Myocardial BridgingNCT07916272
Coronary Myocardial Bridge and Coronary Plaques on MDCT
An observational study of Myocardial Bridging and Coronary Atherosclerosis, run by Sohag University at 1 site in Egypt.
Trial summary
Myocardial bridging is a condition in which a segment of a coronary artery passes through the heart muscle instead of running on its surface. This study aims to determine the prevalence of coronary myocardial bridging and investigate its relationship with coronary atherosclerotic plaques using multidetector computed… Read more about this study
- Who is it for?
- Any ageHealthy volunteers can take part
- Conditions the study is for
- Myocardial Bridging, Coronary Atherosclerosis
- How many people
- 50 participants
- Where
- 1 siteEgypt
- Study dates
- 20 Oct 2026to Aug 2027
- Phase
- Observational
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages Any age
- All sexes
- Healthy volunteers accepted
- Child, Adult, Older adult
Study population: The study population will consist of patients referred to the Diagnostic and Interventional Radiology Department at Sohag University Hospital and New Sohag University Hospital to undergo coronary CT angiography. At least 50 patients of both sexes, without age restrictions, will be included in this prospective observational study to assess the prevalence of coronary myocardial bridging and its relationship with coronary atherosclerotic plaques.
Who may be able to join
- All patients referred to the Radiology Department of Sohag University Hospital and New Sohag University Hospital for coronary CT angiography.
Who cannot join
- Patients with contraindications to CT examination due to radiation-related risks.
- Patients with known allergy to iodinated contrast media or impaired renal function (serum creatinine > 1.5 mg/dL or estimated glomerular filtration rate < 30 mL/min).
- Patients with heart rate or rhythm incompatible with electrocardiographically gated scanning (heart rate > 70 beats/min or uncontrolled atrial fibrillation).
- Patients with an Agatston calcium score > 400.
- Uncooperative patients or those who do not provide informed consent
Trial locations and contacts
1 site in 1 country. Contact the study team or a site near you to ask about taking part.
Egypt1 site, 1 recruiting
- Recruiting
Sohag University Hospital
Sohag, Sohag Governorate
Abdelaziz Aly, 201154419400, aliabdelazeez2@gmail.com
Amr Mostafa Kadry, 201005356935
About this study
Official title: The Prevalence of Coronary Myocardial Bridge on Multidetector Computed Tomography and Its Relation to Coronary Plaques
Myocardial bridging is a condition in which a segment of a coronary artery passes through the heart muscle instead of running on its surface. This study aims to determine the prevalence of coronary myocardial bridging and investigate its relationship with coronary atherosclerotic plaques using multidetector computed tomography coronary angiography (MDCT-CA).
The study will include at least 50 patients referred for coronary CT angiography at Sohag University Hospital and New Sohag University Hospital. CT images will be evaluated to identify myocardial bridges, determine their location, measure their length and depth, and assess the presence, location, and characteristics of coronary atherosclerotic plaques.
The findings will be analyzed to investigate the association between myocardial bridging and coronary atherosclerotic plaques.
Read the detailed description
Myocardial bridging is an anatomical variant characterized by an intramyocardial course of a segment of an epicardial coronary artery. Although it is frequently considered a benign finding, several studies have suggested an association between myocardial bridging and coronary atherosclerotic plaque formation, particularly in the coronary segment proximal to the bridged segment.
This prospective observational study aims to determine the prevalence of coronary myocardial bridging using multidetector computed tomography coronary angiography (MDCT-CA) and investigate its relationship with coronary atherosclerotic plaques.
The study will be conducted at the Diagnostic and Interventional Radiology Departments of Sohag University Hospital and New Sohag University Hospital. At least 50 patients referred for coronary CT angiography will be included, without age or sex restrictions.
Coronary CT angiography examinations will be performed using 128-row or 160-row multidetector CT scanners. The imaging protocol will include coronary calcium scoring and contrast-enhanced coronary CT angiography with electrocardiographic gating.
The coronary arteries, including the right coronary artery, left main coronary artery, left anterior descending artery, and left circumflex artery, will be evaluated for the presence of myocardial bridging and coronary atherosclerotic plaques.
For each detected myocardial bridge, the following parameters will be assessed:
- Involved coronary artery and anatomical location.
- Length of the bridged segment, measured from its entry into the myocardium to its re-emergence onto the epicardial surface.
- Depth of the myocardial bridge, measured as the maximum thickness of the overlying myocardial fibers.
Coronary atherosclerotic plaques will be assessed regarding their presence, location, and characteristics. The findings will subsequently be analyzed to investigate the relationship between myocardial bridging and coronary atherosclerotic plaques.
The collected data will be statistically analyzed to determine the prevalence of myocardial bridging and evaluate its association with coronary atherosclerotic plaques.
- Conditions
- Myocardial Bridging, Coronary Atherosclerosis
- Keywords
- Myocardial Bridge Myocardial Bridging Coronary Atherosclerotic Plaques Coronary CT Angiography Multidetector Computed Tomography MDCT
- Medical subject headings
- Myocardial Bridging, Coronary Artery Disease
What is being measured
The primary outcome is the main question the study is designed to answer.
Number of participants with Prevalence of Coronary Myocardial Bridging
Determination of the prevalence of coronary myocardial bridging among patients undergoing multidetector computed tomography coronary angiography (MDCT-CA), based on the identification of intramyocardial coronary artery segments.
Measured: Day 1 (At the time of coronary CT angiography examination"
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted4 Nov 2026
- Study start20 Oct 2026
- Primary completionJun 2027 (estimated)
- Study completionAug 2027 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (1)Papers the sponsor has linked to this study.
- Other trials for Myocardial BridgingStudies of the same condition, open and under way.
- More trials run by Sohag UniversityThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Observational
- Observational model
- Other
- Time perspective
- Prospective
- Enrolment
- 50 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Sohag University
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Abdelaziz Aly Mohamed, Sohag University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07916272
- Sponsor's protocol ID
- Soh-Med-26-10-13MS
- Status last verified
- Oct 2026
- First submitted
- 30 Oct 2026
- Last updated
- 4 Nov 2026
- Results posted
- No
- Data monitoring committee
- Yes
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No: Individual participant data will not be shared with other researchers to maintain patient confidentiality and protect personal information. Study results may be disseminated in scientific publications in aggregate form without identifying individual participants.
Publications
Rovera C, Moretti C, Bisanti F, De Zan G, Guglielmo M. Myocardial Bridging: Review on the Role of Coronary Computed Tomography Angiography. J Clin Med. 2023 Sep 13;12(18):5949. doi: 10.3390/jcm12185949.
PubMed 37762890
Study at a glance
From the registry record, last updated by the sponsor on 4 Nov 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- The Prevalence of Coronary Myocardial Bridge on Multidetector Computed Tomography and Its Relation to Coronary Plaques
- ClinicalTrials.gov ID
- NCT07916272
- Acronym / sponsor ID
- Soh-Med-26-10-13MS
- Conditions
- Myocardial Bridging, Coronary Atherosclerosis
- Keywords
- Myocardial Bridge Myocardial Bridging Coronary Atherosclerotic Plaques Coronary CT Angiography Multidetector Computed Tomography MDCT
- Study type
- Observational
- Recruitment status
- Recruiting
- Enrolment
- 50 participants (estimated)
- Lead sponsor
- Sohag UniversityUniversity, hospital or other
- Study start
- 20 Oct 2026 (actual)
- Primary completion
- Jun 2027 (estimated)
- Study completion
- Aug 2027 (estimated)
- First posted
- 4 Nov 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
Myocardial bridging is a condition in which a segment of a coronary artery passes through the heart muscle instead of running on its surface. This study aims to determine the prevalence of coronary myocardial bridging and investigate its relationship with coronary atherosclerotic plaques using multidetector computed tomography coronary angiography (MDCT-CA).
The study will include at least 50 patients referred for coronary CT angiography at Sohag University Hospital and New Sohag University Hospital. CT images will be evaluated to identify myocardial bridges, determine their location, measure their length and depth, and assess the presence, location, and characteristics of coronary atherosclerotic plaques.
The findings will be analyzed to investigate the association between myocardial bridging and coronary atherosclerotic plaques.
Detailed description
Myocardial bridging is an anatomical variant characterized by an intramyocardial course of a segment of an epicardial coronary artery. Although it is frequently considered a benign finding, several studies have suggested an association between myocardial bridging and coronary atherosclerotic plaque formation, particularly in the coronary segment proximal to the bridged segment.
This prospective observational study aims to determine the prevalence of coronary myocardial bridging using multidetector computed tomography coronary angiography (MDCT-CA) and investigate its relationship with coronary atherosclerotic plaques.
The study will be conducted at the Diagnostic and Interventional Radiology Departments of Sohag University Hospital and New Sohag University Hospital. At least 50 patients referred for coronary CT angiography will be included, without age or sex restrictions.
Coronary CT angiography examinations will be performed using 128-row or 160-row multidetector CT scanners. The imaging protocol will include coronary calcium scoring and contrast-enhanced coronary CT angiography with electrocardiographic gating.
The coronary arteries, including the right coronary artery, left main coronary artery, left anterior descending artery, and left circumflex artery, will be evaluated for the presence of myocardial bridging and coronary atherosclerotic plaques.
For each detected myocardial bridge, the following parameters will be assessed:
- Involved coronary artery and anatomical location.
- Length of the bridged segment, measured from its entry into the myocardium to its re-emergence onto the epicardial surface.
- Depth of the myocardial bridge, measured as the maximum thickness of the overlying myocardial fibers.
Coronary atherosclerotic plaques will be assessed regarding their presence, location, and characteristics. The findings will subsequently be analyzed to investigate the relationship between myocardial bridging and coronary atherosclerotic plaques.
The collected data will be statistically analyzed to determine the prevalence of myocardial bridging and evaluate its association with coronary atherosclerotic plaques.
Study design
- Observational model
- Other
- Time perspective
- Prospective
Who may qualify
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Child, Adult, Older adult
- Study population
- The study population will consist of patients referred to the Diagnostic and Interventional Radiology Department at Sohag University Hospital and New Sohag University Hospital to undergo coronary CT angiography. At least 50 patients of both sexes, without age restrictions, will be included in this prospective observational study to assess the prevalence of coronary myocardial bridging and its relationship with coronary atherosclerotic plaques.
Key inclusion criteria (1 listed)
- All patients referred to the Radiology Department of Sohag University Hospital and New Sohag University Hospital for coronary CT angiography.
Key exclusion criteria (5 listed)
- Patients with contraindications to CT examination due to radiation-related risks.
- Patients with known allergy to iodinated contrast media or impaired renal function (serum creatinine > 1.5 mg/dL or estimated glomerular filtration rate < 30 mL/min).
- Patients with heart rate or rhythm incompatible with electrocardiographically gated scanning (heart rate > 70 beats/min or uncontrolled atrial fibrillation).
- Patients with an Agatston calcium score > 400.
- Uncooperative patients or those who do not provide informed consent
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Primary outcome
Number of participants with Prevalence of Coronary Myocardial Bridging
Time frame: Day 1 (At the time of coronary CT angiography examination"
Determination of the prevalence of coronary myocardial bridging among patients undergoing multidetector computed tomography coronary angiography (MDCT-CA), based on the identification of intramyocardial coronary artery segments.
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 4 Nov 2026.
- Results publication: PubMed 37762890Rovera C, Moretti C, Bisanti F, De Zan G, Guglielmo M. Myocardial Bridging: Review on the Role of Coronary Computed Tomography Angiography. J Clin Med. 2023 Sep 13;12(18):5949. doi: 10.3390/jcm12185949.
- Individual participant dataSharing planned: No. Individual participant data will not be shared with other researchers to maintain patient confidentiality and protect personal information. Study results may be disseminated in scientific publications in aggregate form without identifying individual participants.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
An observational study of Myocardial Bridging and Coronary Atherosclerosis, run by Sohag University at 1 site in Egypt.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 1 inclusion and 5 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: looking for participants now, as of the sponsor's last update on 4 Nov 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Egypt. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Each site lists its own contact: choose the nearest one under Trial locations. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Number of participants with Prevalence of Coronary Myocardial Bridging (time frame: Day 1 (At the time of coronary CT angiography examination"). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT07916272, which also lists 1 linked publication.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 4 Nov 2026.