly shared. De-identified data may be made available from the corresponding author upon reasonable request and subject to institutional and ethical approval.
Publications
Ruetzler K, Smilowitz NR, Berger JS, Devereaux PJ, Maron BA, Newby LK, de Jesus Perez V, Sessler DI, Wijeysundera DN. Diagnosis and Management of Patients With Myocardial Injury After Noncardiac Surgery: A Scientific Statement From the American Heart Association. Circulation. 2021 Nov 9;144(19):e287-e305. doi: 10.1161/CIR.0000000000001024. Epub 2021 Oct 4.
PubMed 34601955
Study at a glance
From the registry record, last updated by the sponsor on 28 Oct 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Incidence and Perioperative Risk Factors of Myocardial Injury After Noncardiac Surgery Following Transurethral Resection of Bladder Tumor: A Prospective Observational Study
- ClinicalTrials.gov ID
- NCT07900035
- Acronym / sponsor ID
- TUR-MINS / MINS-TUR-2025-01
- Keywords
- mycardial injury after noncardiac surgery, High-Sensitivity Cardiac Troponin T, Transurethral Resection, Perioperative Myocardial Injury.
- Study type
- Observational
- Recruitment status
- Completed
- Enrolment
- 89 participants (actual)
- Lead sponsor
- Haseki Training and Research HospitalUniversity, hospital or other
- Study start
- 1 May 2025 (actual)
- Primary completion
- 20 Dec 2025 (actual)
- Study completion
- 20 Dec 2025 (actual)
- First posted
- 28 Oct 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
This prospective observational study aims to determine the incidence of myocardial injury after noncardiac surgery (MINS) in adult patients undergoing elective transurethral resection of the prostate (TURP) or transurethral resection of bladder tumor (TURBT). High-sensitivity cardiac troponin T (hs-cTnT) levels are measured preoperatively, 1 hour after surgery, and 48 hours postoperatively. Demographic, clinical, anesthetic, and intraoperative variables are prospectively recorded to explore perioperative factors associated with the development of MINS. The primary outcome is the incidence of MINS within 48 hours after surgery.
Detailed description
This prospective, observational, single-center cohort study is designed to evaluate the incidence of myocardial injury after noncardiac surgery (MINS) in adult patients undergoing elective transurethral resection procedures, including transurethral resection of the prostate (TURP) and transurethral resection of bladder tumor (TURBT).
Eligible patients are enrolled consecutively during the study period. The anesthetic technique is not assigned by the investigators and is selected according to routine clinical practice based on the patient's clinical condition, suitability for the technique, patient preference, and the attending anesthesiologist's judgment. Patients may receive either general anesthesia or spinal anesthesia according to standard perioperative care.
Perioperative monitoring includes electrocardiography, pulse oximetry, noninvasive blood pressure measurement, and routine hemodynamic assessment. Intraoperative variables, including blood pressure, heart rate, oxygen saturation, anesthetic technique, type of transurethral procedure, surgery duration, intravenous fluid administration, vasopressor requirement, and clinically relevant hemodynamic or rhythm disturbances, are prospectively recorded.
High-sensitivity cardiac troponin T (hs-cTnT) concentrations are measured at three predefined time points: preoperatively before anesthesia, 1 hour after surgery, and 48 hours postoperatively. MINS is defined according to postoperative hs-cTnT criteria after exclusion of overt non-ischemic causes of troponin elevation. A postoperative hs-cTnT concentration of 20 to <65 ng/L is considered diagnostic when accompanied by an absolute increase of at least 5 ng/L from the preoperative value, whereas a postoperative hs-cTnT concentration of ≥65 ng/L fulfills the biomarker criterion for MINS. Ischemic symptoms or electrocardiographic changes are not required for the diagnosis.
The primary outcome is the incidence of MINS within the first 48 hours after transurethral resection. Secondary objectives include evaluation of perioperative changes in hs-cTnT concentrations and exploratory assessment of demographic, clinical, anesthetic, procedural, and intraoperative factors associated with the development of MINS.
Potential associated factors include age, sex, American Society of Anesthesiologists physical status, cardiovascular and other relevant comorbidities, type of transurethral procedure, anesthetic technique, duration of surgery, intraoperative hypotension, hypertension, bradycardia, tachycardia, hypoxemia, arrhythmia, ST-segment changes, vasopressor requirement, atropine administration, and perioperative intravenous fluid administration.
As this is an observational study, no study-specific therapeutic intervention is performed and perioperative management is conducted according to routine clinical practice.
Study design
- Observational model
- Cohort
- Time perspective
- Prospective
- Number of arms
- 1
| Arm | Type | Receives |
|---|---|---|
| Patients Undergoing Transurethral Resection | – | –Adult patients undergoing elective transurethral resection of the prostate (TURP) or transurethral resection of bladder tumor (TURBT) are prospectively observed. The anesthetic technique (general or spinal anesthesia) is selected according to routine clinical practice and is not assigned by the investigators. |
Who may qualify
- Ages
- 18 years and older
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
- Study population
- Adult patients undergoing elective TURP or TURBT at the participating tertiary hospital.
Key inclusion criteria (4 listed)
- Age ≥18 years
- ASA physical status I-III
- Scheduled for elective transurethral resection of the prostate (TURP) or transurethral resection of bladder tumor (TURBT)
- Written informed consent provided
Key exclusion criteria (9 listed)
- Refusal to participate
- Myocardial infarction within the previous 6 months
- Recent pulmonary embolism
- Cardioversion within the previous 6 months
- Surgery within the previous month
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Primary outcome
Incidence of Myocardial Injury After Noncardiac Surgery (MINS)
Time frame: Within 48 hours after surgery
Percentage of participants who meet the predefined high-sensitivity cardiac troponin T (hs-cTnT) criteria for MINS within 48 hours after surgery. MINS is defined as a postoperative hs-cTnT concentration of 20 to <65 ng/L with an absolute increase of at least 5 ng/L from the preoperative value, or a postoperative hs-cTnT concentration ≥65 ng/L, after exclusion of overt non-ischemic causes of troponin elevation. Unit of Measure: Percentage of participants with MINS Measurement Tool/Parameter: High-sensitivity cardiac troponin T (hs-cTnT)
7 secondary outcomes
Change in High-Sensitivity Cardiac Troponin T Concentration
Time frame: Preoperative baseline, 1 hour after surgery, and 48 hours after surgery
Peak Postoperative hs-cTnT Concentration
Time frame: Within 48 hours after surgery
Association Between Age and MINS
Time frame: Preoperative assessment through 48 hours after surgery
Association Between Body Mass Index and MINS
Time frame: Preoperative assessment through 48 hours after surgery
Association Between ASA Physical Status and MINS
Time frame: Preoperative assessment through 48 hours after surgery
Association Between Congestive Heart Failure and MINS
Time frame: Preoperative assessment through 48 hours after surgery
Association Between Hypertension and MINS
Time frame: Preoperative assessment through 48 hours after surgery
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 28 Oct 2026.
- Background: PubMed 34601955Ruetzler K, Smilowitz NR, Berger JS, Devereaux PJ, Maron BA, Newby LK, de Jesus Perez V, Sessler DI, Wijeysundera DN. Diagnosis and Management of Patients With Myocardial Injury After Noncardiac Surgery: A Scientific Statement From the American Heart Association. Circulation. 2021 Nov 9;144(19):e287-e305. doi: 10.1161/CIR.0000000000001024. Epub 2021 Oct 4.
- Individual participant dataSharing planned: No. Individual participant data will not be publicly shared. De-identified data may be made available from the corresponding author upon reasonable request and subject to institutional and ethical approval.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
The record lists no contact. Use the official record to reach the sponsor.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
An observational study of Myocardial Injury After Noncardiac Surgery (MINS), run by Haseki Training and Research Hospital at 1 site in Turkey (Türkiye).
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 4 inclusion and 9 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 28 Oct 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Turkey (Türkiye). Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Incidence of Myocardial Injury After Noncardiac Surgery (MINS) (time frame: Within 48 hours after surgery). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT07900035, which also lists 1 linked publication.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 28 Oct 2026.