Postoperative PainNCT07913633
Comparison Of Ultrasound Guided Transversus Abdominis Plane Block Versus Wound Infiltration With Local Anesthetics for Post Operative Analgesia
A study testing Ultrasound-Guided Transversus Abdominis Plane Block, Local Anesthetic Wound Infiltration and Bupivacaine in people with Postoperative Pain and Hernia, Inguinal, run by Mayo Hospital Lahore at 1 site in Pakistan.
Trial summary
This randomized controlled trial compared two methods of pain relief after inguinal hernia repair: an ultrasound-guided transversus abdominis plane (TAP) block and local anesthetic injection around the surgical wound. The study tested the hypothesis that average pain scores differed between the two methods. Read more about this study
- Who is it for?
- Ages 18 to 60 years, men only
- Conditions the study is for
- Postoperative Pain, Hernia, Inguinal
- What is being tested?
- Ultrasound-Guided Transversus Abdominis Plane Block, Local Anesthetic Wound Infiltration and Bupivacaine
- Type of treatment
- Injection or infusion, Surgery or procedure
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 80 participants
- Where
- 1 sitePakistan
- Study dates
- 1 Jan 2026to 30 Jun 2026
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 60 years
- Men only
- No healthy volunteers
- Adult
Who may be able to join
- Male patients aged 18-60 years.
- Patients undergoing elective inguinal hernia repair.
- American Society of Anesthesiologists physical status I or II.
Who cannot join
- Coagulopathies.
- Renal insufficiency.
- Congestive heart failure.
- Contraindications to local anesthetics.
- Chronic opioid dependence.
- Drug addiction.
- Body mass index greater than 35 kg/m².
Trial locations and contacts
1 site in 1 country.
About this study
Official title: Comparison Of Ultrasound Guided Transversus Abdominis Plane Block Versus Wound Infiltration With Local Anesthetics for Post Operative Analgesia After Inguinal Hernia Repair
This randomized controlled trial compared two methods of pain relief after inguinal hernia repair: an ultrasound-guided transversus abdominis plane (TAP) block and local anesthetic injection around the surgical wound. The study tested the hypothesis that average pain scores differed between the two methods.
The study was conducted in the Department of Anesthesia at King Edward Medical University/an affiliated hospital in Lahore. Eighty male patients aged 18-60 years who underwent planned inguinal hernia repair were included. Patients were randomly assigned by a lottery method to two groups of 40 patients each. One group received an ultrasound-guided TAP block, in which bupivacaine, a local anesthetic, was injected into a space between the abdominal muscle layers to numb the nerves supplying the surgical area. The other group received the same dose of bupivacaine injected into and around the wound margins. Both groups also received paracetamol and diclofenac for pain relief.
The main outcome was the average pain score four hours after treatment. Pain was assessed using a visual analogue scale ranging from 0 to 10, where 0 represented no pain and 10 represented the worst pain. Further pain assessments continued for up to 24 hours after surgery, and patients were monitored for complications related to either procedure.
- Conditions
- Postoperative Pain, Hernia, Inguinal
- Being tested
- Ultrasound-Guided Transversus Abdominis Plane Block, Local Anesthetic Wound Infiltration, Bupivacaine
- Keywords
- Ultrasound-Guided Transversus Abdominis Plane Block, Local Wound Infiltration, Bupivacaine, Inguinal Hernia Repair, Postoperative Analgesia
- Medical subject headings
- Pain, Postoperative, Hernia, Inguinal
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Ultrasound-Guided Transversus Abdominis Plane BlockProcedure or surgery
Under ultrasound guidance, a 25-gauge spinal needle was advanced using an in-plane approach into the plane between the internal oblique and transversus abdominis muscles. Bupivacaine was injected after identification of the target plane, and its spread was confirmed by ultrasound.
Local Anesthetic Wound InfiltrationProcedure or surgery
The surgeon injected bupivacaine into and around the surgical wound margins using a 20-mL syringe and a 25-gauge needle.
BupivacaineDrug
Bupivacaine, 0.5%, 1.5 mg/kg, administered into the transversus abdominis plane.
| Study group | Role | What they receive |
|---|---|---|
| Group A-Ultrasound-Guided Transversus Abdominis Plane Block | Experimental | Forty patients received an ultrasound-guided transversus abdominis plane block with 0.5% bupivacaine at a dose of 1.5 mg/kg immediately after completion of inguinal hernia repair. Receives: Procedure: Ultrasound-Guided Transversus Abdominis Plane Block; Drug: Bupivacaine |
| Group B-Local Anesthetic Wound Infiltration | Active comparator | Forty patients received wound infiltration with 0.5% bupivacaine at a dose of 1.5 mg/kg for pain relief after inguinal hernia repair. Receives: Procedure: Local Anesthetic Wound Infiltration; Drug: Bupivacaine |
What is being measured
The primary outcome is the main question the study is designed to answer.
Mean Pain Score at 4 Hours After Treatment
Postoperative pain was assessed using a visual analogue scale ranging from 0 to 10, where 0 represented no pain and 10 represented the worst pain. Higher scores indicated greater pain intensity. Mean pain scores were compared between patients who received an ultrasound-guided transversus abdominis plane block and those who received local anesthetic wound infiltration.
Measured: 4 Hours After Treatment
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted3 Nov 2026
- Study start1 Jan 2026
- Primary completion30 Jun 2026
- Study completion30 Jun 2026
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Postoperative PainStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Prevention
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Single blind
- Who is masked
- Participant
- Enrolment
- 80 participants (actual)
Sponsor and investigators
- Lead sponsor
- Mayo Hospital Lahore
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Adeel Ahmed, Mayo Hospital Lahore
- Investigators
- Sadia Ali, Principal investigator, Mayo Hospital Lahore
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07913633
- Sponsor's protocol ID
- Mayo11
- Status last verified
- Oct 2026
- First submitted
- 28 Oct 2026
- Last updated
- 3 Nov 2026
- Results posted
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
Study at a glance
From the registry record, last updated by the sponsor on 3 Nov 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Comparison Of Ultrasound Guided Transversus Abdominis Plane Block Versus Wound Infiltration With Local Anesthetics for Post Operative Analgesia After Inguinal Hernia Repair
- ClinicalTrials.gov ID
- NCT07913633
- Acronym / sponsor ID
- Mayo11
- Conditions
- Postoperative Pain, Hernia, Inguinal
- Keywords
- Ultrasound-Guided Transversus Abdominis Plane Block, Local Wound Infiltration, Bupivacaine, Inguinal Hernia Repair, Postoperative Analgesia
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 80 participants (actual)
- Lead sponsor
- Mayo Hospital LahoreUniversity, hospital or other
- Study start
- 1 Jan 2026 (actual)
- Primary completion
- 30 Jun 2026 (actual)
- Study completion
- 30 Jun 2026 (actual)
- First posted
- 3 Nov 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
This randomized controlled trial compared two methods of pain relief after inguinal hernia repair: an ultrasound-guided transversus abdominis plane (TAP) block and local anesthetic injection around the surgical wound. The study tested the hypothesis that average pain scores differed between the two methods.
The study was conducted in the Department of Anesthesia at King Edward Medical University/an affiliated hospital in Lahore. Eighty male patients aged 18-60 years who underwent planned inguinal hernia repair were included. Patients were randomly assigned by a lottery method to two groups of 40 patients each. One group received an ultrasound-guided TAP block, in which bupivacaine, a local anesthetic, was injected into a space between the abdominal muscle layers to numb the nerves supplying the surgical area. The other group received the same dose of bupivacaine injected into and around the wound margins. Both groups also received paracetamol and diclofenac for pain relief.
The main outcome was the average pain score four hours after treatment. Pain was assessed using a visual analogue scale ranging from 0 to 10, where 0 represented no pain and 10 represented the worst pain. Further pain assessments continued for up to 24 hours after surgery, and patients were monitored for complications related to either procedure.
Study design
- Primary purpose
- Prevention
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Single blind (participant)
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| Group A-Ultrasound-Guided Transversus Abdominis Plane Block | Experimental | Procedure: Ultrasound-Guided Transversus Abdominis Plane Block, Drug: BupivacaineForty patients received an ultrasound-guided transversus abdominis plane block with 0.5% bupivacaine at a dose of 1.5 mg/kg immediately after completion of inguinal hernia repair. |
| Group B-Local Anesthetic Wound Infiltration | Active comparator | Procedure: Local Anesthetic Wound Infiltration, Drug: BupivacaineForty patients received wound infiltration with 0.5% bupivacaine at a dose of 1.5 mg/kg for pain relief after inguinal hernia repair. |
Who may qualify
- Ages
- 18 to 60 years
- Sex
- Male only
- Healthy volunteers
- Not accepted
- Age groups
- Adult
Key inclusion criteria (3 listed)
- Male patients aged 18-60 years.
- Patients undergoing elective inguinal hernia repair.
- American Society of Anesthesiologists physical status I or II.
Key exclusion criteria (7 listed)
- Coagulopathies.
- Renal insufficiency.
- Congestive heart failure.
- Contraindications to local anesthetics.
- Chronic opioid dependence.
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Ultrasound-Guided Transversus Abdominis Plane BlockUnder ultrasound guidance, a 25-gauge spinal needle was advanced using an in-plane approach into the plane between the internal oblique and transversus abdominis muscles. Bupivacaine was injected after identification of the target plane, and its spread was confirmed by ultrasound. | Procedure or surgery | Group A-Ultrasound-Guided Transversus Abdominis Plane Block |
| Local Anesthetic Wound InfiltrationThe surgeon injected bupivacaine into and around the surgical wound margins using a 20-mL syringe and a 25-gauge needle. | Procedure or surgery | Group B-Local Anesthetic Wound Infiltration |
| BupivacaineBupivacaine, 0.5%, 1.5 mg/kg, administered into the transversus abdominis plane. | Drug | Group A-Ultrasound-Guided Transversus Abdominis Plane Block, Group B-Local Anesthetic Wound Infiltration |
Primary outcome
Mean Pain Score at 4 Hours After Treatment
Time frame: 4 Hours After Treatment
Postoperative pain was assessed using a visual analogue scale ranging from 0 to 10, where 0 represented no pain and 10 represented the worst pain. Higher scores indicated greater pain intensity. Mean pain scores were compared between patients who received an ultrasound-guided transversus abdominis plane block and those who received local anesthetic wound infiltration.
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 3 Nov 2026.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
Sadia Ali principal investigator
Mayo Hospital Lahore
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Ultrasound-Guided Transversus Abdominis Plane Block, Local Anesthetic Wound Infiltration and Bupivacaine in people with Postoperative Pain and Hernia, Inguinal, run by Mayo Hospital Lahore at 1 site in Pakistan.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 3 inclusion and 7 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 3 Nov 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Pakistan. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Mean Pain Score at 4 Hours After Treatment (time frame: 4 Hours After Treatment). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 3 Nov 2026.