Clinical trials: Anaphylactic Reaction
Perioperative/Postoperative Complications, Anaphylaxis
Diagnosis and Allergen Identification of Perioperative Anaphylaxis
Perioperative anaphylaxis may lead to fatal respiratory and/or circulatory events, yet both clinical diagnosis and management are challenging.
- Conditions
- Perioperative/Postoperative Complications, Anaphylaxis, Tryptase, Allergens
- Trial name
- NCT06793163
- Where
- 6 sites in China
- Volunteers
- 115 people
- Sponsor
- Peking University First Hospital
Upper Respiratory Tract Infection;, Acute Tracheobronchitis
A Registry Study on Reduning（a Chinese Medicine Injection）Used in Hospitals in China
This study was advocated by Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences in January 2013.
- Trial name
- NCT01824719
- Where
- China
- Volunteers
- 3,000 people
- Sponsor
- China Academy of Chinese Medical Sciences
Anaphylaxis, Biphasic Anaphylactic Reaction
SHARED Study (Saguenay Hospitals Anaphylaxis Rule for Early Discharge)
Anaphylaxis is a potentially fatal condition with a prevalence between 0.05 and 2% in the general population. This is therefore a frequent reason for emergency visits.
- Conditions
- Anaphylaxis, Biphasic Anaphylactic Reaction, Rebound Anaphylactic Reaction
- Trial name
- SHARED (NCT04755881)
- Testing
- Occurence of biphasic reaction following anaphylaxis
- Where
- Canada
- Volunteers
- 191 people
- Sponsor
- Université de Sherbrooke
Milk Allergy, Anaphylaxis
Safety of Oral Immunotherapy for Cow's Milk Allergy in School-aged Children
The purpose of this study is to study the number of Participants with Adverse Events as a Measure of Safety and Tolerability.
- Trial name
- NCT01361347
- Testing
- milk
- Where
- Finland
- Volunteers
- 28 people
- Sponsor
- Tampere University Hospital
Wheat Allergy, Anaphylaxis Food
Major Allergen in Wheat Anaphylaxis in Thai Population
To study Major allergen in Wheat anaphylaxis in Thai population To study and compare demographic data between group of wheat anaphylaxis
- Conditions
- Wheat Allergy, Anaphylaxis Food, Anaphylaxis Exercise
- Trial name
- NCT03487315
- Testing
- immunoblot
- Where
- Thailand
- Volunteers
- 36 people
- Sponsor
- Mahidol University
Mastocytosis
Molecular Mechanisms and Diagnosis of Mastocytosis
Mastocytosis is a disorder characterized by presence of excessive numbers of mast cells in skin, bone marrow and internal organs.
- Trial name
- NCT00336076
- Testing
- Collection of blood and bone marrow
- Where
- United States
- Volunteers
- 136 people
- Sponsor
- University of Michigan
Food Allergy
Registry of Food Allergy Oral Immunotherapy Treatment
The purpose of this patient registry is to demonstrate safety and efficacy of food oral immunotherapy in food allergic patients. Factors that lead to adverse reactions will be identified.
- Trial name
- NCT03059589
- Where
- United States
- Volunteers
- 2,000 people
- Sponsor
- Food Allergy Support Team
Pneumonia;, Bronchitis
A Registry Study on Tanreqing（a Chinese Medicine Injection）Used in Hospitals in China
This study was advocated by Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences in December 2012.
- Trial name
- NCT01824732
- Where
- China
- Volunteers
- 3,000 people
- Sponsor
- China Academy of Chinese Medical Sciences
Fish Allergy, Food Hypersensitivity
FASC: Fish Allergy in Spanish Children - A Study of New Cases of Fish Allergy in Children and Adolescents
Fish allergy is one of the leading causes of food-induced allergic reactions in children, but the clinical presentation and patterns of sensitization vary considerably among patients and geographical regions.
- Conditions
- Fish Allergy, Food Hypersensitivity, IgE-Mediated Food Allergy
- Trial name
- FASC (NCT07727148)
- Volunteers
- 120 people
- Sponsor
- Carmelo Escudero
Pompe Disease
Alglucosidase Alfa Pompe Safety Sub-Registry
To collect uniform and meaningful data on patients with Pompe disease who experience anaphylaxis, severe allergic reactions, and/or signals of severe cutaneous and/or systemic immune complex-mediated reactions following treatment…
- Trial name
- NCT01710813
- Testing
- alglucosidase alfa
- Where
- 18 sites in United States, Belgium and 4 more
- Volunteers
- 110 people
- Sponsor
- Genzyme, a Sanofi Company
Upper Respiratory Tract Infection, Acute Tracheobronchitis
A Registry Study of 100 Thousand Cases of Pediatric Patients on Reduning Injection（a Chinese Medicine Injection）Used in Hospitals in China
This study was advocated by Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences in February 2018.
- Trial name
- NCT03461692
- Testing
- patients under 14 years of age using Reduning injeciton
- Volunteers
- 100,000 people
- Sponsor
- China Academy of Chinese Medical Sciences
Peanut Allergy
Study of Tolerance to Oral Peanut
Open pilot study of peanut oral immunotherapy in 22 children with peanut allergy
- Trial name
- STOP (NCT01259804)
- Testing
- Peanut oral immunotherapy
- Where
- United Kingdom
- Volunteers
- 22 people
- Sponsor
- Cambridge University Hospitals NHS Foundation Trust
Tree Nut Allergy
Re-Introducing Nuts in Allergic Patients
This study aims to compare the safety and the compliance to different procedures (A: at home or B: at the hospital) for introducing tree nuts into the diet of patients with Immunoglobulin E (IgE)-mediated allergy to the…
- Trial name
- ReINA (NCT04151069)
- Testing
- Procedure A, Procedure B, Control group
- Where
- Greece
- Volunteers
- 60 people
- Sponsor
- National and Kapodistrian University of Athens
Epinephrine, Hypersensitivity, Immediate
Pharmacokinetics and Safety of a Single Dose of Epinephrine Nasal Spray in Paediatric Allergy Patients
This Phase 2, open-label, single-arm study will evaluate the pharmacokinetics, pharmacodynamics, safety, and tolerability of a single dose of epinephrine nasal spray (ENS) in children and adolescents 2 to 17 years of age with a…
- Conditions
- Epinephrine, Hypersensitivity, Immediate, Anaphylaxis
- Trial name
- NCT07891780
- Testing
- Epinephrine Nasal Spray, 2.5 mg, Epinephrine Nasal Spray, 5.25 mg
- Where
- 2 sites in United States
- Volunteers
- 44 people
- Sponsor
- Hikma Pharmaceuticals USA Inc.
Penicillin Allergy
Oral Penicillin Challenge and Allergy De-labeling in Children
The primary purpose of this study is to investigate the portion of penicillin allergy labels that are not true allergies using oral amoxicillin challenges among pediatric patients.
- Trial name
- NCT05563610
- Testing
- Amoxicillin 500mg
- Where
- United States
- Volunteers
- 31 people
- Sponsor
- Phoenix Children's Hospital
Allergy, Allergic Reactions
Maximum Lysis on Thromboelastography as a Marker of Systemic Severity in Acute Allergic Reactions
The purpose of this research is to better understand the mechanisms behind allergic reactions.
- Conditions
- Allergy, Allergic Reactions, Anaphylaxis, Biomarkers / Blood
- Trial name
- NCT07905911
- Testing
- Thromboelastogram
- Where
- United States
- Volunteers
- 250 people
- Sponsor
- Mayo Clinic
Anaphylaxis Food
Predicting Peanut Anaphylaxis and Reducing Epinephrine
This research study is testing a new way to look for the early stages of anaphylaxis. Eligible participants will have a small monitor (transepidermal water loss) placed on the forearm during a food challenge (for peanut…
- Trial name
- PrePARE (NCT05696236)
- Testing
- Transepidermal water loss (TEWL) monitor and stopping rules, Monitor (TEWL) without stopping rules
- Where
- United States
- Volunteers
- 51 people
- Sponsor
- University of Michigan
Allergic Asthma
Pharmacosurveillance Data Repository of Patients With and Without History of Anaphylactic Reactions Subsequent to Xolair Dosing
This study will establish a clinical data and serum repository of anaphylaxis cases associated with Xolair administration and control patients who have received Xolair without associated anaphylaxis.
- Trial name
- X-PAND (NCT00813748)
- Testing
- Xolair
- Where
- 7 sites in United States
- Volunteers
- 118 people
- Sponsor
- Genentech, Inc.
Mastocytosis, Anaphylaxis
Blood Factors in Mastocytosis and Unexplained Anaphylaxis and Flushing
This study will 1) identify characteristics of bone marrow mast cells in patients with unexplained anaphylaxis and flushing or with mastocytosis and 2) determine whether mastocytosis might be the underlying cause of unexplained…
- Trial name
- NCT00047918
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Anaphylaxis, Allergy
Mechanisms of Anaphylaxis
The purpose of this study is to explore different mechanisms for anaphylaxis and find novel biomarkers for this hypersensitivity syndrome.
- Conditions
- Anaphylaxis, Allergy, Transfusion Reaction, Febrile Transfusion Reaction
- Trial name
- ANAMEK (NCT03182491)
- Testing
- Biomarkers (platelet activating factor [PAF], anaphylatoxins) and basophil activation test (BAT)
- Where
- Norway
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Haukeland University Hospital