Oxidative StressNCT07904598
Turmeric Extract and Oxidative Stress in Muaythai Athletes and Sedentary Men
A study testing Turmeric Extract and Structured Muaythai Training in people with Oxidative Stress, run by Sinan Ağlar at 1 site in Turkey (Türkiye).
Trial summary
This study examined whether taking turmeric extract for 28 days affects oxidative stress and antioxidant defenses in healthy men who practice Muaythai and men who do not exercise regularly. Oxidative stress occurs when reactive molecules exceed the body's protective defenses and can damage cells. Read more about this study
- Who is it for?
- Ages 18 to 25 years, men onlyHealthy volunteers can take part
- Conditions the study is for
- Oxidative Stress
- What is being tested?
- Turmeric Extract and Structured Muaythai Training
- Type of treatment
- Pill or oral medicine, Lifestyle or therapy programme
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 44 participants
- Where
- 1 siteTurkey (Türkiye)
- Study dates
- 15 Jan 2025to 15 Feb 2025
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 25 years
- Men only
- Healthy volunteers accepted
- Adult
Who may be able to join
- Healthy men aged 18-25 years residing in Van, Türkiye.
- Non-smokers and non-drinkers.
- Provision of written informed consent.
- For the Muaythai groups: regular Muaythai practice for at least eight years, training six days per week, and placement among the top three in a Turkish national championship or selection for the national team.
- For the sedentary groups: no sports background and no regular exercise participation.
Who cannot join
- Failure to meet the inclusion criteria.
- Allergic reactions to turmeric identified during pre-supplementation allergy screening in participants considered for the supplementation groups.
Trial locations and contacts
1 site in 1 country.
Turkey (Türkiye)1 site
Van Yuzuncu Yil University, Faculty of Science, Biochemistry Laboratory
Van, Van, 65100
About this study
Official title: Determination of Oxidative Stress Levels and Some Antioxidant Activities in Muaythai Athletes Using Turmeric Extract
This study examined whether taking turmeric extract for 28 days affects oxidative stress and antioxidant defenses in healthy men who practice Muaythai and men who do not exercise regularly. Oxidative stress occurs when reactive molecules exceed the body's protective defenses and can damage cells.
The study included 44 healthy men aged 18-25 years in four groups of 11: Muaythai athletes without supplementation, Muaythai athletes taking turmeric extract, men who did not exercise regularly and received no supplementation, and men who did not exercise regularly and took turmeric extract. Participants were first categorized as Muaythai athletes or sedentary individuals according to their physical activity status. Within each category, participants were randomly allocated to the turmeric supplementation group or the control group using a lottery method.
The supplementation groups received 400 mg of turmeric extract daily for 28 days. The athlete groups followed a structured Muaythai training program. Blood samples were collected on Day 1 and Day 28 to measure malondialdehyde, a marker of oxidative stress, and catalase and reduced glutathione, which are involved in the body's antioxidant defenses. Changes over time were evaluated within and between groups.
Read the detailed description
To minimize the acute effects of exercise on oxidative stress and biochemical parameters, all participants underwent a three-day period of complete rest before each blood sampling session. Venous blood samples were collected at baseline (Day 1) and at the end of the intervention (Day 28).
- Conditions
- Oxidative Stress
- Being tested
- Turmeric Extract, Structured Muaythai Training
- Keywords
- Muaythai, Turmeric Extract, Antioxidants, Malondialdehyde, Catalase, Glutathione
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Turmeric ExtractDietary supplement
Participants in the Muaythai plus turmeric and sedentary plus turmeric groups received one capsule containing 400 mg of turmeric root extract (Solgar), standardized to 93% total curcuminoids (372 mg), once daily after the evening meal for 28 days.
Structured Muaythai TrainingBehavioural
Participants in both Muaythai athlete groups followed a structured Muaythai training program based on progressive overload for 28 days.
| Study group | Role | What they receive |
|---|---|---|
| Muaythai Control Group | Active comparator | Eleven male Muaythai athletes aged 18-25 years followed a structured Muaythai training program for 28 days without turmeric supplementation. Blood samples were collected on Days 1 and 28. Receives: Behavioral: Structured Muaythai Training |
| Muaythai Plus Turmeric Group | Experimental | Eleven male Muaythai athletes aged 18-25 years received 400 mg of turmeric extract daily for 28 days and followed a structured Muaythai training program. Blood samples were collected on Days 1 and 28. Receives: Dietary Supplement: Turmeric Extract; Behavioral: Structured Muaythai Training |
| Sedentary Control Group | No intervention | Eleven healthy sedentary men aged 18-25 years received no turmeric supplementation and did not participate in the structured Muaythai training program during the 28-day study. Blood samples were collected on Days 1 and 28. |
| Sedentary Plus Turmeric Group | Experimental | Eleven healthy sedentary men aged 18-25 years received 400 mg of turmeric extract daily for 28 days and did not participate in the structured Muaythai training program. Blood samples were collected on Days 1 and 28. Receives: Dietary Supplement: Turmeric Extract |
What is being measured
The primary outcome is the main question the study is designed to answer.
Change in malondialdehyde (MDA) level
Change in blood malondialdehyde (MDA) level from Day 1 to Day 28, measured spectrophotometrically and expressed in µmol/L.
Measured: Baseline (Day 1) and Day 28
Change in catalase (CAT) activity
Change in blood catalase (CAT) activity from Day 1 to Day 28, measured spectrophotometrically and expressed in U/mL.
Measured: Baseline (Day 1) and Day 28
Change in reduced glutathione (GSH) level
Change in blood reduced glutathione (GSH) level from Day 1 to Day 28, measured spectrophotometrically and expressed in µmol/L.
Measured: Baseline (Day 1) and Day 28
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted29 Oct 2026
- Study start15 Jan 2025
- Primary completion15 Feb 2025
- Study completion15 Feb 2025
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Oxidative StressStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Basic science
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Model description
- Four parallel groups of 11 participants each were studied: Muaythai athletes without supplementation, Muaythai athletes receiving turmeric extract, sedentary men without supplementation, and sedentary men receiving turmeric extract. Supplementation consisted of 400 mg of turmeric extract daily for 28 days. Participants remained in their respective groups throughout the study. Blood samples were collected on Days 1 and 28.
- Masking
- None (open label)
- Enrolment
- 44 participants (actual)
Sponsor and investigators
- Lead sponsor
- Sinan Ağlar
- Sponsor type
- Other government
- Responsible party
- Sponsor-investigator, Sinan Ağlar, Ministry of National Education, Turkey
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07904598
- Sponsor's protocol ID
- AGLAR-MUAYTHAI-001
- Status last verified
- Oct 2026
- First submitted
- 23 Oct 2026
- Last updated
- 3 Nov 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- Undecided: A decision on sharing de-identified individual participant data has not yet been made.
Study at a glance
From the registry record, last updated by the sponsor on 3 Nov 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Determination of Oxidative Stress Levels and Some Antioxidant Activities in Muaythai Athletes Using Turmeric Extract
- ClinicalTrials.gov ID
- NCT07904598
- Acronym / sponsor ID
- AGLAR-MUAYTHAI-001
- Conditions
- Oxidative Stress
- Keywords
- Muaythai, Turmeric Extract, Antioxidants, Malondialdehyde, Catalase, Glutathione
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 44 participants (actual)
- Lead sponsor
- Sinan AğlarOther government
- Study start
- 15 Jan 2025 (actual)
- Primary completion
- 15 Feb 2025 (actual)
- Study completion
- 15 Feb 2025 (actual)
- First posted
- 29 Oct 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
This study examined whether taking turmeric extract for 28 days affects oxidative stress and antioxidant defenses in healthy men who practice Muaythai and men who do not exercise regularly. Oxidative stress occurs when reactive molecules exceed the body's protective defenses and can damage cells.
The study included 44 healthy men aged 18-25 years in four groups of 11: Muaythai athletes without supplementation, Muaythai athletes taking turmeric extract, men who did not exercise regularly and received no supplementation, and men who did not exercise regularly and took turmeric extract. Participants were first categorized as Muaythai athletes or sedentary individuals according to their physical activity status. Within each category, participants were randomly allocated to the turmeric supplementation group or the control group using a lottery method.
The supplementation groups received 400 mg of turmeric extract daily for 28 days. The athlete groups followed a structured Muaythai training program. Blood samples were collected on Day 1 and Day 28 to measure malondialdehyde, a marker of oxidative stress, and catalase and reduced glutathione, which are involved in the body's antioxidant defenses. Changes over time were evaluated within and between groups.
Detailed description
To minimize the acute effects of exercise on oxidative stress and biochemical parameters, all participants underwent a three-day period of complete rest before each blood sampling session. Venous blood samples were collected at baseline (Day 1) and at the end of the intervention (Day 28).
Study design
- Primary purpose
- Basic science
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Number of arms
- 4
- Model description
- Four parallel groups of 11 participants each were studied: Muaythai athletes without supplementation, Muaythai athletes receiving turmeric extract, sedentary men without supplementation, and sedentary men receiving turmeric extract. Supplementation consisted of 400 mg of turmeric extract daily for 28 days. Participants remained in their respective groups throughout the study. Blood samples were collected on Days 1 and 28.
| Arm | Type | Receives |
|---|---|---|
| Muaythai Control Group | Active comparator | Behavioral: Structured Muaythai TrainingEleven male Muaythai athletes aged 18-25 years followed a structured Muaythai training program for 28 days without turmeric supplementation. Blood samples were collected on Days 1 and 28. |
| Muaythai Plus Turmeric Group | Experimental | Dietary Supplement: Turmeric Extract, Behavioral: Structured Muaythai TrainingEleven male Muaythai athletes aged 18-25 years received 400 mg of turmeric extract daily for 28 days and followed a structured Muaythai training program. Blood samples were collected on Days 1 and 28. |
| Sedentary Control Group | No intervention | –Eleven healthy sedentary men aged 18-25 years received no turmeric supplementation and did not participate in the structured Muaythai training program during the 28-day study. Blood samples were collected on Days 1 and 28. |
| Sedentary Plus Turmeric Group | Experimental | Dietary Supplement: Turmeric ExtractEleven healthy sedentary men aged 18-25 years received 400 mg of turmeric extract daily for 28 days and did not participate in the structured Muaythai training program. Blood samples were collected on Days 1 and 28. |
Who may qualify
- Ages
- 18 to 25 years
- Sex
- Male only
- Healthy volunteers
- Accepted
- Age groups
- Adult
Key inclusion criteria (5 listed)
- Healthy men aged 18-25 years residing in Van, Türkiye.
- Non-smokers and non-drinkers.
- Provision of written informed consent.
- For the Muaythai groups: regular Muaythai practice for at least eight years, training six days per week, and placement among the top three in a Turkish national championship or selection for the national team.
- For the sedentary groups: no sports background and no regular exercise participation.
Key exclusion criteria (2 listed)
- Failure to meet the inclusion criteria.
- Allergic reactions to turmeric identified during pre-supplementation allergy screening in participants considered for the supplementation groups.
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Turmeric ExtractParticipants in the Muaythai plus turmeric and sedentary plus turmeric groups received one capsule containing 400 mg of turmeric root extract (Solgar), standardized to 93% total curcuminoids (372 mg), once daily after the evening meal for 28 days. | Dietary supplement | Muaythai Plus Turmeric Group, Sedentary Plus Turmeric Group |
| Structured Muaythai TrainingParticipants in both Muaythai athlete groups followed a structured Muaythai training program based on progressive overload for 28 days. | Behavioural | Muaythai Control Group, Muaythai Plus Turmeric Group |
Primary outcome
Change in malondialdehyde (MDA) level
Time frame: Baseline (Day 1) and Day 28
Change in blood malondialdehyde (MDA) level from Day 1 to Day 28, measured spectrophotometrically and expressed in µmol/L.
Change in catalase (CAT) activity
Time frame: Baseline (Day 1) and Day 28
Change in blood catalase (CAT) activity from Day 1 to Day 28, measured spectrophotometrically and expressed in U/mL.
Change in reduced glutathione (GSH) level
Time frame: Baseline (Day 1) and Day 28
Change in blood reduced glutathione (GSH) level from Day 1 to Day 28, measured spectrophotometrically and expressed in µmol/L.
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 3 Nov 2026.
- Individual participant dataSharing planned: Undecided. A decision on sharing de-identified individual participant data has not yet been made.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
The record lists no contact. Use the official record to reach the sponsor.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Turmeric Extract and Structured Muaythai Training in people with Oxidative Stress, run by Sinan Ağlar at 1 site in Turkey (Türkiye).
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 5 inclusion and 2 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 3 Nov 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Turkey (Türkiye). Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Change in malondialdehyde (MDA) level (time frame: Baseline (Day 1) and Day 28). The study lists 3 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 3 Nov 2026.