PeriodontitisNCT07900802
Comparing Aloe Vera Gel and Clindamycin Gel Added to Scaling and Root Planing for Periodontitis
A study testing Scaling and Root Planing in people with Periodontitis and Clindamycin Gel, run by Suez Canal University at 1 site in Egypt.
Trial summary
Periodontitis is an inflammatory disease affecting the tissues that support the teeth. Scaling and root planing is a standard nonsurgical treatment, but additional local treatments may help improve clinical periodontal outcomes and reduce bacterial load. Read more about this study
- Who is it for?
- Ages 20 to 45 yearsHealthy volunteers can take part
- Conditions the study is for
- Periodontitis, Clindamycin Gel, Aloe Vera Gel
- What is being tested?
- Scaling and Root Planing
- Type of treatment
- Pill or oral medicine, Injection or infusion, Surgery or procedure
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 30 participants
- Where
- 1 siteEgypt
- Study dates
- 12 Apr 2023to 15 Aug 2026
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 20 to 45 years
- All sexes
- Healthy volunteers accepted
- Adult
Who may be able to join
- Adults aged 20 to 45 years.
- Both sexes.
- Systemically healthy individuals.
- At least 20 natural teeth.
- Periodontal pockets measuring 4-5 mm.
- Participants diagnosed with Stage II, Grade B periodontitis.
Who cannot join
- Systemic conditions that may adversely affect periodontal status, including diabetes mellitus, hypertension, and atherosclerosis.
- Periodontal treatment within the previous 6 months.
- Antimicrobial therapy within the previous 3 months.
- Smoking or alcoholism.
- Pregnancy or lactation.
- Parafunctional habits.
Trial locations and contacts
1 site in 1 country.
Egypt1 site
Suez Canal University, Faculty of Dentistry
Ismailia, Ismailia/Alsalam, 41511
About this study
Official title: Clinical and Microbiological Evaluation of Aloe Vera Gel and Clindamycin Gel as an Adjunct to Non-Surgical Treatment of Periodontitis: A Comparative Study
Periodontitis is an inflammatory disease affecting the tissues that support the teeth. Scaling and root planing is a standard nonsurgical treatment, but additional local treatments may help improve clinical periodontal outcomes and reduce bacterial load. This study compared scaling and root planing alone with scaling and root planing combined with locally applied Aloe vera gel or clindamycin gel in adults with periodontitis. The study evaluated clinical periodontal parameters and anaerobic bacterial counts at baseline and at 1 and 3 months after treatment. The objective was to compare the clinical and microbiological outcomes of the three treatment approaches.
Read the detailed description
This single-blind, three-arm clinical study evaluated the clinical and microbiological outcomes of locally applied Aloe vera gel and clindamycin gel as adjuncts to nonsurgical periodontal therapy.
The study included 30 adults aged 20-45 years with periodontitis, comprising 10 participants in each treatment arm. Participants were selected from the Periodontology Clinic, Faculty of Dentistry, Suez Canal University, Egypt. All participants received full-mouth scaling and root planing using manual and ultrasonic instrumentation as appropriate, together with oral hygiene instructions.
The three treatment arms were scaling and root planing alone, scaling and root planing combined with local application of Aloe vera gel, and scaling and root planing combined with local application of 2% clindamycin gel. The gels were applied subgingivally into the periodontal pockets using a blunt syringe.
Clinical periodontal assessments included plaque index, gingival index, probing pocket depth, and clinical attachment level. Gingival crevicular fluid samples were collected for microbiological assessment of anaerobic bacterial counts using culture methods.
Clinical and microbiological assessments were performed at baseline and at 1 and 3 months after treatment. The study was approved by the Research Ethics Committee, Faculty of Dentistry, Suez Canal University (approval number 522/2022). Written informed consent was obtained from participants before study procedures.
- Being tested
- Scaling and Root Planing
- Keywords
- Periodontitis; Aloe vera gel; Clindamycin gel; Scaling and root planing; Clinical attachment level; Probing pocket depth; Anaerobic bacteria
- Medical subject headings
- Periodontitis
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Scaling and Root PlaningProcedure or surgery
Participants received full-mouth scaling and root planing using manual and ultrasonic instrumentation as appropriate, together with oral hygiene instructions.
| Study group | Role | What they receive |
|---|---|---|
| Scaling and Root Planing Alone | Active comparator | Participants received full-mouth scaling and root planing using manual and ultrasonic instrumentation as appropriate, together with oral hygiene instructions. No adjunctive Aloe vera or clindamycin gel was applied. Receives: Procedure: Scaling and Root Planing |
| Aloe Vera Gel Plus Scaling and Root Planing | Active comparator | Locally prepared Aloe vera gel was applied subgingivally into the periodontal pockets using a blunt syringe to fill the sulcus to its deepest point following scaling and root planing. The thesis describes Aloe vera leaf extract with hydroxypropyl methylcellulose and preservatives in the formulation. Receives: Procedure: Scaling and Root Planing |
| Clindamycin Gel Plus Scaling and Root Planing | Active comparator | Locally prepared 2% clindamycin gel was applied subgingivally into the periodontal pockets using a blunt syringe following scaling and root planing. The thesis describes a carboxymethylcellulose-based gel formulation. Receives: Procedure: Scaling and Root Planing |
What is being measured
The primary outcome is the main question the study is designed to answer.
Change in Clinical Attachment Level
Change in clinical attachment level (CAL), measured in millimeters from the cementoenamel junction to the base of the periodontal pocket. Measurements were obtained using a periodontal probe and a customized acrylic stent to improve reproducibility.
Measured: Baseline, 1 month and 3 months after treatment.
Change in Probing Pocket Depth
Change in probing pocket depth (PPD), measured in millimeters from the free gingival margin to the base of the periodontal pocket using a UNC-15 periodontal probe and a customized acrylic stent.
Measured: Baseline, 1 month and 3 months after treatment.
Secondary outcomes (3)
Anaerobic bacterial count
Change in anaerobic bacterial colony-forming units measured by culture of gingival crevicular fluid samples
Measured: Baseline, 1 month, and 3 months
Change in plaque index score
Plaque Index (PI) Score, ranging from 0 to 3, with higher scores indicating a worse outcome (greater plaque accumulation).
Measured: Baseline, 1 month, and 3 months
Change in gingival index score
Gingival Index (GI) Score, ranging from 0 to 3, with higher scores indicating a worse outcome (greater gingival inflammation).
Measured: Baseline, 1 month, and 3 months
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted28 Oct 2026
- Study start12 Apr 2023
- Primary completion10 Aug 2026
- Study completion15 Aug 2026
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for PeriodontitisStudies of the same condition, open and under way.
- More trials run by Suez Canal UniversityThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Enrolment
- 30 participants (actual)
Sponsor and investigators
- Lead sponsor
- Suez Canal University
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, fatma alzahraa, Suez Canal University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07900802
- Sponsor's protocol ID
- 522/2022
- Status last verified
- Oct 2026
- First submitted
- 21 Oct 2026
- Last updated
- 2 Nov 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- Undecided
Study at a glance
From the registry record, last updated by the sponsor on 2 Nov 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Clinical and Microbiological Evaluation of Aloe Vera Gel and Clindamycin Gel as an Adjunct to Non-Surgical Treatment of Periodontitis: A Comparative Study
- ClinicalTrials.gov ID
- NCT07900802
- Acronym / sponsor ID
- 522/2022
- Keywords
- Periodontitis; Aloe vera gel; Clindamycin gel; Scaling and root planing; Clinical attachment level; Probing pocket depth; Anaerobic bacteria
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 30 participants (actual)
- Lead sponsor
- Suez Canal UniversityUniversity, hospital or other
- Study start
- 12 Apr 2023 (actual)
- Primary completion
- 10 Aug 2026 (actual)
- Study completion
- 15 Aug 2026 (actual)
- First posted
- 28 Oct 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
Periodontitis is an inflammatory disease affecting the tissues that support the teeth. Scaling and root planing is a standard nonsurgical treatment, but additional local treatments may help improve clinical periodontal outcomes and reduce bacterial load. This study compared scaling and root planing alone with scaling and root planing combined with locally applied Aloe vera gel or clindamycin gel in adults with periodontitis. The study evaluated clinical periodontal parameters and anaerobic bacterial counts at baseline and at 1 and 3 months after treatment. The objective was to compare the clinical and microbiological outcomes of the three treatment approaches.
Detailed description
This single-blind, three-arm clinical study evaluated the clinical and microbiological outcomes of locally applied Aloe vera gel and clindamycin gel as adjuncts to nonsurgical periodontal therapy.
The study included 30 adults aged 20-45 years with periodontitis, comprising 10 participants in each treatment arm. Participants were selected from the Periodontology Clinic, Faculty of Dentistry, Suez Canal University, Egypt. All participants received full-mouth scaling and root planing using manual and ultrasonic instrumentation as appropriate, together with oral hygiene instructions.
The three treatment arms were scaling and root planing alone, scaling and root planing combined with local application of Aloe vera gel, and scaling and root planing combined with local application of 2% clindamycin gel. The gels were applied subgingivally into the periodontal pockets using a blunt syringe.
Clinical periodontal assessments included plaque index, gingival index, probing pocket depth, and clinical attachment level. Gingival crevicular fluid samples were collected for microbiological assessment of anaerobic bacterial counts using culture methods.
Clinical and microbiological assessments were performed at baseline and at 1 and 3 months after treatment. The study was approved by the Research Ethics Committee, Faculty of Dentistry, Suez Canal University (approval number 522/2022). Written informed consent was obtained from participants before study procedures.
Study design
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Number of arms
- 3
| Arm | Type | Receives |
|---|---|---|
| Scaling and Root Planing Alone | Active comparator | Procedure: Scaling and Root PlaningParticipants received full-mouth scaling and root planing using manual and ultrasonic instrumentation as appropriate, together with oral hygiene instructions. No adjunctive Aloe vera or clindamycin gel was applied. |
| Aloe Vera Gel Plus Scaling and Root Planing | Active comparator | Procedure: Scaling and Root PlaningLocally prepared Aloe vera gel was applied subgingivally into the periodontal pockets using a blunt syringe to fill the sulcus to its deepest point following scaling and root planing. The thesis describes Aloe vera leaf extract with hydroxypropyl methylcellulose and preservatives in the formulation. |
| Clindamycin Gel Plus Scaling and Root Planing | Active comparator | Procedure: Scaling and Root PlaningLocally prepared 2% clindamycin gel was applied subgingivally into the periodontal pockets using a blunt syringe following scaling and root planing. The thesis describes a carboxymethylcellulose-based gel formulation. |
Who may qualify
- Ages
- 20 to 45 years
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Adult
Key inclusion criteria (6 listed)
- Adults aged 20 to 45 years.
- Both sexes.
- Systemically healthy individuals.
- At least 20 natural teeth.
- Periodontal pockets measuring 4-5 mm.
Key exclusion criteria (6 listed)
- Systemic conditions that may adversely affect periodontal status, including diabetes mellitus, hypertension, and atherosclerosis.
- Periodontal treatment within the previous 6 months.
- Antimicrobial therapy within the previous 3 months.
- Smoking or alcoholism.
- Pregnancy or lactation.
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Scaling and Root PlaningParticipants received full-mouth scaling and root planing using manual and ultrasonic instrumentation as appropriate, together with oral hygiene instructions. | Procedure or surgery | Aloe Vera Gel Plus Scaling and Root Planing, Clindamycin Gel Plus Scaling and Root Planing, Scaling and Root Planing Alone |
Primary outcome
Change in Clinical Attachment Level
Time frame: Baseline, 1 month and 3 months after treatment.
Change in clinical attachment level (CAL), measured in millimeters from the cementoenamel junction to the base of the periodontal pocket. Measurements were obtained using a periodontal probe and a customized acrylic stent to improve reproducibility.
Change in Probing Pocket Depth
Time frame: Baseline, 1 month and 3 months after treatment.
Change in probing pocket depth (PPD), measured in millimeters from the free gingival margin to the base of the periodontal pocket using a UNC-15 periodontal probe and a customized acrylic stent.
3 secondary outcomes
Anaerobic bacterial count
Time frame: Baseline, 1 month, and 3 months
Change in plaque index score
Time frame: Baseline, 1 month, and 3 months
Change in gingival index score
Time frame: Baseline, 1 month, and 3 months
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 2 Nov 2026.
- Individual participant dataSharing planned: Undecided
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
The record lists no contact. Use the official record to reach the sponsor.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Scaling and Root Planing in people with Periodontitis and Clindamycin Gel, run by Suez Canal University at 1 site in Egypt.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 6 inclusion and 6 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 2 Nov 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Egypt. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Change in Clinical Attachment Level (time frame: Baseline, 1 month and 3 months after treatment.). The study lists 2 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 2 Nov 2026.