Clinical trials: Advanced
Cancer
SarCaBon: A Randomised Phase II Trial of Saracatinib Versus Placebo for Cancer-induced Bone Pain
This study is designed to assess whether a drug called Saracatinib is helpful in controlling bone pain from cancer. The investigators do not know if it will be, so half of the patients in the study will receive the drug and half…
- Trial name
- SarCaBon (NCT02085603)
- Testing
- Saracatinib
- Where
- United Kingdom
- Volunteers
- 12 people
- Sponsor
- Sheffield Teaching Hospitals NHS Foundation Trust
Gingival Diseases
Coronally Advanced Flap With Two Different Techniques for the Treatment of Multiple Gingival Recessions
This study compared the clinical outcomes of coronally advanced flap using two different surgical strategies in the treatment of multiple gingival recessions.
- Trial name
- NCT02229669
- Testing
- Horizontal incisions, Oblique incisions
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Paulista University
Caries Class II, Caries,Dental
Clinical Performance of Advanced Self- Adhesivee Resin Composite Hybrid Restorations.
Clinical performance according to modified USPHS criteria of advanced self-Adhesive resin composite hybrid restorations is evaluated for 1 year versus conventional resin composite restorations in posterior teeth.
- Trial name
- NCT04790383
- Testing
- Advanced Self-Adhesive resin composite hybrid restorations (Surefil one (Dentsply Sirona))., Conventional resin composite restoration. (Sphere Tec, (Dentsply Sirona
- Where
- Egypt
- Volunteers
- 63 people, healthy volunteers welcome
- Sponsor
- Rawda Hesham Abd ElAziz
Fallopian Tube Clear Cell Adenocarcinoma, Fallopian Tube Endometrioid Adenocarcinoma
Paclitaxel, Polyglutamate Paclitaxel, or Observation in Treating Patients With Stage III or Stage IV Ovarian Epithelial, Peritoneal Cancer, or Fallopian Tube Cancer
This randomized phase III trial studies paclitaxel to see how well it works compared to polyglutamate paclitaxel or observation only in treating patients with stage III or stage IV ovarian epithelial, peritoneal cancer, or…
- Conditions
- Fallopian Tube Clear Cell Adenocarcinoma, Fallopian Tube Endometrioid Adenocarcinoma, Fallopian Tube Mucinous Adenocarcinoma, Fallopian Tube Serous Adenocarcinoma
- Trial name
- NCT00108745
- Testing
- Clinical Observation, Laboratory Biomarker Analysis, Paclitaxel
- Where
- 315 sites in United States
- Volunteers
- 1,157 people
- Sponsor
- GOG Foundation
Glioblastoma, Sarcoma
New Castle Disease Virus (NDV) in Glioblastoma Multiforme (GBM), Sarcoma and Neuroblastoma
Patients with specific metastatic cancers who failed prior therapeutic regimes will be treated with NDV for at least a year or until disease progression.
- Conditions
- Glioblastoma, Sarcoma, Neuroblastoma
- Trial name
- NCT01174537
- Testing
- New Castle Disease Virus
- Where
- Israel
- Sponsor
- Hadassah Medical Organization
Soft Tissue Sarcoma, Advanced Cancer
RNASARC - Molecular Screening Program of Soft Tissue Sarcomas With Complex Genomic Profile to Detect NTRK1/2/3, ROS1 or ALK Gene Fusions.
This trial is a multicenter, prospective cohort study aiming to describe molecular profiles of soft tissue sarcoma (STS) with complex genomic profiles in particular to assess the incidence of NTRK1/2/3, ROS1 or ALK gene fusions…
- Conditions
- Soft Tissue Sarcoma, Advanced Cancer, Metastatic Cancer
- Trial name
- RNASARC (NCT03375437)
- Testing
- Blood and tumor samples
- Where
- 10 sites in France
- Volunteers
- 376 people
- Sponsor
- Centre Leon Berard
Cystic Fibrosis
ENHANCE- Establishing Natural History in an Advanced New CF Care Era
Measured outcomes for people with CF have improved dramatically over the last 20 years, even prior to the widespread introduction of cystic fibrosis transmembrane conductance regulator (CTFR) modulator treatments.
- Trial name
- NCT05986045
- Testing
- Quality of Life
- Volunteers
- 550 people, healthy volunteers welcome
- Sponsor
- Royal College of Surgeons, Ireland
HIV Infections
A Study of ddC in Patients With AIDS or Advanced AIDS-Related Complex (ARC) Who Have Not Had Success With Zidovudine (AZT)
AMENDED: To provide ddC for patients with AIDS or advanced ARC who have failed treatment with, are intolerant to or are ineligible to receive zidovudine (AZT) and to demonstrate that ddC monotherapy is safe, and tolerable in this…
- Trial name
- NCT00002279
- Testing
- Zalcitabine
- Where
- United States
- Sponsor
- Hoffmann-La Roche
Rectal Neoplasms
Prediction of Response to Neoadjuvant Therapy in Rectal Cancer
The purpose of this study is to determine whether 18F-FDG-PET-CT and texture analysis of MRI performed 9 weeks after Neoadjuvant Chemo-radiotherapy in patients with locally advanced rectal cancer has the ability to identify…
- Trial name
- PRENT-LARC (NCT02439086)
- Testing
- PET-CT Scan
- Where
- United Kingdom
- Volunteers
- 20 people
- Sponsor
- Colchester General Hospital
Sarcoma, Central Nervous System Tumor
Dendritic Cell-based Immunotherapy for Advanced Solid Tumours of Children and Young Adults
Phase I/II, open, prospective clinical trial, historically controlled. The objective is to evaluate the safety and, as a secondary measure, the efficacy of an experimental treatment based on a cellular therapy (vaccination with…
- Trial name
- DEND/TIA (NCT02496520)
- Testing
- dendritic cells, Surgery as needed by the patient´s tumor and stage, Chemotherapy as needed by the patient´s tumor and stage
- Where
- Spain
- Volunteers
- 6 people
- Sponsor
- Clinica Universidad de Navarra, Universidad de Navarra
Sarcoma
BIOmarker Driven Trial of VEGFR2 Inhibitor in Advanced or Metastatic Sarcoma
The aim of this study is to evaluate the efficacy and safety of Apatinib monotherapy for relapsed or refractory advanced bone and soft tissue sarcoma with VEGFR-2 (KDR) 604A>G polymorphism as predictive biomarker
- Trial name
- BIOVAS (NCT04072042)
- Testing
- Apatinib monotherapy
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Ruijin Hospital
Solid Tumor
HS-IT101 Injection in the Treatment of Advanced Solid Tumors
Single-arm, open-label,interventional study evaluating adoptive cell therapy (ACT) with autologous tumor-infiltrating lymphocyte (TIL) infusion (HS-IT101) after lymphodepletion preparative with fludarabine and cyclophosphamide…
- Trial name
- NCT06342336
- Testing
- HS-IT101 Injection
- Where
- China
- Volunteers
- 44 people
- Sponsor
- Hangzhou Huasai Biomedicine Co., Ltd.
Brain Injuries
Implementation Study on Hospital-to-home Advanced Rehabilitation Technologies (ART)
To study the feasibility of the various model of ART rental service for home use, prescribed and supervised by experienced rehabilitation professionals and supported by tech partners, and its efficacy in improving function in…
- Trial name
- R@H (NCT07904624)
- Testing
- ART
- Where
- 3 sites in Singapore
- Volunteers
- 1,000 people
- Sponsor
- National University Hospital, Singapore
Solid Tumor
QUILT-3.036: AMG 337 in Subjects With Advanced or Metastatic Solid Tumors
This is a phase 2 study of AMG 337 in subjects with advanced or metastatic solid tumors that overexpress MET or harbor METex14del mutations resulting in MET exon 14 skipping.
- Trial name
- NCT03147976
- Testing
- AMG 337
- Where
- United States
- Sponsor
- NantPharma, LLC
Neoplasms by Histologic Type
A Trial In Patients With Advanced Cancer And Leukemia
This is a phase 1, dose escalating study to determine the safety of PF-03084014 in patients with advanced cancer and leukemia
- Trial name
- NCT00878189
- Testing
- PF-03084014
- Where
- 10 sites in United States, Italy
- Volunteers
- 72 people
- Sponsor
- Pfizer
Lung Cancer
Temozolomide in Patients With Progressive or Recurrent Non-small Cell Lung Cancer
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. PURPOSE: Phase II trial to study the effect of temozolomide in patients with progressive or recurrent stage…
- Trial name
- NCT00003062
- Testing
- temozolomide
- Where
- 5 sites in Italy, Netherlands and 3 more
- Volunteers
- 70 people
- Sponsor
- European Organisation for Research and Treatment of Cancer - EORTC
Periodontal Diseases, Furcation Defects
Vital Root Amputation in Molars With Advanced Periodontal Furcation Involvement: a Preliminary Study
The goal of this clinical trial is to test in 10 patients with advanced furcation involvement on molars. The main question[s] it aims to answer are: Is it possible to carry out root resection without endodontic treatment on…
- Trial name
- NCT05721313
- Testing
- root resection
- Where
- Italy
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Azienda Ospedaliera, Universitaria Policlinico Vittorio Emanuele
Sarcoma
Weekly Docetaxel and Fixed-Dose Rate Gemcitabine Combination Chemotherapy
To determine the activity of weekly Docetaxel and Gemcitabine in patients with advanced soft tissue sarcoma previously treated with anthracycline and/or ifosfamide 1. Primary endpoint: response rate 2.
- Trial name
- NCT00807261
- Testing
- Gemcitabine and Docetaxel
- Volunteers
- 30 people
- Sponsor
- Asan Medical Center
Child Nutrition Disorders
Sleep Quality and dAGE Intake in Preschool Children
The aim was to evaluate the relationship between dietary AGE intake and sleep quality and some nutrient intake of healthy children aged 3-5 years registered in various nurseries in Ankara.
- Trial name
- NCT07062640
- Where
- Turkey (Türkiye)
- Volunteers
- 304 people, healthy volunteers welcome
- Sponsor
- Karabuk University
Unresectable or Metastatic Melanoma or Advanced Solid Tumors, Melanoma
A Study of APG-115 in as a Monotherapy or Combination With Pembrolizumab in Patients With Metastatic Melanomas or Advanced Solid Tumors
This study aims to assess the safety, tolerability, pharmacokinetics, and preliminary efficacy of APG-115, an MDM2 inhibitor, either alone or in combination with pembrolizumab, a programmed cell death protein-1 (PD-1) inhibitor…
- Conditions
- Unresectable or Metastatic Melanoma or Advanced Solid Tumors, Melanoma, Uveal Melanoma, P53 Mutation
- Trial name
- NCT03611868
- Testing
- Phase 1b: APG-115+pembrolizumab
- Where
- 21 sites in United States, Australia
- Volunteers
- 230 people
- Sponsor
- Ascentage Pharma Group Inc.
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