Acute Kidney InjuryTROP-AKINCT07907887
Evaluation of Postoperative Organ Injury, Risk Factors, and Short-Term Clinical Outcomes in Patients Admitted to Intensive Care After Noncardiac Surgery
An observational study of Acute Kidney Injury and Postoperative Complications, run by Ankara Training and Research Hospital at 1 site in Turkey (Türkiye).
Trial summary
This retrospective observational study examines whether troponin levels measured before surgery are associated with acute kidney injury during the first 48 hours after surgery in patients admitted to intensive care after noncardiac surgery. Troponin is a protein measured in blood that can indicate heart muscle injury. Read more about this study
- Who is it for?
- Ages 18 years and older
- Conditions the study is for
- Acute Kidney Injury, Postoperative Complications
- How many people
- 224 participants
- Where
- 1 siteTurkey (Türkiye)
- Study dates
- 1 Jun 2024to 30 Sep 2026
- Phase
- Observational
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 years and older
- All sexes
- No healthy volunteers
- Adult, Older adult
Study population: Adults aged 18 years or older who were admitted to the intensive care unit at Ankara Training and Research Hospital after emergency or elective noncardiac surgery and had preoperative troponin measurements and postoperative kidney function data available in their medical records. The retrospective cohort comprises 224 unique patients, including patients with chronic kidney disease.
Who may be able to join
- Age 18 years or older at the time of surgery.
- Undergoing emergency or elective noncardiac surgery followed by admission to the intensive care unit.
- Availability of a preoperative troponin measurement.
- Availability of preoperative serum creatinine and postoperative kidney function data sufficient to assess acute kidney injury within the first 48 postoperative hours.
Who cannot join
- Age younger than 18 years.
- Cardiac surgery.
- Insufficient medical record data to assess the primary outcome.
- Duplicate records from the same patient.
Trial locations and contacts
1 site in 1 country.
Turkey (Türkiye)1 site
Ankara Training and Research Hospital
Ankara, Ankara, 06800
About this study
This retrospective observational study examines whether troponin levels measured before surgery are associated with acute kidney injury during the first 48 hours after surgery in patients admitted to intensive care after noncardiac surgery. Troponin is a protein measured in blood that can indicate heart muscle injury. Acute kidney injury is a sudden decline in kidney function.
Existing medical records from 224 patients who underwent emergency or elective surgery will be reviewed. Kidney injury will be assessed using changes in blood creatinine levels and the need for dialysis or other kidney replacement therapy. The study will also examine changes in troponin levels around surgery, length of stay, and survival during hospitalization. No additional tests or treatments are performed for this study.
Read the detailed description
This single-center retrospective cohort study uses routinely collected clinical records of patients admitted to intensive care after noncardiac surgery who have available preoperative troponin measurements and postoperative kidney function data. Both emergency and elective procedures are included, and patients with chronic kidney disease are retained.
The primary objective is to evaluate the association between preoperative troponin concentration and acute kidney injury identified within 48 hours after surgery. Acute kidney injury is assessed using the serum creatinine and renal replacement therapy components of the Kidney Disease: Improving Global Outcomes criteria. Urine output criteria are not used because reliable retrospective measurements are unavailable.
Preoperative troponin is evaluated as a continuous variable and according to the laboratory upper reference limit. The main adjusted analysis accounts for age, Charlson Comorbidity Index, baseline serum creatinine, and surgical urgency. A sensitivity analysis considers chronic kidney disease status in place of baseline creatinine.
Exploratory analyses examine patterns defined by preoperative and first 24-hour postoperative troponin measurements and their association with acute kidney injury. Because troponin and creatinine measurement windows may overlap, these analyses assess associations without assuming that troponin elevation preceded kidney injury. Additional outcomes include acute kidney injury severity, renal replacement therapy, intensive care and hospital length of stay, and intensive care and hospital mortality.
The study involves no assigned intervention or additional diagnostic testing. Registration is being completed retrospectively after data collection and analysis.
- Conditions
- Acute Kidney Injury, Postoperative Complications
- Keywords
- Preoperative Troponin, Troponin T, Noncardiac Surgery, Postoperative Intensive Care, Retrospective Cohort Study
- Medical subject headings
- Acute Kidney Injury, Postoperative Complications
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
| Study group | Role | What they receive |
|---|---|---|
| Noncardiac Surgery ICU Cohort | Patients admitted to intensive care after emergency or elective noncardiac surgery who had preoperative troponin measurements and postoperative kidney function data available in their medical records. This retrospective cohort includes 224 patients. Patients with chronic kidney disease are included. No intervention was assigned as part of the study. |
What is being measured
The primary outcome is the main question the study is designed to answer.
Acute Kidney Injury Within 48 Hours After Surgery
Occurrence of acute kidney injury, defined by an increase in serum creatinine of at least 0.3 mg/dL within 48 hours, an increase to at least 1.5 times the preoperative baseline within the observed 48-hour period, or initiation of renal replacement therapy. Assessment uses the serum creatinine and renal replacement therapy components of KDIGO criteria. Urine output criteria are not used because reliable retrospective data are unavailable.
Measured: From completion of surgery through 48 hours postoperatively.
Secondary outcomes (1)
Severity of Acute Kidney Injury Within 48 Hours After Surgery
Highest acute kidney injury stage reached within the first 48 postoperative hours, classified as KDIGO stage 1, 2, or 3 using available serum creatinine measurements and renal replacement therapy data. Initiation of renal replacement therapy is classified as stage 3. Urine output criteria are not used.
Measured: From completion of surgery through 48 hours postoperatively.
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted30 Oct 2026
- Study start1 Jun 2024
- Primary completion1 Jun 2026
- Study completion30 Sep 2026
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Acute Kidney InjuryStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Observational
- Observational model
- Cohort
- Time perspective
- Retrospective
- Enrolment
- 224 participants (actual)
Sponsor and investigators
- Lead sponsor
- Ankara Training and Research Hospital
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Dilek Kuzukiran Kocatas, Ankara Training and Research Hospital
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07907887
- Sponsor's protocol ID
- E-26-1024
- Acronym
- TROP-AKI
- Status last verified
- Oct 2026
- First submitted
- 26 Oct 2026
- Last updated
- 30 Oct 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No: There is currently no plan to share individual participant data.
Study at a glance
From the registry record, last updated by the sponsor on 30 Oct 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Evaluation of Postoperative Organ Injury, Risk Factors, and Short-Term Clinical Outcomes in Patients Admitted to Intensive Care After Noncardiac Surgery
- ClinicalTrials.gov ID
- NCT07907887
- Acronym / sponsor ID
- TROP-AKI / E-26-1024
- Conditions
- Acute Kidney Injury, Postoperative Complications
- Keywords
- Preoperative Troponin, Troponin T, Noncardiac Surgery, Postoperative Intensive Care, Retrospective Cohort Study
- Study type
- Observational
- Recruitment status
- Completed
- Enrolment
- 224 participants (actual)
- Lead sponsor
- Ankara Training and Research HospitalUniversity, hospital or other
- Study start
- 1 Jun 2024 (actual)
- Primary completion
- 1 Jun 2026 (actual)
- Study completion
- 30 Sep 2026 (actual)
- First posted
- 30 Oct 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
This retrospective observational study examines whether troponin levels measured before surgery are associated with acute kidney injury during the first 48 hours after surgery in patients admitted to intensive care after noncardiac surgery. Troponin is a protein measured in blood that can indicate heart muscle injury. Acute kidney injury is a sudden decline in kidney function.
Existing medical records from 224 patients who underwent emergency or elective surgery will be reviewed. Kidney injury will be assessed using changes in blood creatinine levels and the need for dialysis or other kidney replacement therapy. The study will also examine changes in troponin levels around surgery, length of stay, and survival during hospitalization. No additional tests or treatments are performed for this study.
Detailed description
This single-center retrospective cohort study uses routinely collected clinical records of patients admitted to intensive care after noncardiac surgery who have available preoperative troponin measurements and postoperative kidney function data. Both emergency and elective procedures are included, and patients with chronic kidney disease are retained.
The primary objective is to evaluate the association between preoperative troponin concentration and acute kidney injury identified within 48 hours after surgery. Acute kidney injury is assessed using the serum creatinine and renal replacement therapy components of the Kidney Disease: Improving Global Outcomes criteria. Urine output criteria are not used because reliable retrospective measurements are unavailable.
Preoperative troponin is evaluated as a continuous variable and according to the laboratory upper reference limit. The main adjusted analysis accounts for age, Charlson Comorbidity Index, baseline serum creatinine, and surgical urgency. A sensitivity analysis considers chronic kidney disease status in place of baseline creatinine.
Exploratory analyses examine patterns defined by preoperative and first 24-hour postoperative troponin measurements and their association with acute kidney injury. Because troponin and creatinine measurement windows may overlap, these analyses assess associations without assuming that troponin elevation preceded kidney injury. Additional outcomes include acute kidney injury severity, renal replacement therapy, intensive care and hospital length of stay, and intensive care and hospital mortality.
The study involves no assigned intervention or additional diagnostic testing. Registration is being completed retrospectively after data collection and analysis.
Study design
- Observational model
- Cohort
- Time perspective
- Retrospective
- Number of arms
- 1
| Arm | Type | Receives |
|---|---|---|
| Noncardiac Surgery ICU Cohort | – | –Patients admitted to intensive care after emergency or elective noncardiac surgery who had preoperative troponin measurements and postoperative kidney function data available in their medical records. This retrospective cohort includes 224 patients. Patients with chronic kidney disease are included. No intervention was assigned as part of the study. |
Who may qualify
- Ages
- 18 years and older
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
- Study population
- Adults aged 18 years or older who were admitted to the intensive care unit at Ankara Training and Research Hospital after emergency or elective noncardiac surgery and had preoperative troponin measurements and postoperative kidney function data available in their medical records. The retrospective cohort comprises 224 unique patients, including patients with chronic kidney disease.
Key inclusion criteria (4 listed)
- Age 18 years or older at the time of surgery.
- Undergoing emergency or elective noncardiac surgery followed by admission to the intensive care unit.
- Availability of a preoperative troponin measurement.
- Availability of preoperative serum creatinine and postoperative kidney function data sufficient to assess acute kidney injury within the first 48 postoperative hours.
Key exclusion criteria (4 listed)
- Age younger than 18 years.
- Cardiac surgery.
- Insufficient medical record data to assess the primary outcome.
- Duplicate records from the same patient.
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Primary outcome
Acute Kidney Injury Within 48 Hours After Surgery
Time frame: From completion of surgery through 48 hours postoperatively.
Occurrence of acute kidney injury, defined by an increase in serum creatinine of at least 0.3 mg/dL within 48 hours, an increase to at least 1.5 times the preoperative baseline within the observed 48-hour period, or initiation of renal replacement therapy. Assessment uses the serum creatinine and renal replacement therapy components of KDIGO criteria. Urine output criteria are not used because reliable retrospective data are unavailable.
1 secondary outcome
Severity of Acute Kidney Injury Within 48 Hours After Surgery
Time frame: From completion of surgery through 48 hours postoperatively.
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 30 Oct 2026.
- Individual participant dataSharing planned: No. There is currently no plan to share individual participant data.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
The record lists no contact. Use the official record to reach the sponsor.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
An observational study of Acute Kidney Injury and Postoperative Complications, run by Ankara Training and Research Hospital at 1 site in Turkey (Türkiye).
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 4 inclusion and 4 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 30 Oct 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Turkey (Türkiye). Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Acute Kidney Injury Within 48 Hours After Surgery (time frame: From completion of surgery through 48 hours postoperatively.). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 30 Oct 2026.