Clinical trials: Addiction, Substance
Drug Addiction
Construction of Early Warning Model for the New Psychoactive Substances Using in Adolescents
Based on the biological-psychology-sociological medicine pattern, this study aims to construction an early warning model of the New Psychoactive Substances (NPS) using for adolescents aged 14-35 years old.
- Trial name
- NCT05958641
- Testing
- Questionnaires
- Where
- China
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Wei XIA, PhD
Opioid-Related Disorders, Drug Addiction
Medication Treatment for Opioid Use Disorder in Expectant Mothers: Infant Neurodevelopmental Outcomes Sub-study
This is a sub-study of NIDA CTN Protocol 0080: Medication Treatment for Opioid Use Disorder in Expectant Mothers (MOMs; Unique protocol ID: 2019-0429-1).
- Conditions
- Opioid-Related Disorders, Drug Addiction, Pregnancy Related, Substance Abuse
- Trial name
- MOMs-INO (NCT03911739)
- Testing
- Buprenorphine Injection, Buprenorphine Sublingual Product
- Where
- 10 sites in United States
- Volunteers
- 71 people
- Sponsor
- T. John Winhusen, PhD
Alcohol Addiction, Mouth Diseases
Testing Interventions to Reduce Alcohol Consumption Among Outpatients in a Dental Setting
The investigators wish to investigate the feasibility of using a web based drinking app (www.drinksmeter.com) to reduce alcohol consumption among patients attending an outpatient clinic in a dental setting.
- Trial name
- NCT02374905
- Testing
- Drinksmeter, Brief Advice of Alcohol Use
- Where
- United Kingdom
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- King's College Hospital NHS Trust
Behavior, Addictive, Adolescent - Emotional Problem
"Juego de LLaves": Study Protocol of a Universal School-based Drug Use Prevention Program (PSIDUP)
"Juego de Llaves" is a universal school-based drug prevention program for adolescents aged 12-15 years. The outcome evaluation is critical to determine the quality of preventive interventions.
- Conditions
- Behavior, Addictive, Adolescent - Emotional Problem, Alcohol Abuse, Smoking Behaviors
- Trial name
- PSIDUP (NCT05442294)
- Testing
- Juego de Llaves
- Where
- Spain
- Volunteers
- 2,500 people, healthy volunteers welcome
- Sponsor
- Susana Al-Halabí
Smoking Cessation, Tobacco Use Disorder
Effectiveness of Reducing Smoking in Facilitating Smoking Cessation in Adolescents - 2
Currently one in five high school students smoke. Smoking can harm adolescents well before they reach adulthood by causing a number of immediate, sometimes irreversible, health risks and problems.
- Trial name
- NCT00158158
- Testing
- Usual Care, Smoking Reduction
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- National Institute on Drug Abuse (NIDA)
Substance Abuse, Drug Addiction
Integrating Mindfulness-Based Skills Training Into Brief Outpatient Treatment for Substance Abusing Youth
The proposed study will evaluate the clinical effectiveness of integrating mindfulness-based skills training into a standardized brief group intervention for youth (ages 16 to 24) identified as having problematic substance use.
- Trial name
- NCT00244699
- Testing
- MI Alone or Plus Mindfulness-Based Skills Training
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- Centre for Addiction and Mental Health
Cannabis, Addictive Behavior
Validation of the Cannabis Abuse Screening Test in General Practice(GP-CAST)
In France, consumption levels of alcohol, tobacco and cannabis remain high despite changes in regulations aimed at limiting access to these products and repeated prevention campaigns.
- Conditions
- Cannabis, Addictive Behavior, General Practice, Primary Care
- Trial name
- GP-CAST (NCT05633043)
- Where
- 5 sites in France
- Volunteers
- 660 people, healthy volunteers welcome
- Sponsor
- University Hospital, Clermont-Ferrand
Alcohol Related Disorders, Substance Related Disorders
The Co-Venture Trial: A Cluster Randomized Trial of Personality-targeted Interventions on Adolescent Substance Use and Cognitive Outcomes
The Preventure Program is the first and only school-based alcohol and drug prevention program that has been shown to prevent onset and growth in alcohol and substance misuse in British and Canadian youth.
- Trial name
- NCT01655615
- Testing
- Preventure programme
- Where
- Canada
- Volunteers
- 3,900 people, healthy volunteers welcome
- Sponsor
- St. Justine's Hospital
Alcohol Abuse, Drug Abuse
Personality-targeted Interventions for Adolescent Alcohol Misuse
Personality targeted cognitive behavioural interventions have been shown to be effective in reducing alcohol and drug misuse in adult substance abusers (Conrod et al., 2000) and adolescent drinkers (Conrod et al, in press).
- Conditions
- Alcohol Abuse, Drug Abuse, Depression, Panic Disorder
- Trial name
- Preventure (NCT00344474)
- Testing
- PRE-Venture: Personality Risk Education
- Where
- United Kingdom
- Volunteers
- 710 people, healthy volunteers welcome
- Sponsor
- King's College London
Opioid-Related Disorders, Stimulant-Related Disorder
Preventing Parental Opioid and/or Methamphetamine Addiction Within DHS-Involved Families: PRE-FAIR
Young parents aged 16 to 30, involved in the DHS system for child welfare or self-sufficiency needs are at risk for opioid use disorder and/or methamphetamine use disorder (OUD; MUD).
- Conditions
- Opioid-Related Disorders, Stimulant-Related Disorder, Child Neglect, Mental Health Impairment
- Trial name
- PRE-FAIR (NCT05380440)
- Testing
- Prevention Adaptation of Families Actively Improving Relationships (PRE-FAIR), Standard Case Management and Referral
- Where
- United States
- Volunteers
- 241 people, healthy volunteers welcome
- Sponsor
- Chestnut Health Systems
Cannabis Use, Cannabis Dependence
Neuroimaging of Adolescent Cannabis Use Treatment
This study is testing whether brain activity related to learning can help predict how well teens respond to a treatment program designed to reduce cannabis use.
- Conditions
- Cannabis Use, Cannabis Dependence, Cannabis Use Disorder, Cannabis Abuse
- Trial name
- ACT (NCT07340554)
- Testing
- Contingency Management, Elastic Net Regression
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Indiana University
Alcohol Use Disorder (AUD)
Social Identity Mapping for Adolescent Recovery
The goal of this clinical trial is to address the gap between clinical treatment and adolescents' lived social environments by developing and testing a novel, interactive intervention-SIM-AiR-that directly targets social risk and…
- Trial name
- SIMAiR (NCT07474207)
- Testing
- SIM-AiR
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Massachusetts General Hospital
Opioid Related Disorders, Opiate Addiction
Monitoring Patterns of Prescribing to Identify Changes in Access to ER/LA Opioid Analgesics
Changes in prescribing will be compared in prescribers from specialties whose prescribing is hypothesized to be relatively unaffected by the REMS (such as oncologists and hospice providers) versus those for whom the REMS could…
- Conditions
- Opioid Related Disorders, Opiate Addiction, Narcotic Abuse, Drug Abuse
- Trial name
- NCT02920775
- Testing
- Non-interventional study - retrospective database review
- Volunteers
- 360,000 people
- Sponsor
- ER/LA Opioid REMS Program Companies (RPC)
Opiate Dependence, Drug Dependence
A Randomized Acceptability and Safety Study of Suboxone Induction in Heroin Users (P05042)(COMPLETED)
The purpose of this study is to assess the acceptability and safety of Suboxone in heroin users as a replacement therapy for opioid dependency by comparing the clinical response of participants who are inducted directly onto…
- Conditions
- Opiate Dependence, Drug Dependence, Substance Dependence
- Trial name
- NCT00604188
- Testing
- Suboxone (SCH 000484), Subutex (SCH 028444)
- Volunteers
- 188 people
- Sponsor
- Merck Sharp & Dohme LLC
Benzodiazepine Dependence, Benzodiazepine Abuse
Prevention of Benzodiazepine Misuse in Primary Care
Benzodiazepines and benzodiazepine-like hypnotics (z-drugs) are prevalent and addictive narcotics. Guidelines recommend restricted prescription of these drugs for anxiety and insomnia.
- Conditions
- Benzodiazepine Dependence, Benzodiazepine Abuse, Substance Use Disorders
- Trial name
- NCT04533230
- Testing
- Educational intervention with prescription feedback, Information on treatment guidelines
- Where
- Sweden
- Sponsor
- Karolinska Institutet
Opioid Related Disorders, Opiate Addiction
Evaluation of Drug Utilization Patterns for Extended Release/Long Acting Opioids and Comparator Products
A drug utilization study will be performed to describe trends in the number of prescriptions and patients for class REMS ER/LA opioids and comparator products.
- Conditions
- Opioid Related Disorders, Opiate Addiction, Narcotic Abuse, Drug Abuse
- Trial name
- NCT02925806
- Testing
- Non-interventional study - retrospective database review
- Volunteers
- 5,575,834 people
- Sponsor
- ER/LA Opioid REMS Program Companies (RPC)
Narcotic Addiction, Neonatal Abstinence Syndrome
Can Ondansetron Prevent Neonatal Abstinence Syndrome (NAS) in Babies Born to Narcotic-dependent Women
The Investigators hope to learn if they can prevent or lessen the symptoms of neonatal abstinence syndrome (NAS) in babies born to narcotic-dependent mothers by using the drug ondansetron in the mothers prior to delivery and…
- Trial name
- AIM2NAS (NCT01965704)
- Testing
- Ondansetron
- Where
- 8 sites in United States
- Volunteers
- 196 people
- Sponsor
- Stanford University
Drug-withdrawal., Drug Abuse
Clinical Studies on the Therapeutic Effects of Mirtazapine on Drug-craving in Cocaine Addicts.
INTRODUCTION. One of the main problems of the treatment of cocaine-dependent patients is the high rate of relapses occurs within the first months after detoxification.
- Conditions
- Drug-withdrawal., Drug Abuse, Drug-induced Depressive State, AOD Craving
- Trial name
- MADC (NCT01949571)
- Testing
- Mirtazapine (REMERON, Schering-Plough-Organon)
- Where
- Mexico
- Volunteers
- 64 people
- Sponsor
- Instituto Nacional de Psiquiatría Dr. Ramón de la Fuente
Asperger's Disorder, Asperger Disorder
QAIAx - SGI/SI Smart Health Cities: Microcity Enclave Program (Quantum SI/AGI Agency a/k/a AI City Hall Project - UPSTO App Nos. 64/074,526, 64/063,557, 64/105,164, 63/903,181, 63/729,428, 64/125,360; USPTO EO 9424 Assignment ID: 2101042 / ARN: REEL/FRAME: 76481/0026 - OUSD-R&E, Department of War)
BRIEF SUMMARY A. "What is the purpose of this study?" BACKGROUND. The QAIAx clinical trial (Quantum SI/SGI Public Health Agency), known operationally as the "AI City Hall Project," represents a landmark intergovernmental research…
- Conditions
- Asperger's Disorder, Asperger Disorder, Autism Disorder, Autism
- Trial name
- QAIAx (NCT07661823)
- Testing
- AI City Hall Project (AIhealth4u - Public Health Central), AI City Hall Project (QAIAx Microcity A - AI Public Health Central)
- Where
- United States
- Volunteers
- 1,000,000 people, healthy volunteers welcome
- Sponsor
- Veterans Recovery Network Inc.
Addiction, Alcohol, Addiction, Substance
Efficiency of Prevention Program Dedicated to Addictive Behaviors (PREVENTURE) of Vulnerable Teenagers
At the age of 17, in Brittany, 94.9% of adolescents have experimented alcohol consumption 78.1% within a month and 25.5% report repeated episodes of Intensive Punctual Alcohol.
- Trial name
- PREVADO (NCT04599270)
- Testing
- PREVENTURE Program, Routine care
- Where
- 5 sites in France
- Volunteers
- 700 people
- Sponsor
- University Hospital, Brest