Clinical trials: Acute Viral Bronchiolitis
Acute Bronchiolitis
Efficacy Of Combined Nebulized Hypertonic Saline and Chest Percussion Therapy in Acute Viral Bronchiolitis
This study will examine the efficacy of combined nebulized hypertonic saline with chest percussion therapy in patients age 0 to 24 months admitted to the general inpatient pediatrics unit with acute bronchiolitis.
- Trial name
- NCT06441162
- Testing
- Nebulized 3% sodium chloride solution, Chest percussion cups
- Where
- United States
- Volunteers
- 75 people
- Sponsor
- NYU Langone Health
Bronchiolitis
Safety of Airway Clearance in Non-hospitalized Infants With Acute Viral Bronchiolitis
Bronchiolitis is a disease that can occur in a mild form and moderate, and often does not require hospitalization. The technique of prolonged slow expiration followed by cough caused in children not hospitalized with mild and…
- Trial name
- NCT03835858
- Testing
- Respiratory physiotherapy
- Where
- Spain
- Volunteers
- 265 people
- Sponsor
- Guadarrama Hospital
Acute Bronchiolitis Due to Respiratory Syncytial Virus, Bronchiolitis Acute
Mucociliary Clearance Techniques for Acute Bronchiolitis
To assess the efficacy of mucociliary clearance techniques in non-hospitalised infants with a first episode of mild to moderate acute bronchiolitis.
- Conditions
- Acute Bronchiolitis Due to Respiratory Syncytial Virus, Bronchiolitis Acute, Bronchiolitis Acute Viral
- Trial name
- CLEARBRONCH (NCT06689631)
- Testing
- Respiratory Physiotherapy
- Volunteers
- 70 people
- Sponsor
- Universidad de León
Bronchiolitis, Viral
Etude PROTECT : Prognostic Role of Tapse Evaluation in Children's bronchioliTis
In this prospective study, we aim to evaluate the association between an echocardiographic marker of right ventricular systolic function, the TAPSE (Tricuspid Annular Plane Systolic Excursion), and poor outcome in patients…
- Trial name
- PROTECT (NCT07209956)
- Testing
- Echocardiographic assessment of TAPSE
- Where
- France
- Volunteers
- 46 people
- Sponsor
- University Hospital, Bordeaux
Acute Bronchiolitis, Viral Bronchiolitis
Internal Jugular Vein Respiratory Variability as a Marker of Disease Severity in Infant Bronchiolitis
This prospective observational cohort study evaluates whether respiratory-cycle variation in internal jugular vein (IJV) diameter, measured by point-of-care ultrasound, correlates with clinical disease severity in infants 1-23…
- Conditions
- Acute Bronchiolitis, Viral Bronchiolitis, Respiratory Syncytial Virus Infections
- Trial name
- IJV-BRONCH (NCT07778225)
- Testing
- Point-of-Care Ultrasonography
- Where
- Turkey (Türkiye)
- Volunteers
- 120 people
- Sponsor
- Eskisehir Osmangazi University
Acute Viral Bronchiolitis
High Flow Therapy vs Hypertonic Saline in Bronchiolitis
The purpose of this study is to demonstrate that heated, humidified, high-flow nasal cannula (HHHFNC) is superior to hypertonic saline solution (HSS) in the treatment of moderate acute viral bronchiolitis in infants in improving…
- Trial name
- NCT01873144
- Testing
- Epinephrine 1/1000, HSS 3%, HHHFNC
- Where
- 2 sites in Spain
- Volunteers
- 75 people
- Sponsor
- Ministry of Health, Spain
Acute Viral Bronchiolitis
Efficacy of 3% Hypertonic Saline in Acute Viral Bronchiolitis
The purpose of this study is to determine whether nebulized hypertonic saline solution reduces the admission rate 48 hours after initial treatment in the emergency department, when compared to normal saline solution (control).
- Trial name
- GUERANDE (NCT01777347)
- Testing
- 3% Saline, 0.9% Normal Saline
- Where
- 21 sites in France
- Volunteers
- 778 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Acute Viral Bronchiolitis
KL-6 Protein as a Biomarker of Lung Injury in Viral Bronchiolitis
Serum KL-6 protein has been described as a biomarker of epithelial lung injury in Respiratory Syncytial Virus bronchiolitis. The investigators can imagine that epithelial injury intensity has consequences on immediate and later…
- Trial name
- NCT01437956
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University Hospital, Clermont-Ferrand
Bronchiolitis
Peak Tidal Inspiratory Flow in Infants With Moderate to Severe Acute Viral Bronchiolitis
This aim of this study is to measure the peak tidal inspiratory flow (PTIF), using spirometry, in young infants with moderate to severe acute viral bronchiolitis (AVB).
- Trial name
- DEBIB (NCT03298217)
- Testing
- Measurement of the peak tidal inspiratory flow (PTIF)
- Where
- France
- Volunteers
- 50 people
- Sponsor
- University Hospital, Montpellier
Bronchiolitis
Nebulized 5% Hypertonic Saline for the Treatment of Bronchiolitis
The investigators reasoned that a hypertonic saline concentration higher than 3% could be safe and more efficacious in the treatment of bronchiolitis, alleviating severe symptoms and preventing the need for hospitalization in…
- Trial name
- NCT01016249
- Testing
- Treatment 1. (5% Hypertonic saline + Epinephrine), Treatment 3. (3% Hypertonic saline + Epinephrine), Treatment 2. (Normal saline + Epinephrine)
- Where
- Qatar
- Volunteers
- 187 people
- Sponsor
- Hamad Medical Corporation
Acute Bronchiolitis
Viral Epidemiology of Bronchiolitis After Nirsevimab Implementation and Respiratory Evolution in Infants
Acute bronchiolitis in infants, mainly caused by the Respiratory Syncytial Virus (RSV), is a public health issue, in terms of morbidity and hospital costs.
- Trial name
- EBINIR (NCT06636955)
- Testing
- biobank, follow up
- Where
- France
- Volunteers
- 900 people
- Sponsor
- University Hospital, Rouen
Respiratory Syncytial Virus Infections, Severe Acute Respiratory Infection
Effectiveness of Immunization in Preventing Severe Acute Respiratory Infection RSV in Children Under 6 Months in Bogotá
This study aims to evaluate the real-world effectiveness of two preventive immunization strategies against Respiratory Syncytial Virus (RSV)-associated severe acute respiratory infection in infants less than six months of age in…
- Conditions
- Respiratory Syncytial Virus Infections, Severe Acute Respiratory Infection, Bronchiolitis, Viral, Viral Respiratory Tract Infection
- Trial name
- NCT07279298
- Testing
- RSVpreF vaccine (Abrysvo) and Nirsevimab (Beyfortus) or unexposed
- Where
- Colombia
- Volunteers
- 1,097 people
- Sponsor
- Bogotá District Health Secretariat
Bronchiolitis Acute Viral
Eliminating Monitor Overuse Trial (EMO Trial)
The purpose of this study is to identify the optimal deimplementation strategies for an overused practice: continuous pulse oximetry monitoring of children hospitalized with bronchiolitis who are not receiving supplemental oxygen.
- Trial name
- NCT05132322
- Testing
- Educational Outreach, Audit & Feedback (unit level), Audit & Feedback (real time, individual-level)
- Where
- 51 sites in United States, Canada
- Volunteers
- 9,265 people
- Sponsor
- Children's Hospital of Philadelphia
Bronchiolitis
The Effectiveness of AAD and IPV to Treat Hospitalized Infants (<2years) With Acute Viral Bronchiolitis.
The purpose of this study is to investigate the effectiveness of two airway clearance techniques; Intrapulmonary Percussive Ventilation and Assisted Autogenic Drainage in hospitalized infants under the age of 2 with acute viral…
- Trial name
- NCT02126748
- Testing
- inhalation 4ml hypertonic saline 3% 3x/day, Intrapulmonary Percussive Ventilation, Assisted Autogenic Drainage
- Where
- Belgium
- Volunteers
- 103 people
- Sponsor
- Vrije Universiteit Brussel
Bronchiolitis
Inhaled Hypertonic Saline Use in the Emergency Department to Treat Acute Viral Bronchiolitis
Acute viral bronchiolitis is an extremely common childhood disease, responsible for approximately 17% of childhood admissions to hospital per year, with an annually cost that reaches U$ 500 million.
- Trial name
- NCT02045238
- Testing
- Hypertonic Saline, Chest X-Ray, Respiratory virus screening test
- Where
- Brazil
- Volunteers
- 32 people
- Sponsor
- University of Sao Paulo
Bronchiolitis Acute Viral, Bronchiolitis
Nasal Bubble Continuous Positive Airway Pressure in Reducing Respiratory Distress in Children With Bronchiolitis
This study is designed to assess the effectiveness of nasal continuous positive airway pressure in reducing respiratory distress in children with bronchiolitis
- Conditions
- Bronchiolitis Acute Viral, Bronchiolitis, Bronchiolitis Acute, Bronchiolitis, Viral
- Trial name
- NCT04989114
- Testing
- nasal continuous positive airway pressure
- Where
- Pakistan
- Volunteers
- 96 people
- Sponsor
- ameer asadullah gull
Bronchiolitis, Acute Bronchiolitis
Risk Factors and Severity of Bronchiolitis in Hospitalized Children at Assiut University Hospital
The purpose of this observational study is to identify the risk factors that make bronchiolitis more severe in infants and toddlers.
- Conditions
- Bronchiolitis, Acute Bronchiolitis, Respiratory Syncytial Virus Infection
- Trial name
- NCT07505420
- Volunteers
- 65 people
- Sponsor
- Assiut University
Bronchiolitis, Viral
Chest Physiotherapy in Infants Between 0 and 12 Months Old With Acute Bronchiolitis SRV(+)
The purpose of this research is to determine the effect of prolonged slow expiration techniques, provoked coughing and standard therapy compared to chest wall manual vibration and standard therapy in infants between 0 and 12…
- Trial name
- NCT02853838
- Testing
- Prolonged slow expiration+provoked coughing, Manual chest wall vibration, Standard Therapy
- Where
- Chile
- Volunteers
- 204 people
- Sponsor
- Universidad del Desarrollo
Angina, Acute Bronchiolitis
Impact of a Multimodal Intervention on Antibiotic Prescribing for Respiratory Infections in Primary Care
Antimicrobial resistance (AMR), considered one of the greatest global threats by the WHO, justifies the development of initiatives to promote appropriate antibiotic use-especially in primary care, where most antibiotics in France…
- Conditions
- Angina, Acute Bronchiolitis, Acute Bronchitis, COPD Exacerbation (AECOPD)
- Trial name
- GRASP (NCT07359287)
- Testing
- Antibiotic prescribing according to guidelines
- Where
- France
- Volunteers
- 4,500 people
- Sponsor
- University Hospital, Caen
Acute Viral Bronchiolitis
Influence of the Nebulizer on the Clinical Efficacy of Hypertonic Saline 3% in Children Aged Less Than 18 Months and Hospitalized With Acute Viral Bronchiolitis
The aim of the investigators study is to compare in children aged less than 18 months and hospitalized for an acute viral bronchiolitis the efficacy of the HS 3% (Mucoclear®, sterile ampoules of 4 ml) nebulised with a…
- Trial name
- NCT01295398
- Testing
- nebulisations
- Where
- France
- Volunteers
- 168 people
- Sponsor
- Assistance Publique Hopitaux De Marseille