Clinical trials: Anaphylaxis
Perioperative/Postoperative Complications, Drug-Induced Anaphylaxis
Perioperative Anaphylaxis in Patients Attending University Hospitals (Egypt - UK).
Perioperative anaphylaxis is associated with significant morbidity and mortality. Most textbooks describe it as a rare event of the order of 1 in 10 to 1 in 20,000 general anaesthetic cases.
- Trial name
- NCT03393091
- Where
- 2 sites in Egypt, United Kingdom
- Volunteers
- 480 people, healthy volunteers welcome
- Sponsor
- Assiut University
Asthma in Children, Allergy
Advanced Multimodal Wireless Vital Signs Monitoring for Patients With Asthma and Anaphylaxis
The primary objective of this study is to assess the function and reliability of a non-invasive, skin-like electronic sensor. We hypothesize that this skin sensor will address an unmet need to wirelessly, noninvasively, and…
- Trial name
- NCT04360213
- Testing
- Advanced multimodal wireless vital signs monitor
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Northwestern University
Hypersensitivity
Coreg and HSRs-Updated Analysis
A cluster of reports of hypersensitivity reactions among patients who switched from carvedilol (immediate release formulation, referred to hereafter as carvedilol) to carvedilol extended release was received during the initial…
- Trial name
- NCT01316952
- Testing
- Carvedilol immediate release only, Carvedilol extended release only, Long acting β-blockers
- Volunteers
- 1 people
- Sponsor
- GlaxoSmithKline
Status Epilepticus, Anaphylaxis
Smartphone Apps for Pediatric Resuscitation
Medication errors are common in children. Characteristics of errors during critical situations in the Emergency Department are ill-defined and might be more frequent than previously thought.
- Trial name
- SMARTER (NCT02958605)
- Testing
- Smartphone apps, Handbook
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- St. Justine's Hospital
Eczema, Egg Allergy
Promoting Tolerance to Peanut in High-Risk Children
This study will evaluate whether early exposure to peanuts promotes tolerance and provides protection from developing peanut allergy in children who are allergic to eggs or who have severe eczema.
- Conditions
- Eczema, Egg Allergy, Food Allergy
- Trial name
- LEAP (NCT00329784)
- Testing
- Peanut Consumption Group
- Where
- United Kingdom
- Volunteers
- 640 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Hemoptysis, Perioperative Complication
Study of the Role of Hemostasis in Perioperative Anaphylaxis
Anaphylaxis is a severe and life-threatening complication during the perioperative period. Perioperative anaphylaxis is still associated with a significant mortality despite quick and efficient management using epinephrine, the…
- Conditions
- Hemoptysis, Perioperative Complication, Anaphylaxis
- Trial name
- HEMOCANOPE (NCT04825158)
- Volunteers
- 30 people
- Sponsor
- University Hospital, Strasbourg, France
Peanut Allergy, Peanut Hypersensitivity
A Safety and Efficacy Study of PVX108 in Children and Adolescents With Peanut Allergy
The overall aims of this study are to demonstrate that treatment with PVX108 immunotherapy has an acceptable safety profile and is effective for reducing clinical reactivity to peanut protein in children and adolescents with…
- Conditions
- Peanut Allergy, Peanut Hypersensitivity, Peanut-Induced Anaphylaxis, Immune System Diseases
- Trial name
- NCT05621317
- Testing
- PVX-108
- Where
- 14 sites in United States, Australia
- Volunteers
- 95 people
- Sponsor
- Aravax Pty Ltd
Adverse Drug Event, Adverse Drug Reaction
Post-marketing Safety Surveillance of Breviscapine Powder-Injection : a Registry Study
This registry aims to monitor the safety of Breviscapine Powder-Injection and to identify the potential risk factors for the adverse drug reactions.
- Conditions
- Adverse Drug Event, Adverse Drug Reaction, Chinese Medicine, Anaphylactic Reaction
- Trial name
- NCT02559960
- Testing
- Breviscapine Powder-Injection
- Where
- 15 sites in China
- Volunteers
- 20,000 people
- Sponsor
- Zhong Wang
Food Allergy, Anaphylaxis
Evaluation of the Sphingolipid Metabolite S1P as a Novel Biomarker in Food Allergy
Food allergies represent an increasing health concern in the industrialized countries and especially affect pediatric patients. In this population adverse reactions against food compounds can lead to anaphylactic reactions.
- Trial name
- NCT01776489
- Where
- Austria
- Volunteers
- 70 people
- Sponsor
- Medical University of Vienna
Eosinophilic Disease, Immune Deficiency
Screening Protocol for Genetic Diseases of Allergic Inflammation
Background: Mast cells are responsible for most symptoms of allergic reactions. In some allergic diseases, it is unusually easy to cause mast cells to release their contents and cause allergic reactions.
- Conditions
- Eosinophilic Disease, Immune Deficiency, HaTS, Urticaria Anaphylaxis
- Trial name
- NCT00852943
- Where
- United States
- Volunteers
- 834 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Anaphylaxis, Allergy
Clinical Investigation on Allergic-like Reactions and Oculo-respiratory Syndrome After the H1N1 Pandemic Vaccine
During the 2009-2010 immunization campaign against pandemic H1N1, some people reported having allergic-like reactions (anaphylaxis(a shock-like reaction), hives, swelling, etc.).
- Conditions
- Anaphylaxis, Allergy, Oculorespiratory Syndrome, Allergic-like Reactions
- Trial name
- NCT01247415
- Where
- 7 sites in Canada
- Volunteers
- 138 people
- Sponsor
- PHAC/CIHR Influenza Research Network
Anaphylaxis
Acquisition and Long-term Observation of Patients With Severe Allergic Reactions
The Anaphylaxis Registry aims to assess data in a standardized form about symptoms, triggers, cofactors and therapy management from patients who experienced an anaphylactic reaction.
- Trial name
- NCT05210543
- Testing
- not applicable, observational study
- Where
- Germany
- Volunteers
- 20,000 people
- Sponsor
- Charite University, Berlin, Germany
Anaphylaxis
Canadian Anaphylaxis Network- Predicting Recurrence After Emergency Presentation for Allergic REaction
BACKGROUND: Anaphylaxis is the most severe form of allergy that rapidly affects multiple body systems and can be deadly. The highest incidence of anaphylaxis is in children and adolescents.
- Trial name
- CAN-PREPARE (NCT05135377)
- Testing
- Observational
- Where
- 7 sites in Canada
- Volunteers
- 1,682 people
- Sponsor
- Waleed Alqurashi
Child, Anaphylaxis
Observation Periods and Biphasic Reaction Risk Factors in Pediatric Emergency Anaphylaxis Cases
This study reviews the medical records of children who presented to the pediatric emergency department of Adnan Menderes University Hospital with a diagnosis of anaphylaxis between January 2014 and December 2024.
- Conditions
- Child, Anaphylaxis, Pediatric Emergency Care, Biphasic Anaphylactic Reaction
- Trial name
- NCT07231393
- Volunteers
- 67 people
- Sponsor
- Aydin Adnan Menderes University
Anaphylaxis
Pharmacokinetics of Intramuscular Adrenaline in Food--Allergic Teenagers
Food allergy affects up to 2% of adults and 8% of children in the United Kingdom (UK), and is a major public health issue. It is the commonest cause of life-threatening allergic reactions (anaphylaxis), which can be fatal.
- Trial name
- PIMAT (NCT03366298)
- Testing
- Epipen 0.3mg, Emerade 300mcg, Emerade 500mcg
- Where
- United Kingdom
- Volunteers
- 12 people
- Sponsor
- Imperial College London
Bronchospasm
Bronchospasm During Anesthetic Induction: Study of Clinical Characteristics and Treatments Administered According to Etiology
Bronchospasm during anaesthesia is a rare but potentially life-threatening event. They are classically part of IgE-dependent anaphylaxis but can also occur as an independent clinical entity, triggered by inflammatory factors such…
- Trial name
- NCT05025709
- Where
- France
- Volunteers
- 31 people
- Sponsor
- Central Hospital, Nancy, France
Food Allergy
One-year Survey of Anaphylaxis in Outpatient Children Allergic to Peanuts, Walnuts/Hazelnuts, Shellfish
In Italy, few data about anaphylaxis due to peanuts in pediatric age are available, conversely data about walnuts/hazelnuts, shellfish/mollusks anaphylaxis have not yet been collected.
- Trial name
- NCT02640560
- Testing
- Food allergy questionnaire, Control Questionnaire
- Volunteers
- 200 people
- Sponsor
- Stefania La Grutta, MD
Peanut Hypersensitivity, Anaphylaxis
PEAnut Anaphylaxis Predictors
Peanut allergy can be life-threatening. Current diagnostic techniques for peanut allergy have high sensitivity, but not high specificity.
- Trial name
- PEAAP (NCT02424136)
- Testing
- Questionnaire, Peanut Skin prick test, Fraction of exhaled nitric oxide
- Where
- Australia
- Volunteers
- 40 people
- Sponsor
- John Hunter Children's Hospital
Peanut and Tree Nut Allergy
Accidental Reactions in Peanut/Tree Nut Allergic Children
Food allergy is an immune reaction, triggered by food protein allergens, of varying severity, from mild local reaction to life threatening anaphylaxis and fatalities.
- Trial name
- ALLERGY (NCT05671471)
- Where
- France
- Volunteers
- 147 people
- Sponsor
- University Hospital, Lille
Food Hypersensitivity, Anaphylaxis
A Study About the Use of Omalizumab in the Treatment of Food Allergy and Anaphylaxis
This was a retrospective, multi-center observational study conducted across four allergy departments in Europe (Berlin, Leipzig, Barcelona, and Basel).
- Trial name
- NCT07027163
- Where
- United States
- Volunteers
- 62 people
- Sponsor
- Novartis Pharmaceuticals