Clinical trials: Acid Base Imbalance
Epilepsy, Metabolic Acidosis
Use of Sodium Bicarbonate in Patients Treated With Topiramate
Effect of oral sodium bicarbonate therapy on renal tubular acidosis in epilepsy patients taking topiramate.
- Conditions
- Epilepsy, Metabolic Acidosis, Tubular Acidosis; Renal
- Trial name
- NCT03354507
- Testing
- Sodium bicarbonate
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- McMaster Children's Hospital
Mitochondrial Encephalopathy, Lactic Acidosis and Stroke-Like Episodes (MELAS Syndrome)
An Open-label Extension Safety Study of MELAS Patients Who Completed TIS6463-203 (PRIZM)
The goal of this clinical trial is to evaluate the long-term safety and tolerability of zagociguat in patients with MELAS who completed study medication treatment in the lead-in study TIS6463-203.
- Trial name
- NCT06961344
- Testing
- zagociguat 15mg
- Where
- 16 sites in United States, Australia and 3 more
- Volunteers
- 37 people
- Sponsor
- Tisento Therapeutics
Ketosis, Epilepsy
Market Research - Acceptability Study for a Range of MCT Products
This is a market research, observational study to evaluate the tolerability and acceptability of MCT supplements for young children and young people with intractable epilepsy, GLUT-1 or PDHD from 3 years to adulthood.
- Conditions
- Ketosis, Epilepsy, Ketogenic Diet, Fatty Acid Oxidation Disorder
- Trial name
- NCT04309149
- Testing
- MCT fats
- Where
- 2 sites in United Kingdom
- Volunteers
- 12 people
- Sponsor
- Dr. Schär AG / SPA
Metabolic Acidosis, Critical Illness
The Threshold of Serum Anion Gap as a Screening Tool for Organic Acidosis
Background: The serum anion gap (AG) is commonly used as a screening tool for acid-base disorders. With modern laboratory techniques using ion-selective electrodes to measure the main electrolyte components of the AG, our…
- Conditions
- Metabolic Acidosis, Critical Illness, Anion Gap Acidosis, Lactic Acidosis
- Trial name
- NCT04975906
- Where
- Singapore
- Volunteers
- 16,475 people
- Sponsor
- Changi General Hospital
Neonatal Encephalopathy, Cell Damage
Inflammation and Metabolic Acidosis at Birth (AGAIN: AutophaGy AcIdosis Newborn)
Protection of brain development is a major aim in the Neonatal Intensive Care Unit. Neonatal encephalopathy (NE) occurs in 1.8 to 7.7 infants per 1000 births.
- Conditions
- Neonatal Encephalopathy, Cell Damage, Metabolic Acidosis, Inflammation
- Trial name
- AGAIN (NCT03897101)
- Where
- 2 sites in Italy
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- University Hospital of Ferrara
Diabetes Mellitus, Type 1
The Impact of Different CSII and CGM Systems on Different Clinical Outcome Variables in Children and Adolescents With Type 1 Diabetes. An Observational Study Form the Norwegian Childhood Diabetes Registry (NCDR)
To examine the effect of continuous subcutaneous insulin infusion (CSII) and continuous glucose monitoring (CGM) on metabolic control, in a large population-based nationwide observational study under real life conditions.
- Trial name
- NCT04201171
- Testing
- CSII and CGM
- Volunteers
- 2,749 people
- Sponsor
- Helse Fonna
Diabetic Ketoacidosis
Cerebral Edema in Pediatric Diabetic Ketoacidosis
The purpose of this trial is to compare two different rates of fluid administration during diabetic ketoacidosis (DKA) treatment in children to determine which fluid administration rate is more beneficial for brain metabolism and…
- Trial name
- NCT00629707
- Testing
- intravenous fluid treatment
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of California, Davis
Diabetic Ketoacidosis
Children with Diabetic Ketoacidosis
In the present work we aim to 1. Response to therapy, During the management of DKA, acid base status, glycemia, and serum electrolytes are measured frequently to monitor the efficacy of treatment, detect complications of DKA and…
- Trial name
- NCT06599203
- Volunteers
- 130 people
- Sponsor
- Assiut University
Diabetes Mellitus, Type 1
Effects of Micronutrient (Chromium) Supplementation on Diabetes
6-8% of USA population has diabetes. Intensive blood glucose control dramatically reduces the devastating complications that result from poorly controlled diabetes.
- Trial name
- NCT01709123
- Testing
- chromium niacinate
- Where
- United States
- Volunteers
- 62 people
- Sponsor
- Louisiana State University Health Sciences Center Shreveport
Metabolic Acidosis
A Study on Bedside Formate Assay as a Diagnostic Tool in Methanol Poisoning
Methanol poisoning is a serious issue, particularly in low- and middle-income countries (LMICs), where outbreaks can devastate communities.
- Trial name
- NCT06881641
- Where
- 6 sites in Bangladesh, India
- Volunteers
- 6,120 people
- Sponsor
- University of Edinburgh
HIV, Hepatitis B
EuroSIDA - Clinical and Virological Outcome of European Patients Infected With HIV
The EuroSIDA study is a prospective observational cohort study of 23,000+ patients followed in 100+ clinics in 35 European countries, Israel and Argentina.
- Conditions
- HIV, Hepatitis B, Hepatitis C, AIDS
- Trial name
- EuroSIDA (NCT02699736)
- Where
- 110 sites in Argentina, Austria and 34 more
- Volunteers
- 23,000 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Sepsis, Acute Kidney Injury
Identifying Risk Factors for Developing AKI in Sepsis
A study to evaluate the prevalence of Acute Kidney Injury (AKI) in patients with Diabetic Ketoacidosis (DKA) and sepsis using data collected prospectively to a patient registry.
- Conditions
- Sepsis, Acute Kidney Injury, Diabetic Ketoacidosis
- Trial name
- NCT04825639
- Testing
- No intervention
- Where
- United Kingdom
- Volunteers
- 300 people
- Sponsor
- Cardiff and Vale University Health Board
Emergence Delirium in Pediatric Anesthesia, Perioperative Ketonemia and Its Association With Recovery Outcomes in Children
"KETOMED: Ketonemia and Risk of Emergence Delirium in Children Undergoing General Anesthesia - A Multicenter Observational Study"
The objective of this observational study is to evaluate the relationship between ketonemia and emergence delirium in children undergoing general anesthesia.
- Trial name
- KETOMED (NCT07249736)
- Where
- Spain
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Hospital Clínico Universitario de Valladolid
Angelman Syndrome
Nutritional Formulation for Angelman Syndrome
Low carbohydrate diets such as the ketogenic (KD) and low glycemic index (LGIT) diets have been shown to be effective in treating drug resistant seizures in children with Angelman syndrome (AS).
- Trial name
- FANS (NCT03644693)
- Testing
- Nutritional Formulation Containing Exogenous Ketones
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- University of Colorado, Denver
Diabetes, Diabetic Ketoacidosis
Evaluation of a Non-invasive Brain Compliance Measurement Device
This is a research study to understand how diabetic ketoacidosis may affect the brain and learning and to see if these changes are transient or permanent.
- Trial name
- NCT01753921
- Testing
- this is not an intervention study, MRI
- Where
- United States
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Stanford University
Metabolic Acidosis, Diabetic Ketoacidosis
Diabetic Ketoacidosis Diagnosis and Management
This is the first and only study conducted on the use of capnography in children diagnosed with DKA to evaluate the initial clinical grading of DKA, monitor clinical improvement, and predict complications such as brain edema.
- Conditions
- Metabolic Acidosis, Diabetic Ketoacidosis, Brain Edema
- Trial name
- NCT06327737
- Testing
- Capnography
- Where
- Turkey (Türkiye)
- Volunteers
- 55 people
- Sponsor
- Akdeniz University
Mitochondrial Diseases
A Long-term Extension of Study RP103-MITO-001 (NCT02023866) to Assess Cysteamine Bitartrate Delayed-release Capsules (RP103) in Children With Inherited Mitochondrial Disease
A long-term extension study to assess the safety, tolerability and efficacy of cysteamine bitartrate delayed-release capsules (RP103) in children with inherited mitochondrial diseases who previously enrolled into study…
- Trial name
- NCT02473445
- Testing
- Cysteamine Bitartrate
- Where
- 5 sites in United States
- Volunteers
- 22 people
- Sponsor
- Amgen
Brain Neoplasms
Fluid Therapy During Brain Tumor Resection in Children
Fluid management of children during neurosurgery is not well established. Hypotonic solutions, commonly still used in pediatric patients, may enhance cerebral edema and worse operative conditions.
- Trial name
- NCT02707549
- Testing
- balanced crystalloid solution (components: sodium chloride, sodium gluconate, sodium acetate, potassium chloride and magnesium chloride), 0.9% sodium chloride
- Where
- Brazil
- Volunteers
- 53 people
- Sponsor
- Federal University of São Paulo