Clinical trials: Anatomical Pathological Condition
Pelvic Organ Prolapse
Comparison of Sacrospinous Ligament Fixation and Uterosacral Ligament Suspension for Apical Prolapse Surgery: A Randomized Clinical Trial
the main aim of this study is to study the anatomical and functional outcomes of two vaginal apical fixation procedures; sacrospinous ligament fixation and uterosacral ligament suspension, for pelvic organ prolapse surgery.
- Trial name
- NCT05668130
- Testing
- Sacrospinous ligament fixation, Uterosacral Ligament Suspension
- Volunteers
- 194 people
- Sponsor
- B.P. Koirala Institute of Health Sciences
Obstructed Defecation Syndrome, Rectocele
Stapled TransAnal Rectal Resection (STARR) With Contour® TranstarTM
The stapled transanal rectal resection (STARR procedure) is an effective treatment for obstructed defecation syndrome (ODS) caused by intussusception and rectocele.
- Conditions
- Obstructed Defecation Syndrome, Rectocele, Intussusception, SNS
- Trial name
- STARR (NCT00673400)
- Testing
- Stapled transanal rectum resection
- Where
- Switzerland
- Volunteers
- 52 people
- Sponsor
- Cantonal Hospital of St. Gallen
Esophageal Atresia, Tracheoesophageal Fistula
Transanastomotic Tube for Proximal Esophageal Atresia With Distal Tracheoesophageal Fistula Repair
This trial will compare the effectiveness of two common surgical practices for Type C esophageal atresia repair: esophageal atresia (EA) with distal tracheoesophageal fistula (TEF).
- Trial name
- TEF (NCT03730454)
- Testing
- Transanastomotic Tube (5FR), No Transanastomotic Tube
- Where
- 10 sites in United States
- Volunteers
- 142 people
- Sponsor
- Phoenix Children's Hospital
Laparoscopic Cholecystectomy, Post Operative Analgesia
Postoperative Pain After Instillation Of Bupivacaine During Laparoscopic Cholecystectomy
This study aims to compare the level of postoperative pain experienced by patients undergoing laparoscopic cholecystectomy with and without the use of intraperitoneal bupivacaine.
- Conditions
- Laparoscopic Cholecystectomy, Post Operative Analgesia, Bupivacaine
- Trial name
- BUPA-LC (NCT07098429)
- Testing
- Bupivacain (Postoperative), Normal (0.9%) saline
- Where
- Pakistan
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Recep Tayyip Erdogan Hospital Pakistan - Muzaffargarh
Lumbar Herniated Disc
US-MR Image Fusion-guided Percutaneous Transforaminal Endoscopic Discectomy for the Treatment of Lumbar Disc Herniation
The purpose of this study is to evaluate the feasibility and efficacy of US-MR image fusion-guided percutaneous transforaminal endoscopic discectomy for the treatment of lumbar disc herniation
- Trial name
- NCT03403244
- Testing
- US-MR image fusion-guided PTED, fluoroscopy-guided PTED
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Third Affiliated Hospital, Sun Yat-Sen University
Inguinal Hernia
Laparoscopic TEP (Total Extra-peritoneal) Repair Vs Open PHS (Prolene Hernia System)
Abdominal wall hernias are common, with a lifetime risk of 27% in men and 3% in women. Inguinal and femoral hernias are the most common affections faced by primary care physicians that require surgical intervention.
- Trial name
- NCT03842852
- Testing
- Inguinal hernia repair
- Where
- Israel
- Volunteers
- 577 people
- Sponsor
- Assuta Medical Center
Developmental Delay, Skeletal Abnormalities
Biomarker for Sly Disease (MPS VII) (BioSly)
Development of a new MS-based biomarker for the early and sensitive diagnosis of Sly disease from blood (plasma)
- Conditions
- Developmental Delay, Skeletal Abnormalities, Hepatomegaly, Splenomegaly
- Trial name
- BioSly (NCT02298699)
- Where
- 5 sites in Egypt, Germany and 2 more
- Sponsor
- CENTOGENE GmbH Rostock
Congenital Diaphragmatic Hernia
Management of Late Presenting Congenital Diaphragmatic Hernia .
Diagnosis and different ways of surgical repair of Congenital diaphragmatic hernia
- Trial name
- NCT07397793
- Testing
- MIS and open surgery repair
- Where
- Egypt
- Volunteers
- 10 people
- Sponsor
- Jehad Emam Abdelrahman
Surgical Site Infection, Groin Hernia
Prophylactic Antibiotics in Groin Hernioplasty
The role of prophylactic antibiotics in preventing surgical site infections (SSI) for clean procedures like groin hernia repair remains controversial.
- Conditions
- Surgical Site Infection, Groin Hernia, Hernioplasty
- Trial name
- NCT07111702
- Testing
- Cefazolin
- Where
- Yemen
- Volunteers
- 100 people
- Sponsor
- Sana'a University
Stenosis
Natural History of Asymptomatic Superior Mesenteric Arterial Stenosis.
The aim of this study was to evaluate asymptomatic superior mesenteric artery (SMA) stenosis prognosis according to the presence of coeliac artery (CA) and/or inferior mesenteric artery (IMA) associated stenosis.
- Trial name
- NCT04785105
- Testing
- No intervention
- Where
- France
- Volunteers
- 77 people
- Sponsor
- Hospices Civils de Lyon
Pelvic Organ Prolapse
Validation Study for Robotic Surgery Simulator
A study to determine whether completing a rigorous simulation protocol could provide novice robotic surgeons with actual advanced surgical skills in an operating room setting.
- Trial name
- NCT01618994
- Testing
- Performing robotic supracervical hysterectomy
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- Atlantic Health System
Chronic Rhinosinusitis (CRS), Chronic Rhinosinusitis (CRS) With and Without Nasal Polyps
The German National CRS Registry (GenreCRS): Clinical Evaluation of the New European Academy for Allergy and Clinical Immunology (EAACI) Criteria for CRSwNP Disease Control, Remission and Cure in a Real-World Evidence Study Approach
The objective of the study is to establish a registry of patients diagnosed with Chronic Rhinosinusitis with and without Nasal Polyps (CRSwNP/CRSsNP) to collect comprehensive longitudinal real-world evidence from specialised…
- Trial name
- GenreCRS (NCT06815211)
- Volunteers
- 500 people
- Sponsor
- Ärzteverband Deutscher Allergologen e.V.
Epithelial High Grade Serous Ovarian Cancer
Elements of Adaptive Immunity in Epithelial Ovarian Cancer
The study seeks to evaluate the presence and correlation with clinical outcome of several components of adaptive immunity (TILs, TLS, plasma cells and PD-L1 expression) in tumor specimens of patients with EOC treated with…
- Trial name
- NCT07528911
- Testing
- Assessment of elements of adaptive immunity in tumor biopsies
- Where
- Greece
- Volunteers
- 687 people
- Sponsor
- Hellenic Cooperative Oncology Group
Nevus, Seborrheic Keratosis (SK)
Impact of Skin Type on Wonud Healing and Scarring Following Facial Skin Surgery
The goal of this observational study is to learn how an individual's skin type influences the wound healing process and scar formation in Chinese patients undergoing facial dermatologic surgery.
- Conditions
- Nevus, Seborrheic Keratosis (SK), Cyst, Lipoma
- Trial name
- NCT07384299
- Where
- China
- Volunteers
- 173 people
- Sponsor
- Union Hospital, Tongji Medical College, Huazhong University of Science and Technology
Tamsulosin, Extracorporeal Shock Wave Lithotripsy
The Efficacy and Safety of Medical Expulsive Therapy After Extracorporeal Shock Wave Lithotripsy (ESWL) in Pediatric Urolithiasis
The aim of this study is to evaluate the clinical efficacy and safety of MET after ESWL in pediatric urolithiasis.
- Conditions
- Tamsulosin, Extracorporeal Shock Wave Lithotripsy, Stone, Kidney, Stone, Urinary
- Trial name
- NCT05759767
- Testing
- Tamsulosin
- Where
- Egypt
- Volunteers
- 120 people
- Sponsor
- Mansoura University
Sarcopenia, Respiratory Function Impaired
Respiratory Sarcopenia in Institutionalized Older Adults in the Region of Murcia
Objectives: The objectives of this study are to describe the prevalence of respiratory sarcopenia in institutionalized older adults.
- Trial name
- NCT06130800
- Where
- Spain
- Volunteers
- 127 people, healthy volunteers welcome
- Sponsor
- Felipe León Morillas
Autoimmune Polyendocrinopathy Candidiasis Ectodermal Dystrophy (Apeced), Alopecia Areata
Evaluate the Efficacy and Safety of Ruxolitinib on Hair Regrowth in Patients With Autoimmune Polyendocrinopathy Candidiasis Ectodermal Dystrophy (APECED)-Associated Alopecia Areata
Background: Autoimmune polyendocrinopathy candidiasis ectodermal dystrophy (APECED) is a problem of the immune system. In people with APECED, the immune system makes a mistake and attacks the body.
- Trial name
- NCT05398809
- Testing
- Ruxolitinib
- Where
- United States
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Surgery
Caudal Block Versus Ultrasound Guided Ilioinguinal/Iliohypogastric Block in Pediatric Patient
The caudal block is the most common technique for inguinal surgery. Increased use of ultrasound in regional analgesia techniques has been improved the practise of the peripheral nerve blocks.
- Trial name
- NCT03258736
- Testing
- inguinal hernia surgery
- Where
- Turkey (Türkiye)
- Volunteers
- 110 people
- Sponsor
- Istanbul University
Splenomegaly; Congestive, Chronic, Panhematopenia; Splenic
Ultrasound Guided Microwave Ablation of Splenomegaly in Children
Children with liver cirrhosis frequently develops portal hypertension. One of the serious complications to portal hypertension is splenomegaly, which may result in pancytopenia, especially thrombocytopenia that may cause bleeding…
- Conditions
- Splenomegaly; Congestive, Chronic, Panhematopenia; Splenic, Portal Hypertension
- Trial name
- NCT05050994
- Testing
- Microwave ablation
- Where
- Sweden
- Volunteers
- 10 people
- Sponsor
- Karolinska Institutet
Rectal Prolapse
Comparison of Sclerotherapy Agents Used for Rectal Prolapse Treatment in Children
Introduction Patients with rectal prolapse are treated with injection sclerotherapy, which is the most often used first-line surgical technique.
- Trial name
- Prolapse (NCT06353230)
- Testing
- injection 5% phenol in almond oil, injection 15% hypertonic saline, injection 50% dextrose water
- Where
- Pakistan
- Volunteers
- 93 people
- Sponsor
- King Edward Medical University