Clinical trials: Acute Wounds
Acute Blunt Soft Tissue Injuries/Contusions
Efficacy and Safety of Diclofenac Sodium Topical Gel 1% Compared to Placebo in Subjects With Acute Blunt Trauma Injuries
This study will assess the analgesic efficacy of DSG 1% compared to placebo in the reduction of the pain associated with acute blunt trauma injuries.
- Trial name
- NCT02290821
- Where
- 10 sites in United States
- Volunteers
- 215 people
- Sponsor
- Novartis
Acute Spinal Cord Injury, Spinal Cord Injuries
Safety, Feasibility, and Efficacy of TSCS on Stabilizing Blood Pressure for Acute Inpatients With SCI
Current forms of pharmacologic and non-pharmacologic treatments for hypotension and orthostatic hypotension (OH) remain inadequate during acute inpatient rehabilitation (AIR) following a traumatic spinal cord injury (SCI).
- Conditions
- Acute Spinal Cord Injury, Spinal Cord Injuries, Neuromodulation, Traumatic Spinal Cord Injury
- Trial name
- NCT06000592
- Testing
- Digitimer
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Jill M. Wecht, Ed.D.
Post-COVID-19 Condition, Ulcerative Colitis
Emerging Indications for Hyperbaric Oxygen Treatment
This study will evaluate the effectiveness of hyperbaric oxygen therapy (HBOT) on treating emerging indications (i.e., conditions that have shown to potentially benefit from HBOT) using the Multicenter Registry for Hyperbaric…
- Conditions
- Post-COVID-19 Condition, Ulcerative Colitis, Crohn Disease, Calciphylaxis
- Trial name
- NCT07240649
- Testing
- Hyperbaric oxygen treatment (HBOT), 100% Oxygen
- Volunteers
- 100 people
- Sponsor
- Jay C. Buckey Jr.
Acute Pain Due to Trauma
Efficacy and Safety of Methoxyflurane (Penthrox) for the Treatment of Acute Pain in Minor Trauma
This study investigates the treatment of acute pain, an unpleasant feeling caused by an injury. The overall purpose of the study is to gain more information that the pain relief medicine Penthrox(Methoxyflurane) administered…
- Trial name
- STOP! (NCT01420159)
- Testing
- Methoxyflurane
- Where
- 6 sites in United Kingdom
- Volunteers
- 300 people
- Sponsor
- Medical Developments International Limited
Urolithiasis, Urologic Diseases
Effectiveness of Drainage by PCN vs. JJ in Patients With Symptoms of Obstructive Kidney Disease Caused by Urolithiasis
To investigate the effectiveness of percutaneous nephrostomy catheter placement versus retrograde double J catheter placement in patients with symptoms of obstructive kidney disease (with either infection and/or pain and/or…
- Conditions
- Urolithiasis, Urologic Diseases, Urinary Calculi, Urinary Obstruction
- Trial name
- STONE (NCT04594161)
- Testing
- Percutaneous Nephrostomy, Double J catheter
- Where
- Netherlands
- Volunteers
- 204 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Ankle Inversion Sprain
Changes in the Ankle Range of Motion Following Subtalar Joint Manipulation
The purpose of the study is to determine whether manipulation of the subtalar joint (one of the two joints of the ankle) has an effect on ankle range of motion in a group of ankles that have sustained a subacute inversion ankle…
- Trial name
- NCT00981331
- Testing
- Subtalar joint manipulation
- Where
- 2 sites in Canada
- Volunteers
- 28 people
- Sponsor
- Canadian Memorial Chiropractic College
Burns
CONTINUED ACCESS PROTOCOL: Demonstration of the Safety and Effectiveness of ReCell® Combined With Meshed Skin Graft for Reduction of Donor Area in the Treatment of Acute Burn Injuries
The overall purpose of this is study to provide continued access to the ReCell device following completion of protocol CTP001-6, and allow for collection of supplementary clinical outcome data for the ReCell device when used as…
- Trial name
- NCT02994654
- Testing
- ReCell
- Where
- 6 sites in United States
- Volunteers
- 12 people
- Sponsor
- Avita Medical
Trauma Injury, Pain
Ketamine for Acute Pain Management After Trauma
The purpose of this study is to compare the effectiveness of Ketamine drip along with usual care and usual care alone on trauma patients and to longitudinally quantify the pain experience of patients during hospitalization.
- Conditions
- Trauma Injury, Pain, Opioid Use
- Trial name
- KAPT (NCT04129086)
- Testing
- Ketamine plus usual care, Usual Care
- Where
- United States
- Volunteers
- 305 people
- Sponsor
- The University of Texas Health Science Center, Houston
Burn Wound
Safety Study of a Novel Wearable Phototherapy System for the Management of Acute Burn Wounds
The primary purpose of this first-in-human, early feasibility study is to assess safety and feasibility of the Low-Irradiance Monochromatic Biostimulation (LIMB) System as a phototherapeutic intervention for the management of…
- Trial name
- NCT03948360
- Testing
- Low-Irradiance Monochromatic Biostimulation (LIMB) Device, Standard of Care
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Rogers Sciences Inc.
Knee Injury, Knee Osteoarthritis
Monitoring Of Helsingborg Acute Knee Injuries (MOHAK)
Using magnetic resonance imaging (MRI), laboratory analyses and patient reported outcomes, the overall aim of this study is to investigate structural injuries and biochemical alterations in the acutely injured knee and to relate…
- Trial name
- NCT01382173
- Where
- Sweden
- Volunteers
- 192 people
- Sponsor
- Lund University
Postoperative Pain, Acute, Opioid Use
Randomized Trial of Narcotic vs Non-Narcotic Pain Modulation After Labrum Repair
The purpose of this study is to determine if patients age 15 to 30 years old being treated for shoulder labrum repair and SLAP lesions have significant differences in pain levels postoperatively when treated with a combination…
- Conditions
- Postoperative Pain, Acute, Opioid Use, Labral Tear, Glenoid
- Trial name
- NCT05974423
- Testing
- Tylenol, Ibuprofen, and Oxycodone, Tylenol and Ibuprofen only
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- The Cooper Health System
Lung Injury
Acute Lung Injury After Aortic Valve Surgery
The purpose of this prospective, randomized clinical trial is to understand and measure lung injuries caused by CPB in aortic valve surgery.
- Trial name
- NCT01184313
- Testing
- aortic valve surgery with CPB
- Where
- Finland
- Volunteers
- 100 people
- Sponsor
- University of Oulu
Patellar (or Kneecap) Instability and Mal-alignment, Patellar Dislocation
MPFL Reconstruction Versus Rehabilitation
This study involves patients between the ages of 16 and 25 and have been diagnosed with a first-time traumatic patellar dislocation within the past 3 months.
- Trial name
- ANTI-GLIDE (NCT06926699)
- Testing
- Medial Patellofemoral Ligament Reconstruction, Rehabilitation
- Sponsor
- McMaster University
Sprains and Strains
Ankle Manual Therapy for Ankle Sprains
The purpose of this study is to determine the effect of using ankle manual therapy procedures on clinical outcomes in individuals with post-acute ankle sprains.
- Trial name
- AMT (NCT00888498)
- Testing
- Passive Positioning, High-Velocity, Low-Amplitude Stretch, Slow, Mobilization Stretch
- Where
- United States
- Volunteers
- 189 people
- Sponsor
- University of the Pacific
Trauma
Pragmatic, Randomized Optimal Platelet and Plasma Ratios
Pragmatic, Randomized, Optimal Platelet and Plasma Ratios (PROPPR)is a Phase III trial designed to evaluate the difference in 24-hour and 30-day mortality among subjects predicted to receive massive transfusion ([MT] (defined as…
- Trial name
- PROPPR (NCT01545232)
- Testing
- 1:1:1 Blood Transfusion Ratio, 1:1:2 Blood Transfusion Ratio
- Where
- 12 sites in United States, Canada
- Volunteers
- 680 people
- Sponsor
- The University of Texas Health Science Center, Houston
Anterior Cruciate Ligament Injuries, Anterior Cruciate Ligament Rupture
Treatment of Acute ACL Injuries in Young Patients Using a Rebound ACL Brace
This study evaluates the use of a brace in acute anterior cruciate ligament (ACL) injuries in children and adolescents. Half of the participants will receive a so called rebound ACL brace together with a standardized rehab…
- Conditions
- Anterior Cruciate Ligament Injuries, Anterior Cruciate Ligament Rupture, Anterior Cruciate Ligament Tear
- Trial name
- NCT04185532
- Testing
- Rebound ACL brace and physioterapy, Physioterapy
- Where
- Sweden
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Frida Hansson, MD
Chronic Lower Leg Ulcer, Diabetic Lower Extremity Ulcers
Use of Hydroprep Wound Therapy With Motion Negative Pressure Therapy for Treatment of Chronic Lower Extremity Wounds
Use of a motorized waterjet to debride wounds to improve healing outcomes.
- Conditions
- Chronic Lower Leg Ulcer, Diabetic Lower Extremity Ulcers, Pressure Injuries, Traumatic Wounds and Injuries
- Trial name
- NCT07653165
- Testing
- Motion NPWT
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- West Boca Center for Wound Healing
Spinal Cord Injuries
Minocycline and Perfusion Pressure Augmentation in Acute Spinal Cord Injury
While research in animal models of spinal cord injury have provided many promising insights, human studies have failed to produce effective therapies.
- Trial name
- NCT00559494
- Testing
- Minocycline, SCPP augmentation, SCPP control
- Where
- Canada
- Volunteers
- 52 people
- Sponsor
- University of Calgary
Head Trauma, Image, Body
Rapid MRI for Acute Pediatric Head Trauma
Pediatric head trauma is a leading cause of morbidity and mortality for children/adolescents. The current standard of care regarding imaging modality when concerned for an acute head injury is CT.
- Trial name
- NCT03291964
- Testing
- Rapid Brain MRI
- Where
- United States
- Volunteers
- 76 people
- Sponsor
- Oregon Health and Science University
Aortic Dissection
Zenith® TXD Post-market Surveillance in Japan
The study is a post-market surveillance study required by Japanese Regulatory Authorities as a condition of approval
- Trial name
- NCT02663739
- Testing
- Zenith® TXD
- Where
- 27 sites in Japan
- Volunteers
- 57 people
- Sponsor
- Cook Group Incorporated