Clinical trials: Abnormal Labor
Obstructed Labor
Use of Preoperative Sodium Bicarbonate Among Women With Obstructed Labor
The goal of this clinical trial is to determine a universal safe and effective dose of sodium bicarbonate for use among women with Obstructed labour to treat acidosis.
- Trial name
- SoBicOL-II (NCT06579690)
- Testing
- 8.4% sodium bicarbonate solution, 0.9% Normal Saline
- Where
- Uganda
- Volunteers
- 472 people
- Sponsor
- Busitema University
Primary Postpartum Haemorrhage
Comparative Study on the Effects of Sublingual Misoprostol in Addition to Standard AMTSL in Low Risk Parturients in LASUTH, Ikeja.
Postpartum haemorrhage is the leading cause of maternal haemorrhage globally. With active management of labour 3 to 16.5% of parturients still experience postpartum haemorrhage.
- Trial name
- NCT02424201
- Testing
- Misoprostol, vitamin c
- Volunteers
- 660 people, healthy volunteers welcome
- Sponsor
- Lagos State University
Obstetric Complication, Vaginal Bleeding
Reliability of Simple Sonographic Findings Acquired With Hand-held Apparatuses to Inform Obstetric Diagnosis
the study aims to assess the reliability of ultrasound findings measured by hand held ultrasound probes used by operators with variable experience in a low resource hospital.
- Conditions
- Obstetric Complication, Vaginal Bleeding, Eclampsia Preeclampsia, Obstructed Labor
- Trial name
- NCT03856307
- Testing
- point of care ultrasound
- Where
- Sierra Leone
- Volunteers
- 300 people
- Sponsor
- Doctors with Africa - CUAMM
Labour Dystocia
Oral Sodium Bicarbonate for the Prevention of Labour Dystocia
Sodium bicarbonate is often used by athletes to improve their muscle's ability to contract and power their activity. It works by decreasing the risk of lactic acid build-up, which causes cramping and fatigue.
- Trial name
- Labour-Aide (NCT06249061)
- Testing
- oral sodium bicarbonate
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Liz Darling
Pregnancy, Pregnancy Complications
AI-POCUS for Maternal and Neonatal Health in Ethiopia
Maternal and neonatal health remains one of the most pressing global health challenges, particularly in low- and middle-income countries (LMICs).
- Conditions
- Pregnancy, Pregnancy Complications, Preterm Birth, Fetal Growth Restriction
- Trial name
- AIM-ETH (NCT07171086)
- Testing
- AI-POCUS (BabyChecker, Delft Imaging), AI-POCUS (Edan, China)
- Where
- Ethiopia
- Volunteers
- 1,059 people, healthy volunteers welcome
- Sponsor
- Tsinghua University
Uterine Atony, Uterine Tone Disorders
Intravenous Versus Intramuscular Administration of Methylergonovine for Uterine Contraction in Cesarean Sections
Insufficient uterine tone resulting in atony can potentiate hemorrhage and adverse outcomes for the parturient. Oxytocin is the first pharmacologic agent used, followed by methylergonovine, carboprost, and misoprostol.
- Conditions
- Uterine Atony, Uterine Tone Disorders, Postpartum Hemorrhage
- Trial name
- NCT03303235
- Testing
- Methylergonovine
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Postpartum Hemorrhage
Treatment of Postpartum Hemorrhage With Misoprostol: Fever Study
This study seeks to assess whether populations of women in Latin America outside Quito, Ecuador are at increased risk for developing elevated body temperature above 40.0°C following PPH treatment with 800mcg sublingual…
- Trial name
- NCT02163616
- Testing
- Misoprostol
- Where
- 2 sites in Argentina
- Volunteers
- 635 people, healthy volunteers welcome
- Sponsor
- Gynuity Health Projects
Postpartum Hemorrhage, Uterine Atony
ED90 Determination of Carbetocin for the Prevention of Uterine Atony in Women Undergoing an Elective Cesarean Delivery
The purpose of this trial is to determine the effective dose of carbetocin which would prevent the occurrence of postpartum uterine atony in 90% of women undergoing an elective cesarean delivery.
- Trial name
- NCT01579201
- Testing
- Carbetocin
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- Maisonneuve-Rosemont Hospital
Maternal Death Affecting Fetus or Newborn, Delivery Complication
Impact of a Smartphone Intervention on Tanzanian Women's Childbirth Location
This study investigates whether training Community Health Workers (CHW) to use a smartphone-based prenatal counseling application as a "job aid" instead of the existing paper based standard is associated with increased women's…
- Conditions
- Maternal Death Affecting Fetus or Newborn, Delivery Complication, Obstetric Complication, Birth Injuries
- Trial name
- SUSTAIN1 (NCT03161184)
- Testing
- SUSTAIN Smartphone training of CHW (SP+), SUSTAIN Paperbased training of CHW (SOC)
- Volunteers
- 572 people, healthy volunteers welcome
- Sponsor
- University of Toronto
Postpartum Hemorrhage
Fever After Misoprostol Administration for the Treatment of Primary Postpartum Hemorrhage
This study will evaluate side effects after sublingual misoprostol (600 mcg) as a first-line treatment for primary postpartum hemorrhage (PPH) due to suspected uterine atony.
- Trial name
- NCT01080846
- Testing
- Misoprostol
- Where
- Ecuador
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Gynuity Health Projects
Postpartum Hemorrhage
RUBY Post-Market Registry on the Jada® System
The RUBY Study is a multicenter, observational, post-market registry designed to collect observational data on patients treated with the Jada System in the post-market setting.
- Trial name
- RUBY (NCT04995887)
- Testing
- Jada® System
- Where
- 16 sites in United States
- Volunteers
- 809 people
- Sponsor
- Alydia Health
Uterine Bleeding, Atony, Uterine
Questionnaire for Obstetricians and Anesthesiologist
The research was planned as a face-to-face survey evaluation. The questionnaire will be applied to obstetricians and anesthesiologists working in public and private hospitals.
- Conditions
- Uterine Bleeding, Atony, Uterine, Cesarean Section Complications
- Trial name
- NCT05089721
- Where
- Turkey (Türkiye)
- Volunteers
- 200 people
- Sponsor
- Gazi University
Gestational Diabetes
Role of HbA1c in Predicting Adverse Pregnancy Outcomes
This study aims to determine the reference value of HbA1c that can be used to predict adverse pregnancy outcomes. These adverse outcomes include LGA fetus, shoulder dystocia, caesarean section, pre-term birth, pre-eclampsia and…
- Trial name
- NCT06676254
- Where
- Malaysia
- Volunteers
- 195 people
- Sponsor
- National University of Malaysia
Postpartum Hemorrhage
Comparison of IV Ergonovine With IM Carboprost, With Oxytocin IV, During Cesarean Section for Failure to Progress
Patients having Cesarean section after they have been in labor for many hours bleed much more, in average twice as much, as compared with patients having an elective Cesarean section.
- Trial name
- NCT01869556
- Testing
- Oxytocin, Ergot, Carboprost
- Where
- Canada
- Volunteers
- 105 people, healthy volunteers welcome
- Sponsor
- Samuel Lunenfeld Research Institute, Mount Sinai Hospital
Pregnancy
Relevance of Ultrasound Screening for Foetal Macrosomia
Management of fetal macrosomia is based on a suspicion of macrosomia (no certainty before birth). This management is an artificial induction of labour for an earlier delivery and therefore a lower fetal weight gain.
- Trial name
- USmacro (NCT04443205)
- Testing
- Data record
- Where
- France
- Volunteers
- 3,000 people
- Sponsor
- CHU de Reims
Preterm Birth, Early Intervention
Movement Imitation Therapy for Preterm Babies (MIT-PB) - A Pilot Study
Background: Very preterm babies are at high risk for developmental disorders. Prechtl's General Movements (GMs) Assessment is a valuable and reliable tool in infants until three months corrected age for predicting their further…
- Conditions
- Preterm Birth, Early Intervention, General Movements
- Trial name
- NCT07449312
- Testing
- Movement Imitation Therapy for Preterm Babies (MIT-PB), Usual care Physiotherapy
- Where
- Switzerland
- Volunteers
- 80 people
- Sponsor
- University of Zurich
Birth; Prolonged
Acceptability Assessment of an Optimized Birthing Position
This qualitative study evaluates the acceptability of positioning pregnant women in labour in an optimized position, which consists in the hyperflexion of the legs and the loss of the lumbar lordosis.
- Trial name
- NCT04056793
- Testing
- Optimized birthing position
- Where
- Switzerland
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire Vaudois
Delivery Problem, Cervix; Pregnancy
Effects of Systematic Cervical Exam Training on Labor and Delivery Care
All physicians, nurses, and nurse midwives working on Labor and Delivery will be required to complete cervical exam simulation training.
- Conditions
- Delivery Problem, Cervix; Pregnancy, Pregnancy Related
- Trial name
- NCT04421768
- Testing
- cervical exam training
- Where
- United States
- Volunteers
- 1,125 people, healthy volunteers welcome
- Sponsor
- Wake Forest University Health Sciences
Labor Stage, First, Prolonged Labor
Maternal Maneuvers During Prolonged Labor
This pilot, randomized control trial will test whether or not a specific circuit of position changes improves maternal outcomes in cases of prolonged labor.
- Trial name
- CIRCUIT (NCT06636149)
- Testing
- Circuit of maternal position changes during labor
- Where
- United States
- Volunteers
- 82 people
- Sponsor
- Washington University School of Medicine
Dystocia
Use of Acupuncture for Stimulation of Labour
Hypothesis:Acupuncture can be used as stimulation of labour in case of primary og secondary inertia. A randomized controlled trial including 150 pregnant women Acupuncture has become a natural part of the range of obstetric…
- Trial name
- NCT00279071
- Testing
- Acupuncture og acupressure when diagnosed with dystocia
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Herning Hospital