Dental Plaque AccumulationCHX; EOMWNCT07919561
EFFECTIVENESS OF DILUTED CHLORHEXIDINE AND ESSENTIAL OIL BASED MOUTHWASHES ON PLAQUE IN ORTHODONTIC PATIENTS- A RANDOMIZED CONTROLLED TRIAL
A study testing diluted 0.2% Chlorhexidine mouthwash and Essential Oil-Based Mouthwash in people with Dental Plaque Accumulation, run by Rehman Medical Institute - RMI at 1 site in Pakistan.
Trial summary
This randomized clinical trial compares the effectiveness of a chlorhexidine mouthwash with an essential-oil-based mouthwash in improving oral health outcomes. Participants will be assigned to one of the two mouthwash groups and will use the assigned mouthwash according to the study protocol. Read more about this study
- Who is it for?
- Ages 14 to 40 yearsHealthy volunteers can take part
- Conditions the study is for
- Dental Plaque Accumulation
- What is being tested?
- diluted 0.2% Chlorhexidine mouthwash and Essential Oil-Based Mouthwash
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 30 participants
- Where
- 1 sitePakistan
- Study dates
- 10 Jul 2025to 10 Jan 2026
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 14 to 40 years
- All sexes
- Healthy volunteers accepted
- Child, Adult
Who may be able to join
- a. Patient with mild to moderate gingivitis (OPI scores more than 2 on any three standard teeth) b. No prior use of phenytoin, cyclosporin, or any other medication known to cause gingival enlargement medication c. No systemic problems like Diabetes mellitus, blood disorder etc d. Age above 14 years with completely erupted permanent dentition e. Patient who are under comprehensive orthodontic treatment for at least 3 months f. Mild to moderate crowding (up to 6mm)
Who cannot join
- a. Pregnant women and lactating mother b. Enamel defects (enamel hypoplasia or fluorosis discoloration) c. Periodontal intervention done in the last six months (surgical or non-surgical)
Trial locations and contacts
1 site in 1 country.
About this study
This randomized clinical trial compares the effectiveness of a chlorhexidine mouthwash with an essential-oil-based mouthwash in improving oral health outcomes. Participants will be assigned to one of the two mouthwash groups and will use the assigned mouthwash according to the study protocol. Oral health parameters will be assessed at baseline and after the follow-up period to determine and compare the effects of the two mouthwashes.
Read the detailed description
This study is a randomized clinical trial designed to compare the effectiveness of two mouthwash formulations: chlorhexidine mouthwash and an essential-oil-based mouthwash.
Eligible participants will be enrolled according to the predefined inclusion and exclusion criteria and randomly allocated into two groups. Group 1 (G1) will receive chlorhexidine mouthwash, while Group 2 (G2) will receive an essential-oil-based mouthwash.
Baseline oral health measurements will be recorded before the intervention. Participants will then use their assigned mouthwash according to the study protocol. Follow-up assessment will be performed after 3 months, and the relevant oral health outcomes will be recorded.
The outcomes measured at baseline and follow-up will be compared within and between the two groups to determine the effectiveness of the two mouthwash interventions. The study findings will help evaluate the comparative effects of chlorhexidine and essential-oil-based mouthwash on the selected oral health outcomes.
- Conditions
- Dental Plaque Accumulation
- Being tested
- diluted 0.2% Chlorhexidine mouthwash, Essential Oil-Based Mouthwash
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
diluted 0.2% Chlorhexidine mouthwashOther
Diluted 0.2% chlorhexidine mouthwash administered to participants assigned to G1 according to the study protocol.
Essential Oil-Based MouthwashOther
Essential oil-based mouthwash administered to participants assigned to G2 according to the study protocol.
| Study group | Role | What they receive |
|---|---|---|
| G1 (diluted 0.2% chlorhexidine mouthwash) | Experimental | G1 (diluted 0.2% chlorhexidine mouthwash) Receives: Other: diluted 0.2% Chlorhexidine mouthwash |
| G2 (essential oil based mouthwashes) | Experimental | G2 (essential oil based mouthwashes) Receives: Other: Essential Oil-Based Mouthwash |
What is being measured
The primary outcome is the main question the study is designed to answer.
The Orthodontic Plaque Index (OPI)
Change in the Orthodontic Plaque Index (OPI) score from baseline to 3 months was used to assess the effectiveness of the intervention.
Measured: Baseline to 3 months
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted5 Nov 2026
- Study start10 Jul 2025
- Primary completion10 Jan 2026
- Study completion10 Jan 2026
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Dental Plaque AccumulationStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Model description
- Participants are randomly assigned to one of two parallel intervention groups: G1 (Chlorhexidine mouthwash) or G2 (Essential Oil Based Mouthwash). Outcomes are assessed after 3 months.
- Masking
- Triple blind
- Who is masked
- Participant, Investigator, Outcomes assessor
- Enrolment
- 30 participants (actual)
Sponsor and investigators
- Lead sponsor
- Rehman Medical Institute - RMI
- Sponsor type
- University, hospital or other
- Responsible party
- Sponsor
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT07919561
- Sponsor's protocol ID
- RMI-2026-RCT
- Acronym
- CHX; EOMW
- Status last verified
- Oct 2026
- First submitted
- 30 Oct 2026
- Last updated
- 5 Nov 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Study at a glance
From the registry record, last updated by the sponsor on 5 Nov 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- EFFECTIVENESS OF DILUTED CHLORHEXIDINE AND ESSENTIAL OIL BASED MOUTHWASHES ON PLAQUE IN ORTHODONTIC PATIENTS- A RANDOMIZED CONTROLLED TRIAL
- ClinicalTrials.gov ID
- NCT07919561
- Acronym / sponsor ID
- CHX; EOMW / RMI-2026-RCT
- Conditions
- Dental Plaque Accumulation
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 30 participants (actual)
- Lead sponsor
- Rehman Medical Institute - RMIUniversity, hospital or other
- Study start
- 10 Jul 2025 (actual)
- Primary completion
- 10 Jan 2026 (actual)
- Study completion
- 10 Jan 2026 (actual)
- First posted
- 5 Nov 2026 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
This randomized clinical trial compares the effectiveness of a chlorhexidine mouthwash with an essential-oil-based mouthwash in improving oral health outcomes. Participants will be assigned to one of the two mouthwash groups and will use the assigned mouthwash according to the study protocol. Oral health parameters will be assessed at baseline and after the follow-up period to determine and compare the effects of the two mouthwashes.
Detailed description
This study is a randomized clinical trial designed to compare the effectiveness of two mouthwash formulations: chlorhexidine mouthwash and an essential-oil-based mouthwash.
Eligible participants will be enrolled according to the predefined inclusion and exclusion criteria and randomly allocated into two groups. Group 1 (G1) will receive chlorhexidine mouthwash, while Group 2 (G2) will receive an essential-oil-based mouthwash.
Baseline oral health measurements will be recorded before the intervention. Participants will then use their assigned mouthwash according to the study protocol. Follow-up assessment will be performed after 3 months, and the relevant oral health outcomes will be recorded.
The outcomes measured at baseline and follow-up will be compared within and between the two groups to determine the effectiveness of the two mouthwash interventions. The study findings will help evaluate the comparative effects of chlorhexidine and essential-oil-based mouthwash on the selected oral health outcomes.
Study design
- Primary purpose
- Treatment
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Triple blind (participant, investigator, outcomes assessor)
- Number of arms
- 2
- Model description
- Participants are randomly assigned to one of two parallel intervention groups: G1 (Chlorhexidine mouthwash) or G2 (Essential Oil Based Mouthwash). Outcomes are assessed after 3 months.
| Arm | Type | Receives |
|---|---|---|
| G1 (diluted 0.2% chlorhexidine mouthwash) | Experimental | Other: diluted 0.2% Chlorhexidine mouthwashG1 (diluted 0.2% chlorhexidine mouthwash) |
| G2 (essential oil based mouthwashes) | Experimental | Other: Essential Oil-Based MouthwashG2 (essential oil based mouthwashes) |
Who may qualify
- Ages
- 14 to 40 years
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Child, Adult
Key inclusion criteria (1 listed)
- a. Patient with mild to moderate gingivitis (OPI scores more than 2 on any three standard teeth) b. No prior use of phenytoin, cyclosporin, or any other medication known to cause gingival enlargement medication c. No systemic problems like Diabetes mellitus, blood disorder etc d. Age above 14 years with completely erupted permanent dentition e. Patient who are under comprehensive orthodontic treatment for at least 3 months f. Mild to moderate crowding (up to 6mm)
Key exclusion criteria (1 listed)
- a. Pregnant women and lactating mother b. Enamel defects (enamel hypoplasia or fluorosis discoloration) c. Periodontal intervention done in the last six months (surgical or non-surgical)
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| diluted 0.2% Chlorhexidine mouthwashDiluted 0.2% chlorhexidine mouthwash administered to participants assigned to G1 according to the study protocol. | Other | G1 (diluted 0.2% chlorhexidine mouthwash) |
| Essential Oil-Based MouthwashEssential oil-based mouthwash administered to participants assigned to G2 according to the study protocol. | Other | G2 (essential oil based mouthwashes) |
Primary outcome
The Orthodontic Plaque Index (OPI)
Time frame: Baseline to 3 months
Change in the Orthodontic Plaque Index (OPI) score from baseline to 3 months was used to assess the effectiveness of the intervention.
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 5 Nov 2026.
- Individual participant dataSharing planned: No
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
The record lists no contact. Use the official record to reach the sponsor.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing diluted 0.2% Chlorhexidine mouthwash and Essential Oil-Based Mouthwash in people with Dental Plaque Accumulation, run by Rehman Medical Institute - RMI at 1 site in Pakistan.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 1 inclusion and 1 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 5 Nov 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Pakistan. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
The Orthodontic Plaque Index (OPI) (time frame: Baseline to 3 months). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 5 Nov 2026.