Clinical trials: AI
Intracranial Hemorrhages, Acute Ischemic Stroke
AI Assisted Reader Evaluation in Acute Computed Tomography (CT) Head Interpretation
This study has been added as a sub study to the Simulation Training for Emergency Department Imaging 2 study (ClinicalTrials.gov ID NCT05427838).
- Conditions
- Intracranial Hemorrhages, Acute Ischemic Stroke, Hydrocephalus, Cerebral Infarction
- Trial name
- AI-REACT (NCT06018545)
- Testing
- Ground truthing, Reading
- Where
- 4 sites in United Kingdom
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- Oxford University Hospitals NHS Trust
Uterine Fibroid, Uterine Sarcoma
A Prospective Validation Study of Radiomics in the Differential Diagnosis of Uterine Leiomyoma and Uterine Sarcoma
In our previous study, based on the multi-center clinical big data collected from January 2012 to January 2025, we have completed the construction of a multimodal early warning model for the malignant transformation of uterine…
- Conditions
- Uterine Fibroid, Uterine Sarcoma, AI (Artificial Intelligence), Radiomic
- Trial name
- NCT07269535
- Testing
- No intervention (observational study)
- Volunteers
- 500 people
- Sponsor
- Tongji Hospital
Lung Cancer
Evaluation of Use of Diagnostic AI for Lung Cancer in Practice
This study investigates ways of improving radiologists performance of the classification of CT-scans as cancerous or non-cancerous. Participants interact with an AI to classify CT-scans under three different conditions.
- Trial name
- NCT03780582
- Testing
- AI-human interaction
- Where
- Hong Kong
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Ensemble Group Holdings, LLC
Urinary Stones, Prostate Cancer
Development of an AI-Agent for Urological Disease Diagnosis and Treatment
Urological diseases such as urinary stones, prostate cancer, and bladder cancer are very common and often require highly specialized diagnosis and treatment.
- Conditions
- Urinary Stones, Prostate Cancer, Bladder Cancer
- Trial name
- NCT07721935
- Where
- 3 sites in China
- Volunteers
- 2,000 people
- Sponsor
- Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
Root Canal Treatment in Children Primary Molars, Postoperative Pain
Efficiency of Sonic Activation During Root Canal Treatment of Primary Molars on Postoperative Pain and Facial Expressions
This study was conducted to evaluate the efficiency of sonic activation of 5%sodium hypochlorite during root canal treatment of primary molars on postoperative pain and facial expressions.
- Conditions
- Root Canal Treatment in Children Primary Molars, Postoperative Pain, Facial Expressions, Facial Emotions
- Trial name
- NCT07138937
- Testing
- Root canal treatment in primary molars with irreversible pulpitis, EDDY system for sonic activation of irrigation, side-vented needle
- Where
- Egypt
- Volunteers
- 30 people
- Sponsor
- Suez Canal University
Colorectal Cancer, Lung Metastases
AI Prediction Model and Risk Stratification for Lung Metastasis in Colorectal Cancer
Background: To assist clinicians with diagnosis and optimal treatment decision-making, we attempted to develop and validate an artificial intelligence prediction model for lung metastasis (LM) in colorectal cancer (CRC) patients.
- Trial name
- NCT05816902
- Testing
- The location of the patient's treatment
- Volunteers
- 2,779 people
- Sponsor
- Peking Union Medical College
Children
AI Based Multi-modal Parameter of Peripheral Blood Cells (MMPBC) Predicts Survival Risk in Critically Ill Children
This study aims to investigate whether an AI prediction model based on blood cell multi-modal data can achieve early warning of survival risk in critically ill children through a large-scale multi-center cohort of critically ill…
- Trial name
- NCT06034639
- Where
- China
- Volunteers
- 3 people
- Sponsor
- Zhujiang Hospital
Myopia
AI-Stratified Myopia Control for Children in Remote Areas
This cluster-randomized controlled trial aims to evaluate the effectiveness and cost-effectiveness of an artificial intelligence-based, risk-stratified, tiered intervention model for childhood myopia prevention and control in…
- Trial name
- NCT07825428
- Testing
- Routine Screening and Referral, AI-Guided Tiered Management
- Where
- 3 sites in China
- Volunteers
- 1,600 people, healthy volunteers welcome
- Sponsor
- Shanghai Eye Disease Prevention and Treatment Center
Cerebral Palsy Children
Rehabilitation Assessment of Motor Function In Cerebral Palsy Using Explainable AI
The goal of this observational study is to develop and validate an AI-based prediction model for functional mobility and gait outcomes in children with cerebral palsy using low-cost clinical and gait data collected in…
- Trial name
- NCT07629024
- Testing
- AI-Based Functional Mobility and Gait Assessment
- Where
- 4 sites in Pakistan
- Volunteers
- 200 people
- Sponsor
- Riphah International University
Varicose Veins of Lower Limb, Spider Veins
CLaCS Using 0.2% Aetoxysklerol Foam and 70% Glucose for the Treatment of Lower Limb Telangiectasias
This randomized, controlled, non-inferiority trial aims to compare the efficacy of two sclerosants used in the CLaCS (CryoLaser and CryoSclerotherapy) method for treating telangiectasias and reticular varicose veins.
- Conditions
- Varicose Veins of Lower Limb, Spider Veins, Reticular Leg Veins
- Trial name
- CLACSO (NCT07073742)
- Testing
- CLaCS
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- Charles University, Czech Republic
Pediatric Brain Tumors, Glioma
AI-Assisted MRI Molecular Subtyping in Pediatric Brain Tumors
This multicenter observational cohort study aims to develop and validate an artificial intelligence (AI)-assisted diagnostic system for preoperative molecular subtyping of pediatric brain tumors using routine magnetic resonance…
- Conditions
- Pediatric Brain Tumors, Glioma, Medulloblastoma, Ependymoma
- Trial name
- NCT07703605
- Volunteers
- 1,400 people
- Sponsor
- Huashan Hospital
Anxiety Depression
AI-INFORMED PEER-MENTORING BEHAVIORAL INTERVENTION FOR ANXIETY AND DEPRESSION PRIMARY PREVENTION IN YOUTH
The goal of this clinical trial will be to evaluate the efficacy of an AI-informed peer-mentoring program to improve stress management and social skills and reduce the risk of depressive and anxiety symptoms in healthy…
- Trial name
- PeerMentorAnxD (NCT07472894)
- Testing
- Peer-mentoring behavioral intervention, Health Education
- Where
- 2 sites in Greece, Italy
- Volunteers
- 1,680 people, healthy volunteers welcome
- Sponsor
- University of Patras
Type 1 Diabetes, Type 2 Diabetes
ACCESS: AI for pediatriC diabetiC Eye examS Study
The purpose of this study is to determine if providing in clinic point-of-care autonomous AI diabetic retinopathy exams improves screening rates compared to standard of care referral to an eye care provider, in a randomized…
- Trial name
- ACCESS (NCT05131451)
- Testing
- Point of Care Autonomous AI diabetic retinopathy exam
- Where
- United States
- Volunteers
- 164 people
- Sponsor
- Johns Hopkins University
Laparoscopic Surgery
Laparoscopic Skills Acquisition Using an AI-enhanced Game-based Simulation Tool Compared With a Laparoscopic Simulator Box Trainer
The goal of this clinical trial is to learn whether an AI-enhanced, game-based laparoscopic simulation tool can improve laparoscopic skills training and help increase surgical capacity in surgical trainees and other healthcare…
- Trial name
- CAMELs-RCT (NCT07276022)
- Testing
- AI-enhanced game-based simulation tool (Laptitude), Laparoscopic simulator box trainer (SurgTrac)
- Where
- 3 sites in Guatemala, India and 1 more
- Volunteers
- 157 people
- Sponsor
- University of Edinburgh
Dental Anxiety in Children, Behavior Management
AI-Generated Personalized Story Book to Improve Patient Behaviour
Dental anxiety and uncooperative behavior frequently interfere with the successful delivery of dental treatment in children and may increase the need for pharmacological behavior management.
- Conditions
- Dental Anxiety in Children, Behavior Management, Pediatric Dental Anxiety
- Trial name
- AI-STORY (NCT07778134)
- Testing
- AI-Generated Personalized Dental Storybook, Standard Dental Storybook, Standard Behavior Guidance
- Where
- Turkey (Türkiye)
- Volunteers
- 69 people, healthy volunteers welcome
- Sponsor
- Eskisehir Osmangazi University
X-Ray, AI (Artificial Intelligence)
Clinical Application of Automated Interpretation System for Chest X-Ray Images Based on Multimodal Large Models
There's a global shortage of radiologists. Radiology AI's automatic reporting is key for boosting efficiency and meeting patient needs, especially in resource-poor areas.
- Conditions
- X-Ray, AI (Artificial Intelligence), Radiology
- Trial name
- NCT07117266
- Testing
- radiologists reference AI reports
- Where
- 3 sites in China
- Volunteers
- 296 people, healthy volunteers welcome
- Sponsor
- Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Colonic Neoplasms
The Influence of Artificial Intelligence (AI )Assisted Polyp Detection (Discovery System) on Visual Gaze Patterns During Real-time Colonoscopy
In this study, the investigators aim to assess the influence of a computer-aided detection (CADe) system on the visual gaze patterns of endoscopists in order to further understand the effect of AI during real-time colonoscopy.
- Trial name
- REVEAL (NCT05619614)
- Testing
- eye-tracking glasses
- Where
- Netherlands
- Volunteers
- 52 people
- Sponsor
- Radboud University Medical Center
Coronary Artery Disease, Atherosclerosis
CaRi-Heart Assessment of Risk and Evaluation of Inflammation in Coronary CT Angiography (CARE-CCTA)
This study evaluates the use of CaRi-Heart® analysis, an artificial-intelligence (AI) software tool that measures inflammation in the coronary arteries using images already captured during a standard Coronary CT Angiography…
- Conditions
- Coronary Artery Disease, Atherosclerosis, Cardiovascular Inflammation
- Trial name
- CARE-CCTA (NCT07220304)
- Testing
- CaRi-Heart® Analysis
- Where
- 18 sites in United States
- Volunteers
- 15,000 people
- Sponsor
- Corazon Medical PC
Colorectal Cancer Metastatic, Colorectal Cancer Stage III
COLONYVAQ™, a Quantum-Classical Guided Personalized Neoantigen Vaccine for MSS Stage III Colorectal Cancer
This is an early phase I, single-arm, open-label clinical study designed to evaluate the safety, tolerability, and feasibility of COLONYVAQ-CRC, a physics-aware, quantum-classical AI-guided personalized neoantigen peptide…
- Conditions
- Colorectal Cancer Metastatic, Colorectal Cancer Stage III, Colorectal Cancer Stage IV
- Trial name
- COLONYVAQ™-CRC (NCT07328087)
- Testing
- Experimental: COLONYVAQ-CRC + mFOLFOX6 or CAPOX + Nivolumab
- Where
- Greece
- Volunteers
- 12 people
- Sponsor
- Biogenea Pharmaceuticals Ltd.
Artificial Intelligence
A Study to Assess the Impact of an Artificial Intelligence (AI) System on Chest X-ray Reporting
The study has an initial short retrospective component but is predominately a prospective study with two main parts. Initially during a 1 month period whilst reporters are familiarising themselves with the software two local…
- Trial name
- NCT05489471
- Testing
- Artificial intelligence review
- Volunteers
- 20,000 people
- Sponsor
- Hull University Teaching Hospitals NHS Trust