Clinical trials: Adhesion
Bladder Injury, Complications; Cesarean Section
Cystoinflation to Prevent Bladder Injury in Obstetrics and Gynaecology Surgery
Part1:The healthy pregnant women with previous operative deliveries admitted for elective C-section will be counselled and conditioned informed consent will be taken to be included in either study group if dense pelvic adhesions…
- Conditions
- Bladder Injury, Complications; Cesarean Section, Adhesions Pelvic
- Trial name
- NCT04302545
- Testing
- Cystoinflation
- Where
- Pakistan
- Volunteers
- 564 people, healthy volunteers welcome
- Sponsor
- Shazia Saaqib
Ovarian Carcinoma
Immunohistochemical Expression of Epithelial Cell Adhesion Molecule (EpCAM) in Epithelial Ovarian Carcinoma
Cancer stem cells (CSCs) can undergo self-renewal and differentiation. EpCAM is a 40-kDa type I transmembrane glycoprotein composed of a large extracellular domain, one transmembrane region, and a small intracellular domain of 26…
- Trial name
- NCT05576519
- Where
- 2 sites in Egypt
- Volunteers
- 50 people
- Sponsor
- Sohag University
Poor Aesthetic of Existing Restoration of Tooth, Dental Restoration Failure of Marginal Integrity
The Effect of Different Adhesion Strategies on the Clinical Success
The study will involve 41 people who regularly seek treatment at clinics. Participants must be in generally good health and be older than eighteen.
- Conditions
- Poor Aesthetic of Existing Restoration of Tooth, Dental Restoration Failure of Marginal Integrity, Unacceptable Morphology of Tooth Restoration, Secondary Caries
- Trial name
- NCT06500546
- Testing
- Treatment of cervical lesions
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- Istanbul University
Pneumoperitoneum
CO2 Absorption During Laparoscopy
CO2 absorption from the pneumoperitoneum increases over time during laparoscopic procedures. Adding 4% of oxygen to the carbon dioxide was shown in rabbits to decrease CO2 resorbtion through prevention of mesothelial hypoxia.
- Trial name
- NCT01340989
- Testing
- alteration of the insufflation gas, full conditioning, standard pneumoperitoneum
- Where
- Belgium
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University Hospital, Gasthuisberg
Orthodontics
Evaluation of the Contamination of Ligatures
This crossover, in-vivo study was carried out with 10 patients who have been started to be treated at Orthodontics Department. 3 elastomeric ligatures were examined in terms of microbiological and surface roughness.
- Trial name
- NCT04185987
- Testing
- Leone slide low friction elastomeric ligature, RMO tough - o energy elastomeric ligature, Dentsply sili tie elastomeric ligature
- Where
- Turkey (Türkiye)
- Volunteers
- 10 people
- Sponsor
- University of Gaziantep
Capsule Opacification, Tissue Adhesions
Evaluate Capsular Apposition to Intraocular Lens
In this study, the investigators examined the capsule-IOL interaction including anterior and posterior capsule adhesion, contact between posterior capsule and the posterior edge of intraocular lense (IOL), configuration of…
- Conditions
- Capsule Opacification, Tissue Adhesions, Aphakia - Lens Capsule Present, Opacification of Intraocular Lens
- Trial name
- NCT01605812
- Where
- China
- Volunteers
- 150 people
- Sponsor
- Wenzhou Medical University
Thalassemia, Sickle Cell Disease
Alefacept and Allogeneic Hematopoietic Stem Cell Transplantation
Allogeneic blood and marrow transplantation remains the only viable cure for children who suffer from many serious non-malignant hematological diseases. Transplantation, however, carries a high risk of fatal complications.
- Conditions
- Thalassemia, Sickle Cell Disease, Glanzmann Thrombasthenia, Wiskott-Aldrich Syndrome
- Trial name
- NCT01319851
- Testing
- Alefacept
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- Emory University
Small Bowel Obstruction, Small Bowel Adhesion
Comparison of Early Operative Treatment and 48 h Conservative Treatment in Small Bowel Obstruction
This study will compare the results of early surgery after 12 h conservative treatment and 48 h conservative treatment of adhesive small bowel obstruction.
- Conditions
- Small Bowel Obstruction, Small Bowel Adhesion, Strangulation of Ileum
- Trial name
- COTACSO (NCT03139149)
- Testing
- Adhesiolysis, X-ray diagnostics, Computer tomography
- Where
- Russia
- Volunteers
- 200 people
- Sponsor
- Pirogov Russian National Research Medical University
Leukocyte Adhesion Deficiency
Long-Term Follow-Up (LTFU) for Gene Therapy of Leukocyte Adhesion Deficiency-I (LAD-I)
This Long-Term Follow-Up (LTFU) for Gene Therapy of Leukocyte Adhesion Deficiency-I (LAD-I) is a continuation of a Phase 1/2 clinical study to evaluate the safety and efficacy of the infusion of autologous hematopoietic stem…
- Trial name
- NCT06282432
- Where
- 3 sites in United States, Spain and 1 more
- Volunteers
- 9 people
- Sponsor
- Rocket Pharmaceuticals Inc.
Tissue Adhesions
A Trial to Reduce Adhesions Following a Primary Cesarean Section
The primary objective of this study is to determine whether the use of Seprafilm reduces the incidence rate of adhesion formation following a primary C-section.
- Trial name
- NCT01819467
- Testing
- Seprafilm
- Where
- United States
- Volunteers
- 29 people
- Sponsor
- South East Area Health Education Center, Wilmington, NC
Atherosclerosis, Coronary Disease
Effects of Angiotensin-Converting Enzyme Inhibitor (Ramipril) Therapy on Blood Vessel Inflammation
This study will determine the effects of angiotensin-converting enzyme (ACE) inhibitor (trade name Ramipril) therapy on inflammation and stiffness of artery walls.
- Conditions
- Atherosclerosis, Coronary Disease, Vasculitis
- Trial name
- NCT00005928
- Testing
- Ramipril
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Childhood Kidney Neoplasm, Clear Cell Renal Cell Carcinoma
Studying Biomarkers in Samples From Younger Patients With Kidney Cancer
This laboratory study is looking into biomarkers in samples from younger patients with kidney cancer. Studying samples of tissue from patients with cancer in the laboratory may help doctors learn more about changes that occur in…
- Conditions
- Childhood Kidney Neoplasm, Clear Cell Renal Cell Carcinoma, Congenital Mesoblastic Nephroma, Rhabdoid Tumor of the Kidney
- Trial name
- NCT01642095
- Testing
- Laboratory Biomarker Analysis
- Where
- United States
- Sponsor
- Children's Oncology Group
Acne Vulgaris
Serum Intercellular Adhesion Molecule -1 in Acne Vulgaris Patients : Effect of Montelukast
The aim of this study is to: 1. Evaluation of serum soluble intercellular adhesion molecule-1 (sICAM-1) level in acne vulgaris and compare it to control group 2.
- Trial name
- NCT06340984
- Testing
- Montelukast 10 Mg Oral Tablet
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- South Valley University
Surgical Adhesions
Study of PXL01 Versus Placebo to Inhibit Adhesion Formation After Flexor Tendon Surgery
The objectives of the study are to assess efficacy, safety, and handling of PXL01 in patients with flexor tendon injury in zone I or II.
- Trial name
- PHSU02 (NCT01022242)
- Testing
- PXL01
- Where
- 15 sites in Denmark, Germany and 1 more
- Volunteers
- 138 people
- Sponsor
- Pergamum AB
Congenital Heart Disease in Children
BAX602 in Preventing the Adhesion Around Great Cardiac Vessels in Pediatric Patients With Congenital Heart Disease Undergoing Re-do Open Heart Surgery (Japan Trial)
Congenital heart disease occurs in about 1% of live births and can range from (1) naturally curable conditions that require no treatment to (2) conditions that require multiple immediate operations or refractory severe…
- Trial name
- NCT05647161
- Testing
- BAX602, No Intervention
- Where
- 6 sites in Japan
- Volunteers
- 34 people
- Sponsor
- Baxter Healthcare Corporation
Epithelial Ovarian Cancer
Seprafilm™ for the Prevention of Intraperitoneal Adhesions and Improved Delivery of Therapy in Women Undergoing Staging and Intraperitoneal Chemotherapy for Advanced Ovarian Cancer
The purpose of this research is to determine if a film to prevent adhesions will improve the area of distribution of a contrast dye (representative of chemotherapy) in the abdominal cavity (belly) of women who have undergone…
- Trial name
- NCT01095367
- Testing
- Seprafilm™
- Where
- 2 sites in United States, Canada
- Volunteers
- 15 people
- Sponsor
- University of British Columbia
Nasal Synechiae, Adhesions of Nasal Cavity
Study of Mitomycin C and Nasal Splint to Treat Nasal Synechiae
This study evaluates whether Mitomycin C is an effective alternative to septal splints in the treatment of nasal synechiae.
- Conditions
- Nasal Synechiae, Adhesions of Nasal Cavity, Nasal Adhesions, Tissue Adhesions
- Trial name
- NCT00966056
- Testing
- Mitomycin C, Teflon nasal septal splint
- Where
- India
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Karnataka Institute of Medical Sciences
Small Bowel Obstruction
Early Small Bowel Obstruction Following Laparotomy For Trauma
The formation of intraperitoneal adhesion following abdominal surgery is accepted by clinicians as an inevitable consequence. More than 90% of patients undergoing a surgical procedure in the abdomen will develop intraperitoneal…
- Trial name
- NCT01068340
- Where
- United States
- Volunteers
- 571 people
- Sponsor
- University of Southern California
Syncope, Pediatric
Pediatric Adhesion and New Dermal Approach Study
The purpose of this study is to see if the Zio® monitor device can be worn by children for up to 14-days and to determine if the skin preparation process will provide good adherence to the skin and clear signal quality.
- Conditions
- Syncope, Pediatric, Congenital Athymia, Congenital Heart Disease
- Trial name
- PANDA (NCT07118124)
- Testing
- Zio monitor
- Where
- 4 sites in United States
- Volunteers
- 36 people
- Sponsor
- iRhythm Technologies, Inc.
Surgery, Abdominal Adhesion
Predicting Abdominal Reoperation
Nationwide retrospective study, to predict the risk of abdominal reoperation.
- Trial name
- NCT05516420
- Volunteers
- 72,270 people
- Sponsor
- Radboud University Medical Center