Alveolar Ridge Preservation Post-Extraction Bone Healing Dental Implant Site Development Tooth LossAA-IPRF-PDDGNCT07916545
Effect of Ascorbic Acid-Loaded I-PRF With Partially Demineralized Dentin Graft on Alveolar Ridge Preservation
A study testing Alveolar Ridge Preservation Using Partially Demineralized Dentin Graft alone, Alveolar Ridge Preservation Using PDDG Combined with I-PRF and Alveolar Ridge Preservation Using PDDG Combined with Ascorbic Acid-Loaded I-PRF in people with Alveolar Ridge Preservation Post-Extraction Bone Healing Dental Implant Site Development Tooth Loss and Alveolar Bone Regeneration Following Odontectomy, run by Nahda University.
Trial summary
The goal of this clinical trial is to find out which treatment best preserves the jawbone after tooth extraction in adults planning to receive a dental implant later. The study will investigate whether adding vitamin C to a mixture of tooth particles and a material prepared from the participant's own blood helps… Read more about this study
- Who is it for?
- Ages 18 to 60 yearsHealthy volunteers can take part
- Conditions the study is for
- Alveolar Ridge Preservation Post-Extraction Bone Healing Dental Implant Site Development Tooth Loss, Alveolar Bone Regeneration Following Odontectomy, Assisted Alveolar Bone Healing After Dental Extraction
- What is being tested?
- Alveolar Ridge Preservation Using Partially Demineralized Dentin Graft alone, Alveolar Ridge Preservation Using PDDG Combined with I-PRF and Alveolar Ridge Preservation Using PDDG Combined with Ascorbic Acid-Loaded I-PRF
- Type of treatment
- Injection or infusion, Surgery or procedure
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 48 participants
- Where
- No sites listed yet
- Study dates
- 30 Oct 2026to 30 Jun 2027
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 60 years
- All sexes
- Healthy volunteers accepted
- Adult
Who may be able to join
- Patients aged 18-60 years. ⁴⁷
- ASA Type I medically healthy patients with no significant medical history. ⁴⁷
- Non-restorable teeth indicated for extraction followed by delayed implant placement. ⁴⁸
- Patients eligible for immediate implant placement but facing factors that prevent implant placement at the time of extraction. ⁴⁸
- Patients requiring alveolar ridge preservation before planned dental implant placement.
- Presence of ST IB sockets after extraction. ⁴²-⁴⁴
Show all 10Show fewer
- periodontally healthy adjacent teeth. ⁴⁸
- Adequate oral hygiene plaque index ≤15% and willingness to comply with the study protocol and follow-up visits. ⁴⁷
- Cooperative patients willing to comply with the 4-month follow-up period. ⁴⁷
- Ability to understand and sign the informed consent form. ⁴⁷
Who cannot join
- Uncontrolled systemic diseases affecting bone healing (e.g., uncontrolled diabetes mellitus).
- History of radiotherapy or chemotherapy involving the head and neck region.
- Current use of medications known to influence bone metabolism (e.g., bisphosphonates, denosumab, long-term corticosteroids).
- Smokers or tobacco users.
- Pregnancy or lactation.
- Acute uncontrolled infection extraction site.
Show all 9Show fewer
- Patients with poor oral hygiene or untreated active periodontal disease.
- Psychiatric patients, or those with a learning disability, or those unable to give consent
- Patients unable or unwilling to attend follow-up visits.
Trial locations and contacts
No sites are listed yet. Contact the study team or a site near you to ask about taking part.
About this study
Official title: Effect of Ascorbic Acid-Loaded Injectable Platelet-Rich Fibrin Combined With Partially Demineralized Dentin Graft on Alveolar Ridge Preservation: A Randomized Controlled Clinical Trial
The goal of this clinical trial is to find out which treatment best preserves the jawbone after tooth extraction in adults planning to receive a dental implant later.
The study will investigate whether adding vitamin C to a mixture of tooth particles and a material prepared from the participant's own blood helps preserve the jawbone and improve bone healing.
Read more
The main questions it aims to answer are
- Does adding vitamin C help preserve the width of the jawbone after tooth extraction?
- Does it improve new bone formation compared with the other treatments?
Researchers will compare three treatments to determine whether adding a blood-based material, with or without vitamin C, improves bone preservation.
- The first group will receive small particles prepared from their own extracted tooth.
- The second group will receive tooth particles mixed with a healing material prepared from their own blood.
- The third group will receive tooth particles mixed with the same blood-based material containing vitamin C.
Participants will undergo tooth extraction and receive one of these treatments. They will attend follow-up visits during the healing period.
Researchers will:
- Examine the treated area during follow-up visits.
- Take three-dimensional dental scans before treatment and four months later to measure changes in jawbone width and height.
- Collect a small bone sample during dental implant placement to examine new bone formation and healing.
The study will help determine whether adding vitamin C to the blood-based material provides additional benefits for preserving the jawbone before dental implant placement.
Read the detailed description
This study evaluates approaches to preserve the alveolar ridge following tooth extraction before delayed dental implant placement.
The study uses a partially demineralized dentin graft prepared from the participant's extracted tooth as the grafting material. It also investigates whether combining this graft with injectable platelet-rich fibrin (I-PRF), with or without added ascorbic acid (vitamin C), may influence bone healing and ridge preservation.
The rationale for using dentin is based on its potential as an autologous graft material. I-PRF provides an autologous blood-derived component. The addition of vitamin C is being investigated as a possible way to influence the healing response.
The study will assess changes in alveolar ridge dimensions and examine bone tissue collected during implant placement. Histological and histomorphometric analysis will help characterize new bone formation, residual graft material, and connective tissue within the healing site.
The findings may provide information about the role of vitamin C-enriched I-PRF when combined with autogenous dentin grafts for alveolar ridge preservation.
- Conditions
- Alveolar Ridge Preservation Post-Extraction Bone Healing Dental Implant Site Development Tooth Loss, Alveolar Bone Regeneration Following Odontectomy, Assisted Alveolar Bone Healing After Dental Extraction, Alveolar Bone Preservation
- Being tested
- Alveolar Ridge Preservation Using Partially Demineralized Dentin Graft alone, Alveolar Ridge Preservation Using PDDG Combined with I-PRF, Alveolar Ridge Preservation Using PDDG Combined with Ascorbic Acid-Loaded I-PRF
- Keywords
- Alveolar Ridge Preservation, autogenous graft materials, Partially Demineralized Dentin Graft, autogenous particulate dentin, Sticky Dentin, Ascorbic Acid-loaded I-PRF, assisted alveolar bone healing post extraction
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Alveolar Ridge Preservation Using Partially Demineralized Dentin Graft aloneProcedure or surgery
Alveolar ridge preservation following atraumatic tooth extraction using an autogenous partially demineralized dentin graft (PDDG) prepared from the extracted tooth. The graft will be placed into the extraction socket, covered with an absorbable gelatin sponge, and secured with sutures. No injectable platelet-rich fibrin (I-PRF) or ascorbic acid will be added.
Alveolar Ridge Preservation Using PDDG Combined with I-PRFProcedure or surgery
Alveolar ridge preservation using an autogenous partially demineralized dentin graft (PDDG) mixed with injectable platelet-rich fibrin (I-PRF) prepared from the participant's peripheral blood. The resulting sticky dentin mixture will be placed into the extraction socket, covered with an absorbable gelatin sponge, and secured with sutures.
Alveolar Ridge Preservation Using PDDG Combined with Ascorbic Acid-Loaded I-PRFProcedure or surgery
Alveolar ridge preservation using an autogenous partially demineralized dentin graft (PDDG) mixed with injectable platelet-rich fibrin (I-PRF) containing ascorbic acid. The resulting AA-Sticky Dentin mixture will be placed into the extraction socket, covered with an absorbable gelatin sponge, and secured with sutures.
| Study group | Role | What they receive |
|---|---|---|
| Partially Demineralized Dentin Graft Alone | Active comparator | Participants will undergo alveolar ridge preservation following atraumatic tooth extraction using an autogenous partially demineralized dentin graft (PDDG) prepared from the extracted tooth. The graft will be placed into the extraction socket, covered with an absorbable gelatin sponge, and secured with sutures. No injectable platelet-rich fibrin (I-PRF) or ascorbic acid will be added. Receives: Procedure: Alveolar Ridge Preservation Using Partially Demineralized Dentin Graft alone |
| Partially Demineralized Dentin Graft Combined with I-PRF | Experimental | Participants will undergo alveolar ridge preservation using an autogenous partially demineralized dentin graft (PDDG) mixed with injectable platelet-rich fibrin (I-PRF) prepared from the participant's peripheral blood. The resulting mixture, referred to as Sticky Dentin, will be placed into the extraction socket, covered with an absorbable gelatin sponge, and secured with sutures. Receives: Procedure: Alveolar Ridge Preservation Using PDDG Combined with I-PRF |
| Ascorbic Acid-Loaded I-PRF Combined with PDDG | Experimental | Participants will undergo alveolar ridge preservation using an autogenous partially demineralized dentin graft (PDDG) mixed with injectable platelet-rich fibrin (I-PRF) containing ascorbic acid. The resulting mixture, referred to as AA-Sticky Dentin, will be placed into the extraction socket, covered with an absorbable gelatin sponge, and secured with sutures. Receives: Procedure: Alveolar Ridge Preservation Using PDDG Combined with Ascorbic Acid-Loaded I-PRF |
What is being measured
The primary outcome is the main question the study is designed to answer.
Change in Radiographic Horizontal Alveolar Ridge Width
The change in horizontal alveolar ridge width will be assessed using cone-beam computed tomography (CBCT) scans obtained at baseline before alveolar ridge preservation and 4 months postoperatively. Measurements will be performed at the extraction site using standardized anatomical reference points and consistent measurement procedures. The change in ridge width from baseline to 4 months will be compared among the three study groups.
Measured: Baseline (before alveolar ridge preservation) to 4 months postoperatively.
Secondary outcomes (1)
Histomorphometric Analysis of Core Bone Biopsy Specimens
Histomorphometric analysis will be performed on core bone biopsy specimens collected from the alveolar ridge preservation sites during implant osteotomy 4 months postoperatively. The analysis will assess the percentages of newly formed bone, mature bone, and residual dentin graft particles in the specimens, and the results will be compared among the three study groups.
Measured: 4 months after alveolar ridge preservation, during implant osteotomy. 4 months after alveolar ridge preservation, during implant osteotomy.
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted4 Nov 2026
- Study start30 Oct 2026 (estimated)
- Primary completion30 Mar 2027 (estimated)
- Study completion30 Jun 2027 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (59)Papers the sponsor has linked to this study.
- Other trials for Alveolar Ridge Preservation Post-Extraction Bone Healing Dental Implant Site Development Tooth LossStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Model description
- Randomized Controlled Trial (RCT) This study will be designed as a prospective, three-arm, parallel-group randomized controlled clinical trial. Group (1) Graft PDDG alone. Group (2) (PDDG) combined with(I-PRF); (Sticky Dentin). Group (3) Ascorbic Acid-loaded I-PRF combined with (PDDG); (AA-stick dentin).
- Masking
- Single blind
- Who is masked
- Outcomes assessor
- Enrolment
- 48 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Nahda University
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Mahmoud Ebrahim Ahmed Elsaadawy, Nahda University
- Investigators
- Mohamed Sherif EL-Mofty, Professor, Study chair, Faculty of Dentistry, Nahda University Beni-Suef, Egypt.Shaimaa Hamdy Abd El-Azeem, Study director, : Department of Oral Medicine, Diagnosis and Periodontology, Faculty of Dentistry, Nahda University Beni-Suef, Egypt.
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07916545
- Sponsor's protocol ID
- 00D-9-26-8
- Acronym
- AA-IPRF-PDDG
- Status last verified
- Oct 2026
- First submitted
- 17 Oct 2026
- Last updated
- 4 Nov 2026
- Results posted
- No
- Data monitoring committee
- Yes
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No: Individual participant data will not be shared with other researchers. Only aggregated study results may be disseminated through scientific publications, while participant confidentiality and data privacy will be maintained in accordance with institutional ethical requirements.
Publications
Steigmann L, Di Gianfilippo R, Steigmann M, Wang HL. Classification Based on Extraction Socket Buccal Bone Morphology and Related Treatment Decision Tree. Materials (Basel). 2022 Jan 19;15(3):733. doi: 10.3390/ma15030733.
PubMed 35160679Fawzy El-Sayed KM, Nguyen N, Dorfer CE. Ascorbic Acid, Inflammatory Cytokines (IL-1beta/TNF-alpha/IFN-gamma), or Their Combination's Effect on Stemness, Proliferation, and Differentiation of Gingival Mesenchymal Stem/Progenitor Cells. Stem Cells Int. 2020 Aug 17;2020:8897138. doi: 10.1155/2020/8897138. eCollection 2020.
PubMed 32879629Heimes D, Schiegnitz E, Kuchen R, Kammerer PW, Al-Nawas B. Buccal Bone Thickness in Anterior and Posterior Teeth-A Systematic Review. Healthcare (Basel). 2021 Nov 30;9(12):1663. doi: 10.3390/healthcare9121663.
PubMed 34946389Castells-Mira E, Sanchez-Benito F, Alminana-Pastor PJ, Lopez-Roldan A. Radiographic and histomorphometric evaluation of Autogenous Particulated Dentin for Alveolar Ridge Preservation: A Systematic Review and Meta-analyses. J Clin Exp Dent. 2025 Oct 17;17(11):e1404-e1421. doi: 10.4317/jced.63147. eCollection 2025 Oct.
PubMed 41466863Alrmali A, Saleh MHA, Mazzocco J, Zimmer JM, Testori T, Wang HL. Auto-dentin platelet-rich fibrin matrix is an alternative biomaterial for different augmentation procedures: A retrospective case series report. Clin Exp Dent Res. 2023 Dec;9(6):993-1004. doi: 10.1002/cre2.808. Epub 2023 Nov 7.
PubMed 37933487Elbehwashy MT, Hosny MM, Elfana A, Nawar A, Fawzy El-Sayed K. Clinical and radiographic effects of ascorbic acid-augmented platelet-rich fibrin versus platelet-rich fibrin alone in intra-osseous defects of stage-III periodontitis patients: a randomized controlled clinical trial. Clin Oral Investig. 2021 Nov;25(11):6309-6319. doi: 10.1007/s00784-021-03929-1. Epub 2021 Apr 12.
PubMed 33842996Sherif MA, Anter E, Graetz C, El-Sayed KF. Injectable platelet-rich fibrin with vitamin C as an adjunct to non-surgical periodontal therapy in the treatment of stage-II periodontitis: a randomized controlled clinical trial. BMC Oral Health. 2025 May 23;25(1):772. doi: 10.1186/s12903-025-06115-x.
PubMed 40410805Tada A, Miura H. The Relationship between Vitamin C and Periodontal Diseases: A Systematic Review. Int J Environ Res Public Health. 2019 Jul 11;16(14):2472. doi: 10.3390/ijerph16142472.
PubMed 31336735Um IW, Kim YK, Mitsugi M. Demineralized dentin matrix scaffolds for alveolar bone engineering. J Indian Prosthodont Soc. 2017 Apr-Jun;17(2):120-127. doi: 10.4103/jips.jips_62_17.
PubMed 28584412Bertoldi C, Generali L, Cortellini P, Lalla M, Luppi S, Tomasi A, Zaffe D, Salvatori R, Bergamini S. Influence of Tooth-Brushing on Early Healing after Access Flap Surgery: A Randomized Controlled Preliminary Study. Materials (Basel). 2021 May 29;14(11):2933. doi: 10.3390/ma14112933.
PubMed 34072369Zhou LL, Yuan W, Zhang X, Chen L, Graetz C. Alveolar Ridge Preservation in Posterior Extraction Sockets: A Literature Review and Proposal of a Novel Therapeutic Classification. Clin Cosmet Investig Dent. 2026 Mar 20;18:584600. doi: 10.2147/CCIDE.S584600. eCollection 2026.
PubMed 419091011. Melek L, Marwan ES. 2016. Evaluation of "Autogenous Bioengineered Injectable PRF-Tooth Graft" Combination (ABIT) in Reconstruction of Maxillary Alveolar Ridge Defects. Saudi J Dent Res. 8:86-96.
Cagetti MG, Wolf TG, Tennert C, Camoni N, Lingstrom P, Campus G. The Role of Vitamins in Oral Health. A Systematic Review and Meta-Analysis. Int J Environ Res Public Health. 2020 Feb 3;17(3):938. doi: 10.3390/ijerph17030938.
PubMed 32028631Binderman I, Hallel G, Nardy C, Yaffe A, Sapoznikov L. A novel procedure to process extracted teeth for immediate grafting of autogenous dentin. J Interdiscip Med Dent Sci. 2014;2:154.
Mani A, Mani S, Sachdeva S, Sodhi JK, Vora HR, Gholap S. 2021. Post-Surgical Care in Surgical Periodontics. Int J Periodontol Implantol. 6:74-78.
Study at a glance
From the registry record, last updated by the sponsor on 4 Nov 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Effect of Ascorbic Acid-Loaded Injectable Platelet-Rich Fibrin Combined With Partially Demineralized Dentin Graft on Alveolar Ridge Preservation: A Randomized Controlled Clinical Trial
- ClinicalTrials.gov ID
- NCT07916545
- Acronym / sponsor ID
- AA-IPRF-PDDG / 00D-9-26-8
- Conditions
- Alveolar Ridge Preservation Post-Extraction Bone Healing Dental Implant Site Development Tooth Loss, Alveolar Bone Regeneration Following Odontectomy, Assisted Alveolar Bone Healing After Dental Extraction, Alveolar Bone Preservation
- Keywords
- Alveolar Ridge Preservation, autogenous graft materials, Partially Demineralized Dentin Graft, autogenous particulate dentin, Sticky Dentin, Ascorbic Acid-loaded I-PRF, assisted alveolar bone healing post extraction
- Study type
- Interventional
- Recruitment status
- Not yet recruiting
- Enrolment
- 48 participants (estimated)
- Lead sponsor
- Nahda UniversityUniversity, hospital or other
- Study start
- 30 Oct 2026 (estimated)
- Primary completion
- 30 Mar 2027 (estimated)
- Study completion
- 30 Jun 2027 (estimated)
- First posted
- 4 Nov 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
The goal of this clinical trial is to find out which treatment best preserves the jawbone after tooth extraction in adults planning to receive a dental implant later.
The study will investigate whether adding vitamin C to a mixture of tooth particles and a material prepared from the participant's own blood helps preserve the jawbone and improve bone healing.
The main questions it aims to answer are
- Does adding vitamin C help preserve the width of the jawbone after tooth extraction?
- Does it improve new bone formation compared with the other treatments?
Researchers will compare three treatments to determine whether adding a blood-based material, with or without vitamin C, improves bone preservation.
- The first group will receive small particles prepared from their own extracted tooth.
- The second group will receive tooth particles mixed with a healing material prepared from their own blood.
- The third group will receive tooth particles mixed with the same blood-based material containing vitamin C.
Participants will undergo tooth extraction and receive one of these treatments. They will attend follow-up visits during the healing period.
Researchers will:
- Examine the treated area during follow-up visits.
- Take three-dimensional dental scans before treatment and four months later to measure changes in jawbone width and height.
- Collect a small bone sample during dental implant placement to examine new bone formation and healing.
The study will help determine whether adding vitamin C to the blood-based material provides additional benefits for preserving the jawbone before dental implant placement.
Detailed description
This study evaluates approaches to preserve the alveolar ridge following tooth extraction before delayed dental implant placement.
The study uses a partially demineralized dentin graft prepared from the participant's extracted tooth as the grafting material. It also investigates whether combining this graft with injectable platelet-rich fibrin (I-PRF), with or without added ascorbic acid (vitamin C), may influence bone healing and ridge preservation.
The rationale for using dentin is based on its potential as an autologous graft material. I-PRF provides an autologous blood-derived component. The addition of vitamin C is being investigated as a possible way to influence the healing response.
The study will assess changes in alveolar ridge dimensions and examine bone tissue collected during implant placement. Histological and histomorphometric analysis will help characterize new bone formation, residual graft material, and connective tissue within the healing site.
The findings may provide information about the role of vitamin C-enriched I-PRF when combined with autogenous dentin grafts for alveolar ridge preservation.
Study design
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Single blind (outcomes assessor)
- Number of arms
- 3
- Model description
- Randomized Controlled Trial (RCT) This study will be designed as a prospective, three-arm, parallel-group randomized controlled clinical trial. Group (1) Graft PDDG alone. Group (2) (PDDG) combined with(I-PRF); (Sticky Dentin). Group (3) Ascorbic Acid-loaded I-PRF combined with (PDDG); (AA-stick dentin).
| Arm | Type | Receives |
|---|---|---|
| Partially Demineralized Dentin Graft Alone | Active comparator | Procedure: Alveolar Ridge Preservation Using Partially Demineralized Dentin Graft aloneParticipants will undergo alveolar ridge preservation following atraumatic tooth extraction using an autogenous partially demineralized dentin graft (PDDG) prepared from the extracted tooth. The graft will be placed into the extraction socket, covered with an absorbable gelatin sponge, and secured with sutures. No injectable platelet-rich fibrin (I-PRF) or ascorbic acid will be added. |
| Partially Demineralized Dentin Graft Combined with I-PRF | Experimental | Procedure: Alveolar Ridge Preservation Using PDDG Combined with I-PRFParticipants will undergo alveolar ridge preservation using an autogenous partially demineralized dentin graft (PDDG) mixed with injectable platelet-rich fibrin (I-PRF) prepared from the participant's peripheral blood. The resulting mixture, referred to as Sticky Dentin, will be placed into the extraction socket, covered with an absorbable gelatin sponge, and secured with sutures. |
| Ascorbic Acid-Loaded I-PRF Combined with PDDG | Experimental | Procedure: Alveolar Ridge Preservation Using PDDG Combined with Ascorbic Acid-Loaded I-PRFParticipants will undergo alveolar ridge preservation using an autogenous partially demineralized dentin graft (PDDG) mixed with injectable platelet-rich fibrin (I-PRF) containing ascorbic acid. The resulting mixture, referred to as AA-Sticky Dentin, will be placed into the extraction socket, covered with an absorbable gelatin sponge, and secured with sutures. |
Who may qualify
- Ages
- 18 to 60 years
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Adult
Key inclusion criteria (10 listed)
- Patients aged 18-60 years. ⁴⁷
- ASA Type I medically healthy patients with no significant medical history. ⁴⁷
- Non-restorable teeth indicated for extraction followed by delayed implant placement. ⁴⁸
- Patients eligible for immediate implant placement but facing factors that prevent implant placement at the time of extraction. ⁴⁸
- Patients requiring alveolar ridge preservation before planned dental implant placement.
Key exclusion criteria (9 listed)
- Uncontrolled systemic diseases affecting bone healing (e.g., uncontrolled diabetes mellitus).
- History of radiotherapy or chemotherapy involving the head and neck region.
- Current use of medications known to influence bone metabolism (e.g., bisphosphonates, denosumab, long-term corticosteroids).
- Smokers or tobacco users.
- Pregnancy or lactation.
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Alveolar Ridge Preservation Using Partially Demineralized Dentin Graft aloneAlveolar ridge preservation following atraumatic tooth extraction using an autogenous partially demineralized dentin graft (PDDG) prepared from the extracted tooth. The graft will be placed into the extraction socket, covered with an absorbable gelatin sponge, and secured with sutures. No injectable platelet-rich fibrin (I-PRF) or ascorbic acid will be added. | Procedure or surgery | Partially Demineralized Dentin Graft Alone |
| Alveolar Ridge Preservation Using PDDG Combined with I-PRFAlveolar ridge preservation using an autogenous partially demineralized dentin graft (PDDG) mixed with injectable platelet-rich fibrin (I-PRF) prepared from the participant's peripheral blood. The resulting sticky dentin mixture will be placed into the extraction socket, covered with an absorbable gelatin sponge, and secured with sutures. | Procedure or surgery | Partially Demineralized Dentin Graft Combined with I-PRF |
| Alveolar Ridge Preservation Using PDDG Combined with Ascorbic Acid-Loaded I-PRFAlveolar ridge preservation using an autogenous partially demineralized dentin graft (PDDG) mixed with injectable platelet-rich fibrin (I-PRF) containing ascorbic acid. The resulting AA-Sticky Dentin mixture will be placed into the extraction socket, covered with an absorbable gelatin sponge, and secured with sutures. | Procedure or surgery | Ascorbic Acid-Loaded I-PRF Combined with PDDG |
Primary outcome
Change in Radiographic Horizontal Alveolar Ridge Width
Time frame: Baseline (before alveolar ridge preservation) to 4 months postoperatively.
The change in horizontal alveolar ridge width will be assessed using cone-beam computed tomography (CBCT) scans obtained at baseline before alveolar ridge preservation and 4 months postoperatively. Measurements will be performed at the extraction site using standardized anatomical reference points and consistent measurement procedures. The change in ridge width from baseline to 4 months will be compared among the three study groups.
1 secondary outcome
Histomorphometric Analysis of Core Bone Biopsy Specimens
Time frame: 4 months after alveolar ridge preservation, during implant osteotomy. 4 months after alveolar ridge preservation, during implant osteotomy.
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 4 Nov 2026.
- Background: PubMed 35160679Steigmann L, Di Gianfilippo R, Steigmann M, Wang HL. Classification Based on Extraction Socket Buccal Bone Morphology and Related Treatment Decision Tree. Materials (Basel). 2022 Jan 19;15(3):733. doi: 10.3390/ma15030733.
- Background: PubMed 32879629Fawzy El-Sayed KM, Nguyen N, Dorfer CE. Ascorbic Acid, Inflammatory Cytokines (IL-1beta/TNF-alpha/IFN-gamma), or Their Combination's Effect on Stemness, Proliferation, and Differentiation of Gingival Mesenchymal Stem/Progenitor Cells. Stem Cells Int. 2020 Aug 17;2020:8897138. doi: 10.1155/2020/8897138. eCollection 2020.
- Background: PubMed 34946389Heimes D, Schiegnitz E, Kuchen R, Kammerer PW, Al-Nawas B. Buccal Bone Thickness in Anterior and Posterior Teeth-A Systematic Review. Healthcare (Basel). 2021 Nov 30;9(12):1663. doi: 10.3390/healthcare9121663.
- Background: PubMed 41466863Castells-Mira E, Sanchez-Benito F, Alminana-Pastor PJ, Lopez-Roldan A. Radiographic and histomorphometric evaluation of Autogenous Particulated Dentin for Alveolar Ridge Preservation: A Systematic Review and Meta-analyses. J Clin Exp Dent. 2025 Oct 17;17(11):e1404-e1421. doi: 10.4317/jced.63147. eCollection 2025 Oct.
- Background: PubMed 37933487Alrmali A, Saleh MHA, Mazzocco J, Zimmer JM, Testori T, Wang HL. Auto-dentin platelet-rich fibrin matrix is an alternative biomaterial for different augmentation procedures: A retrospective case series report. Clin Exp Dent Res. 2023 Dec;9(6):993-1004. doi: 10.1002/cre2.808. Epub 2023 Nov 7.
- Background: PubMed 33842996Elbehwashy MT, Hosny MM, Elfana A, Nawar A, Fawzy El-Sayed K. Clinical and radiographic effects of ascorbic acid-augmented platelet-rich fibrin versus platelet-rich fibrin alone in intra-osseous defects of stage-III periodontitis patients: a randomized controlled clinical trial. Clin Oral Investig. 2021 Nov;25(11):6309-6319. doi: 10.1007/s00784-021-03929-1. Epub 2021 Apr 12.
- Background: PubMed 40410805Sherif MA, Anter E, Graetz C, El-Sayed KF. Injectable platelet-rich fibrin with vitamin C as an adjunct to non-surgical periodontal therapy in the treatment of stage-II periodontitis: a randomized controlled clinical trial. BMC Oral Health. 2025 May 23;25(1):772. doi: 10.1186/s12903-025-06115-x.
- Background: PubMed 31336735Tada A, Miura H. The Relationship between Vitamin C and Periodontal Diseases: A Systematic Review. Int J Environ Res Public Health. 2019 Jul 11;16(14):2472. doi: 10.3390/ijerph16142472.
- Background: PubMed 28584412Um IW, Kim YK, Mitsugi M. Demineralized dentin matrix scaffolds for alveolar bone engineering. J Indian Prosthodont Soc. 2017 Apr-Jun;17(2):120-127. doi: 10.4103/jips.jips_62_17.
- Background: PubMed 34072369Bertoldi C, Generali L, Cortellini P, Lalla M, Luppi S, Tomasi A, Zaffe D, Salvatori R, Bergamini S. Influence of Tooth-Brushing on Early Healing after Access Flap Surgery: A Randomized Controlled Preliminary Study. Materials (Basel). 2021 May 29;14(11):2933. doi: 10.3390/ma14112933.
- Background: PubMed 41909101Zhou LL, Yuan W, Zhang X, Chen L, Graetz C. Alveolar Ridge Preservation in Posterior Extraction Sockets: A Literature Review and Proposal of a Novel Therapeutic Classification. Clin Cosmet Investig Dent. 2026 Mar 20;18:584600. doi: 10.2147/CCIDE.S584600. eCollection 2026.
- Background1. Melek L, Marwan ES. 2016. Evaluation of "Autogenous Bioengineered Injectable PRF-Tooth Graft" Combination (ABIT) in Reconstruction of Maxillary Alveolar Ridge Defects. Saudi J Dent Res. 8:86-96.
- Individual participant dataSharing planned: No. Individual participant data will not be shared with other researchers. Only aggregated study results may be disseminated through scientific publications, while participant confidentiality and data privacy will be maintained in accordance with institutional ethical requirements.
Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
Mohamed Sherif EL-Mofty, Professor study chair
Faculty of Dentistry, Nahda University Beni-Suef, Egypt.
Shaimaa Hamdy Abd El-Azeem study director
: Department of Oral Medicine, Diagnosis and Periodontology, Faculty of Dentistry, Nahda University Beni-Suef, Egypt.
Questions about this trial
What is this clinical trial studying?
A study testing Alveolar Ridge Preservation Using Partially Demineralized Dentin Graft alone, Alveolar Ridge Preservation Using PDDG Combined with I-PRF and Alveolar Ridge Preservation Using PDDG Combined with Ascorbic Acid-Loaded I-PRF in people with Alveolar Ridge Preservation Post-Extraction Bone Healing Dental Implant Site Development Tooth Loss and Alveolar Bone Regeneration Following Odontectomy, run by Nahda University.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 10 inclusion and 9 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: opening soon, as of the sponsor's last update on 4 Nov 2026. Status can change between updates, so confirm with the study contact before making plans.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact Mahmoud Ebrahim El-Saadawy, BDS (+201000559354, mahmoudelsaadawy061293@gmail.com), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Change in Radiographic Horizontal Alveolar Ridge Width (time frame: Baseline (before alveolar ridge preservation) to 4 months postoperatively.). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT07916545, which also lists 59 linked publications.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 4 Nov 2026.