Clinical trials: Airway Clearance
Cystic Fibrosis in Children
Effect of Lumacaftor/Ivacaftor in Children With Cystic Fibrosis Homozygote for F508del on Small Airway Function
To obtain prospective real world data of the effect of lumacaftor/ivacaftor or tezacaftor/ ivacaftor on small airway disease in children aged 6-18 years with cystic fibrosis (CF) homozygous for F508del.
- Trial name
- ROOTS (NCT04138589)
- Where
- 2 sites in Germany, Netherlands
- Volunteers
- 30 people
- Sponsor
- University Medical Center Groningen
Gastro-oesophageal Reflux
Influence of Airway Clearance Techniques on GOR in Infants
The purpose of this study is to determine whether Assisted Autogenic Drainage (AAD) or bouncing combined with Assisted Autogenic Drainage (BAAD), induces or aggravates acid and non-acid gastro-oesophageal reflux in infants under…
- Trial name
- NCT03346174
- Testing
- AAD, BAAD
- Where
- Belgium
- Volunteers
- 105 people
- Sponsor
- Vrije Universiteit Brussel
Cystic Fibrosis
The Use of Visual Feedback in Airway Clearance
Cystic Fibrosis (CF) patients perform airway clearance incorporating various breathing strategies, to clear secretions from their lungs.
- Trial name
- NCT01546779
- Testing
- Tri-Gym
- Where
- Israel
- Volunteers
- 40 people
- Sponsor
- Sheba Medical Center
Cystic Fibrosis (CF)
Effectiveness of Gamified Mobile Health Apps for Airway Clearance Therapy in Children and Adolescents With Cystic Fibrosis
The aim of this randomized controlled trial is to evaluate the effectiveness of gamified mobile health (mHealth) applications for airway clearance therapy in children and adolescents with cystic fibrosis.
- Trial name
- EGmACT-CF (NCT06958094)
- Testing
- Gamified mobile health applications, Conventional Airway Clearance Therapy, Combination Treatment
- Where
- Spain
- Volunteers
- 36 people
- Sponsor
- Universidad de Córdoba
Gastro-esophageal Reflux
Safety Study of Airway Clearance Techniques in Infants.
The purpose of this study is to determine whether three airway clearance techniques ( Bouncing, Assisted Autogenic Drainage ( AAD) and bouncing and AAD) provoke or aggravate gastro-esophageal reflux in infants under the age of 1…
- Trial name
- NCT02128867
- Testing
- Assisted Autogenic Drainage (AAD), bouncing and AAD, bouncing
- Where
- Belgium
- Volunteers
- 159 people, healthy volunteers welcome
- Sponsor
- Vrije Universiteit Brussel
Viral Bronchiolitis
Respiratory Physical Therapy on the Cardiac Autonomic Modulation Paediatric Patients
The present study investigated the influence of respiratory affections on the heart rate variability (HRV) of paediatric patients.
- Trial name
- NCT01354561
- Testing
- Respiratory physical therapy
- Where
- Brazil
- Volunteers
- 24 people
- Sponsor
- University of Sao Paulo
Primary Ciliary Dyskinesia, Kartagener Syndrome
Effect of Game Based Approach on Oxygenation, Functional Capacity and Quality of Life in Primary Ciliary Dyskinesia
Impaired pulmonary function, decreased physical activity, functional capacity and depending on these factors are reported in patients with primary ciliary dyskinesia in recent studies.
- Conditions
- Primary Ciliary Dyskinesia, Kartagener Syndrome, Immotile Cilia Syndrome
- Trial name
- NCT03832491
- Testing
- Home based therapy, Game and home based therapy
- Where
- Turkey (Türkiye)
- Volunteers
- 32 people
- Sponsor
- Hacettepe University
Bronchiolitis Acute
Bronchiolitis Clearance Airways With Seaserum
The objective of this study is to show that the use of electrodialyzed seawater reduces the duration (in days) of symptoms in acute infant bronchiolitis compared with the use of saline solution in infants aged 1 month to less…
- Trial name
- B-CLASS (NCT06177197)
- Testing
- Physiomer, Saline solution
- Where
- 8 sites in France
- Volunteers
- 458 people
- Sponsor
- University Hospital, Brest
Lung Disease
The Effectiveness of BreatheMAX Breathing Device on Secretion Clearance
The purpose of this study is to determined effects of BreatheMAX on secretion clearance.
- Trial name
- ESMOSC (NCT01090804)
- Testing
- BreatheMAX breathing device
- Where
- Thailand
- Volunteers
- 14 people
- Sponsor
- Khon Kaen University
Airway Clearance, Mechanical Insufflation-exsufflation
Mechanical Insufflation-Exsufflation in Critically Ill Patients
Mechanical insufflation-exsufflation (MI-E) is an established airway clearance technique for patients with chronic conditions like neuromuscular diseases.
- Conditions
- Airway Clearance, Mechanical Insufflation-exsufflation, Mechanical Insufflation-exsufflation Session ( With Cough Assist), Delphi Study
- Trial name
- DELMI-E (NCT07420946)
- Testing
- Delphi Questionnaire
- Where
- 4 sites in Italy, Spain and 1 more
- Volunteers
- 30 people
- Sponsor
- Medipol University
Cystic Fibrosis, Bronchiectasis
Adherence to Airway Clearance. Novel Approaches to Improving Adherence
An airway clearance technique (ACT) is one of the core treatments for children with chronic lung diseases who are unable to clear their secretions effectively.
- Trial name
- NCT02906826
- Testing
- Video game
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- University of British Columbia
Cystic Fibrosis
The Addition of Non-Invasive Ventilation To Airway Clearance Techniques In Adults With Cystic Fibrosis
Cystic Fibrosis (CF) is a genetic disorder of altered ion transport across cell membranes which is characterised by the production of thickened bodily secretions, affecting the function of organs such as the pancreas and the…
- Trial name
- NIV (NCT01885650)
- Testing
- Airway Clearance Techniques
- Where
- United Kingdom
- Volunteers
- 14 people
- Sponsor
- Royal Brompton & Harefield NHS Foundation Trust
COPD (Chronic Obstructive Pulmonary Disease), Cystic Fibrosis (CF)
ELECTROVEST: Electro-Stimulation Vibratory Vest for Pulmonary Rehabilitation in Patients With Chronic Respiratory Diseases
This study will evaluate the effectiveness, safety, and tolerability of a novel wearable device, the ELECTROVEST, designed to improve airway clearance in patients with chronic respiratory diseases.
- Conditions
- COPD (Chronic Obstructive Pulmonary Disease), Cystic Fibrosis (CF), Bronchiectasis Adult, Asthma Bronchiale
- Trial name
- Electrovest (NCT07175012)
- Testing
- ELECTROVEST, The Vest® Model 105
- Where
- Spain
- Volunteers
- 21 people
- Sponsor
- Hospitales Universitarios Virgen del Rocío
Cystic Fibrosis
Resistive Inspiratory Manoeuvre as Airway Clearance Technique in Cystic Fibrosis
This trial aims to analyze whether the resistive inspiratory manoeuvre (RIM) performed previously to autogenic drainage (AD) technique improves the effectiveness in terms of mucus clearance during a typical bronchial drainage…
- Trial name
- NCT02261987
- Testing
- Autogenic drainage (AD), Resistive inspiratory manoeuvre (RIM), Resistive inspiratory manoeuvre+autogenic drainage
- Where
- 4 sites in Spain
- Volunteers
- 32 people
- Sponsor
- Universidad San Jorge
Primary Ciliary Dyskinesia
Respiratory Physiotherapy Performed by Simeox In Patients With Primary Ciliary Dyskinesia
Primary ciliary dyskinesia (PCD) is characterized by impaired airway clearance and mucus stagnation. This results in recurrent upper and lower respiratory tract infections often leading to chronic inflammation and, if not treated…
- Trial name
- NCT04793724
- Testing
- Simeox, PARI O PEP
- Where
- Czechia
- Volunteers
- 30 people
- Sponsor
- University Hospital, Motol
Bronchiectasis Adult, Bronchiectasis With Acute Exacerbation
Airway Clearance by Fiberoptic Bronchoscopy in Bronchiectasis Followed by Gentamicin and Dexamethason Injection
Fiberoptic Bronchoscopic Removal of Secretions and Antibiotic Injection
- Trial name
- NCT06906354
- Testing
- Airway Clearance by Fiberoptic Bronchoscopy in Bronchiectasis Followed by Gentamicin and Dexamethason Injection
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Alexandria University
Bronchiolitis
Safety of Airway Clearance in Non-hospitalized Infants With Acute Viral Bronchiolitis
Bronchiolitis is a disease that can occur in a mild form and moderate, and often does not require hospitalization. The technique of prolonged slow expiration followed by cough caused in children not hospitalized with mild and…
- Trial name
- NCT03835858
- Testing
- Respiratory physiotherapy
- Where
- Spain
- Volunteers
- 265 people
- Sponsor
- Guadarrama Hospital
Cystic Fibrosis, Airway Clearance Impairment
IPV vs CPT for Airway Clearance During CF Exacerbation
Intrapulmonary Percussive Ventilation (IPV) will show greater improvements in Forced Expiatory Volume in 1 second (FEV1) shorter duration of stay, and greater time to next pulmonary exacerbation in pediatric Cystic Fibrosis…
- Trial name
- NCT03261219
- Testing
- Intrapulmonary Percussive ventilation, Chest Physiotherapy Vest (Incourage)
- Sponsor
- University of Florida
Kartagener Syndrome
Pathogenesis of Primary Ciliary Dyskinesia (PCD) Lung Disease
The overall short-term goals of this project include the following: 1) identify the genes that are key to the function of respiratory cilia to protect the normal lung; and 2) the effects of genetic mutations that adversely affect…
- Trial name
- NCT00807482
- Where
- United States
- Volunteers
- 1,800 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Cystic Fibrosis
Positive Expiratory Pressure During Inhalation of Hypertonic Saline in Patients With Cystic Fibrosis
This trial aims to analyze whether the inhalation of hypertonic saline combined with a positive expiratory pressure (PEP) device increases the amount of sputum expectorated during the chest physiotherapy session ( inhalation +…
- Trial name
- NCT02303808
- Testing
- INHALATION WITH PEP DEVICE (Acapella Duet)
- Where
- Spain
- Volunteers
- 20 people
- Sponsor
- Universidad San Jorge