Clinical trials: Amoxicillin
Mycobacterium Abscessus Pulmonary Disease, Mycobacterium Abscessus Infection
Testing a Novel Combination Treatment (Arm D) Versus Standard of Care for Intensive Phase Treatment for Mycobacterium Abscessus Pulmonary Disease in People With or Without Cystic Fibrosis in the Finding the Optimal Regimen for Mycobacterium Abscessus Treatment (FORMaT) Adaptive Platform Trial
The goal of this clinical trial is to learn if a new combination antibiotic treatment (Arm D) works to treat a rare lung condition called mycobacterium abscessus pulmonary disease in people of any age and sex, when compared to…
- Conditions
- Mycobacterium Abscessus Pulmonary Disease, Mycobacterium Abscessus Infection, Non-Tuberculous Mycobacterial (NTM) Infections, Non-Tuberculous Mycobacteria Pulmonary Disease
- Trial name
- FORMaT-EVOLVE (NCT07485010)
- Testing
- Sulbactam 25mg/kg -Durlobactam 25mg/kg (Every 6 hours), Ceftriaxone for Injection, Amoxicillin
- Volunteers
- 300 people
- Sponsor
- The University of Queensland
Chronic Cough
Finnish Children´s Protracted Cough
Prolonged cough lasting more than four weeks is common in children, but the best treatment is often unclear when no underlying disease can be found.
- Trial name
- FINNCHICO (NCT07582549)
- Testing
- Fluticasone propionate inhalation, Amoxicillin-clavulanic acid oral suspension
- Where
- Finland
- Volunteers
- 100 people
- Sponsor
- Tampere University Hospital
Pediatric, Bacterial Infections
A Pharmacokinetic Study of LP-001 in Children With a Bacterial Infection
The purpose of this study is to determine the pharmacokinetic profiles of LP-001, an amoxicillin and clavulanate formulation compared to the pharmacokinetic profiles of Augmentin ES-600 for use in pediatric patients with a…
- Trial name
- NCT05584683
- Testing
- Amoxicillin potassium clavulanate, Amoxicillin potassium clavulanate (Augmentin ES-600)
- Where
- United States
- Volunteers
- 39 people
- Sponsor
- Kaizen Bioscience Co.
Infections, Bacterial
A Pharmacokinetics and Safety Study of Augmentin ES-600 in Children With CAP and ABRS
The purpose of this study is to evaluate the pharmacokinetics, safety or tolerability through treatment emergent adverse event (TEAE) and to explore primary and secondary clinical response of treatment with Augmentin ES in…
- Trial name
- NCT05340257
- Testing
- Augmentin ES
- Where
- 2 sites in Brazil
- Sponsor
- GlaxoSmithKline
Community-acquired Pneumonia
Comparison of Efficacy of Oral Amoxicillin Versus Intravenous Ceftriaxone
The efficacy of oral amoxicillin is considered equal to that of ceftriaxone in community-acquired pneumonia among children. Also, there are some factors that contradict the usage of ceftriaxone, like antibiotic resistance…
- Trial name
- NCT06532409
- Testing
- Amoxicillin/CA, IV ceftriaxone
- Where
- Pakistan
- Volunteers
- 114 people
- Sponsor
- RESnTEC, Institute of Research
Non-Severe Pneumonia With Wheeze
Indiaclen Short Course Amoxycillin Therapy for Pneumonia With Wheeze
Background: The current Integrated management of childhood infections (IMCI) algorithm prescribes that children with wheeze and fast breathing presenting to first level health facilities are given antibiotics if they continue to…
- Trial name
- NCT00407394
- Testing
- Amoxycillin
- Where
- India
- Volunteers
- 2,000 people
- Sponsor
- King George's Medical University
Pneumonia
Efficacy of Single Versus Double Dose of Oral Amoxicillin for Non-Severe Pneumonia in Children
The World Health Organization's (WHO) standard case management strategy for reducing acute respiratory infection (ARI) related mortality recommends oral cotrimoxazole and oral amoxicillin as first line drugs for the treatment of…
- Trial name
- NCT00130013
- Testing
- Oral Amoxicillin
- Where
- Pakistan
- Volunteers
- 900 people
- Sponsor
- ARI Research Cell
Malaria, Diarrhea
Integrated Community Case Management Study in Eastern Province, Zambia
This study will provide important evidence to the Ministry of Community Development, Mother and Child Health (MCDMCH) and the Ministry of Health (MOH) on how to effectively implement iCCM with a focus on improving both the flow…
- Conditions
- Malaria, Diarrhea, Pneumonia
- Trial name
- NCT02866097
- Testing
- mHealth inventory management, Supportive supervision, ICCM current standard of care
- Where
- Zambia
- Volunteers
- 3,840 people
- Sponsor
- Zambia Center for Applied Health Research and Development
Bacterial Infections
Effect of Bifidobacterium Breve PRL2020 (an Amoxicillin-clavulanate-resistant Strain) on Gastrointestinal Symptoms and Gut Microbiota Composition in Children Treated With Amoxicillin or Amoxicillin/Clavulanate
Amoxicillin or Amoxicillin/Clavulanic acid antibiotic therapy has been shown to be associated with disrupting the microbiota population particularly Bifidobacterium, which may have further GI clinical implications.
- Trial name
- NCT05840588
- Testing
- Antibiotic Treatment, Probiotic Bifidobacterium breve PRL2020 (Brevicillin®) treatment
- Where
- Italy
- Volunteers
- 121 people
- Sponsor
- Liaquat University of Medical & Health Sciences
Pregnancy Related
Phase 1 Study of the Pharmacokinetics of Amoxicillin in Pregnancy
The study design is a prospective phase I pharmacokinetic study focused on dosing of 500 mg oral amoxicillin administration in pregnant women in the 2nd and 3rd trimester.
- Trial name
- NCT05309928
- Testing
- Amoxicillin
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- University of Alabama at Birmingham
Pharmacokinetics, Amoxicillin-clavulanate
Pediatric Antibiotic Dosing in Extracorporal Membrane Oxygenation (PADECMO)
Pharmacokinetics of antibiotics in critically ill neonates, infants and children on extracorporeal membrane oxygenation (ECMO).
- Conditions
- Pharmacokinetics, Amoxicillin-clavulanate, Piperacillin-tazobactam, Meropenem
- Trial name
- PADECMO (NCT06426836)
- Testing
- Amoxicillin-clavulanate, Piperacillin-tazobactam, Meropenem
- Where
- 3 sites in Belgium
- Volunteers
- 300 people
- Sponsor
- University Hospital, Ghent
Amoxicillin Allergy
Diagnosing Drug Allergy: the T is the Key
The goal of this clinical trial is to validate a newly developed test in the diagnosis of patients with amoxicillin allergy (i.e. T-cell activation test).
- Trial name
- TAT (NCT06409884)
- Testing
- T-cell activation test using intracellular markers
- Where
- Belgium
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- University Hospital, Antwerp
Acute Otitis Media
A Single, High-Dose Azithromycin Extended Release (60 mg/kg) Compared With 10 Days of High-Dose Amoxicillin Clavulanate in Children With Ear Infections at High Risk of Persistent/Recurrent Ear Infections
A phase 3 randomized, multicenter, double blind, double dummy study to assess the efficacy, safety, and compliance of a single dose of azithromycin extended release compared with a 10-day course of amoxicillin/clavulanate twice…
- Trial name
- NCT00643292
- Testing
- amoxicillin/clavulanate postassium (Augmentin ES-600), azithromycin SR
- Where
- 48 sites in United States, Argentina and 11 more
- Volunteers
- 902 people
- Sponsor
- Pfizer
Acute Uncomplicated Appendicitis
Efficacy of Non Operative Treatment With Amoxicillin/Clavulanic Acid Versus Surgical Treatment in Acute Uncomplicated Appendicitis in Children
The majority of children with uncomplicated acute appendicitis may be considered for either a non-operative or an operative management.
- Trial name
- NACAC (NCT07587450)
- Testing
- Amoxi Clavulanate, appendicectomy
- Where
- 10 sites in France
- Volunteers
- 724 people
- Sponsor
- University Hospital, Toulouse
Tonsillitis
Efficacy Study of Pristinamycin Versus Amoxicillin to Treat Tonsillitis Induced by Streptococcus in Children
The primary objective of this study is to demonstrate the non-inferiority, at the assessment visit (V3 (D10/D14)), in terms of bacteriological efficacy of pristinamycin (PRI) administered for 4 days versus amoxicillin (AMX)…
- Trial name
- PRI-angine (NCT00393744)
- Testing
- pristinamycin, amoxicillin
- Where
- France
- Volunteers
- 395 people
- Sponsor
- Sanofi
Bronchitis, Acute, Community-acquired Pneumonia
Multimodal Stewardship Programme to Improve Antibiotic Prescribing for Children With Lower Respiratory Tract Infections
Children with lower respiratory tract infection (LRTI) are still often prescribed antibiotics in ways that depart from national guidelines.
- Conditions
- Bronchitis, Acute, Community-acquired Pneumonia, Respiratory Tract Infections
- Trial name
- PRACTICE-LRTI (NCT07893834)
- Testing
- PRACTICE-LRTI multimodal antimicrobial stewardship programme
- Where
- Finland
- Volunteers
- 50,000 people
- Sponsor
- Tampere University
Syphilis, Congenital
Congenital Syphilis Treatment Trial (CONSISTENT) in Neonates
The Investigator hypothesize that the treatment efficacy will be similar in both study arms. Secondary outcomes and endpoints will characterize safety by comparing adverse events (AEs), tolerability, and adherence to therapy in…
- Trial name
- NCT07457385
- Testing
- Benzathine Penicillin, Amoxicillin
- Where
- 11 sites in United States
- Volunteers
- 374 people
- Sponsor
- University of Alabama at Birmingham
Acute Otitis Media
Comparison of Amoxicillin and Amoxicillin + Clavulanic Acid in Treating Acute Otitis Media in Children
This study aims to compare the effectiveness of two treatments for children with acute otitis media (middle ear infection). The two treatments being compared are amoxicillin alone and a combination of amoxicillin plus clavulanic…
- Trial name
- NCT06895135
- Testing
- Amoxicillin, Clavulanic Acid
- Volunteers
- 162 people
- Sponsor
- University of Health Sciences Lahore
Buruli Ulcer
Beta-Lactam Containing Regimen for the Shortening of Buruli Ulcer Disease Therapy
Buruli ulcer (BU) is a skin Neglected Tropical Disease (NTD) that is caused by Mycobacterium ulcerans. It affects skin, soft tissues and bones causing long-term morbidity, stigma and disability.
- Trial name
- BLMs4BU (NCT05169554)
- Testing
- Standard [RC8]: rifampicin plus clarithromycin (RC) therapy for 8 weeks., Investigational [RCA4]: standard (RC) plus amoxicillin/clavulanate (A) for 4 weeks.
- Where
- 3 sites in Benin
- Volunteers
- 140 people
- Sponsor
- Fundacion Agencia Aragonesa para la Investigacion y Desarrollo (ARAID)
Otitis Maedia
Special Drug Use Investigation for CLAVAMOX® (Amoxicillin/Clavulanate) Pediatrics Dry Syrup (Every Indication Excluded Otitis Media)
This post-marketing surveillance study of CLAVAMOX® was designed to collect and assess the information on proper use, such as safety and efficacy, under actual use conditions, targeting pediatric Japanese patients with diseases…
- Trial name
- NCT01406275
- Testing
- Amoxicillin and clavulanate
- Volunteers
- 363 people
- Sponsor
- GlaxoSmithKline