Clinical trials: Advanced
Persistent Atrial Fibrillation, Persistent Atrial Fibrillation Longstanding
Catheter Ablation of Advanced Forms of Atrial Fibrillation
The purpose of this study is to evaluate feasibility, safety, and efficacy of pulmonary vein isolation combined with posterior left atrial isolation and multiple linear lesions in both atria in patients with persistent and…
- Trial name
- ENDO MAZE (NCT07446244)
- Testing
- Endovascular ablation set mimicking cox maze 4 procedure.
- Where
- Slovenia
- Volunteers
- 50 people
- Sponsor
- University Medical Centre Ljubljana
Pregnancy
Randomized Trial of Advanced Provision Emergency Contraception Among Women With Gonorrhea or Chlamydia
The purpose of this trial is to determine whether providing non-contracepting women with gonorrhea or chlamydial infection with advanced provision emergency contraception (APEC) and condoms decreases their risk of becoming…
- Trial name
- NCT00520455
- Testing
- levonorgestrel 0.75mg taken twice 12 hours apart (Plan B) and condoms
- Where
- United States
- Volunteers
- 177 people
- Sponsor
- University of Washington
Solid Tumors
Safety Study of ASONEP (Sonepcizumab/LT1009) to Treat Advanced Solid Tumors
The purpose of this study is to determine the safety, tolerability and highest dose of ASONEP that can safely be administered to patients with cancer who are no longer being helped by standard treatments.
- Trial name
- ASONEP (NCT00661414)
- Testing
- ASONEP (sonepcizumab/LT1009)
- Where
- 3 sites in United States
- Volunteers
- 37 people
- Sponsor
- Lpath, Inc.
Mixed Tumor, Mullerian
Paclitaxel and Carboplatin in Women With Malignant Mixed Mullerian Tumors (MMMT) of the Uterus
The goal of this clinical research study is to find out if the combination of paclitaxel and carboplatin chemotherapy can shrink or slow the growth of mixed mullerian tumors (MMMT) of the uterus.
- Trial name
- NCT00502203
- Testing
- Carboplatin, Paclitaxel
- Where
- 4 sites in United States
- Volunteers
- 23 people
- Sponsor
- M.D. Anderson Cancer Center
Bone Marrow Replaced Via Transplant
Multi-omic Characterization of Pediatric and Adult Patients Undergoing Hematopoietic Stem Cell Transplantation and Advanced Cell Therapies
Allogeneic hematopoietic stem cell transplantation (HCT) and advanced cellular therapies, including chimeric antigen receptor T-cell (CAR-T) therapy, are potentially curative treatments for a wide range of malignant and…
- Trial name
- NCT07464483
- Testing
- Collection of stool, urine, serum, and saliva samples; histological evaluation of biopsy specimens
- Where
- Italy
- Volunteers
- 260 people
- Sponsor
- IRCCS Azienda Ospedaliero-Universitaria di Bologna
Rhabdomyosarcoma, Malignant Peripheral Nerve Sheath Tumors
Trial of Dasatinib in Advanced Sarcomas
This study will examine the response rate and the 6-month progression-free survival rates of subjects with advanced sarcoma treated with dasatinib.
- Conditions
- Rhabdomyosarcoma, Malignant Peripheral Nerve Sheath Tumors, Chondrosarcoma, Sarcoma, Ewing's
- Trial name
- NCT00464620
- Testing
- Dasatinib
- Where
- 20 sites in United States
- Volunteers
- 366 people
- Sponsor
- Sarcoma Alliance for Research through Collaboration
Pulmonary Arterial Hypertension (PAH), Premature Infants
PNEUMOSTEM® for Improving Respiratory Outcomes in Very Premature Infants Diagnosed With Early Pulmonary Arterial Hypertension
The goal of this clinical trial is to evaluate the safety and potential efficacy of PNEUMOSTEM® for improving respiratory outcomes in very premature infants diagnosed with Early Pulmonary Arterial Hypertension.
- Trial name
- REVIVE-PH (NCT07368088)
- Testing
- PNEUMOSTEM®
- Where
- South Korea
- Volunteers
- 12 people
- Sponsor
- Samsung Medical Center
Lung Cancer
Methylated Genes in Blood as Biomarkers for Advanced Lung Cancer
The purpose of this study is to study whether the presence of lung cancer in your body can be detected by testing the blood, and if the results of these blood tests change as your tumor shrinks or grows.
- Trial name
- NCT00579462
- Testing
- Blood and Tissue studies
- Where
- United States
- Volunteers
- 281 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Dental Caries in Children, Tooth Erosion
3D Scanning as an Advanced Tool for Identifying Tooth Lesions in Children
This study focuses on assessing dental caries, erosive tooth wear, and fluorosis in primary teeth using a 3D intraoral digital scanner.
- Conditions
- Dental Caries in Children, Tooth Erosion, Fluorosis, Dental, Dental Caries
- Trial name
- NCT06829550
- Testing
- indirect- 3D digital scanning
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Indiana University
Endometrial Cancer
Danazol in Treating Patients With Advanced or Recurrent Endometrial Cancer
RATIONALE: Hormone therapy may be an effective treatment for endometrial cancer. PURPOSE: Phase II trial to study the effectiveness of danazol in treating patients with advanced or recurrent endometrial cancer.
- Trial name
- NCT00003946
- Testing
- danazol
- Where
- 73 sites in United States, Canada
- Sponsor
- Gynecologic Oncology Group
Ovarian Cancer, Endometrial Cancer
Phase 1, Safety and Tolerability Study of XmAb541 in Advanced Solid Tumors
The primary purpose of this study is to determine whether the investigational drug XmAb541 is safe and well tolerated, and to determine an optimal and safe dose(s) for further study.
- Conditions
- Ovarian Cancer, Endometrial Cancer, Germ Cell Tumor, Testicular Germ Cell Tumor
- Trial name
- NCT06276491
- Testing
- XmAb541
- Where
- 27 sites in United States, Belgium and 4 more
- Volunteers
- 282 people
- Sponsor
- Xencor, Inc.
Advanced Cancer
Complementary and Alternative Medicine Usage Among Participants Enrolled in Phase I Oncology Clinical Trials
Primary Objective: · The primary objective is to estimate the prevalence of use of complementary and alternative medicine (CAM) in patients with advanced malignancies who are seen in the Phase I clinic at MD Anderson Cancer…
- Trial name
- NCT00949390
- Testing
- Questionnaire
- Where
- United States
- Volunteers
- 309 people
- Sponsor
- M.D. Anderson Cancer Center
Breast Cancer
Combination Chemotherapy Followed By Peripheral Stem Cell Transplantation in Treating Patients With Advanced Breast Cancer
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Combining chemotherapy with peripheral stem cell transplantation may allow the doctor to give higher doses of…
- Trial name
- NCT00004174
- Testing
- filgrastim, cyclophosphamide, paclitaxel
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Northwestern University
Palliative Care, Wearable Electronic Devices
Wearable and Patient-reported Outcome-based Continuous Assessment and Support Alerts in Palliative Care
Non-professional carers (typically family members) play a critical role in providing adequate home care. This research explores the use of wearable sensors (WS) and electronic patient-reported outcome (ePRO) surveys to monitor…
- Conditions
- Palliative Care, Wearable Electronic Devices, Patient Reported Outcome Measures, Cancer
- Trial name
- wePRO-CASA (NCT05273580)
- Testing
- Garmin VivoSmart 4, mema - ilumivu
- Where
- Australia
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Royal North Shore Hospital
Locally Advanced Non-small Cell Lung Cancer
ISoToxic Accelerated RadioTherapy in Locally Advanced Non-small Cell Lung Cancer: The Phase I/II I-START Trial
The I-START trial is designed to determine the highest doses of radiotherapy that can safely be used in locally advanced non-small cell lung cancer (NSCLC).
- Trial name
- I-START (NCT01537991)
- Testing
- Radiotherapy
- Where
- 2 sites in United Kingdom
- Volunteers
- 81 people
- Sponsor
- Lisette Nixon
CD19 Positive, CD22 Positive
Modified Immune Cells (CD19-CD22 CAR T Cells) in Treating Patients With Recurrent or Refractory CD19 Positive, CD22 Positive Leukemia or Lymphoma
This phase I/II trial studies the side effects and best dose of modified immune cells called CD19-CD22 chimeric antigen receptor (CAR) T cells in treating patients with CD19 positive(+), CD22+ B-acute lymphoblastic leukemia…
- Conditions
- CD19 Positive, CD22 Positive, Minimal Residual Disease, Progressive Disease
- Trial name
- NCT04029038
- Testing
- Autologous CD19/CD22 Chimeric Antigen Receptor T-cells, Cyclophosphamide, Fludarabine
- Where
- United States
- Sponsor
- M.D. Anderson Cancer Center
Lung Cancer, Malignant Mesothelioma
Radiofrequency Ablation in Treating Patients With Refractory or Advanced Lung Cancer
RATIONALE: Radiofrequency ablation uses high-frequency electric current to kill tumor cells. CT-guided radiofrequency ablation may be effective treatment for lung cancer.
- Conditions
- Lung Cancer, Malignant Mesothelioma, Metastatic Cancer, Thymoma and Thymic Carcinoma
- Trial name
- NCT00024076
- Testing
- radiofrequency ablation
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Jonsson Comprehensive Cancer Center
Rectal Cancer
Short Running Head Obesity in Rectal Cancer Patients
There is a controversy regarding the effect of the two Body Mass Index (BMI) extremes on the oncological outcome of rectal cancer.
- Trial name
- NCT04759638
- Where
- Jordan
- Volunteers
- 294 people
- Sponsor
- King Hussein Cancer Center
Lung Cancer
High-Dose 3-Dimensional Conformal Radiation Therapy in Treating Patients With Inoperable Stage I, Stage II, or Stage IIIA Non-Small Cell Lung Cancer
RATIONALE: Using computer systems that create a 3-dimensional picture of the tumor to plan treatment may enable doctors to provide more effective radiation therapy that will cause less damage to normal tissue.
- Trial name
- NCT00062335
- Testing
- radiation therapy
- Where
- 7 sites in Belgium, France and 1 more
- Volunteers
- 14 people
- Sponsor
- European Organisation for Research and Treatment of Cancer - EORTC
Cancer, Solid Tumor
Oral AMXT 1501 Dicaprate in Combination With IV DFMO
A Phase 1B/2A study will be conducted to establish safety and dose level of AMXT 1501 dicaprate in combination with IV DFMO, in cancer patients.
- Conditions
- Cancer, Solid Tumor, Solid Carcinoma, Advanced Cancer
- Trial name
- NCT05500508
- Testing
- AMXT1501, DFMO
- Where
- 7 sites in United States, Australia
- Volunteers
- 15 people
- Sponsor
- Aminex Therapeutics, Inc.
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