Clinical trials: Acute Exacerbation
Asthma, Acute Asthma
Single Dose Oral Dexamethasone Versus Multi-dose Prednisolone in the Treatment of Acute Exacerbations of Asthma in Children
A trial to investigate if a single dose of the oral corticosteroid, Dexamethasone is as effective in treating exacerbations of asthma in children as 3 days of treatment with another oral corticosteroid, Prednisolone
- Trial name
- NCT03698630
- Testing
- Prednisolone Sodium Phosphate, Dexamethasone
- Where
- Ireland
- Volunteers
- 250 people
- Sponsor
- University College Dublin
Acute Exacerbation of Chronic Obstructive Pulmonary Disease
The Severity Assessment Model for AECOPD With Combination of Disease and Syndrome
The establishment of the AECOPD severity assessment model can quickly and accurately evaluate the condition, which is of great significance for standardizing diagnosis and treatment, improving efficacy, and improving prognosis.
- Trial name
- NCT06918353
- Testing
- Diagnosis and Severity Grading of AECOPD Disease
- Where
- China
- Volunteers
- 1,500 people
- Sponsor
- Henan University of Traditional Chinese Medicine
Asthma Acute, Asthma in Children
User-Friendly Spirometer and Mobile App for Self-Management and Home Monitoring of Asthma Patients
The primary goal of this proposal is to use an in-home, smartphone-enabled, hand-held spirometer to determine the FEV1% predicted ranges that predict the Yellow Zone threshold.
- Conditions
- Asthma Acute, Asthma in Children, Asthma Chronic, Asthma Attack
- Trial name
- NCT03642418
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of California, San Francisco
Cystic Fibrosis
High Frequency Chest Wall Oscillation and Cystic Fibrosis
High frequency chest wall oscillation (HFCWO) has been shown to increase tracheal mucus clearance compared with a control group.
- Trial name
- NCT01057524
- Testing
- High Frequency Chest Wall Oscillation (HFCWO), Usual airway clearance
- Where
- United Kingdom
- Volunteers
- 56 people
- Sponsor
- Imperial College London
Asthma, Reactive Airway Disease
Comparison of Oral Dexamethasone Doses in Asthma Exacerbation
Hypothesis: A 2-day course of oral dexamethasone is the superior option for the resolution of symptoms and prevention of relapse in the emergency department (ED) management of mild-moderate asthma exacerbations.
- Trial name
- NCT00942201
- Testing
- Dexamethasone
- Where
- United States
- Volunteers
- 125 people, healthy volunteers welcome
- Sponsor
- Rady Children's Hospital, San Diego
Safety of NHF in Acute Hypercapnic AECOPD
NHF in Acute Hypercapnic Acute Exacerbation of COPD
Patients with AECOPD and NIV failure and in absence will be treated with NHF device. Inclusion criteria are pH < 7,38 and pCO2 > 45 mm Hg. Patients were treated if pH >7,38 or refusal of therapy.
- Trial name
- NCT03523481
- Where
- Germany
- Volunteers
- 38 people
- Sponsor
- Jens Bräunlich, MD
Pulmonary Disease, Chronic Obstructive, Lung Diseases, Obstructive
Does Positive Expiratory Pressure Mask Therapy Improve Recovery From Acute Exacerbations of Chronic Obstructive Pulmonary Disease?
This study aims to identify whether the addition of positive expiratory pressure (PEP) mask therapy to standard medical care improves clinically important outcomes in individuals with acute exacerbations of chronic obstructive…
- Trial name
- NCT01101282
- Testing
- Positive expiratory pressure (PEP) mask therapy
- Where
- 2 sites in Australia
- Volunteers
- 92 people
- Sponsor
- La Trobe University
Asthma; Status, Asthma in Children
Pragmatic RCT of High-dose Oral Montelukast for Moderate and Severe Pediatric Acute Asthma Exacerbations
Objective: To determine the extent to which high-dose (30mg) oral montelukast, added to standard treatment in children with moderate and severe acute exacerbations improves outcomes.
- Conditions
- Asthma; Status, Asthma in Children, Asthma Acute, Asthma Attack
- Trial name
- NCT03277170
- Testing
- Montelukast Oral Granules
- Where
- United States
- Sponsor
- Vanderbilt University Medical Center
Cystic Fibrosis
Comprehensive Exercise Training Program During Hospitalization for an Acute CF Exacerbation
This protocol was designed to assess if when subjects with CF are admitted to the hospital for a pulmonary exacerbation if a comprehensive exercise program (moderate to high intensity aerobic, resistance, flexibility and balance…
- Trial name
- NCT01759342
- Testing
- Aerobic exercise, Resistance exercise, Flexibility and postural exercise
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- University of Alabama at Birmingham
Asthma, Status Asthmaticus
Bilevel Positive Airway Pressure (BiPAP) for the Treatment of Moderate to Severe Acute Asthma Exacerbations
Bilevel Positive Airway Pressure (BiPAP) is increasingly being reported as an effective and safe method of respiratory support for children with severe asthma exacerbations unresponsive to standard therapies and with impending…
- Trial name
- NCT02347462
- Testing
- Bilevel Positive Airway Pressure (BiPAP) (Trilogy BiPAP, Philips Respironics), Standard care
- Where
- Canada
- Sponsor
- University of British Columbia
Childhood Asthma With Acute Exacerbation
Comparison of Nebulizers vs Metered-Dose Inhalers With Spacer Device For Treatment Of Childhood Wheeze
The goal of this randomized controlled trial is to compare two different devices for the administration of the standard protocol drug.
- Trial name
- NCT06201156
- Testing
- Metered Dose Inhaler With Spacer Device
- Where
- Pakistan
- Volunteers
- 160 people
- Sponsor
- Khyber Teaching Hospital
Acute Exacerbation of COPD
Non Invasive Ventilation With NAVA vs ASV for AECOPD
Non invasive ventilation is the standard of care in managing patients with exacerbation of chronic obstructive pulmonary disease.
- Trial name
- NCT04414891
- Testing
- Non invasive ventilation
- Where
- India
- Volunteers
- 76 people
- Sponsor
- Post Graduate Institute of Medical Education and Research, Chandigarh
COPD - Chronic Obstructive Pulmonary Disease, Muscle Atrophy
Progressive Resistance Training of the Extensor Muscle of the Thigh in COPD-patients Hospitalized With an Exacerbation
We want to test the hypothesis, that resistance training by the use of weigth cuffs on the angle can prevent loss or improve the strength of the quadriceps muscle in COPD patients admitted to hospital due to an exacerbation.
- Trial name
- NCT01812460
- Testing
- Intervention-training-group
- Where
- Denmark
- Sponsor
- Frederikssunds Hospital, Denmark
Asthma
Airflow Obstruction and Biomarkers of Airway Inflammation During and Following Acute Exacerbations of Childhood Asthma
This study is a longitudinal single-center pilot study designed to describe changes in lung function and levels of noninvasive biomarkers of airway inflammation in children ages 6-18 years over two months following…
- Trial name
- NCT01227070
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Seattle Children's Hospital
Asthma
A Comparison of Combivent UDV (Ipratropium 500mcg and Salbutamol 2.5mg) and Salbutamol UDV Alone (2.5mg)
To compare the bronchodilator efficacy of ipratropium plus salbutamol (Combivent) with salbutamol alone given every 20 minutes for three doses in asthmatic children with severe acute exacerbation
- Trial name
- NCT00273962
- Testing
- ipratropium plus salbutamol UDV, salbutamol UDV
- Where
- 10 sites in Philippines
- Volunteers
- 500 people
- Sponsor
- Boehringer Ingelheim
COPD
The Role of Physical Activity for Acute Exacerbations of COPD
The investigators plan to study the association between physical activity, malnutrition and sarcopenia and the occurrence of acute exacerbations of COPD / the evolution of the COPD assessment test (CAT) over 1 year in a…
- Trial name
- NCT03855670
- Where
- Switzerland
- Volunteers
- 42 people
- Sponsor
- Cantonal Hospital of St. Gallen
Asthma
A Study To Assess The Safety And Effectiveness Of Medrol® In Acute Asthma In Indian Patients
The present study is designed to collect data on real world experience on use of Medrol in acute asthma in Indian patients.
- Trial name
- NCT00971893
- Testing
- Oral Methylprednisolone Tablets
- Sponsor
- Pfizer
Acute Otitis Media (AOM), Strep Pharyngitis
Evaluation of the Medentum Diagnostik Platform for Pediatric ENT Conditions and Asthma
This study evaluates the diagnostic performance, usability, and clinical utility of the Medentum Diagnostik platform, a multisensor device with integrated software and artificial intelligence, in pediatric patients with asthma…
- Conditions
- Acute Otitis Media (AOM), Strep Pharyngitis, Asthma Exacerbation, Pediatric Asthma
- Trial name
- NCT07500532
- Testing
- Diagnostik home-based platform: multisensor device, software application, and artificial-intelligence algorithms that predict diagnosis of AOM and strep pharyngitis, Diagnostik home-based platform: multisensor device, software application, and artificial-intelligence algorithms that predict diagnosis of wheeze/asthma exacerbation, Routine Asthma Management (in-person and telehealth visits)- Control Group
- Where
- United States
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- Medentum Innovations
Asthma, Acute Asthma
Budesonide Inhalation Suspension for Acute Asthma in Children
The purpose of this study is to determine whether the addition of budesonide inhalation suspension (BIS) to the standard therapy of albuterol, ipratropium bromide, and systemic corticosteroids (SCS) for moderate to severe asthma…
- Conditions
- Asthma, Acute Asthma, Reactive Airway Exacerbation
- Trial name
- NCT00393367
- Testing
- Budesonide inhalation suspension (0.5 mg/2mL) 2mg, albuterol (5mg/mL) 7.5 or 10mg, Prednisolone, prednisone, or methylprednisolone, Albuterol, ipratropium bromide
- Where
- United States
- Volunteers
- 179 people
- Sponsor
- Children's Hospital of Philadelphia
Angina, Acute Bronchiolitis
Impact of a Multimodal Intervention on Antibiotic Prescribing for Respiratory Infections in Primary Care
Antimicrobial resistance (AMR), considered one of the greatest global threats by the WHO, justifies the development of initiatives to promote appropriate antibiotic use-especially in primary care, where most antibiotics in France…
- Conditions
- Angina, Acute Bronchiolitis, Acute Bronchitis, COPD Exacerbation (AECOPD)
- Trial name
- GRASP (NCT07359287)
- Testing
- Antibiotic prescribing according to guidelines
- Where
- France
- Volunteers
- 4,500 people
- Sponsor
- University Hospital, Caen