Clinical trials: Aggressive Behavior, open to volunteers
Aggressive B-Cell Lymphoma
G-Pola-GemOx in Refractory/Relapsed Aggressive B-Cell Lymphoma
The goal of this phase 2 trial is to test the safety and efficacy of G-Pola-GemOx as induction therapy in patients with Refractory/Relapsed Aggressive B-Cell Lymphoma.
- Trial name
- NCT07184788
- Testing
- Glofitamab, Polatuzumab Vedotin, Gemcitabine, and Oxaliplatin as Induction Therapy
- Volunteers
- 80 people
- Sponsor
- Navy General Hospital, Beijing
Social Exclusion, Aggression
Motivational Interviewing-Based Training
The middle school period is the period when children begin to experience physical, emotional and social development and try to adapt to psychological changes.
- Conditions
- Social Exclusion, Aggression, Bullying of Child
- Trial name
- NCT06972030
- Testing
- Motivational interviewing
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people
- Sponsor
- Muş Alparslan University
Autism Spectrum Disorder
VGN-Ex05e in Patients With Autism Spectrum Disorder Associated With Severe Self-Injurious and Aggressive Behaviors
To evaluate the safety and tolerability of intracerebral injection of VGN-Ex05e in the nucleus accumbens of patients with autism spectrum disorder.
- Trial name
- NCT07433517
- Testing
- VGN-Ex05e
- Volunteers
- 6 people
- Sponsor
- Shanghai Jiao Tong University School of Medicine
Child Behavior Problem, Disruptive Behavior
Step-by-Step: Evaluation of a Stepped Care Model
The primary aim of this project is to examine the effectiveness of a stepped care model of interventions for children's defiant or aggressive behavior problems.
- Conditions
- Child Behavior Problem, Disruptive Behavior, Oppositional Defiant Disorder, Conduct Problems
- Trial name
- NCT06902649
- Testing
- Internet-based parenting support, "YourSkills" for children/youth, Step-by-step parent support
- Where
- Sweden
- Volunteers
- 210 people
- Sponsor
- Karolinska Institutet
Diffuse Large B-cell Lymphoma and Aggressive B-cell Lymphomas
Tumour Immune and Ki-67 Scoring Methods as Prognostic Biomarkers in Diffuse Large B-cell Lymphoma and Aggressive B-cell Lymphomas
Diffuse large B-cell lymphoma (DLBCL) is the most common aggressive non-Hodgkin lymphoma with heterogeneity in its clinical presentations, biological behaviour and response to therapy (1-4).
- Trial name
- NCT07804173
- Where
- Egypt
- Volunteers
- 70 people
- Sponsor
- Sohag University
Prader-Willi Syndrome
Regulating Together for Prader-Willi Syndrome: A Group Behavioral Therapy for Emotion Dysregulation
The goal of this study is to help teens with Prader-Willi Syndrome (PWS) and their families learn practical strategies for managing issues like irritability, meltdowns, and anxiety.
- Trial name
- RT-PWS (NCT07607730)
- Testing
- Regulating Together group therapy
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Children's Mercy Hospital Kansas City
Conduct Disorder
Lisdexamfetamine For the Treatment of Conduct Disorder in Children
About 2 in every 100 Australian children have conduct disorder, a serious mental health condition characterised by antisocial behaviours like aggression and rule breaking.
- Trial name
- LiFT-CD (NCT07923617)
- Testing
- Lidexamfetamine
- Volunteers
- 30 people
- Sponsor
- Orygen
ADHD - Attention Deficit Disorder With Hyperactivity, Irritability
Predictors of Improvements in Irritability and Aggression in Children With ADHD Treated With CNS Stimulants
Impulsive Aggression and chronic irritability (IACI) often occur together and are one of the most common reasons children present for behavioral health (BH) care.
- Conditions
- ADHD - Attention Deficit Disorder With Hyperactivity, Irritability, Aggression Childhood
- Trial name
- NCT06871488
- Testing
- CNS Stimulant, CNS Stimulant open label first phase
- Where
- United States
- Volunteers
- 136 people
- Sponsor
- Milton S. Hershey Medical Center
Desmoplastic Small Round Cell Tumor, Synovial Sarcoma
Pasireotide as Maintenance Treatment in Synovial Sarcoma and Desmoplastic Small Round Cell Tumor
PAMSARC is a non-commercial interventional Phase 2 clinical trial of academic research institutions, with its primary goal being to improve medical treatment of fusion driven Desmoplastic small round cell tumor (DSRCT) and…
- Trial name
- PAMSARC (NCT06456359)
- Testing
- Signifor
- Where
- 4 sites in Germany
- Volunteers
- 28 people
- Sponsor
- University Hospital Heidelberg
Autism, Intellectual Disabilities With Other Behavioral Symptoms
Regulating Together for Intellectual Disability and Autism: A Group Behavioral Therapy for for Emotion Dysregulation
The goal of this study is to help children with autism and a co-occurring intellectual disability and their families learn practical strategies for managing issues like irritability, aggression, and other challenging behaviors.
- Conditions
- Autism, Intellectual Disabilities With Other Behavioral Symptoms, Intellectual Disability
- Trial name
- RT-ID (NCT07624448)
- Testing
- Regulating Together group therapy
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Children's Mercy Hospital Kansas City
Thyroid Cancer
This Study is Mainly About Finding Incidence Among Other Factors of Thyroid Cancer in Patient with Benign Disease As MNG to Early Discover of the Malignancy to Save the Patient from Aggressive Procedure
The purpose of the present study was to evaluate the prevalence of thyroid cancer in patients who had thyroidectomy for MNG, and analyze patient-related parameters to identify type and risk factors associated with incidental…
- Trial name
- NCT06730971
- Testing
- Total thyroidectomy
- Volunteers
- 300 people
- Sponsor
- Asmaa Mohamed Emam
Aggressive Spinal Hemangiomas
Aggressive Spinal Hemangioma
This research is a case series analysis to evaluate aggressive vertebral hemangiomas. It focuses on clinical presentation, diagnostic imaging accuracy (X-ray, MRI, MSCT, angiography), and treatment efficacy.
- Trial name
- NCT06996873
- Volunteers
- 30 people
- Sponsor
- Assiut University
Breast Cancer
Clinical and Biological Study of Early-onset Breast Cancer and the Influence of the Reproductive Cycle on the Aggressiveness of the Disease
The incidence of breast cancer is increasing, particularly among young women. Cancers in young women are associated with a poor prognosis. The causes remain poorly understood.
- Trial name
- ARTEMIS (NCT07601152)
- Testing
- No Intervention: Observational Cohort
- Where
- France
- Volunteers
- 1,000 people
- Sponsor
- Institut Cancerologie de l'Ouest
Conduct Disorder, Mentalization Based Therapy
Using Mentalization Based Therapy to Support Children and Adolescents Referred to Specialist Mental Health Services in the NHS for Aggressive and/or Violent Behaviour
The MICA Study is a research project that has been designed to work out how helpful mentalisation based therapy is. This is a new type of support that helps young people make sense of their own behaviours and feelings, and those…
- Conditions
- Conduct Disorder, Mentalization Based Therapy, Violent Behavior, Aggressive Behaviour
- Trial name
- MICA (NCT07091721)
- Testing
- Mentalization based therapy (MBT), Support as usual
- Where
- 8 sites in United Kingdom
- Volunteers
- 632 people
- Sponsor
- Anna Freud
Lymphoid Malignancies
The OPAL Study: AVM0703 for Treatment of Lymphoid Malignancies
This is an open-label, Phase 1/2 study designed to characterize the safety, tolerability, Pharmacokinetics(PK), and preliminary antitumor activity of AVM0703 administered as a single intravenous (IV) infusion to patients with…
- Trial name
- OPAL (NCT04329728)
- Testing
- AVM0703
- Where
- 11 sites in United States
- Volunteers
- 144 people
- Sponsor
- AVM Biotechnology Inc
Aggression
Virtual Reality Intervention (VR-GINSO) for Reducing Aggression in Young Offenders
The goal of this clinical trial is to see if a specific intervention program that uses virtual reality (VR) helps young people reduce aggressive behavior more than the same program without VR or their usual treatment.
- Trial name
- VR-GINSO (NCT07484919)
- Testing
- Virtual Reality, Active Control, Treatment as usual
- Where
- Spain
- Volunteers
- 110 people
- Sponsor
- Universidad Francisco de Vitoria
Bullying of Child, Bullying Victimisation
REThink for Mental Health of the Youths in Romania
In order to test the effect of the intervention, a multi-center randomized control trial (RCT) will be conducted to test the efficacy of the REThink interventions on improving bullying (both victimization and aggression) and…
- Conditions
- Bullying of Child, Bullying Victimisation, Bullying
- Trial name
- REThink (NCT06646159)
- Testing
- REThink Intervention
- Where
- Romania
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Babes-Bolyai University
Mental Health Issue
The Relationship Between Internet-use Behavior and Mental Health in Youth
Introduction: WHO defines youth as 15-24 years age group. At this stage, the brain is still under development, with high impulsiveness, being fond of stimulation and yearning for peer life.
- Trial name
- NCT06284551
- Where
- Taiwan
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Problem Behavior, Aggression
Basic and Applied Research on Extinction Bursts
Although highly effective, treatments like FCT include extinction, which can have adverse side effects. The extinction burst, an increase in the frequency or intensity of destructive behavior at the start of treatment, is the…
- Conditions
- Problem Behavior, Aggression, Self Injury
- Trial name
- NCT05925101
- Testing
- Extinction-only condition, Rate-drop condition, Rate-hold condition
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Rutgers, The State University of New Jersey
Violence, Adolescent
Addressing Root Causes for Gun Violence Prevention (ARC-GVP)
The goal of this study is to help build the evidence base for a locally-relevant youth firearm violence prevention program in Washington D.C., a city experiencing disparities in youth firearm violence outcomes.
- Conditions
- Violence, Adolescent, Firearm Injury, Aggression
- Trial name
- NCT05887973
- Testing
- The T.R.I.G.G.E.R Project
- Where
- United States
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- University of Michigan