Juvenile Idiopathic ArthritisInfraAJINCT07914179
The Use of Infrared Cameras for Detecting Juvenile Idiopathic Arthritis
A study testing standardized evaluation and single IRT session and a minimal blood test in people with Juvenile Idiopathic Arthritis and Infrared Thermography, run by Centre Hospitalier Universitaire, Amiens at 1 site in France.
Trial summary
Juvenile idiopathic arthritis (JIA) is the most common chronic rheumatic disease in children, causing persistent joint inflammation, pain, and functional impairment. Current monitoring relies on clinical scores, laboratory markers, and imaging, which are often resource intensive. Read more about this study
- Who is it for?
- Ages 2 to 16 years
- Conditions the study is for
- Juvenile Idiopathic Arthritis, Infrared Thermography, Joint Inflammation
- What is being tested?
- standardized evaluation and single IRT session and a minimal blood test
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 60 participants
- Where
- 1 siteFrance
- Study dates
- 24 Aug 2026to Oct 2028
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 2 to 16 years
- All sexes
- No healthy volunteers
- Child
Who may be able to join
- children aged 2-16 years with clinically suspected arthritis affecting the knee, ankle, wrist, or hand, irrespective of disease stage,
- control group : children with non-inflammatory conditions and no history of autoimmune or inflammatory disease.
Who cannot join
- other inflammatory or non-inflammatory diseases or recent trauma/surgery explaining joint symptoms,
- local skin conditions interfering with infrared imaging, and treatments or comorbidities likely to alter joint or body temperature.
Trial locations and contacts
1 site in 1 country. Contact the study team or a site near you to ask about taking part.
France1 site, 1 recruiting
- Recruiting
CHRU Amiens
Amiens, 80480
Djamal-Dine Djeddi, Pr, 33+322087632, djeddi.djamal-dine@chu-amiens.fr
Maud ULLMO ULLMO, MD
About this study
Juvenile idiopathic arthritis (JIA) is the most common chronic rheumatic disease in children, causing persistent joint inflammation, pain, and functional impairment. Current monitoring relies on clinical scores, laboratory markers, and imaging, which are often resource intensive. Infrared thermography (IRT) is a non-invasive, radiation-free method that detects skin temperature changes potentially reflecting joint inflammation. Evidence in pediatric populations is limited, but IRT could provide an objective, reproducible, and child-friendly tool. This study aims to evaluate IRT's diagnostic accuracy by comparing it with clinical scores, laboratory markers, and ultrasound Doppler, to assess its utility as a complementary monitoring tool.
Patients with JIA will undergo clinical examination, routine blood tests, and IRT at baseline, 1 month, and 3 months. Control patients will participate in a single IRT session and, a CRP/ESR/blood test; if a biological workup is already planned as part of their routine care, existing results will be collected, and no additional sampling will be performed. IRT will follow a standardized protocol, including an acclimatization period, predefined positioning, and acquisition of three consecutive images per joint. After completion of the study, JIA patients will resume their standard-of-care follow-up.
- Conditions
- Juvenile Idiopathic Arthritis, Infrared Thermography, Joint Inflammation, Diagnostic Imaging, Pediatrics
- Being tested
- standardized evaluation, single IRT session and a minimal blood test
- Keywords
- Juvenile idiopathic arthritis, Infrared thermography, Joint inflammation, Diagnostic imaging, Pediatrics, Case-control study
- Medical subject headings
- Arthritis, Juvenile, Arthritis
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
standardized evaluationOther
Patients with JIA will undergo a standardized evaluation including a clinical joint examination, routine blood tests (CRP, NFS, ionogram, liver function, coagulation), and IRT of selected joints
single IRT session and a minimal blood testOther
Control patients will undergo a single IRT session and a minimal blood test (CRP, ESP, blood count). IRT will be performed under controlled conditions with a defined joint positioning, 15-30 minutes of acclimatization, and acquisition of three consecutive images per joint.
| Study group | Role | What they receive |
|---|---|---|
| Patients with JIA | Experimental | Not described Receives: Other: standardized evaluation |
| Control patients | Active comparator | Not described Receives: Other: single IRT session and a minimal blood test |
What is being measured
The primary outcome is the main question the study is designed to answer.
variation of IRT measure between both groups
variation of IRT measure between both groups
Measured: at baseline
variation of IRT measure between both groups
variation of IRT measure between both groups
Measured: at 1 month
variation of IRT measure between both groups
variation of IRT measure between both groups
Measured: at 3 months
Secondary outcomes (8)
longitudinal changes in thermographic measurements
longitudinal changes in thermographic measurements by comparing temperature differences (ΔT) between baseline (D0) and 3 months
Measured: at 3 months
correlation of longitudinal changes in thermographic measurements with clinical parameters
Measured: at 3 months
correlation of longitudinal changes in thermographic measurements with functional parameters
Measured: at 3 months
correlation of longitudinal changes in thermographic measurements with biological parameters
Measured: at 3 months
correlation of diagnostic performance of IRT with clinical examination
Measured: at 3 months
correlation of diagnostic performance of IRT with ultrasounds
Measured: at 3 months
correlation of diagnostic performance of IRT with MRI
Measured: at 3 months
reproducibility of IRT measurements
Measured: at 3 months
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted3 Nov 2026
- Study start24 Aug 2026
- Primary completionAug 2028 (estimated)
- Study completionOct 2028 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Juvenile Idiopathic ArthritisStudies of the same condition, open and under way.
- More trials run by Centre Hospitalier Universitaire, AmiensThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Screening
- Allocation
- Non-randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Enrolment
- 60 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Centre Hospitalier Universitaire, Amiens
- Sponsor type
- University, hospital or other
- Responsible party
- Sponsor
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07914179
- Sponsor's protocol ID
- PI2026_843_0096
- Acronym
- InfraAJI
- Status last verified
- Oct 2026
- First submitted
- 13 Oct 2026
- Last updated
- 3 Nov 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Study at a glance
From the registry record, last updated by the sponsor on 3 Nov 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- The Use of Infrared Cameras for Detecting Juvenile Idiopathic Arthritis
- ClinicalTrials.gov ID
- NCT07914179
- Acronym / sponsor ID
- InfraAJI / PI2026_843_0096
- Conditions
- Juvenile Idiopathic Arthritis, Infrared Thermography, Joint Inflammation, Diagnostic Imaging, Pediatrics
- Keywords
- Juvenile idiopathic arthritis, Infrared thermography, Joint inflammation, Diagnostic imaging, Pediatrics, Case-control study
- Study type
- Interventional
- Recruitment status
- Recruiting
- Enrolment
- 60 participants (estimated)
- Lead sponsor
- Centre Hospitalier Universitaire, AmiensUniversity, hospital or other
- Study start
- 24 Aug 2026 (actual)
- Primary completion
- Aug 2028 (estimated)
- Study completion
- Oct 2028 (estimated)
- First posted
- 3 Nov 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
Juvenile idiopathic arthritis (JIA) is the most common chronic rheumatic disease in children, causing persistent joint inflammation, pain, and functional impairment. Current monitoring relies on clinical scores, laboratory markers, and imaging, which are often resource intensive. Infrared thermography (IRT) is a non-invasive, radiation-free method that detects skin temperature changes potentially reflecting joint inflammation. Evidence in pediatric populations is limited, but IRT could provide an objective, reproducible, and child-friendly tool. This study aims to evaluate IRT's diagnostic accuracy by comparing it with clinical scores, laboratory markers, and ultrasound Doppler, to assess its utility as a complementary monitoring tool.
Patients with JIA will undergo clinical examination, routine blood tests, and IRT at baseline, 1 month, and 3 months. Control patients will participate in a single IRT session and, a CRP/ESR/blood test; if a biological workup is already planned as part of their routine care, existing results will be collected, and no additional sampling will be performed. IRT will follow a standardized protocol, including an acclimatization period, predefined positioning, and acquisition of three consecutive images per joint. After completion of the study, JIA patients will resume their standard-of-care follow-up.
Study design
- Primary purpose
- Screening
- Allocation
- Non-randomised
- Intervention model
- Parallel groups
- Masking
- None (open label)
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| Patients with JIA | Experimental | Other: standardized evaluation |
| Control patients | Active comparator | Other: single IRT session and a minimal blood test |
Who may qualify
- Ages
- 2 to 16 years
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Child
Key inclusion criteria (2 listed)
- children aged 2-16 years with clinically suspected arthritis affecting the knee, ankle, wrist, or hand, irrespective of disease stage,
- control group : children with non-inflammatory conditions and no history of autoimmune or inflammatory disease.
Key exclusion criteria (2 listed)
- other inflammatory or non-inflammatory diseases or recent trauma/surgery explaining joint symptoms,
- local skin conditions interfering with infrared imaging, and treatments or comorbidities likely to alter joint or body temperature.
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| standardized evaluationPatients with JIA will undergo a standardized evaluation including a clinical joint examination, routine blood tests (CRP, NFS, ionogram, liver function, coagulation), and IRT of selected joints | Other | Patients with JIA |
| single IRT session and a minimal blood testControl patients will undergo a single IRT session and a minimal blood test (CRP, ESP, blood count). IRT will be performed under controlled conditions with a defined joint positioning, 15-30 minutes of acclimatization, and acquisition of three consecutive images per joint. | Other | Control patients |
Primary outcome
variation of IRT measure between both groups
Time frame: at baseline
variation of IRT measure between both groups
variation of IRT measure between both groups
Time frame: at 1 month
variation of IRT measure between both groups
variation of IRT measure between both groups
Time frame: at 3 months
variation of IRT measure between both groups
8 secondary outcomes
longitudinal changes in thermographic measurements
Time frame: at 3 months
correlation of longitudinal changes in thermographic measurements with clinical parameters
Time frame: at 3 months
correlation of longitudinal changes in thermographic measurements with functional parameters
Time frame: at 3 months
correlation of longitudinal changes in thermographic measurements with biological parameters
Time frame: at 3 months
correlation of diagnostic performance of IRT with clinical examination
Time frame: at 3 months
correlation of diagnostic performance of IRT with ultrasounds
Time frame: at 3 months
correlation of diagnostic performance of IRT with MRI
Time frame: at 3 months
reproducibility of IRT measurements
Time frame: at 3 months
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 3 Nov 2026.
- Individual participant dataSharing planned: No
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing standardized evaluation and single IRT session and a minimal blood test in people with Juvenile Idiopathic Arthritis and Infrared Thermography, run by Centre Hospitalier Universitaire, Amiens at 1 site in France.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 2 inclusion and 2 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: looking for participants now, as of the sponsor's last update on 3 Nov 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in France. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact Djamal-Dine DJEDDI, Pr (33+322035590, Djeddi.Djamal-Dine@chu-amiens.fr), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
variation of IRT measure between both groups (time frame: at baseline). The study lists 3 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 3 Nov 2026.