Clinical trials: Acute Illness
Influenza Nos or Influenza-like Illness, Acute Respiratory Infections
A Study to Determine the Causes and Identify Increases in Influenza-Like Illness (ILI) in Mexico
The purpose of this observational study is to characterize individuals in Mexico who seek medical care for influenza-like illness (ILI) and Severe Acute Respiratory Infection (SARI), describe seasonal pattern of the pathological…
- Trial name
- NCT02378090
- Where
- 6 sites in Mexico
- Volunteers
- 888 people
- Sponsor
- Mexican Emerging Infectious Diseases Clinical Research Network
Pneumonia, Childhood Pneumonia
mHealth for Pneumonia Prevention
In Pakistan, pneumonia and recurrent wheeze in children under five pose significant threats to children's health. Despite being preventable, more than 90,000 children die each year due to pneumonia in Pakistan, making it one of…
- Conditions
- Pneumonia, Childhood Pneumonia, Infectious Disease, Acute Respiratory Infection
- Trial name
- NCT04493047
- Testing
- Mobile health (mHealth) for pneumonia
- Where
- Pakistan
- Volunteers
- 520 people, healthy volunteers welcome
- Sponsor
- University of Edinburgh
Acute Febrile Illness
Evaluation of the DPP II Assay in Laos
Fever is the most frequent symptom in patients seeking care globally. Several causative agents of febrile illness have been described with a high prevalence in South East Asia.
- Trial name
- NCT04299607
- Testing
- DPP Fever Panel II assay and DPP Micro Readers
- Where
- Laos
- Volunteers
- 300 people
- Sponsor
- Foundation for Innovative New Diagnostics, Switzerland
Critical Illness
Evaluation of the Association Between Day and Time of Admission to Critical Care and Acute Hospital Outcome
A retrospective analysis of the Case Mix Programme database to evaluate the association between day and time of admission to critical care and acute hospital outcome for unplanned admissions to adult, general critical care units…
- Trial name
- NCT02751164
- Testing
- Day/time of admission to the critical care unit
- Volunteers
- 195,428 people
- Sponsor
- Intensive Care National Audit & Research Centre
Acute Lower Respiratory Illness
Cookstove Replacement for Prevention of ALRI and Low Birthweight in Nepal
At our field site in southern Nepal, acute respiratory illness (ARI) has been a leading cause of mortality among young children.
- Trial name
- NCT00786877
- Testing
- Improved biomass cookstove with exterior ventilation, Phase 2 intervention arm (LPG stove)
- Where
- Nepal
- Volunteers
- 4,678 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins Bloomberg School of Public Health
Critically Ill, Acute Lung Injury
Respiratory Mechanics and Pleural Effusion
The investigators aim to compare the respiratory mechanics in acute lung injury (ALI)/acute respiratory diseases syndrome (ARDS) patients with and without pleural effusion.
- Conditions
- Critically Ill, Acute Lung Injury, ARDS
- Trial name
- NCT00258518
- Testing
- mechanical ventilation/CT Scan
- Where
- Italy
- Volunteers
- 60 people
- Sponsor
- Policlinico Hospital
Respiratory Infection, COVID-19 Respiratory Infection
COVID-Like Illness Respiratory Pathogens. A Prospective Cohort on the COVID-19 Post-acute Condition
Identifying multiorgan sequalae and complications through high quality, prospective matched controlled studies throughout the course of COVID-19 is important for the acute and long-term management of patients and for health…
- Conditions
- Respiratory Infection, COVID-19 Respiratory Infection, Sequelae of; Infection
- Trial name
- CLEAR (NCT05047666)
- Volunteers
- 1,232 people
- Sponsor
- Bernhard Nocht Institute for Tropical Medicine
Malnutrition
Optimising Antibiotic Treatment for Sick Malnourished Children
Children with severe malnutrition who are admitted sick to hospitals have a high mortality, usually because of infection. All children with severe malnutrition admitted to hospitals are treated with antibiotics.
- Trial name
- FLACSAM-PK (NCT02746276)
- Testing
- Ceftriaxone, Metronidazole
- Where
- Kenya
- Volunteers
- 81 people
- Sponsor
- University of Oxford
Febrile Illness, Acute Cardiovascular Disease
Medication List in and Out of Hospital
30 patients acute hospitalized to medical ward and their medication records are examined. It is to be recorded how the investigators find information about medicine use by the reception when they do not follow the patient.
- Conditions
- Febrile Illness, Acute Cardiovascular Disease, Acute Respiratory Disease
- Trial name
- NCT01288846
- Where
- Norway
- Volunteers
- 30 people
- Sponsor
- University of Oslo
Fever
Biomarkers of Mortality and Morbidity in Children Hospitalized With Fever
The objective of this study is to identify clinically informative biomarkers of host defense pathways with potential utility as diagnostic and prognostic tools among children hospitalized with acute febrile illness in a…
- Trial name
- NCT04726826
- Testing
- Diagnostic and prognostic biomarkers
- Where
- Uganda
- Volunteers
- 2,500 people
- Sponsor
- University of Alberta
Influenza, Influenza Like Illness
Seasonal Influenza Vaccine Effectiveness Study in Kenya
Influenza is an important cause of acute respiratory infections (ARI) worldwide. Seasonal influenza causes an estimated 250,000-500,000 deaths and 3-5 million severe illnesses each year (WHO, 2009), and pandemic 2009 H1N1…
- Conditions
- Influenza, Influenza Like Illness, Severe Acute Respiratory Illness
- Trial name
- NCT01432340
- Testing
- Seasonal influenza vaccine
- Where
- 2 sites in Kenya
- Volunteers
- 10,000 people, healthy volunteers welcome
- Sponsor
- Gideon Emukule
Respiratory Disease, Asthma in Children
Utility of Continuous Pulse Oximetry for Pediatric Patients With Stable Respiratory Illness
This is a randomized, prospective study to determine if there is a difference in hospital length of stay between patients receiving continuous hardwire cardiorespiratory monitoring and those receiving intermittent vital signs…
- Conditions
- Respiratory Disease, Asthma in Children, Pneumonia in Children, Bronchiolitis Acute
- Trial name
- NCT04407806
- Testing
- Continous Pulse oximeter, Intermittent Pulse oximeter
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- Corewell Health East
COVID-19
Rehabilitation in Severely Ill Inpatients With COVID-19
Inpatient rehabilitation of severe-to-critical COVID-19 patients(A longitudinal, single-center retrospective cohort)
- Trial name
- NCT05104411
- Testing
- Rehabilitative intervention
- Where
- South Korea
- Volunteers
- 37 people
- Sponsor
- Seoul National University Bundang Hospital
Respiratory Distress Syndrome, Pediatric, Altitude Hypoxia
Altitude and Outcomes in Pediatric ARDS: A Multicenter Study
This multicenter observational study will evaluate the association between geographic altitude, availability of critical care resources, and clinical outcomes in children with pediatric acute respiratory distress syndrome…
- Conditions
- Respiratory Distress Syndrome, Pediatric, Altitude Hypoxia, High Altitude Effects
- Trial name
- LARed-ALT (NCT07193771)
- Testing
- Geographic Altitude
- Where
- 20 sites in Bolivia, Chile and 3 more
- Volunteers
- 1,600 people
- Sponsor
- Latin American Pediatric Collaborative Network
Sepsis
Prediction of Disease Severity in Young Children Presenting With Acute Febrile Illness in Resource-limited Settings
Note that this is a study that is co-sponsored by Medecins Sans Frontieres, Spain, and the University of Oxford. The primary objective is to develop a risk prediction algorithm, combining measurements of host biomarkers and…
- Trial name
- SPOT-SEPSIS (NCT04285021)
- Where
- 6 sites in Bangladesh, Cambodia and 3 more
- Volunteers
- 3,433 people
- Sponsor
- Medecins Sans Frontieres, Spain
Post-Acute COVID-19 Syndrome
Care for Veterans Post-COVID-19
The evidence-based Concordant Care approach involves engaging in processes that: 1) validate the patient's experience, 2) develop a shared understanding of the condition, and 3) create a patient-centered, whole health-oriented…
- Trial name
- NCT05787379
- Testing
- Concordant Care Training, Education Packet Training
- Where
- United States
- Volunteers
- 348 people
- Sponsor
- VA Office of Research and Development
Gastrointestinal Infection, Respiratory Viral Infection
Wells and Enteric Disease Transmission Trial (WET - Trial)
Approximately 40 million people in the US are served by private wells, many of which are untreated. The investigators estimate that 1.29 million cases of gastrointestinal illness (GI) per year are attributed to consuming water…
- Trial name
- NCT04258059
- Testing
- Active household UV water treatment device, Inactive household UV water treatment device
- Where
- United States
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Temple University
Acute Febrile Illnesses
Validation of Promising Biomarker Assays to Assess Their Diagnostic Performance Characteristics
This project aims to evaluate the performance characteristics of rapid tests to differentiate bacterial from non-bacterial infection in febrile adults and children presenting at OPDs (outpatient departments) i.e.("fever triage…
- Trial name
- NCT03047642
- Testing
- Biomarker assay
- Where
- 3 sites in Brazil, Gabon and 1 more
- Volunteers
- 2,000 people
- Sponsor
- Foundation for Innovative New Diagnostics, Switzerland
Acute Lymphoblastic Leukemia (ALL), Critical Illness
Animal Assisted Interactions With Animal Robot in the Intensive Care Unit (ICU)
The purpose of this study is to: 1. Establish the feasibility and acceptability of a therapeutic robot, Paro, for critically ill patients admitted to the Pediatric Intensive Care Unit 2.
- Conditions
- Acute Lymphoblastic Leukemia (ALL), Critical Illness, Physical Therapy Modalities, Occupational Therapy
- Trial name
- PARO (NCT05075395)
- Testing
- PARO therapy seal
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- University of Nebraska
Acute Febrile Illness
Causes and Outcomes of Febrile Illness in Health Facilities in Rural South and Southeast Asia
This prospective multi-site observational study aims to describe causes and clinical outcomes of acute febrile illness as well as host biomarkers in patients aged >28 days residing in rural areas in Laos, Myanmar, Thailand, the…
- Trial name
- SEACTN-WP-B (NCT04629053)
- Where
- 4 sites in Bangladesh, Laos and 1 more
- Volunteers
- 7,200 people
- Sponsor
- University of Oxford