Clinical trials: Allergy Drug
Allergies
Multi-center, Pediatric, Open-label, Preference Study of Desloratadine 2.5 mg Reditab (SCH34117) and Zyrtec 5.0 mg Chewable Tablet Medications (Study P04574)(COMPLETED)
This was a randomized, open-label, 2-way cross-over study, comparing desloratadine RediTab 2.5 mg to a marketed chewable antihistamine oral medication (Zyrtec® 5 mg Chewable Tablet).
- Trial name
- NCT00779116
- Testing
- Desloratadine, Zyrtec® (cetirizine)
- Volunteers
- 217 people, healthy volunteers welcome
- Sponsor
- Organon and Co
Overweight, Obesity
Meta-analyses of the Effect of 'Catalytic' Doses of Fructose and Its Epimers on Carbohydrate Metabolism
Despite advances in the prevention and treatment of type 2 diabetes, its prevalence continues to rise worldwide. There is a need for new modalities to improve metabolic control in individuals with type 2 diabetes and those who…
- Conditions
- Overweight, Obesity, Dysglycemia, Prediabetes
- Trial name
- NCT02776722
- Testing
- fructose, allulose, tagatose, or sorbose
- Where
- Canada
- Volunteers
- 1 people, healthy volunteers welcome
- Sponsor
- University of Toronto
Healthy
Preventive Medicine Study of Childhood Atopic Diseases
Under environmental intervention programs, to explore the associations between Environmental Tobacco Smoke (ETS) and changes of pulmonary function, cytokines and new-onset asthma between different groups.
- Trial name
- NCT00960596
- Testing
- Health promotion and health education for smoking habits
- Where
- Taiwan
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Allergy to Fish, Allergy to Shrimp
Pilot Study on Traditional Chinese Medicine and Food Allergy
Recently, there has been an increasing interest in using traditional Chinese medicine for food allergy. The Harvard group has successfully demonstrated the Food Allergy Herbal Formula - FAHF2 completely blocked peanut-induced…
- Conditions
- Allergy to Fish, Allergy to Shrimp, Allergy to Crab
- Trial name
- TCMFA (NCT02490813)
- Testing
- Treatment - Chinese Herbal Formula - X
- Where
- Hong Kong
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Hong Kong Sanatorium & Hospital
Atrial Fibrillation, Coronary Heart Disease
EMPOWER-1: A Multi-site Clinical Cohort Research Study to Reduce Health Inequality
Health inequality and genetic disparity are a significant issue in the United Kingdom (UK). This study focuses on diseases that are associated with significant morbidity and mortality in the UK, and specifically examines the…
- Conditions
- Atrial Fibrillation, Coronary Heart Disease, Cardiovascular Diseases, Heart Failure
- Trial name
- EMPOWER (NCT03987633)
- Where
- United Kingdom
- Volunteers
- 200,000 people, healthy volunteers welcome
- Sponsor
- Future Genetics Limited
Hearing Impaired Children
EarGenie MVP Performance Evaluation
This is a single-group clinical trial to evaluate the performance of the EarGenie minimum viable product (MVP) in normal hearing infants.
- Trial name
- NCT06406088
- Testing
- EarGenie MVP test
- Where
- Australia
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- The Bionics Institute of Australia
Pemphigus, Bullous Pemphigoid
Human Leukocyte Antigen Class II (DRB1 and DQB1) Alleles and Haplotypes Frequencies in Patients With Pemphigus Vulgaris Among the Russian Population
Pemphigus is a rare autoimmune life-threatening blistering condition affecting skin and mucous membranes. Pemphigus belongs to a family of polygenic disorders.
- Conditions
- Pemphigus, Bullous Pemphigoid, Stevens-Johnson Syndrome, Toxic Epidermal Necrolyses
- Trial name
- NCT05284929
- Testing
- A single blood sample for HLA typing
- Where
- Russia
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Sechenov University
Asthma, Reactive Airway Disease
Comparison of Asthma Programs for Schools
The purpose was to evaluate effectiveness and impact of an academic and counseling asthma health education program (SHARP) for fourth- and fifth-grade students diagnosed with asthma.
- Trial name
- CAPS (NCT01625364)
- Testing
- SHARP program, Open Airways for Schools
- Where
- United States
- Volunteers
- 432 people, healthy volunteers welcome
- Sponsor
- University of Texas at Austin
Gestational Diabetes, Glucose Tolerance Impaired in Pregnancy
Food Product for Management of Gestational Diabetes
The goal of this pilot open pre-post clinical trial is to test effects of a wholegrain product in patients with newly diagnosed gestational diabetes.
- Conditions
- Gestational Diabetes, Glucose Tolerance Impaired in Pregnancy, Glucose Tolerance Impaired, Pregnancy Related
- Trial name
- NCT05917808
- Testing
- Ready-to-eat wholegrain porridge
- Where
- Germany
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Stoffwechselzentrum Rhein - Pfalz
Atopic Dermatitis, Eczema
Defining the Skin and Blood Biomarkers of Pediatric Atopic Dermatitis
Atopic dermatitis (AD), also known as eczema, is the most common inflammatory skin disorder of children, affecting 10-20% of children and 1-2% of adults.
- Trial name
- NCT01782703
- Where
- 4 sites in United States
- Volunteers
- 505 people, healthy volunteers welcome
- Sponsor
- Northwestern University
Allergies
Multi-Center, Pediatric, Open-Label, Preference Study of Desloratadine 2.5 mg Reditab (SCH34117) and Zyrtec ® 5.0 mg Chewable Tablet Medications (Study P04573) (Completed)
The primary objective of this study was to determine whether children ages 6-11 years prefer desloratadine RediTabs (2.5 mg) or a marketed competitor (Zyrtec® 5 mg Chewable Tablets).
- Trial name
- NCT00780403
- Testing
- Desloratadine, Zyrtec® (cetirizine)
- Volunteers
- 220 people, healthy volunteers welcome
- Sponsor
- Organon and Co
Asthma
Phenotyping Responses to Systemic Corticosteroids in the Management of Asthma Attacks
This observational study compares the phenotypic variability (clinical and biological) in treatment response to systemic corticosteroids according to the blood eosinophil count and FeNO in physician-diagnosed ≥12-year-old…
- Trial name
- PRISMA (NCT05870215)
- Testing
- Visit 1: Clinical exam and questionnaires, Visit 1: Respiratory physiology, Visit 1: Inflammometry
- Where
- Canada
- Volunteers
- 78 people, healthy volunteers welcome
- Sponsor
- Université de Sherbrooke
Amoxicillin Allergy
Diagnosing Drug Allergy: the T is the Key
The goal of this clinical trial is to validate a newly developed test in the diagnosis of patients with amoxicillin allergy (i.e. T-cell activation test).
- Trial name
- TAT (NCT06409884)
- Testing
- T-cell activation test using intracellular markers
- Where
- Belgium
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- University Hospital, Antwerp
Hereditary Angioedema
Safety and Pharmacokinetics of GNR-038 in Healthy Volunteers
It is an open-label dose-escalating study in sequential cohorts to assess safety and pharmacokinetics of GNR-038.
- Trial name
- NCT04557319
- Testing
- GNR-038, 25 МЕ/kg, GNR-038, 50 МЕ/kg, GNR-038, 100 МЕ/kg
- Where
- Russia
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- AO GENERIUM
Environmental Health Education, Environmental Awareness and Sensitivity
The Effect of Healthy Environment Education on Primary School Students' Attitudes Towards Environment
It is important to explain environmental literacy to every age group and segment of society and to raise awareness. Environmental education provided to younger age groups in particular teaches children to live in harmony with…
- Conditions
- Environmental Health Education, Environmental Awareness and Sensitivity, Climate Change Awareness, Health Knowledge, Attitudes, Practice
- Trial name
- NCT07658781
- Testing
- "I Love and Protect My Environment" Education Program, Control Group
- Where
- Turkey (Türkiye)
- Volunteers
- 113 people, healthy volunteers welcome
- Sponsor
- Aydin Adnan Menderes University
Penicillin Allergy, Antimicrobial Drug Resistance
A Study of the Impact of Penicillin Allergy on Antimicrobial Resistance and ouTcomes
Penicillin allergy is one of the commonest reported allergies. The presence of a penicillin allergy record in a patients notes leads to the avoidance of recommended first-line penicillin antibiotics and the use of alternative…
- Conditions
- Penicillin Allergy, Antimicrobial Drug Resistance, AMR
- Trial name
- IMPAART (NCT07177690)
- Where
- United Kingdom
- Volunteers
- 214 people, healthy volunteers welcome
- Sponsor
- University of Leeds
Acute Myeloid Leukemia in Children
Individualized Treatment of Pediatric R/R AML Based on Transcriptomic Profile and in Vitro Drug Sensitivity Test
Acute myeloid leukemia (AML) accounts for about 15% to 20% of childhood leukemia, but the death rate accounts for about 50%. About 20-30% of children with AML did not achieve complete response (CR) after 2 induction treatments…
- Trial name
- NCT06233526
- Testing
- Chemotherapy regiments based on the transcriptomic profile and in vitro drug sensitivity test
- Where
- China
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- The Children's Hospital of Zhejiang University School of Medicine
Asthma
Study of Inhaled Glucocorticosteroids/Long-Acting Bronchodilator Drugs in Subjects With Asthma That Have Been Taking Inhaled Glucocorticosteroids (Study P04705AM1)
This study is being conducted to demonstrate the non-inferiority between two inhaled glucocorticosteroids and long-acting bronchodilator combination drugs called mometasone furoate/formoterol fumarate in a metered-dose inhaler…
- Trial name
- NCT00424008
- Testing
- Mometasone furoate/formoterol (MF/F) MDI, Fluticasone propionate/salmeterol (F/SC) DPI
- Volunteers
- 722 people, healthy volunteers welcome
- Sponsor
- Organon and Co
Drug Hypersensitivity
Management of Drug Hypersensitivity in Children
The aim of this study is (1) to assess the incidence of suspected drug allergies in a pediatric hospital and the proportion in which these reactions are confirmed to be allergic; (2) to evaluate the diagnostic values of the…
- Trial name
- DHC (NCT02031120)
- Where
- Switzerland
- Volunteers
- 207 people, healthy volunteers welcome
- Sponsor
- University Hospital, Geneva
Asthma, Dental Caries
Herbal Lollipops on Oral Bacterial Levels and DMFT/Dmft Scores of Children With Asthma Using Inhalers
Young children with asthma who use drugs for their asthma are at higher risk for tooth decay. These drugs can cause (1) dry mouth from less saliva secretion and (2) acid mouth that causes teeth to become soft and bacteria to…
- Trial name
- Lollipops (NCT01147835)
- Testing
- Chinese Licorice Root
- Where
- United States
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- University of Nebraska