Clinical trials: ALS
ALS
Exposure to Neurotoxins as Risk Factors for ALS
Chemicals called neurotoxins can harm the nervous system. Amyotrophic lateral sclerosis (ALS) is a progressive disease affecting movement.
- Trial name
- NCT00340301
- Where
- United States
- Volunteers
- 397 people
- Sponsor
- National Institute of Environmental Health Sciences (NIEHS)
Amyotrophic Lateral Sclerosis
Staging System in Amyotrophic Lateral Sclerosis
Recently two staging systems have been proposed for amyotrophic lateral sclerosis (ALS), based on clinical milestones The King's college clinical staging system (1) and ALS Milano-Torino Staging (ALS-MITOS) (2).
- Trial name
- Biostaging (NCT04858555)
- Where
- 2 sites in France
- Volunteers
- 50 people
- Sponsor
- University Hospital, Limoges
Amyotrophic Lateral Sclerosis
Home Care Needs and Current Nursing Status of Patients With Amyotrophic Lateral Sclerosis
The purpose of this study is to comprehensively investigate and analyze the home care needs and status quo of ALS patients in China, and to clarify their home care needs and status quo, so as to provide reference for the…
- Trial name
- NCT04953481
- Testing
- survey
- Where
- China
- Volunteers
- 252 people
- Sponsor
- Peking University Third Hospital
Amyotrophic Lateral Sclerosis
Investigation on Home Care Needs of ALS Patients and Their Caregivers
The research target 1. To investigate the home nursing knowledge needs of ALS patients; 2. Investigate the needs of ALS caregivers for home nursing knowledge; 3.
- Trial name
- NCT04950231
- Testing
- The questionnaire survey
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Peking University Third Hospital
Muscular Dystrophy, Duchenne, Orthotic Devices
The Effect of a Muscle-mimicking, Fabric-type Shoulder Orthosis on Functional Movements of the Upper Limb in Patients With Neuromuscular Disorder
The goal of this clinical trial is to investigate the effect of a muscle-mimicking, fabric-type shoulder orthosis on functional movements of the upper limb in patients with neuromuscular disorder.
- Conditions
- Muscular Dystrophy, Duchenne, Orthotic Devices, Upper Extremity, Neuromuscular Diseases (NMD)
- Trial name
- NCT06363357
- Testing
- Shoulder orthosis
- Where
- South Korea
- Volunteers
- 8 people
- Sponsor
- Seoul National University Hospital
Amyotrophic Lateral Sclerosis
Relationship Between Respiratory Functional Tests and Image Thoracic Techniques in Patients With Neuromuscular Diseases
It is very important monitoring respiratory muscle function in patients with amyotrophic lateral sclerosis (ALS). We have at our disposal Respiratory Functional Tests (forced vital capacity (FVC), maximal mouth-inspiratory force…
- Trial name
- NCT01090674
- Testing
- No intervention
- Where
- Spain
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau
Amyotrophic Lateral Sclerosis
Methodology Study of Novel Outcome Measures to Assess Progression of ALS
The primary objectives of the study are to estimate and rank-order the longitudinal standardized mean changes over 6 months and over 12 months, for a set of outcome measures administered to participants with amyotrophic lateral…
- Trial name
- NCT02611674
- Where
- 21 sites in United States, Belgium and 7 more
- Volunteers
- 138 people
- Sponsor
- Biogen
Amyotrophic Lateral Sclerosis
Study of Gene Polymorphisms Involved in the Metabolism and Action of Vitamin D in Amyotrophic Lateral Sclerosis
This is a case-control study performed on a biological collection. The polymorphisms present on a pre-defined list of genes will be studied for 400 Amyotrophic Lateral Sclerosis (sporadic type) DNA samples and 400 control DNA…
- Trial name
- SLA_Vit_D (NCT02893605)
- Where
- France
- Volunteers
- 800 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Amyotrophic Lateral Sclerosis
Sleep Disorders and the Onset and Progression of ALS
200 cases of ALS patients were collected to explore whether sleep disorders are related to earlier onset age, and whether sleep disorders accelerate the progress of ALS and shorten the survival time of ALS patients.
- Trial name
- NCT04952038
- Testing
- sleep disorder
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Peking University Third Hospital
Poliomyelitis, Postpoliomyelitis Syndrome
Study of "Post-Polio Syndrome"
Polio or poliomyelitis is the disease caused by the poliovirus. The virus attacks cells in the spinal cord and causes symptoms of fever, sore throat, headache, vomiting, and stiffness of the neck.
- Trial name
- NCT00001185
- Where
- United States
- Volunteers
- 360 people
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Amyotrophic Lateral Sclerosis
Inspiratory Muscle Training With Powerbreath Device in Patients With ALS
Abstract: Context/background: people affected by Amyotrophic Lateral Sclerosis (ALS) see their own life totally disturbed after the diagnosis.
- Trial name
- NCT04889248
- Testing
- Inspiratory Muscle Training with Powerbreath IMT device.
- Where
- Spain
- Volunteers
- 20 people
- Sponsor
- Universidad Francisco de Vitoria
Amyotrophic Lateral Sclerosis
A Registered Cohort Study on Amyotrophic Lateral Sclerosis
Amyotrophic lateral sclerosis (ALS) is a kind of motor neuron degeneration disorder without effective therapy. This registered cohort study will provide further insights into the clinical course of ALS, and investigate…
- Trial name
- NCT04008329
- Where
- China
- Volunteers
- 2,000 people
- Sponsor
- First Affiliated Hospital of Fujian Medical University
Amyotrophic Lateral Sclerosis
Neuromuscular Magnetic Stimulation in ALS Patients
Aim of the study is to verify whether neuromuscular magnetic stimulation can improve muscle function in spinal-onset Amyotrophic Lateral Sclerosis (ALS) patients.
- Trial name
- NMS-ALS (NCT03618966)
- Testing
- Neuromuscular magnetic stimulation (NMMS)
- Volunteers
- 22 people
- Sponsor
- University of Roma La Sapienza
ALS, Amyotrophic Lateral Sclerosis
NYSCF Scientific Discovery Biobank
The New York Stem Cell Foundation (NYSCF) Research Institute is performing this research to accelerate diverse disease research using cells from the body (such as skin or blood cells) to make stem cells and other types of cells…
- Conditions
- ALS, Amyotrophic Lateral Sclerosis, Alzheimer Disease, Alzheimer Disease, Early Onset
- Trial name
- NCT06203106
- Testing
- Biological Sample Collection
- Where
- United States
- Volunteers
- 10,000 people
- Sponsor
- New York Stem Cell Foundation Research Institute
IGF-1 Deficiency
IGF-1, IGFBP3, ALS Normative Ranges in Healthy Pediatric Spanish Population
To determine the normative ranges of the Insulin-like Growth Factor 1 (IGF-1), Insulin-like growth factor-binding protein 3 (IGFBP-3), Acid-Labile Subunit (ALS) according to age, sex and pubertal stage of a healthy paediatric…
- Trial name
- EDISON (NCT01676090)
- Where
- 9 sites in Spain
- Volunteers
- 304 people, healthy volunteers welcome
- Sponsor
- Ipsen
Amyotrophic Lateral Sclerosis (ALS)
Personalized Antisense Oligonucleotide Therapy for a Participant With TARDBP ALS
This research project entails delivery of a personalized antisense oligonucleotide (ASO) drug designed for a single participant with amyotrophic lateral sclerosis (ALS) due to a pathogenic variant in TARDBP.
- Trial name
- NCT07703462
- Testing
- nL-TARDB-002
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- n-Lorem Foundation
ALS, Amyotrophic Lateral Sclerosis
A Study to Explore the Role of Gut Flora in ALS
This study seeks to correlate microbiome sequencing data with information provided by patients and their medical records regarding ALS
- Conditions
- ALS, Amyotrophic Lateral Sclerosis, Motor Neuron Disease
- Trial name
- NCT04150809
- Testing
- No intervention
- Where
- United States
- Sponsor
- ProgenaBiome
Amyotrophic Lateral Sclerosis, Cognitive Impairment
Edinburgh Cognitive and Behavioural Amyotrophic Lateral Sclerosis Screen in Norway: A Prospective Cohort Study
This study evaluate use of a translated Norwegian version of the Edinburgh cognitive and behavioral amyotrophic lateral sclerosis screen (ECAS-N) as an early predictor in car-driving, working and use of advanced life-prolonging…
- Trial name
- NCT03578796
- Testing
- ECAS-N, MoCA, CDR
- Where
- Norway
- Volunteers
- 31 people
- Sponsor
- Haukeland University Hospital
Other Developmental Disorders of Speech and Language
A Speech Sound and Phonemic Awareness Intervention in Flemish Early Childhood Education
The language intervention 'Kaatje Klank' is designed for stimulating the speech production and speech perception skills of 4-year-olds in an early childhood educational setting, in order to stimulate early literacy skills.
- Trial name
- NCT02313025
- Testing
- speech sound intervention, World-project
- Where
- Belgium
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- KU Leuven
Amyotrophic Lateral Sclerosis, Frontotemporal Dementia
Open-label Extension (OLE) Study of WVE-004 in Patients With C9orf72-associated Amyotrophic Lateral Sclerosis (ALS) and/or Frontotemporal Dementia (FTD)
This is an OLE study conducted to evaluate the safety, tolerability, pharmacokinetics (PK), pharmacodynamics (PD), and clinical effects of WVE-004 in adult participants with ALS, FTD, or mixed ALS/FTD phenotype with a documented…
- Trial name
- NCT05683860
- Testing
- WVE-004 10 mg Q12W
- Where
- 3 sites in Netherlands, United Kingdom
- Volunteers
- 8 people
- Sponsor
- Wave Life Sciences USA, Inc.