Clinical trials: ACTH
Sarcoid Uveitis
(ACTH) for the Treatment of Sarcoid Uveitis
Sarcoidosis is a multisystem granulomatous disease that can affect nearly any organ in the body. While most commonly affecting the lungs, vision threatening eye involvement occurs in approximately 25% of patients with sarcoid.
- Trial name
- ACTH (NCT03473964)
- Testing
- H.P. Acthar gel
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- John Huang, MD
Preterm Birth Complication, Stress Related Disorder
Effect of Maternal Odor and Kangaroo Care on Serum Cortisol and Comfort Levels in Preterm Infants: a Randomised Trial
Aims and objectives: Studies on stress are generally aimed at young children and infants. However, in the neonatal period, "especially in preterm babies", this issue was not given enough attention and was almost completely…
- Conditions
- Preterm Birth Complication, Stress Related Disorder, Cortisol Overproduction
- Trial name
- NCT05607706
- Testing
- Exposure to maternal odor
- Where
- Turkey (Türkiye)
- Volunteers
- 92 people, healthy volunteers welcome
- Sponsor
- Istanbul Nisantasi University
Feeding Difficulty
The Association of Hormones and Peptides With Nutritional Consequences in Children With Feeding Difficulty.
To study the role of ghrelin, leptin, adiponectin, neuropeptide Y (NPY), orexin A, IGF-1, IGFBP-1, IGFBP-3, and corticotrophin-releasing hormone (CRH) in the nutritional status in children with feeding difficulty, and further to…
- Trial name
- NCT03045978
- Where
- Taiwan
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Chang Gung Memorial Hospital
West Syndrome
Prevention of West Syndrome With Low-dose Adrenocorticotropin Hormone (ACTH)
West syndrome (WS) is a specific type of epilepsy (or seizure disorder) that has three features: infantile spasms (type of seizure), loss of milestones, and a specific pattern on electroencephalogram (EEG or brain wave test)…
- Trial name
- PREVENT-WS (NCT01367964)
- Testing
- adrenocorticotropin hormone
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- Ann & Robert H Lurie Children's Hospital of Chicago
Nephrotic Syndrome
Adrenocorticotropic Hormone (ACTH) for Frequently Relapsing and Steroid Dependent Nephrotic Syndrome
In childhood nephrotic syndrome, the kidneys leak protein, causing body swelling and a variety of possible complications such as infection, blood clots, and kidney failure.
- Trial name
- NCT02132195
- Testing
- ACTH
- Where
- 16 sites in United States
- Volunteers
- 31 people
- Sponsor
- Emory University
Pituitary Adenoma 1, Acth-Secreting
Pituitary Adenoma and Serum Lipid
Pituitary adenomas are usually benign monoclonal neoplasms caused by a mixture of pituicyte alterations together with a changed endocrine and paracrine regulatory milieu.
- Trial name
- NCT04021212
- Where
- China
- Volunteers
- 1,000 people
- Sponsor
- Shandong Provincial Hospital
Sarcoidosis
Registry for Advanced Sarcodiosis
Registry with evaluation and genetic information of patients with advanced sarcoidosis and matched sarcoidosis
- Trial name
- REAS (NCT03769987)
- Testing
- observation
- Where
- United States
- Volunteers
- 800 people
- Sponsor
- University of Cincinnati
Proteinuria
Availability Study of ACTH to Treat Children SRNS/SDNS
Primary nephrotic syndrome(NS) is a common children renal disease.About 20% primary nephrotic syndrome are steroid-dependent and steroid-resistant.Low serum cortisol is one of the main relapse reasons.Adrenocorticotropic…
- Trial name
- NCT02972346
- Testing
- ACTH
- Where
- China
- Volunteers
- 42 people
- Sponsor
- Xinhua Hospital, Shanghai Jiao Tong University School of Medicine
Obesity, Childhood, Hyperphagia
Early Genetic Identification of Obesity
TITLE: Whole genetic approach in Early Genetic Identification of Obesity (WEGIO) DESIGN: Multicenter epidemiological study STUDY POPULATION: Participants at risk for a syndromic or a monogenic genetic obesity, incl.
- Conditions
- Obesity, Childhood, Hyperphagia, Retinopathy, Syndactyly
- Trial name
- WEGIO (NCT06239064)
- Testing
- Genetic testing via blood collection
- Where
- 37 sites in Germany
- Volunteers
- 1,000 people
- Sponsor
- Rolfs Consulting und Verwaltungs-GmbH (RCV)
Kidney Diseases
Idiopathic Focal Segmental Glomerulosclerosis (FSGS) and Treatment With ACTH
FSGS is an immunologic disorder wherein circulating immune proteins cause damage to the kidneys and progressive injury and scarring.
- Trial name
- NCT01155141
- Testing
- H.P. Acthar Gel
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Stanford University
Bardet-Biedl Syndrome, POMC Deficiency
Phase 3 Crossover Trial of Two Formulations of Setmelanotide in Participants With Specific Gene Defects in the MC4R Pathway
A trial to compare the weekly and daily formulations of setmelanotide in participants with genetic defects in the melanocortin-4 receptor pathway.
- Trial name
- NCT05194124
- Testing
- Setmelanotide 2 mg, Setmelanotide 2.5 mg, Setmelanotide 3 mg
- Where
- 7 sites in United States, Canada and 4 more
- Volunteers
- 19 people
- Sponsor
- Rhythm Pharmaceuticals, Inc.
Infantile Spasms, Non-Intractable
Decreasing Parental Stress of Caregivers of Infants With Infantile Spasms by Using Telemedicine Technology
This study plans to learn more about how the use of new telemedicine technology can help with parental stress, costs, and overall satisfaction in care.
- Trial name
- NCT04086992
- Testing
- Remote monitoring
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of Colorado, Denver
Lupus Nephritis
ACTHar in the Treatment of Lupus Nephritis
Systemic Lupus Erythematosus (SLE) is a disease in which the immune system attacks the healthy cells and tissues, causing inflammation that can damage organs in the body.
- Trial name
- ACTHar (NCT02226341)
- Testing
- CellCept, ACTHar gel
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- Columbia University
Cushing's Disease
Mifepristone in Children With Refractory Cushing's Disease
Study objectives are to obtain safety, pharmacokinetic, and pharmacodynamic data on the effect of mifepristone on glucose metabolism, body weight and the growth-hormone-IGF in children with refractory Cushing's disease.
- Trial name
- NCT01925092
- Testing
- mifepristone
- Where
- United States
- Sponsor
- Corcept Therapeutics